Thesis (M.S.)--Ohio University, March, 1988. / Title from PDF t.p.

Implementation of production planning and scheduling systems at Synlait Milk Ltd. for its process manufacturing plant required a project be carried out. Socio-technical considerations as well as ease-of-use for the end-users of a planning system were found to be of the utmost importance in the implementation of a production planning and control system. Implementation options for the systems were weighed and a viable solution found.

The master´s thesis „Study of the of the order in the selected business” is focused on the analyse of the manufacturing order flow in the company První brněnská strojírna Velká Bíteš, a. s. Thesis is divided onto three particular parts. Theoretical part is focused on the research of the professional literature elaborating topics related to process engineering and order management. Analytical part includes description of current state of the manufacturing order flow through the company and SWOT analyses. Proposal part intends to find and elaborate a possible improvement in order to optimize current process.

Cette thèse traite la fabrication de pièces composites par le procédé « Resin Transert Molding » (RTM), appliquée à des tubes de protections thermiques assemblées dans des propulseurs de systèmes d’armes. Ces travaux ont pour objectif de démontrer la faisabilité d’utilisation de ce procédé pour la fabrication de ces pièces complexes. C’est le préformage, première étape du procédé de fabrication par RTM, qui est étudié dans le cadre de cette thèse. Cette étape est cruciale du point de vue de la faisabilité de l’étape d’injection qui la suit dans le procédé RTM mais aussi pour s’assurer de la qualité de la pièce composite finale obtenue. L’objectif des travaux de thèse est triple. Il faut tout d’abord développer le protocole de fabrication répétable adapté pour garantir l’obtention de préformes conformes. Ce protocole devra être viable du point de vue industriel. Pour cela, une démarche expérimentale a été mise en place. Un pilote de laboratoire puis un pilote industriel ont permis de comprendre et maitriser les phénomènes survenant en cours de préformage en faisant varier les paramètres procédé pour la fabrication de nombreux prototypes. Un modèle macroscopique prédictif de la forme globale des plis obtenus à partir des paramètres procédés a été développé à l’aide des observations expérimentales. Un modèle mésoscopique, à l’échelle de la maille élémentaire, a été écrit également. Il permet de prédire, à partir des données constitutives du matériau et d’une géométrie de pièce, la déformation de compaction et de cisaillement, modes de sollicitations prépondérants en cours de préformage, subie par le renfort en cours de la première étape du procédé de fabrication. Ces modèles mésoscopique et macroscopique couplés permettent le développement d’un outil global qui, de manière théorique et prédictive, assure la faisabilité d’une pièce de géométrie connue avec un matériau connu et fournit les paramètres « procédé » optimum pour assurer sa fabrication future. Les phénomènes de déformation en cisaillement et compaction apparaissant sur la tresse en cours de préformage sont donc identifiés et connus. Le procédé de fabrication est optimisé et l’outil prédictif permet d’envisager et tester en amont un changement de matériau, de géométrie de pièce à fabriquer ou de cahier descharges industriel. / This study deals with the manufacture of composite parts by the process "Resin Transert Molding" (RTM), applied to thermal protection tubes. This work aims to demonstrate the feasibility of using this method for the production of these complex parts. This study deals with the first step of the RTM process, the fiber performing. This is critical from the standpoint of the feasibility of injecting step that follows in the RTM process but also to ensure the quality of the final composite part obtained. The aim of the thesis is threefold. Must first develop the manufacturing protocol adapted to ensure repeatable obtaining preforms compliant. This protocol should be viable to the industrial point of view. For this purpose, an experimental approach was implemented. A pilot laboratory and an industrial pilot helped to understand and master the phenomena occurring during forming varying the process parameters for the production of many prototypes. A macroscopic model predictive of overall shape folds obtained from the process parameters has been developed with the experimental observations. A mesoscopic model, the scale of the unit cell was also writing. It can predict, based on the specifications of the material and part geometry, the deformation of compaction and shear stresses. These models mesoscopic and macroscopic allow the development of a global tool that, theoretically predictive and ensures the feasibility of a piece of known geometry with a known material parameters and provides the "process" to ensure its optimum manufacturing future. The phenomena of compaction and shear strain appearing on the braid during preforming are identified and known. The manufacturing process is optimized and the predictive tool allows to explore and test upstream change of material, part geometry in manufacturing or industrial specifications.

This thesis is called "Management of project activities in the enterprises of light industry" and deals with the analysis of the management of project activities, including procurement assessment made objects in terms of quantity and quality, time and cost. The theoretical part is included research issues relating to the manufacture, production processes and their associated characteristics. The practical part describes the characteristics of a social organization, the analysis of manufacturing processes aimed at product realization, production planning, resource management, preparation and production management and quality policy, including an analysis of the produced object. On the basis of these analyzes were set out proposals for a more effective management of the company and improve the functioning of the company in the long run.

<p dir="ltr">The purification of most active pharmaceutical ingredients (APIs) is primarily achieved through crystallization, conducted in batch, semi-batch, or continuous modes. Recently, continuous crystallization has gained interest in the pharmaceutical industry for its potential to reduce manufacturing costs and maintenance. Crystal characteristics such as size, purity, and polymorphism significantly affect downstream processes like filtration and tableting, as well as physicochemical properties like bioavailability, flowability, and compressibility. Developing an optimal operation that meets the critical quality attributes (CQAs) of these crystal properties is essential.</p><p dir="ltr">This dissertation begins by focusing on designing an innovative integrated crystallization system to enhance control over crystalline material properties. The system expands the attainable region of crystal size distribution (CSD) by incorporating multiple Mixed-Suspension Mixed-Product Removal (MSMPR) units and integrating wet milling, classification, and a recycle loop, enhancing robustness and performance. Extensive simulations and experimental data validate the framework, demonstrating significant improvements in efficiency and quality. The framework is further generalized to optimize crystallizer networks for controlling critical quality attributes such as mean size, yield, and CSD by evaluating various network configurations to identify optimal operating parameters.</p><p dir="ltr">The final part of this work concentrates on using the framework to improve continuous production of a commercial API, Atorvastatin calcium (ASC), aiming for higher yield and lower costs. This approach establishes an attainable region to increase crystal sizes and productivity. Due to ASC’s nucleation-dominated nature, the multi-stage system could not grow the crystals sufficiently to bypass granulation, the bottleneck process in ASC manufacturing. Therefore, spherical agglomeration was proposed as an intensification process within an integrated two-stage crystallization spherical agglomeration system to control the size and morphology of ASC crystals and improve downstream processing and tableting. This method proved highly successful, leading to the development of an end-to-end continuous manufacturing process integrating reaction, crystallization, spherical agglomeration, filtration, and drying. This modular system effectively addressed challenges in integrating various unit operations into a coherent continuous process with high production rates.</p>