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Effect of FTY720 on the growth and invasion ability of androgenindependent prostate cancer cellsZhou, Chun, 周純 January 2005 (has links)
published_or_final_version / abstract / Anatomy / Master / Master of Philosophy
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S-allylcysteine (SAC) and S-allylmercaptocysteine (SAMC), water soluble garlic derivatives, suppress growth and invasion of androgen-independent prostate cancer, under in vitro and in vivo conditionsChu, Qingjun., 褚慶軍. January 2006 (has links)
published_or_final_version / abstract / Anatomy / Doctoral / Doctor of Philosophy
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The potential clinical applications of garlic-derived S-allylmercaptocysteine in the treatment of hormone refractory prostatecancerHoward, Edward William. January 2007 (has links)
published_or_final_version / abstract / Anatomy / Doctoral / Doctor of Philosophy
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Structure-function studies of secreted PDZ domain-containing protein 2(sPDZD2)鄭珊, Cheng, Shan, Amy. January 2007 (has links)
published_or_final_version / abstract / Physiology / Master / Master of Philosophy
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Dissecting the therapeutic potential of FTY720: a fungus derived metabolite, on advanced prostatecancerChua, Chee-wai., 蔡志偉. January 2008 (has links)
published_or_final_version / Anatomy / Doctoral / Doctor of Philosophy
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STRUCTURE AND FUNCTION ANALYSIS OF PAR-4El-Guendy, Nadia M. 01 January 2002 (has links)
Par-4 is a leucine zipper domain protein that induces apoptosis on its own in certain cancer cells and in Ras-transformed cells, but not in normal or immortalized cells. Par-4 induces apoptosis by activation of the Fas death receptor pathway and co-parallel inhibition of NF-B transcription activity. Cells that are resistant to apoptosis by Par-4 alone, however, are greatly sensitized by Par-4 to the action of other pro-apoptotic insults such as growth factor withdrawal, TNF, ionizing radiation, intracellular calcium elevation, or those involved in neuronal degeneration such as Alzheimer's, Parkinson's, Huntington's and Stroke. Previous studies have suggested that the apoptosis-sensitization potential of Par-4 is dependent upon inhibition of PKC or WT1 cell survival function by direct interaction between the leucine zipper domain at the carboxy-terminus of Par-4 and the zinc finger domains of PKC or WT1. In this study, I performed structure-function analysis using GFP-fusion proteins and deletion mutants to identify the functional localization and domains of Par-4 that are essential for apoptosis induction. My findings suggest that apoptosis by Par-4 is dependent on its translocation to the nucleus for induction of apoptosis. A bipartite nuclear localization signal sequence corresponding to amino acids 137-155 was necessary for nuclear translocation of Par-4. Importantly, the core residues 137-204 in the center part of Par-4 were necessary and sufficient to induce Fas pathway activation, inhibition of nuclear NF-B transcription activity and apoptosis. These findings imply that binding of Par-4 via its leucine zipper domain to other proteins is dispensable for apoptosis by Par-4.
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Changes in collagen metabolism in benign and malignant human prostatic tissueBurns-Cox, Nicholas January 1999 (has links)
No description available.
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Body Image and Quality of Life among Men with Prostate CancerHarrington, Joanne Mary January 2007 (has links)
It is estimated that more than 218,000 men will be diagnosed with prostate cancer in the year 2007. With a mean age at diagnosis of 72, and extended long-term survival, prostate cancer represents a significant health problem among older men. Despite the fact that the treatment for prostate cancer has significant effects upon one's physical appearance and functional ability, there exists a gap in the literature regarding body image in men with prostate cancer. Additionally, there is a large gap in our knowledge of the relationship of body image and QOL in men with prostate cancer.The purpose of this study was to describe changes in body image and quality of life among men with prostate cancer, to describe the relationship between the two, and to explore the differences in body image and quality of life related to treatment, age, duration of therapy and body mass index.The sample consisted of one hundred and thirty-two older men (> age 60) with prostate cancer, recruited from the oncology and urology out-patient departments at an urban Veterans Affairs Medical Center. The participants completed 2 established questionnaires, the Body Image Scale and the Quality of Life Index Cancer Version. Descriptive and inferential statistics were used in the analysis.For purposes of analysis, the sample was grouped according to treatment with ADT as part of therapy for prostate cancer. The ADT-naive group composed 34.1% of the sample (n = 45); the ADT group composed 65.9% of the sample (n = 87). Whether or not one received ADT was correlated with body image change: those men who received ADT had a greater perception of negative change. There was, however, no difference in quality of life between men who received ADT and men who did not. Neither age nor duration of therapy had any relationship with the perceptions of change in body image or quality of life. A significant negative correlation was demonstrated between body image change and quality of life overall, and with each of the domains.
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Mechanistic studies on CYP17 (17#alpha#-hydroxylase-17,20-lyase)Lee-Robichaud, Peter January 1995 (has links)
No description available.
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Characterization of Laminin Binding Integrin Internalization in Prostate Cancer CellsDas, Lipsa, Anderson, Todd A., Gard, Jaime M.C., Sroka, Isis C., Strautman, Stephanie R., Nagle, Raymond B., Morrissey, Colm, Knudsen, Beatrice S., Cress, Anne E. 05 1900 (has links)
Laminin binding integrins 6 (CD49f) and 3 (CD49c) are persistently but differentially expressed in prostate cancer (PCa). Integrin internalization is an important determinant of their cell surface expression and function. Using flow cytometry, and first order kinetic modeling, we quantitated the intrinsic internalization rates of integrin subunits in a single cycle of internalization. In PCa cell line DU145, 6 integrin internalized with a rate constant (k(actual)) of 3.25min(-1), threefold faster than 3 integrin (1.0min(-1)), 1.5-fold faster than the vitronectin binding v integrin (CD51) (2.2min(-1)), and significantly slower than the unrelated transferrin receptor (CD71) (15min(-1)). Silencing of 3 integrin protein expression in DU145, PC3, and PC3B1 cells resulted in up to a 1.71-fold increase in k(actual) for 6 integrin. The internalized 6 integrin was targeted to early endosomes but not to lamp1 vesicles. Depletion of 3 integrin expression resulted in redistribution of 64 integrin to an observed cell-cell staining pattern that is consistent with a suprabasal distribution observed in epidermis and early PIN lesions in PCa. Depletion of 3 integrin increased cell migration by 1.8-fold, which was dependent on 61 integrin. Silencing of 6 integrin expression however, had no significant effect on the k(actual) of 3 integrin or its distribution in early endosomes. These results indicate that 3 and 6 integrins have significantly different internalization kinetics and that coordination exists between them for internalization. J. Cell. Biochem. 118: 1038-1049, 2017.
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