The One-to-One project is initiated in schools across the country but there is no research on how it affects the students' physical work environment and health from a holistic perspective. Both national, public and private schools face a need to develop the work environment, especially for the students, as the school implements the One-to-One PCs. The study aims to investigate the impact of One-to-One computers on students’ physical and mental health in a work environmental perspective in a secondary school. This study examines: How does the introduction of One-to-One PCs affect mental and physical work environment for pupils in an upper secondary school with vocational training? The study was conducted as a quantitative survey of students at a Swedish secondary school. The result includes that students feel the school work is not geared towards working with a computer as a tool, and that there is a lot that can be done regarding school environment. The study discusses aspects of pupils' health and changes that could improve the school environment.