The aim of this study is to determine the extent to which Quality Management Practices has been effectively adopted and implemented by Pakistani manufacturing companies and to identify best practices for adoption by the companies. The study employed primary and secondary data sources to determine the relationship between QM and Productivity. The study used quantitative methodology for data collection and analysis. The survey responses were categorised into foreign owned companies (FOC's) and local owned companies (LOC's). The outcome of the descriptive and statistical analysis of the survey responses and secondary data of the companies found that, although most of the companies were aware of the significance of the QM practices and Productivity, FOC's were found to have performed highly better in the adoption and implementation of QM practices in their companies compared to locally owned companies. The study also revealed that there is positive relationship between quality and productivity of the manufacturing companies. The evidence deduced from the study shows that foreign owned companies have performed better compared to local owned companies in terms of quality and productivity. Furthermore, the evidence from this study also points out that, automobile sector of Pakistan performed well in the adoption and implementation of QM practices. Strong positive link between quality and productivity was found in the case of automobile companies. This study therefore recommends for manufacturing companies in Pakistan to effectively adopt and implement Quality management practices that encapsulate the study's framework for adoption of QM practices (see figure 7.1).

This thesis is concerned with computerised forensic 3-D facial reconstruction as a means of identification and involves the restoration of the face on the skull in an attempt to achieve a close likeness of the individual when alive. The reconstruction process begins with the biological identification of the skeletal remains, (age, sex, ancestry and build). Facial reconstruction is then carried out and essentially works by building the “face” up from the skull using soft tissue thicknesses at specific locations from existing data. However, it is used as a last resort on skeletonised, badly decomposed or mutilated corpses, when no other information is available; even then it is only accepted as corroborative evidence in court. It is performed in the hope that it may stimulate recognition, and consequently narrow the field of identification, allowing other tests to be carried out, such as radiographic and/or dental comparisons, DNA analysis or other means, to establish positive identification. The advantages of the computerised method over the manual clay reconstruction are speed, rapid editing capability, production of images that can be stored and reconstructions repeated at any time if required. Furthermore, in many cases, the original skull instead of a cast or model may be used for reconstruction because the 3-D computerised procedure is rapid and non invasive. However, the most significant advantage of this technique with regard to the aims and objectives of the thesis is that a number of alternative reconstructions may be produced sequentially for the same skull by using different facial templates from the database that meet the anthropological/biological criteria of the skull. The issues addressed by the study and therefore its main aims are: a) evaluation and b) improvement of the reliability of facial reconstruction using 3-D computer graphics. The methodology involved initially digitizing a skull using a low-power laser scanner and a video camera interfaced to a computer. From a database of previously scanned faces, ten facial templates were selected that matched the anthropological criteria of each of the skulls, i.e. age, sex, ancestry and build. Landmarks with their corresponding soft tissue thicknesses were then located and placed on the skull and the equivalent ones on the face. The 3-D computer graphics then reconstructed the face by morphing (warping) the facial template over the skull by matching the corresponding landmarks on the skull and face with the appropriate soft tissue thicknesses at those landmark locations. The soft tissue thicknesses used at their specific landmark locations also matched the anthropological criteria of the skulls, since soft tissue depths are dependent on age, sex, ancestry and build. One of the major problems with any reconstruction which affect its reliability for identification is the uncertainty of the shape of some of the individual characteristics of soft tissue structures such as shape of lips, ears and nose/nasal tip since there is not direct information on the skull regarding the shape of some of these features. In addition, with the laser scanning system, the faces within the database all have closed eyes, because of the potential laser hazard to the eyes. Thus it is necessary to add “opened” eyes, head and facial hair (where appropriate) to give a realistic appearance to the face. The software provides the facility to export a 2-D view in a TIFF or JPEG format from the 3-D reconstructed image. The file can then be imported into a police identi-kit system such as E-FIT™, which allows the addition of features. In this study five skulls of known individuals were used for reconstruction in the manner explained. Ten facial templates which fulfilled the anthropological criteria (age, sex, ancestry and build) for each skull were used for the rebuilding process, thus totalling fifty reconstructions. The study employed a psychological resemblance test (experiment 1) where 20 different assessors, were asked to select in each case study, the best three matches of the ten reconstructions with the ante-mortem photograph of the individual during life. The results from these tests were correlated with a mathematical shape analysis assessment using Procrustes Analysis in which, the skull was compared in turn with each of the ten facial templates of each case study (experiment 2).The ranking of the assessors’ reconstruction choice was correlated with the ranking of the Procrustes Analysis by using Spearman’s Rank Order Correlation. The results indicate that although not statistically significant, it would seem however, that in some of the case studies, the mathematical approach using Procrustes Analysis does seems to capture some perceptual similarity in human observers. Experiment 3, similar to experiment 1, was a further psychological resemblance test, which involved implementing E-Fit features on four of the ten reconstructed images per case study. Assessors were asked to select the closest E-Fit image match with the ante-mortem photograph. Again, results indicated that, although not statistically significant, adding E-Fit feature to the images appears to improve perceptual similarity in human observers, provided, the limitations of adding these characteristics are addressed. Furthermore, there also appears to be good agreement in most of the case studies between the two psychological resemblance tests using the two different sets of assessors in experiment 1 and 3 (reconstruction choice and E-Fit choice, respectively). Further work involving anthropometric comparisons and using two methods of assessment (landmark line matching between images and proportion indices) was also carried out (experiment 4). It was found that matching landmark lines between images appeared to be only of limited value due to the images not being aligned at exactly the same viewpoint and magnification. It should be appreciated that because the thesis was based on recognition and was not an anthropometric study, precise alignment of viewpoints was not a requirement. Hence using the same data from the study, although images were in the frontal view, they were not aligned to the accuracy acceptable for an anthropometric study as there was no requirement to so. It would appear that, although there was some correspondence between the discrepant distances and the first and second ranked reconstructions, no firm conclusions could be drawn from this technique and therefore does not assist in understanding the way observers made their choices. Further tests would need to be carried out (beyond the scope of the thesis) to reach any firm conclusions. Undoubtedly, given the complex nature of the recognition process, it would have been desirable to use reconstructions of persons known to the assessors rather than asking them to assess unfamiliar persons, since it is well established that familiar faces are easier to recognize than those that are unfamiliar to observers. It should be appreciated however, that, although the study was designed in this way for practical and ethical reasons, it nevertheless does not truly reflect the real operational forensic scenario. Furthermore, recognition/matching is a much more complex process and even a reconstructed face which may be generally morphologically similar to the person in life may not capture perceptual similarity in human observers, especially in an unfamiliar scenario. It is not certain that identification will always occur even when the facial reconstruction bears good resemblance to the target individual.

(no abstract available)

No description available.

The central aim of this dissertation is to make an unambiguous international trade policy recommendation for developing countries grounded on rigorous economic theory. As is generally known, trade models featuring increasing returns to scale and imperfect competition have challenged the mainstream case for free trade which is built upon unrealistic assumptions like constant return to scale and perfect competition. In this context, the core contribution of this dissertation is the restatement of the original free-trade case made by the classical political economists Adam Smith and David Ricardo. This restatement is based on the accurate interpretation of Ricardo's famous numerical example in chapter 7 of the Principles. The classical case for free trade formulated by Smith and Ricardo neither relies on unrealistic assumptions nor the laissez-faire doctrine. On the contrary, it stipulates that free trade should always be accompanied by public policies that expand the provision of public education, job training, health care and infrastructure. Moreover, a widespread policy change towards free trade should always be implemented gradually, in order to take care of those groups who might be affected in the short run by the increased level of international competition and technological progress. The main conclusion of the dissertation is that free trade - as conceived by classical political economy - is the most suitable international trade policy for developed as well developing countries for achieving sustainable economic growth and development. (author's abstract)

(kein Abstract vorhanden) / Series: Discussion Papers SFB International Tax Coordination

Gene expression studies have revealed that there is more than one cellular pathway governing growth inhibition and apoptosis. Mutations in the ras oncogene that(activate ras) are known to lead to the inactivation of genes that are directly involved in these pathways of growth inhibition and apoptosis. Oncogenic activated ras inhibits TGF-P signalling through the down-regulation of RII expression and abrogates apoptotic pathways through down-modulation of PAR-4 gene expression. A majority of pancreatic turnours harbour K-ras point mutations and these mutations dysregulate, the growth inhibition and apoptosis processes. This leads us to hypothesize that K-ras mutant phenotype status in pancreatic turnours will alter the expression of the RII and PAR-4 genes, and would further dysregulate growth inhibitory and apoptotic processes. In this study, the majority of pancreatic turnours showed down-regulation of RII and PAR-4 gene expression. A strong correlation of down-regulation of RII and PAR-4 with K-ras mutational status was observed. In particular, down regulation of PAR-4 correlated with poor survival in patients with pancreatic adenocarcinomas. Blocking the function of oncogenic ras by using a famesyltransferase inhibitor (Frl) restored RII expression and TGF-P signalling, and this caused enhanced sensitivity of cell lines to radiation. The restoration of RH function by FrI was linked to down-modulation of DNA methyltransferase enzyme that is often implicated in hypermethylation of promoters. Over-expression of RII in pancreatic tumour cells led to the restoration of TGF-P signalling and enhancement of radiation sensitivity. Induction of the pro-apoptotic effector gene, bav (bcI-2 family member) by radiation in RII over-expressed pancreatic cancer cells, was found to be a key mechanism involved in radiation sensitivity. Overexpression of PAR-4 sensitized the cells to radiation and this sensitization was linked to down-modulation of radiation induced Bcl-2 protein. Together, these findings strongly suggest that the restoration of function of the key growth inhibitory and cell death genes RII and PAR-4, which are affected by oncogenic ras mutations in pancreatic turnours will restore and enhance cellular responses to radiation induced clonogenic inhibition and apoptosis.

The University of Salford has developed a program in order to improve the control of lower limb orthotics thus improving the ability of paraplegics to walk. Although the system is greatly needed for rehabilitation it is hoped that the final system would enable paraplegics to walk in the community. The present project, which is based on previous designs such as the R. G. O (Reciprocating Gait Orthbsis), strives to add external power at the hips of the R. G. O. The constructed prototype is made of a mechanical skeleton with each leg driven by a brushless motor and a lead screw. The main purpose of this project is to design a control system to control the motion of the legs. The first step in achieving this task was to model the various components of the system separately and then derive a model using system identification that will describe the behaviour of the whole system. The starting point was a mechanical device with two motors mounted one at either hip. A full mathematical analysis of the system is carried out. Once a mathematical model is derived for the RG. O with the two motors it can be used to carry out real time simulations using MATLAB. Once the model is derived it must be validated to make sure it is actually a mathematical representation of the system. The identified model is usually very accurate as it is based on the actual system performance. Then real time simulations of the theoretical and the identified model are compared. If the theoretical model behaves in the same way as the identified model then it is validated and may be used for further work. The models derived using system identification were validated and gave a good comparison when compared to real data. A pole placement controller was designed and tested based on these models. The controller performance was tested with the orthosis unloaded, loaded with artificial loads (a plaster leg weighing 10 Kg). The controller managed to follow the pre-set trajectory reasonably well. The orthosis was then tested with a volunteer in it. Again the performance was very encouraging. The fmal Project will be P. C driven System with the possibility of using NiCAD Batteries as the power source. The main tools, which will be used in order to carry out simulations and comparisons of theoretical and practical results, are MATLAB. The software used was C.

Muscle strength is assumed to be closely related with BMD, the so called determinant of bone strength, however, new methods for bone strength measurement are arising. The purpose of this study was to determine the relationship between bone mineral density (BMD), muscle strength and natural frequency of the radius in the dominant and non-dominant arm in healthy and osteopenic individuals aged between 50-70 years. Sixty sedentary male (thirty healthy and thirty osteopenic) participated this study. Bone mineral density assessment was performed by dual x-ray absorbtiometry (DEXA) and quantitative computed tomography (QCT), whereas muscle strength was measured by an isokinetic dynamometer quantitatively. Natural frequency of the radius was determined by a dual channel frequency analyzer. Differences between BMD, muscle strength and natural frequency in healthy and osteopenic participants according to dominancy were examined by Analysis of Variance (ANOVA). Pearson Product Correlation Coefficient test was conducted to determine the magnitude of the correlation between cortical, trabecular and average BMD, muscle strength and natural frequency. Results demonstrated a statistically significant difference between BMD, natural frequency and muscle strength in the dominant arm of both groups. There was also a significant difference in the non-dominant arm in terms of BMD, natural frequency and muscle strength, except in total work in the non-dominant arms. Moreover, there was a moderate positive correlation between BMD measured by DEXA and natural frequency in the dominant arm (r = ,59 / p &lt / .001) and non-dominant arm (r = 0,64 / p &lt / 0.001), whereas the muscle strength was correlated to BMD with a low positive correlation in terms of peak torque in extension (r = ,36 / p = ,005), peak torque in flexion (r = ,31 / p = ,016), total work in extension (r = ,28 / p = ,030) and total work in flexion (r = ,27 / p = ,041) in the dominant arms. The correlation between muscle strength and BMD was not significant in the non-dominant arm. The highest correlation between natural frequency and bone geometry parameters was observed in cortical thickness (r = ,82 / p = ,02). A statistically significant positive correlation (r = ,81 / p = ,04) was also observed between average BMD measured by QCT and by DEXA. In summary, according to the findings of this study, it can be concluded that vibration analysis is a precise method in predicting bone strength that depends highly on its size, shape and the distribution of its trabecular and cortical components.

Design needs to collaborate with many other disciplines to achieve success. Ergonomics is one of these disciplines that design needs its collaboration. A designed object should be in good relation with the human body and cognitive system to be effectively used by its potential users. Changes in the competitive market have forced firms to enhance product differentiation for achieving market success. Design is widely used as one of the differentiation tools. As a component of design, ergonomics should also be integrated into the design process to fulfill the user requirements. There are success stories of companies integrating ergonomics into their design process and achieving differentiation and success on their products through the results of this integration. Even their marketing strategies are based on this integration. It is observed that there are some missing points in the integration of ergonomics into consumer electronics design which make results in poor interaction with the end users. The background of this problem is investigated by reviewing design processes of four different firms and integration of ergonomics into these processes. The information on the cases is collected by literal information for the former three companies and information based on the participant observation results and company reports for the last company.