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Made available in DSpace on 2014-10-09T12:26:59Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:03:49Z (GMT). No. of bitstreams: 0 / Neste trabalho foram desenvolvidas condições específicas de RP-HPLC para análise de preparações recombinantes e naturais de hLH, de hCG, e de suas subunidades. O hLH e o hCG heterodimérico e suas subunidades e migraram com tempos de retenção (tR) significativamente diferentes, na seguinte ordem de hidrofobicidade crescente: -hCG < -hLH < hCG < hLH < -hCG < -hLH. Nestas condições, onze preparações foram estudadas: o Padrão Internacional recombinante hLH-WHO 96/602, uma preparação comercial recombinante, duas preparações hipofisárias altamente purificadas de hLH, uma preparação recombinante e duas preparações urinárias de hCG e quatro produtos urinários heterogêneos, contendo hLH + hFSH. Todas as preparações de hLH mostraram um tempo de retenção similar para o pico principal (tR = 38,35 ± 0,42 min; DPR = 1,1 %; n = 4 preparações), enquanto o pico principal do hCG migrou cerca de 4% mais rápido, quando comparado a este valor médio. Picos de hLH, hFSH e hCG foram também identificados nas preparações urinárias heterogêneas. O método foi validado para as sete preparações homogêneas, sendo a exatidão, precisão e sensibilidade calculadas com base na curva dose-resposta, altamente linear (r=0,99998; p<0,0001; n=20). A quantificação de diferentes gonadotrofinas nas preparações heterogêneas foi também realizada, embora com claras limitações de exatidão. / Dissertacao (Mestrado) / IPEN/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

京都大学 / 0048 / 新制・課程博士 / 博士(経済学) / 甲第22224号 / 経博第612号 / 新制||経||292(附属図書館) / 京都大学大学院経済学研究科経済学専攻 / (主査)教授 宇仁 宏幸, 教授 久本 憲夫, 教授 久野 秀二 / 学位規則第4条第1項該当 / Doctor of Economics / Kyoto University / DGAM

京都大学 / 新制・課程博士 / 博士(医学) / 甲第23410号 / 医博第4755号 / 新制||医||1052(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 村川 泰裕, 教授 長尾 美紀, 教授 柳田 素子 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

The master thesis focuses on measuring the effectiveness of the legislative activities of the upper chambers of the Czech Republic, France, Spain, Ireland, and the United Kingdom. The selected countries represent Medium-strength, Between medium-strength and weak bicameralism, and weak bicameralism according to the theory of Arend Lijphart. The aim was to compare quantifiable indicators of the legislative process and determine how influential or how effective the upper house in the system is. To achieve the set goal, a comparison of statistical variables was used, as well as a logistic regression analysis, which helped to identify significant influences affecting the legislative process. To collect the necessary data, the automated collection was used using an algorithm in the R environment. It was found that the influence of chambers in the legislative process is approximately aligned with the theory of the strength of bicameralism. The study showed that the influence of the Czech Senate is the second-strongest among the studied countries. At the same time, the study showed that authorship and congruence appear to be the most statistically significant. However, that does not apply universally.

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado. / Currently, it is common for the risks in construction projects to generate significant budgetary deviations due to their null or insufficient identification and quantification. In relation to this point, and with the focus on improving the competitiveness of construction companies when developing and complying with their budgets, it is essential to have an accurate methodology for estimating the contingency associated with risks from an early stage. This allows the contingency amount not to be exceeded, resulting in better reliability and adjustment of the budget assigned for the project, and therefore guaranteeing the expected profitability. This objective can be achieved using applications such as the Monte Carlo method, since through the probabilistic simulations that can be developed through it, it is possible to precisely establish the value of the contingency associated with project risks in study. It is recommended to carry out these evaluations and analyzes before the project starts. In this sense, this research focuses on establishing a sequential methodology that serves as an application tool for any type of construction project, ensuring the optimization of the budget by minimizing the risks associated with the project.

Compliance with the strict dietary regimen for the dialysis patient can be very challenging. Many foods are limited from the diet of a renal patient because of the high potassium content. The physiological consequences of failure to follow a diet prescription can be fatal for the dialysis patient. In an effort to improve patient compliance with nutritional protocols, several potato cooking methods and centrifugation of tomato sauce were investigated for their effects in reducing potassium content. All methods with a 24-hour soak were found to be significant in reducing potassium content of potatoes (P<0.05). However, some of the methods in which the potatoes were not soaked were also found to be effective in reducing potassium content. Slice thickness and volume of cooking water used were found to be two important factors in determining potassium loss. The 4-mm sliced potatoes, which had a mean potassium value of 84 mg/100 g, lost more potassium than the 8-mm ·sliced potatoes with a mean potassium value of 182 mg/100 g (P<0.05). Furthermore, the potatoes cooked in 10 times the amount of water lost more potassium (124 mg/100 g) than those cooked in only 5 times the amount of water (148 mg/100 g) (P<0.05). Soaking in cold versus hot water, agitation of the soak water, or the addition of chemical chelators to the soak water were not shown to be any more effective in reducing the potassium content than the other methods. Sensory data indicated that participants did not have a strong taste preference for potatoes cooked by any one particular method (P<0.05). Centrifugation of tomato sauce, and retention of the solids were found to be effective methods for reducing the potassium content of tomato sauce. There was, however, a significant difference (P<0.05) in the participants' taste preference for the tomato sauce that was centrifuged one time versus the tomato sauce that had been centrifuged twice The results of this study are significant because they suggest that there are more effective, alternative methods for preparing potatoes and tomato sauce than those that are currently being used. This would suggest an increased likelihood for patient adherence to nutritional recommendations.

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第20980号 / 医博第4326号 / 新制||医||1026(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 原田 浩, 教授 松田 道行, 教授 横出 正之 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM