L'approche de la biologie des systèmes vise à intégrer les méthodologies appliquées dans la conception et l'analyse des systèmes technologiques complexes, au sein de la biologie afin de comprendre les principes de fonctionnement globaux des systèmes biologiques. La thèse s'inscrit dans le cadre de la biologie des systèmes et en particulier dans la prolongation d'une méthode issue de ce cadre : la méthode Resource Blance Analysis (RBA). Nous visons dans cette thèse à augmenter le pouvoir prédictif de la méthode via un travail de modélisation tout en gardant un bon compromis entre représentativité des modèles issus de ce cadre et leur résolution numérique efficace. La thèse se décompose en deux grandes parties : la première vise à intégrer les aspects thermodynamiques et cinétiques inhérents aux réseaux métaboliques. La deuxième vise à comprendre l'impact de l'aspect stochastique de la production des enzymes sur le croissance de la bactérie. Des méthodes numériques ont été élaborées pour la résolution des modèles ainsi établis dans les deux cas déterministe et stochastique. / In order to understand the global functioning principals of biological systems, system bio- logy approach aims to integrate the methodologies used in the conception and the analysis of complex technological systems, within the biology. This PhD thesis fits into the system biology framework and in particular the extension of the already existing method Resource Balance Analysis (RBA). We aim in this PhD thesis to improve the predictive power of this method by introducing more complex model. However, this new model should respect a good trade-off between the representativity of the model and its efficient numerical computation. This PhD thesis is decomposed into two major parts. The first part aims the integration of the metabolic network inherent thermodynamical and kinetic aspects. The second part aims the comprehension of the impact of enzyme production stochastic aspect on the bacteria growth. Numerical methods are elaborated to solve the obtained models in both deterministic and stochastic cases.

This thesis is the first study that provides comprehensive empirical evidence on both the impacts of the target interest rate news from the Reserve Bank of Australia (RBA) on the Australian financial markets, and the spillover effects of the target interest rate news from the US Federal Reserves (Fed) and the European Central Bank (ECB) on the Asia Pacific's equity and currency markets. This thesis contributes to the current literature in several ways. First, while there is ample evidence in the literature suggesting that the markets would not react to what is already expected but will react to the news, the current literature on the RBA's target rate effects is still limited to the investigation of the overall announcement impact on the first moment of the Australian market return only. Therefore, this thesis firstly comprehensively investigates the impacts of the unexpected components of the RBA's target rate announcements (or news) on the first two moments of various segments of the Australian financial markets including interest rate changes, the Australian dollar and stock market returns. In so doing, this thesis contributes to the current literature on the impacts of domestic target interest rate news. Second, while the established literature seems to be missing a thorough investigation of the spillover effects of the Fed's and the ECB's news on the Asia Pacific markets, this thesis provides comprehensive evidence on the spillover effects of the Fed's and the ECB's target rate news on both the mean and volatility of the Asia Pacific's stock and currency returns. Furthermore, we not only document the presence of the news spillover effects but also highlight the incremental explanatory power of the target interest rate news in the presence of the indirect effects from the US's and euro area's markets to the Asia-Pacific markets. To this end, this thesis contributes to the literature on spillover effects of foreign target interest rate news. Third, while the literature is silent on how quickly the target interest rate news is absorbed in foreign markets, this thesis takes a step forward and breaks down the daily horizon into the overnight and the intraday horizons. In so doing, the thesis examines the absorption speed of target rate news in the Asia-Pacific markets. This is an important issue because there might be potential for a diverse array of response dynamics across countries due to heterogeneous market developments, nature of monetary policy synchronization, and financial and real integration with the U.S. and the euro area. Specifically, this thesis presents three independent empirical inquiries that contribute to the literature on domestic and spillover effects of the target interest rate news. Chapter 4 provides comprehensive empirical evidence for the impacts of the RBA's target rate news on various segments of the Australian financial markets during the period from 1998 to 2006. We also investigate the spillover effects of the US Fed's news on the Australian financial markets. We show that the RBA's and the Fed's news significantly affect the Australian financial markets in line with a priori expectations. However, while the RBA's news raises volatility in the Australian financial markets, the volatility was significantly lower in all market segments following the Fed's news. The spillover effects of the US Fed's and the ECB's target interest rate news on the mean and the volatility of twelve Asia Pacific's stock markets' returns are examined in Chapter 5, and seven Asia Pacific exchange rates against the US dollar and the euro over the period 1999-2006 are carried out in Chapter 6. The spillover effects on the conditional mean are generally consistent with the literature where a majority of Asia Pacific stock markets shows significant negative returns and a majority of currencies depreciates against the US dollar and the euro in response to the Fed's and the ECB's unexpected rate rises. Furthermore, in response to the two target rate news, the conditional volatility of the Asia Pacific stock markets was higher while the market calming effects have been observed for the currency markets and both the Fed and the ECB news elicit persisting volatility responses. We conjecture that as the ECB's news tends to confirm the Fed's earlier decision, this relationship might help reduce uncertainties in the Asia Pacific currency markets upon the future path of target interest rates from both the Central Banks, which ultimately results in into a lower volatility level. These findings are important not only to the Asia Pacific’s policy makers to help them improve the conduct of monetary policy but also to market participants in designing trading mechanisms as well as risk management strategies in response to both domestic and external interest rate shocks. Furthermore, these findings also shed light on the lead-lag relationship between the Fed and the ECB in making policy decisions. The notion that the ECB follows the Fed in setting its policy is so strong amongst market participants that empirical evidence seems to be crucial. Despite the fact that the ECB's news arrives after the Fed's news, this study provides evidence that the ECB's news has its own merits in the Asia Pacific markets and helps resolve differences in beliefs among market participants.

Diss. Nr. 3009 Wirtschaftswiss. St. Gallen, 2005. / Literaturzverz.

Univ., Diss.--St. Gallen, 2005.

This Ph.D. research project targets Cooper Basin oil reservoirs of very low permeability (approximately 1mD) where injectivities required for water flooding are not achievable. However, the use of injection gases such as CO₂ would not have injectivity problems. CO₂ is abundant in the region and available for EOR use. CO₂ was compared to other CO₂-rich injection gases with a hydrocarbon content including pentane plus components. While the effect of hydrocarbon components up to butane have been investigated in the past, the effect of n-pentane has on impure CO₂ gas streams has not. One particular field of the Cooper Basin was investigated in detail (Field A). However, since similar reservoir and fluid characteristics of Field A are common to the region it is expected that the data measured and developed has applications to many other oil reservoirs of the region and similar reservoirs elsewhere. The aim of this Ph.D. project is to determine the applicability of CO₂ as an injection gas for Enhanced Oil Recovery (EOR) in the Cooper Basin oil reservoirs and to compare CO₂ with other possible CO₂-rich injection gases. The summarised goals of this research are to: • Determine the compatibility of Field A reservoir fluid with CO₂ as an injection gas. • Compare CO₂ to other injection gas options for Field A. • Development of a correlation to predict the effect of nC₅ on MMP for a CO₂- rich injection gas stream. These goals were achieved through the following work: • Extensive experimental studies of the reservoir properties and the effects of interaction between CO₂-rich injection gas streams and Field A reservoir fluid measuring properties related to: • Miscibility of the injection gas with Field A reservoir fluid • Solubility and swelling properties of the injection gas with Field A reservoir fluid • Change in viscosity-pressure relationship of Field A reservoir fluid due to addition of injection gas • A reservoir condition core flood experiment • Compositional simulation of the reservoir condition core flood to compare expected recoveries from different injection gases • Development of a set of Minimum Miscibility Pressure (MMP) measurements targeted at correlating the effect of nC₅ on CO₂ MMP. The key findings of this research are as follows: • Miscibility is achievable at practical pressures for Field A and similar reservoir fluids with pure CO₂ or CO₂-rich injection gases. • For Field A reservoir fluid, viscosity of the remaining flashed liquid will increase at pressures below ~2500psi due to mixing the reservoir fluid with a CO₂-rich injection gas stream. • Comparison of injection gases showed that methane rich gases are miscible with Field A so long as a significant quantity of C₃+ components is also present in the gas stream. • There is a defined trend for effect of nC₅ on MMP of impure CO₂. This trend was correlated with an error of less than 4%. • Even though oil composition is taken into account with the base gas MMP, it still affects the trend for effect of nC₅ on MMP of a CO₂-rich gas stream. • An oil characterisation factor was developed to account for this effect, significantly improving the results, reducing the error of the correlation to only 1.6%. The significance of these findings is as follows: • An injection pressure above ~3000psi should be targeted. At these pressures miscibility is achieved and the viscosity of the reservoir fluid injection gas mix is reduced. • CO₂ should be compared to gases such as Tim Gas should after considering the cost of compression, pipeline costs and distance from source to destination will need to be considered. • The addition of nC₅ will reduce the MMP and increase the recovery factor, however the cost of the nC₅ used would be more than the value of increased oil recovered. • The developed correlation for the effect of nC₅ on impure CO₂ MMP can be used broadly within the limits of the correlation. • Further research using more oils is necessary to validate the developed oil characterisation factor and if successful, using the same or similar method used to improve other correlations. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1369016 / Thesis (Ph.D.) -- University of Adelaide, Australian School of Petroleum, 2009.