Foreign aid is a major flow of income into sub-Saharan African (SSA) countries, averaging roughly 12% of GDP over the last four decades. Yet, SSA countries are characterized by very low per capita output, low human capital attainment, and widespread poverty. This dissertation investigates the macroeconomic and welfare effects of foreign aid to SSA countries. The empirical part of the dissertation studies 22 SSA countries, and uses a cointegrated vector autoregressive analysis (CVAR). This methodology identifies long-run effects without imposing strong statistical priors. I introduce tradable and non-tradable sectors into the analysis to determine if the so-called “Dutch Disease” is the reason for the plight of SSA countries. “Dutch Disease” occurs when a positive shock to foreign aid perversely reduces GDP, by decreasing the relative price of tradable to nontradable goods, thus reducing the size of the tradable sector. While I find that aid reduces GDP in eight countries, this result is inconsistent with the “Dutch Disease” as it is not accompanied by large relative price changes. The analysis controls for a number of country-specific characteristics including extraordinary events. Overall, I find non-positive impacts of foreign aid on GDP and the tradable sector, with a few exceptions. I also consider the reverse causal channel and test whether country-specific macroeconomic variables drive foreign aid flows. I find that GDP, tradable output, and tradable and non-tradable goods prices do affect the amount of aid a country receives in 15 countries. These variables have no impact on foreign aid (aid is considered as weakly exogenous) in six countries. The theoretical part of the dissertation develops two dynamic stochastic general equilibrium — real business cycle — (DSGE-RBC) models to analyze the effects of foreign aid on human capital investment and the business cycle. The distinguishing feature of the models is to embed a human capital investment in a small open economy model of Mendoza (1991). The first model considers one-sector DSGE model, which is followed by two-sector (tradable and non-tradable) DSGE model. Both models distinguish between physical and human capital investment and allow for labor-leisure choice. In the analysis, labor supply and time spent studying or acquiring skills are optimally chosen. The models are calibrated to match the key features of the Kenyan economy. In both models, a positive aid shock initially has a negative impact on labor supply and output. However, the shock subsequently has a positive effect on physical and human capital investment, and time spent studying. This is due to a positive income effect from the shock. A rise in foreign aid increases consumption; consumption smoothing across periods raises physical and human capital investment, labor productivity, and output. I also find that reducing the volatility of aid has a significant positive effect on human capital investment and welfare. Policymakers should focus on reducing the volatility of foreign aid and not solely concentrate on the average level of aid. The analysis of the two-sector DSGE-RBC model incorporates the role for the “Dutch Disease” mechanism. Consistent with the “Dutch Disease”, I find that a shock to foreign aid appreciates the relative price of non-tradable goods that causes the factors of production to reallocate from the tradable sector to the non-tradable sector, leading to a decline in GDP and the tradable output. Finding the “Dutch Disease” result here is not necessarily at odds with the CVAR estimation results as the DSGE-RBC simulation is a short-run analysis and the CVAR estimation is a long-run analysis. / Graduate

The first part analyzes an Endogenous Business Cycle model with embodied technological change. Households take an optimal decision about their spending for consumption and financing of R&D. The probability of a technology invention occurring is an increasing function of aggregate R&D expenditure in the whole economy. New technologies bring higher productivity, but rather than applying to the whole capital stock, they require a new vintage of capital, which first has to be accumulated before the productivity gain can be realized. The model offers some valuable features: Firstly, the response of output following a technology shock is very gradual; there are no jumps. Secondly, R&D is an ongoing activity; there are no distinct phases of research and production. Thirdly, R&D expenditure is pro-cyclical and the real interest rate is counter-cyclical. Finally, long-run growth is without scale effects. The second part analyzes a RBC model in continuous time featuring deterministic incremental development of technology and stochastic fundamental inventions arriving according to a Poisson process. In a special case an analytical solution is presented. In the general case a delay differential equation (DDE) has to be solved. Standard numerical solution methods fail, because the steady state is path dependent. A new solution method is presented which is based on a modified method of steps for DDEs. It provides not only approximations but also upper and lower bounds for optimal consumption path and steady state. Furthermore, analytical expressions for the long-term equilibrium distributions of the stationary variables of the model are presented. The distributions can be described as extended Beta distributions. This is deduced from a methodical result about a delay extension of the Pearson system.

The first part analyzes an Endogenous Business Cycle model with embodied technological change. Households take an optimal decision about their spending for consumption and financing of R&D. The probability of a technology invention occurring is an increasing function of aggregate R&D expenditure in the whole economy. New technologies bring higher productivity, but rather than applying to the whole capital stock, they require a new vintage of capital, which first has to be accumulated before the productivity gain can be realized. The model offers some valuable features: Firstly, the response of output following a technology shock is very gradual; there are no jumps. Secondly, R&D is an ongoing activity; there are no distinct phases of research and production. Thirdly, R&D expenditure is pro-cyclical and the real interest rate is counter-cyclical. Finally, long-run growth is without scale effects. The second part analyzes a RBC model in continuous time featuring deterministic incremental development of technology and stochastic fundamental inventions arriving according to a Poisson process. In a special case an analytical solution is presented. In the general case a delay differential equation (DDE) has to be solved. Standard numerical solution methods fail, because the steady state is path dependent. A new solution method is presented which is based on a modified method of steps for DDEs. It provides not only approximations but also upper and lower bounds for optimal consumption path and steady state. Furthermore, analytical expressions for the long-term equilibrium distributions of the stationary variables of the model are presented. The distributions can be described as extended Beta distributions. This is deduced from a methodical result about a delay extension of the Pearson system.

Data warehouse technology has been successfully integrated into the information infrastructure of major organizations as potential solution for eliminating redundancy and providing for comprehensive data integration. Realizing the importance of a data warehouse as the main data repository within an organization, this dissertation addresses different aspects related to the data warehouse architecture and performance issues. Many data warehouse architectures have been presented by industry analysts and research organizations. These architectures vary from the independent and physical business unit centric data marts to the centralised two-tier hub-and-spoke data warehouse. The operational data store is a third tier which was offered later to address the business requirements for inter-day data loading. While the industry-available architectures are all valid, I found them to be suboptimal in efficiency (cost) and effectiveness (productivity). In this dissertation, I am advocating a new architecture (The Hybrid Architecture) which encompasses the industry advocated architecture. The hybrid architecture demands the acquisition, loading and consolidation of enterprise atomic and detailed data into a single integrated enterprise data store (The Enterprise Data Warehouse) where businessunit centric Data Marts and Operational Data Stores (ODS) are built in the same instance of the Enterprise Data Warehouse. For the purpose of highlighting the role of data warehouses for different applications, we describe an effort to develop a data warehouse for a geographical information system (GIS). We further study the importance of data practices, quality and governance for financial institutions by commenting on the RBC Financial Group case. v The development and deployment of the Enterprise Data Warehouse based on the Hybrid Architecture spawned its own issues and challenges. Organic data growth and business requirements to load additional new data significantly will increase the amount of stored data. Consequently, the number of users will increase significantly. Enterprise data warehouse obesity, performance degradation and navigation difficulties are chief amongst the issues and challenges. Association rules mining and social networks have been adopted in this thesis to address the above mentioned issues and challenges. We describe an approach that uses frequent pattern mining and social network techniques to discover different communities within the data warehouse. These communities include sets of tables frequently accessed together, sets of tables retrieved together most of the time and sets of attributes that mostly appear together in the queries. We concentrate on tables in the discussion; however, the model is general enough to discover other communities. We first build a frequent pattern mining model by considering each query as a transaction and the tables as items. Then, we mine closed frequent itemsets of tables; these itemsets include tables that are mostly accessed together and hence should be treated as one unit in storage and retrieval for better overall performance. We utilize social network construction and analysis to find maximum-sized sets of related tables; this is a more robust approach as opposed to a union of overlapping itemsets. We derive the Jaccard distance between the closed itemsets and construct the social network of tables by adding links that represent distance above a given threshold. The constructed network is analyzed to discover communities of tables that are mostly accessed together. The reported test results are promising and demonstrate the applicability and effectiveness of the developed approach.

93年4月5日中華開發金控公司召開股東會，辦理董監改選，以陳敏薰為首的公司派與以辜仲瑩為首的市場派，爆發激烈的經營權爭奪戰。在爭戰過程中，發現現行法規尚有許多規範不清的模糊地帶，引發爭議，而最後政府均能修訂相關法令予以補強。 中華開發金控會被併購成功，主要因為董監持股不足，加上其股價及經營績效下跌所致。至於中信集團能夠併購成功，則是利用中國人壽及中信證券的短期資金，大量投入購買中華開發金控股票，順利取得經營權。就併購成果而言，中信集團是最大的贏家。但主管機關保住了公股應有的權益，並取得三分之一董監席次，也是贏家。而中華開發本身因此引進新經營團隊，帶來新契機，也算是贏家。所以，最後是中信集團、主管機關與中華開發三贏的結局。 本文建議保險主管機關，適時檢討取消保險業資本適足率（RBC）現行八折優待的措施，並適度提高長期投資的風險係數值，使接近於1，以免除自有資本被灌水的奇異現象。並適度檢討保險業長、短期投資規定，縮減保險業在併購方面的特別優勢，避免因保險業容易併吞銀行業與證券業，而造成保險業一枝獨大的畸形現象，使金融產業失去平衡。另建議主管機關參考先進國家法例，對於「惡意併購」行為訂定明確規範，以作為業者遵循的依據。

When patients and families come to the emergency department seeking medical attention, they come in with many mixed emotions and thoughts. The fast paced, rapid turnover of patients and the chaotic atmosphere may leave patients who visit the emergency department with the perception that staff is uncaring. The purpose of this project was to implement a patient care delivery model, relationship-based care, in the emergency department. The model is comprised of several caring theories including Jean Watson's model of human care and Kristen Swanson's middle range theory of caring. The main goals of the project were to help staff enhance the patient and caregiver interaction, strengthen co-worker relationships, and gain appreciation of the importance of self-care. The intervention was an educational workshop about the relationship-based care model. Eight participants were consented, given a preassessment survey, educated about the model, and then given a postassessment survey. Prior to education, 83% of participants believed strongly that patients and families need to feel cared for during an emergency department visit; this increased to 100% posteducation. Perception about the importance of coworkers' relationships being trusting went from 38% to 50% and the importance of caring for one's self increased from 63% to 100%. It was recommended that the model be implemented in all emergency departments and all staff educated in its use as a way to promote social change through intentional focus on caring in every patient interaction.

<p>This study investigated the associations between IL-4 -590 C/T and IL-10 -1087 A/G polymorphisms and malariometric indexes in the Fulani and the Dogon ethnic groups living in sympatry in Mali and differing in susceptibility to malaria. The correlations between antibodies level and parasitological data as well as splenomegaly were assessed. The impact of IL-4 -590 variants on the levels of the studied antibodies was also studied. </p><p>The allele and genotype frequencies of both studied SNPs differed significantly between the two groups. The Fulani IL-4 T allele carriers had a significantly higher infection prevalence compared with those carrying the CC genotype. No correlation between anti-malarial antibody levels and parasite prevalence was seen in any of the communities. In the Fulani, the increase in total IgE levels was related to the presence of infection. Malaria-specific IgG4 levels were negatively correlated to the number of clones within the Fulani. The Fulani IL-4 T allele carriers had higher total and malaria-specific IgE levels, compared to the CC genotype carriers. These results suggest that the amount of antibodies may not be the key element in the protection against malaria. IgG4 might be involved in protection against malaria. The impact of IL-4 -590 variants on the antibody levels may be affected by other genetic/epigenetic/epistatic or environmental factors. </p><p>In the study in Senegal, multiplicity of infection (MOI) increased after the transmission season in all subjects, except in α-thalassaemic and in G6PD-mutated children, suggesting that α-thalassaemia may protect against infection by certain parasite strains. G6PD-mutated individuals may resist against increase in MOI after the transmission season due to rapid clearance of infection at an early stage. HbAs and the ABO system do not affect MOI in asymptomatic individuals. MOI was positively correlated to parasitemia, and did not vary over age (in the range of 2 to 10 years). No relation between MOI and clinical attack was noted. </p>

This study investigated the associations between IL-4 -590 C/T and IL-10 -1087 A/G polymorphisms and malariometric indexes in the Fulani and the Dogon ethnic groups living in sympatry in Mali and differing in susceptibility to malaria. The correlations between antibodies level and parasitological data as well as splenomegaly were assessed. The impact of IL-4 -590 variants on the levels of the studied antibodies was also studied. The allele and genotype frequencies of both studied SNPs differed significantly between the two groups. The Fulani IL-4 T allele carriers had a significantly higher infection prevalence compared with those carrying the CC genotype. No correlation between anti-malarial antibody levels and parasite prevalence was seen in any of the communities. In the Fulani, the increase in total IgE levels was related to the presence of infection. Malaria-specific IgG4 levels were negatively correlated to the number of clones within the Fulani. The Fulani IL-4 T allele carriers had higher total and malaria-specific IgE levels, compared to the CC genotype carriers. These results suggest that the amount of antibodies may not be the key element in the protection against malaria. IgG4 might be involved in protection against malaria. The impact of IL-4 -590 variants on the antibody levels may be affected by other genetic/epigenetic/epistatic or environmental factors. In the study in Senegal, multiplicity of infection (MOI) increased after the transmission season in all subjects, except in α-thalassaemic and in G6PD-mutated children, suggesting that α-thalassaemia may protect against infection by certain parasite strains. G6PD-mutated individuals may resist against increase in MOI after the transmission season due to rapid clearance of infection at an early stage. HbAs and the ABO system do not affect MOI in asymptomatic individuals. MOI was positively correlated to parasitemia, and did not vary over age (in the range of 2 to 10 years). No relation between MOI and clinical attack was noted.

The diploma thesis deals with the study of Rayleigh-Bénard convection for Rayleigh numbers in the range 1E8-1E14. The evaluated data come from an experiment with cryogenic helium in a cylindrical cell in a configuration with cell diameter D = 30 cm, height L = 30 cm and a second configuration with cell diameter D = 30 cm, height L = 15 cm. Miniature sensors recorded temperature fluctuations over time under various physical conditions and properties of helium. Using MATLAB software, the output parameters of the system (Nusselt and Reynolds numbers) and their dependence on the control parameters (Rayleigh and Prandtl numbers) were determined from the measured data. A new approach to the distribution of measured signals according to the direction of large scale circulation was used in the work, which leads to improved analysis. Reynolds numbers were evaluated using the so-called elliptic method. Furthermore, the work deals with the study of the coherent structure of the large scale circulation inside the cell.

Introduktion: Daratumumab är en monoklonal antikropp som används för att behandla patienter med multipelt myelom (MM), en typ av blodcancer som har sitt ursprung i B-lymfocyter. Daratumumab binder till CD38 som normalt uttrycks på erytrocyternas yta och ger upphov till panreaktivitet vid förenlighetsprövning, som kan maskera kliniskt signifikanta antikroppar. Ditiotreitol (DTT), ett reducerande lösningsmedel, denaturerar den extracellulära domänen av CD38 och därmed hämmar inbindning av daratumumab. DTT-behandling av testerytrocyter vid förenlighetsprövning möjliggör detektion av kliniskt relevanta alloantikroppar.  Syfte: Att verifiera en metod för DTT-behandling av erytrocyter vid förenlighetsprövning, för att detektera alloantikroppar av klinisk relevans och lättare få fram blod till patienter som medicineras med Darzalex.  Metod &amp; materiel: I studien ingick två plasmaprover från patienter med daratumumab behandling. Testerytrocyterna behandlades med olika DTT mängd (80, 160 och 320 L). DTT-behandlade samt obehandlade testerytrocyter testades mot plasmaproverna, negativ kontroll (anti-K) och positiv kontroll (anti-C) vid olika dagar från tillredningsdatum.  Resultat: Daratumumab interferens mot obehandlade testerytrocyter observerades. Reaktionen för samtliga DTT-behandlade testceller vid varje analystillfälle blev negativt, oavsett DTT mängd. Resultaten för den negativa kontrollen visade att det slog positivt vid DTT mängden 80 samt 160 µL och negativ vid 320 µL. Alla reaktioner för den positiva kontrollen var 4+ vid samtliga DTT mängder oavsett analysdag.  Slutsats:  DTT-behandling av erytrocyter inaktiverar CD38 som motverkar panreaktivitet vid serologiska analyser, för att upptäcka eventuella kliniskt signifikanta antikroppar hos patienter som behandlas med daratumumab. Den optimala DTT mängden är 320 µL/1 ml 1% testerytrocyt med upp till 15 dagars hållbarhet vid kylförvaring. / Introduction: Daratumumab is a monoclonal antibody used to treat patients with multiple myeloma (MM), a type of blood cancer that originates in B lymphocytes. Daratumumab binds to CD38, which is expressed on the surface of erythrocytes. This leads to panagglutination in compatibility testing and can mask clinically significant antibodies. Dithiothreitol (DTT), a reductant, denatures the extracellular domain of CD38, thereby inhibiting daratumumab from binding. DTT treatment of RBC-reagents enables the detection of clinically relevant alloantibodies. Purpose: To verify a method for DTT treatment of erythrocytes in compatibility testing, in order to detect alloantibodies of clinical relevance and to ensure that transfusion recipient with Darzalex medication receive compatible blood transfusion. Method: Two plasma samples from daratumumab treated patients were included. RBC-regents were treated with different amounts of DTT (80, 160 and 320 μL). DTT-treated and untreated RBC-reagents were tested against plasma samples, negative control (anti-K) and positive control (anti-C) on different days.  Results: Daratumumab interference with untreated RBC-reagents were observed.  DTT treated RBC-reagents however, showed negative reaction regardless of the amount of DTT used. Results for the negative control showed positive reaction with 80 and 160 µL DTT and negative at 320 µL. Reactions for the positive control were all 4+ no matter the amount of DTT and day it was analyzed.   Conclusion: DTT treatment of erythrocytes inactivates CD38, which prevents panagglutination, to detect any clinically significant antibodies in patients with daratumumab treatment. The optimal DTT amount is 320 µL / 1 ml 1% RBC-reagents and a shelf life of up to 15 days when stored cold.