Magnetic Resonance Spectroscopy is known as a valuable diagnostic tool for physicians as well as a research tool for biochemists. In addition to hydrogen (which is the most abundant atom with nuclear magnetic resonance capability), other species (such as 31P or 13C) are used as well, to obtain certain information such as metabolite concentrations in neural or muscular tissues. However, this requires nuclear magnetic resonance (NMR) transmitter/receivers (coils) capable of operating at multiple frequencies, while maintaining a good performance at each frequency. The objective of this work is to discuss various design approaches used for second-nuclei RF (radio frequency) coils, and to analyze the performance of a particular design, which includes using inductor-capacitor (LC) trap circuits on a 31P coil. The method can be easily applied to other nuclei. The main advantage of this trapping method is the enabling design of second-nuclei coils that are insertable into standard proton coils, maintaining a near-optimum performance for both nuclei. This capability is particularly applicable as MRI field strengths increase and the use of specialized proton coils becomes more prevalent. A thorough performance analysis shows the benefit of this method over other designs, which usually impose a significant signal-to-noise (SNR) sacrifice on one of the nuclei. A methodology based on a modular coil configuration was implemented, which allowed for optimization of LC trap decoupling as well as performance analysis. The 31P coil was used in conjunction with various standard 1H coil configurations (surface/volume/array), using the trap design to overcome the coupling problem (degraded SNR performance) mentioned above. An analytical model was developed and guidelines on trap design were provided to help optimize sensitivity. The performance was analyzed with respect to the untrapped case, using RF bench measurements as well as data obtained from the NMR scanner. Insertability of this coil design was then verified by using it with general-purpose proton coils available. Phantoms were built to mimic the phosphorus content normally found in biologic tissues in order to verify applicability of this coil for in vivo studies. The contribution of this work lies in the quantification of general design parameters to enable “insertable” second-nuclei coils, in terms of the effects on SNR and resonance frequency of a given proton coil.

A target field method approach to the design of RF phase gradient fields, intended for TRASE MRI, produced a superposition of axial currents C_m*sin(m*phi) for m=1,2,3..., and a solenoidal current C_0*z (m=0), where C_m are constants. Omission of terms m>2 produced a phase gradient field with a linear phase and uniform magnitude within a target ROI of 2.5 cm diameter. A set of three RF coils (uniform birdcage, gradient mode birdcage, and 4-loop Maxwell) was found to be sufficient to generate both positive and negative x and y phase gradients. In addition, the phase gradient amplitude can be controlled by simply adjusting the power split to the three RF component coils. Bench measurements of an experimentally constructed 1.8 deg/mm transverse phase gradient showed excellent agreement with predicted results. A linear phase and magnitude within ± 4% of the median value was achieved within the ROI. / October 2015

Field-cycled proton-electron double-resonance imaging (FC-PEDRI) is a technique developed to image the distribution of free radicals in biological samples. This technique is based on the Overhauser Effect that causes an enhancement in the NMR signal by saturating the ESR resonance of unpaired electrons in the sample. FC-PEDRI requires two sources of RF irradiations. To improve the sensitivity and to reduce power deposition in samples, new dual-tuned single coil designs were needed since existing dual-tuned single-coil designs known in the literature cannot operate at two widely separated frequencies. The theory of double-tuned circuits was examined and new circuit models were developed to identify the design requirements. Four new dual-tuned RF coils were developed, namely a dual-tuned split solenoidal coil (2.5 and 78 MHz), a combined saddle-birdcage (CS-B) coil (2.5 and 110 MHz), a 3-endring (3-ER) birdcage (2.5 and 56 MHz) and a 4-endring (4-ER) birdcage (2.5 and 74 MHz). A prototype coil for each design was built for performance evaluation studies and the parameters evaluated were: the Q factors, the signal-to-noise ratio, the transmit sensitivity and the field uniformity. The performance of the NMR-mode of the 3-ER and 4-ER designs was poor because the inherently low-inductance of the birdcage meant that high-value capacitors with high dissipation factors had to be used in the fabrication. A new construction method named as the multilayer self capacitance (MLSC) technique was developed to improve the efficiency of the 4-ER design by creating efficient capacitors within the conductors of the coil itself. The unloaded Q factor of the optimised 4-ER birdcage using the MLSC technique was 267 compared to 100 when commercial capacitors were used.

Magnetic Resonance Imaging (MRI) is a widely used soft-tissue imaging modality that has evolved over the past several years into a powerful and versatile medical diagnostic tool capable of providing in-vivo diagnostic images of human and animal anatomies. Current research efforts in MRI system design are driven by the need to obtain detailed high resolution images with improved image signal-to-noise ratio (SNR) at a given magnetic field strength. Invariably, this requirement demands the development of high performance MRI radio frequency (RF) coils. However, the complexities and stringent requirements of modern clinical MRI systems necessitate the development of new modeling methodologies for the design of high performance RF coils. This dissertation addresses this need by developing a distinct Method of Moments (MoM) modeling approach suitable for the simulation of RF coils loaded with biological tissues. The unique implementation utilizes two distinct basis functions in order to collectively describe the surface current density on the RF coil, and the sum of the volume current density and the displacement current density in the associated biological tissue. By selecting basis functions with similar properties to the actual physical quantities they describe, we avoided spurious solutions normally associated with MoM based implementations. The validity of our modeling method was confirmed by comparisons with analytical solutions as well as physical measurements, yielding good agreement. Furthermore, we applied the MoM based modeling method in the design and development of a novel 4-channel receive-only RF coil for breast imaging in a clinical 1.5T system. The new coil design was inspired by the multi-channel array concept, where multiple conducting strips were arranged in an anatomically conforming profile with the intention of improving sensitivity and SNR. In addition, the coil structure featured an open breast coil concept in order to facilitate MRI-guided biopsy and patient comfort. A comparison of simulation results and actual physical measurements from the prototype RF coil demonstrated good agreement with one another. Also, imaging tests were conducted on a pair of MRI phantoms as well as on a human patient after obtaining proper authorization. The tests revealed good magnetic field homogeneity and a high SNR in the region of interest. In addition, performance comparisons between the prototype 4-channel RF coil and existing high end clinical 4-channel RF breast coils indicated an achievement of superior SNR in conjunction with very good magnetic field homogeneity. Currently, the prototype 4-channel RF coil has outperformed all existing high end clinical 4-channel RF coils used in comparison studies.

No description available.

Magnetic Resonance Imaging at field strengths up to 3 T, has become a default diagnostic modality for a variety of disorders and injuries, due to multiple reasons ranging from its non-invasive nature to the possibility of obtaining high resolution images of internal organs and soft tissues. Despite tremendous advances, MR imaging of certain anatomical regions and applications present specific challenges to be overcome. One such application is MR Musculo-Skeletal Imaging. This work addresses a few difficult areas within MSK imaging from the hardware perspective, with coil solutions for dynamic imaging of knee and high field imaging of hand. Starting with a brief introduction to MR physics, different types of RF coils are introduced in chapter 1, followed by sections on design of birdcage coils, phased arrays and their characterization in chapter 2. Measurements, calculations and simulations, done during the course of this work, have been added to this chapter to give a quantitative feel of the concepts explained. Chapter 3 deals with the construction of a phased array receiver for dynamic imaging of knee of a large animal model, i.e. minipig, at 1.5 T. Starting with details on the various aspects of an application that need to be considered when an MR RF array is designed, the chapter details the complex geometry of the region of interest in a minipig and reasons that necessitate a high density array. The sizes of the individual elements that constitute the array have been arrived at by studying the ratio of unloaded to loaded Q factors and choosing a size that provides the best ratio but still maintains a uniform SNR throughout the movement of the knee. To have a minimum weight and to allow mechanical movement of the knee, the Preamplifiers were located in a separate box. A movement device was constructed to achieve adjustable periodic movement of the knee of the anesthetized animal. The constructed array has been characterized for its SNR and compared with an existing product coil to show the improvement. The movement device was also characterized for its reproducibility. High resolution static images with anatomical details marked have been presented. The 1/g maps show the accelerations possible with the array. Snapshots of obtained dynamic images trace the cruciate ligaments through a cycle of movement of the animal's knee. The hardware combination of a high density phased array and a movement device designed for a minipig's knee was used as a 'reference' and extended in chapter 4 for a human knee. In principle the challenges are similar for dynamic imaging of a human knee with regards to optimization of the elements, the associated electronics and the construction of the movement device. The size of the elements were optimized considering the field penetration / sensitivity required for the internal tissues. They were distributed around the curvature of the knee keeping in mind the acceleration required for dynamic imaging and the direction of the movement. The constructed movement device allows a periodic motion of the lower half of the leg, with the knee placed within the coil, enabling visualization of the tissues inside, while the leg is in motion. Imaging has been performed using dynamic interleaved acquisition sequence where higher effective TR and flip angles are achieved due to a combination of interleaving and segmentation of the sequence. The movement device has been characterized for its reproducibility while the SNR distribution of the constructed RF array has been compared with that of a commercially available standard 8 channel array. The results show the improvement in SNR and acceleration with the constructed geometry. High resolution static images, dynamic snapshots and the 3D segmentation of the obtained images prove the usefulness of the complete package provided in the design, for performing dynamic imaging at a clinically relevant field strength. A simple study is performed in chapter 5 to understand the effects of changes in overlap for coil configurations with different loads and at different frequencies. The noise levels of individual channels and the correlation between them are plotted against subtle changes in overlap, at 64 and 123 MHz. SNR for every overlap setup is also measured and plotted. Results show that achieving critical overlap is crucial to obtain the best possible SNR in those coil setups where the load offered by the sample is low. Chapter 6 of the thesis work deals with coil design for high field imaging of hand and wrists at 7 T, with an aim to achieve ultra high resolution imaging. At this field strength due to the increase in dielectric effects and the resulting decrease in homogeneity, whole body transmit coils are impractical and this has led engineers to design local transmit coils, for specific anatomies. While transmit or transceive arrays are usually preferred, to mitigate SAR effects, the spatial resolution obtained is limited. It is shown that a solution to this, with regards to hand imaging, can be a single volume transmit coil, along with high density receive arrays optimized for different regions of the hand. The use of a phased array for reception provides an increased SNR / penetration under high resolution. A volume transmit coil could pose issues in homogeneity at 7 T, but the specific anatomy of hand and wrist, with comparatively less water content, limits dielectric effects to have homogeneous B_1+ profile over the hand. To this effect, a bandpass birdcage and a 12 channel receive array are designed and characterized. Images of very high spatial resolution (0.16 x 0.16 x 0.16 mm3) with internal tissues marked are presented. In vivo 1/g maps show that an acceleration of up to 3 is possible and the EM simulation results presented show the uniform field along with SAR hotspots in the hand. To reduce the stress created due to the 'superman' position of imaging, provisions in the form of a holder and a hand rest have been designed and presented. Factors that contributed to the stability of the presented design are also listed, which would help future designs of receive arrays at high field strengths. In conclusion, the coils and related hardware presented in this thesis address the following two aspects of MSK imaging: Dynamic imaging of knee and High resolution imaging of hand / wrist. The presented hardware addresses specific challenges and provides solutions. It is hoped that these designs are steps in the direction of improving the existing coils to get a better knowledge and understanding of MSK diseases such as Rheumatoid Arthritis and Osteoarthritis. The hardware can aid our study of ligament reconstruction and development. The high density array and transmit coil design for hand / wrist also demonstrates the benefits of the obtained SNR at 7 T while maintaining SAR within limits. This design is a contribution towards optimizing hardware at high field strength, to make it clinically acceptable and approved by regulatory bodies. / Die Magnetresonanztomographie mit Feldstärken bis zu 3 T ist zu einer Standard- Diag-nosemethode für eine Vielzahl von Erkrankungen und Verletzungen geworden. Das hat mehrere Gründe, angefangen von ihrer nicht-invasiven Natur bis hin zu ihrer Fähigkeit,hochaufgelöste Bilder von inneren Organen und Weichteilen zu erhalten. Trotz enormer Fortschritte stellt die MR-Bildgebung bestimmter anatomischer Regionen oder bei bestimmten Anwendungen und Fragestellungen eine besondere Herausforderung dar. Eine dieser Anwendungen ist die MR-Bildgebung am Muskuloskelettalen System (MSK). Die vorliegende Arbeit befasst sich mit einigen schwierigen Fragestellungen innerhalb der MSK-Bildgebung aus aus der Perspektive der Hardware-Entwicklung: mit Spulendesigns für die dynamische Bildgebung des Knies und mit MR-Bildgebung der Hand bei hohen Magentfeldern. Nach einer kurzen Einführung in die MR-Physik werden in Kapitel 1 dann verschiedene Typen von Hochfrequenz-Spulen (HF-Spulen) vorgestellt, gefolgt in Kapitel 2 mit Abhandlungen des Designs von Birdcage-Spulen, Phased Arrays und deren Charakterisierung. Außerdem enthält das Kapitel Messungen, Berechnungen und Simulationen, die im Rahmen dieser Arbeit durchgeführt wurden, um einen quantitativen Eindruck von den erläuterten Konzepten zu vermitteln. Kapitel 3 befasst sich mit dem Aufbau eines Phased-Array-Empfängers für die dynamische Bildgebung des Knies an einem großen Tiermodell (Minipig) bei 1,5 T. Es werden detailliert verschiedene Aspekte erläutert, die bei der Konstruktion eines RF-Arrays berücksichtigt werden müssen. Des Weiteren beschreibt das Kapitel die komplexe Geometrie des Zielbereichs am Knie des Minipigs und die Gründe für ein Array mitvielen Spulenelementen. ...

Much of the current research in magnetic resonance engineering focuses on reducing the acquisition time for obtaining an image while simultaneously maximizing the Signal to Noise ratio (SNR) of the image. It is known that improvement in imaging time or resolution is obtained at the cost of SNR. Therefore wherever possible, RF coil engineers design the coil in such a manner so as to maximize SNR for that coil design. In one such design consideration, most coil designers prefer placing low impedance preamplifiers near the coil. The further the pre-amplifiers are from the coil, the greater will be the signal loss due to transmission and higher will be its input impedance as perceived at the coil which would degrade inter-coil isolation. Owing to the current trend of using increasing number of receiver channels (32, 64 or 128) for parallel imaging, placing the preamplifiers near the coil would greatly complicate the coil construction. The primary objective of this research was to find the relation between SNR and referred preamp impedance and whether preamps need to be placed on the coil, or if they can be placed outside the magnet at the end of a transmission line which would simplify the construction of large count array. In addition, SNR was studied as a function of coil design parameters - coil loading, array coil separation, and system frequency. Both theoretical and experimental methods were used to undertake this investigation. A popular electromagnetic modeling technique, finite difference time domain (FDTD), was used to model SNR in arrays of two 3 inch loop coils at 3T and 1.5T. Results were also verified through bench measurement at 3T and 1.5T and by evaluating SNR. To verify the robustness of our results and to assess the possibility of using low cost standard 50 ohm preamps, we carried out additional bench measurements at 4.7T. Results demonstrated that preamplifier placement is critical at low field strength. At higher field strength, SNR degradation due to preamplifier placement was less owing to heavier coil loading.

No description available.

No description available.

A fourth gradient channel was implemented to provide slice dependent RF coil phase compensation for arrays in dual-sided or "sandwich" configurations. The use of highly parallel arrays for single echo acquisition magnetic resonance imaging allows both highly accelerated imaging and capture of dynamic and single shot events otherwise inaccessible to MRI. When using RF coils with dimensions on the order of the voxel size, the array coil element phase patterns adversely affect image acquisition, requiring correction. This has previously been accomplished using a pulse of the gradient coil, imparting a linear phase gradient across the sample opposite of that due to the RF coil elements. However, the phase gradient due to the coil elements reverses on opposite sides of the coils, preventing gradient-based phase compensation with sandwich arrays. To utilize such arrays, which extend the imaging field of view of this technique, a fourth gradient channel and coil were implemented to simultaneously provide phase compensation of opposite magnitude to the lower and upper regions of a sample, imparting opposite phase gradients to compensate for the opposite RF coil phase patterns of the arrays. The fourth gradient coil was designed using a target field approach and constructed using printed circuit boards. This coil was integrated with an RF excitation coil, dual-sided receive array, and sample loading platform to form a single imaging probe capable of both ultra-fast and high resolution magnetic resonance imaging. By employing the gradient coil, this probe was shown to simultaneously provide improved phase compensation throughout a sample, enabling simultaneous SEA imaging using arrays placed below and above a sample. The fourth gradient coil also improves the acquisition efficiency of highly accelerated imaging using both arrays for receive. The same imaging probe was shown to facilitate accelerated MR microscopy over the field of view of the entire array with no changes to the hardware configuration. The spatio-temporal imaging capabilities of this system were explored with magnetic resonance elastography.