• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 29
  • 17
  • 9
  • 3
  • 1
  • 1
  • 1
  • 1
  • Tagged with
  • 65
  • 9
  • 9
  • 9
  • 8
  • 8
  • 8
  • 8
  • 8
  • 7
  • 6
  • 6
  • 6
  • 6
  • 6
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Optimal Stock Management of Customized Products in Chemical Industry

Hu, Chan-Ao 22 January 2010 (has links)
Ethylene-vinyl acetate emulsion is the copolymer of vinyl acetate and ethylene, which has been developed as a powerful adhesive base. It effectively bonds substrates such as wood, cotton cloth, hardboard and paperboard. After modifying by adhesives producers, EVA emulsion can bond a great variety of surfaces, particularly effective in bonding polyvinyl chloride films and narrow-pore materials. Adhesives producers provides customized products according to different end users¡¦ needs and consequently have to keep raw materials in stock until orders are placed. The ordering of EVA emulsion is an important issue for adhesives producers because of the seasonal demand pattern and price fluctuation of raw materials. Furthermore, under certain transporting and order restrictions, the ordering quantity is fixed and delivery time has to be made in advance. The multi-period inventory models, including EOQ and ROP, are not suitable for analyzing the ordering of EVA emulsion due to the presupposition of unlimited period. This research is based on the case study for NP chemical, using modified ROP model to explore how the selection of service level and delivery time can effect safety stock, probability of shortage, and inventory cost under the conditions of limited period, seasonal demand, given order quantity, and pre-selecting delivery points. The study also constructs a liquid raw material inventory model with fluctuating price and given order quantity in order to determine the optimal combination of delivery points. The conclusion of this study are presented as follows: 1.Service level doesn¡¦t directly effects the probability of shortage and inventory cost in limited period. 2.The combination of delivery points is the key decision factor because of its causal relationship with the probability of shortage and inventory cost. 3.The optimal combination which leads to the lowest inventory cost can be determined by using the inventory model introduced in this study.
2

Sustainable Polymers Through Creative Design

Arrington, Kyle 03 July 2018 (has links)
Plastics have changed the world of materials due to their high durability, low price, low density, and ease of processing. Unfortunately, the majority of plastic goods produced are discarded instead of recycled, leading to a massive accumulation of plastic waste in landfills and natural habitats. To decrease the impact of plastic waste, sustainable materials and synthetic methods are needed. This dissertation focuses on new strategies for developing renewable and degradable polymers with minimal energy input as well as new methods to blend legacy polyolefins with renewable polymers. The first half of the dissertation focuses on synthesizing polymers using light while the second section focuses on combining traditional polyolefins with renewable polymers. Photo-mediated polymerizations are an attractive alternative to traditional thermal polymerizations due to their ease of setup and the spatiotemporal control afforded by light. Using LED lights also affords a synthetic technique that requires little energy input, thus decreasing the overall environmental impact of the material. In this work, coupling LEDs with a trithiocarbonate allowed for the synthesis of many different polymers and topologies. Bottlebrush polymers synthesized with light afforded molar masses in excess of 11 million Da without the oligomerization of the bottlebrush polymers. These bottlebrush polymers were then used to make reversibly crosslinkable adhesives, allowing for a new example of recyclable adhesives. The second half of the dissertation focuses on developing sustainable polymers using ring-opening metathesis polymerization (ROMP) to combine the properties of polyolefins with renewable polymers. First, polyketones synthesized by ROMP were developed for their potential use as photodegradable polymers. This initial study probed the synthesis of different polyketone monomers and the properties of their respective polymers. Next, a photodegradable and biodegradable thermoplastic elastomer (TPE) was synthesized that incorporated a ketone containing polybutadiene (PB) flanked by polylactide (PLA). The thermomechanical properties were controlled based on the relative length of each block while the rate of photodegradation was controlled by the mol% of ketone incorporated into the PB block. Finally, ABA triblock copolymers of cellulose derivatives and polyolefins were developed for their uses as compatibilizers for blends. With the addition of as little as 1 wt% of the ABA triblock copolymer, the respective blends showed large imp / PHD
3

Ras Opposite, the Drosophila Homologue of Munc18-1, is Important for Motor Axon Maintenance.

Carlson, Nicole E 03 May 2011 (has links)
Amyotrophic Lateral Sclerosis (ALS) is a fatal disease characterized by the progressive degeneration of motor neurons. Although there has been some progress in the identification of genes linked to inherited cases of ALS, the etiology of this disease remains largely unknown. Clinical progression of motor neuron diseases is associated with the degeneration of the axon preceding cell death. Elucidating novel mechanisms important for motor axon maintenance will help gain greater insight into disease pathogenesis. Here, I report that mutations in ras-opposite (rop), which encodes the Drosophila homologue of mammalian Sec1/Munc18, cause progressive degeneration of motor axons while sensory axons are largely unaffected. While mutations in mammalian munc18-1 have been linked to degeneration of the spinal cord, the mechanisms by which this occurs are unknown. Using Drosophila, I found that RNAi-induced knockdown of rop leads to severe motor deficits in adult flies. In addition, I discovered that motor axon degeneration in rop mutants could be delayed by overexpression of the neuronal maintenance factor Nmnat. Interestingly, I found that Rop is localized with Nmnat at the neuromuscular junction and that Rop physically interacts with Nmnat in vivo. These data indicate a novel role for Rop in motor axon maintenance and provide insight into the pathogenesis of neurodegenerative diseases targeting motor neurons, such as ALS.
4

Exploring the Sequence Landscape of the Four-helix Bundle Protein ROP using DeepSequencing

Panneerselvam, Nishanthi January 2013 (has links)
No description available.
5

Catalyseurs organiques photolatents pour la polymérisation par ouverture de cycles différée / Photolatent organocatalysts for delayed ring-opening polymerization

Placet, Emeline 06 November 2018 (has links)
La photopolymérisation est un procédé en plein essor qui permet d’accéder à des matériaux polymères, notamment sous la forme de films ou de revêtements. Néanmoins, celle-ci est majoritairement basée sur un mécanisme de polymérisation radicalaire qui proscrit l’obtention de matériaux totalement biodégradables. Aussi, au cours de cette thèse, nous nous sommes intéressés à la photopolymérisation par ouverture de cycle (photoROP) d’esters et de carbonates cycliques à l’aide de deux grandes familles de photogénérateurs de bases (PBGs). Tout d’abord, des PBGs, pouvant libérer des superbases de type amidine et guanidine cycliques ont été employées pour mener efficacement la photoROP du L-LA et du TMC en solution. Puis, nous nous sommes attachés à développer, sur le modèle des photobases précédentes, de nouveaux PBGs qui libèrent sous irradiation UV des carbènes N-hétérocycliques (NHCs). La libération des NHCs à partir de ces « NHCs photolatents » a été prouvée par RMN 1H et par la formation d’adduits NHC.CS2. De même, ces PBGs se sont révélés actifs pour la photoROP du L-LA et du TMC en solution, mais avec une plus faible efficacité que les PBGs précédents. En effet, les cinétiques de polymérisation sont lentes du fait de la présence de CO2 dans le milieu (libéré lors de l’irradiation UV) qui conduit à la formation d’adduit NHC.CO2 inactif en ROP. Ainsi, la photobase la plus performante, libérant du TBD, a été employée afin d’effectuer la photoROP en masse d’esters cycliques liquides (ε-CL, δ-VL et un mélange innovant L-LA/TMC). Finalement, des réseaux ont été formés par incorporation dans le milieu réactionnel d’un monomère bifonctionnel, permettant d’obtenir sur demande (contrôle temporel) des matériaux réticulés potentiellement entièrement biodégradables. / Photopolymerization is a growing process allowing preparing polymer materials, notably in the form of films or coatings. Nevertheless, it is mostly based on a radical polymerization mechanism that prevents obtaining fully biodegradable materials. The goal of this PhD work was thus to develop the photopolymerization of cyclic esters and carbonates by using two families of photobase generators (PBGs). First, already described PBGs, releasing cyclic amidine and guanidine-type superbases, were effectively employed to carry out the photopolymerization of L-LA and TMC in solution. Then, taking previous PBGs as models, we developed new PBGs able to release N-heterocyclic carbenes (NHCs) under UV irradiation. The release of NHCs from these “photolatent NHCs” was proven both by 1H NMR and by the formation of NHC.CS2 adducts. These PBGs also proved to be active for the ROP of L-LA and TMC in solution, but to a lesser extent than previous photobases. Indeed, slower kinetics of polymerization were observed, which was attributed to the presence of CO2 in the reaction medium (CO2 released by photodegradation of the PBG) that leads to the formation of NHC.CO2 adduct (inactive for ROP). Thus, the most efficient photobase (releasing TBD) was employed to carry out the bulk photopolymerizations of liquid cyclic esters (ε-CL, δ-VL and even an innovative L-LA / TMC mixture). Finally, polymer networks have been formed by incorporating a bifunctional monomer into the reaction medium, allowing the preparation “on demand” (temporal control) of potentially fully biodegradable materials in a one-pot process.
6

Identifying memory address disclosures

North, John January 2015 (has links)
Software is still being produced and used that is vulnerable to exploitation. As well as being in devices in the homes of many people around the world, programs with these vulnerabilities are maintaining life-critical systems such as power-stations, aircraft and medical devices and are managing the creation and distribution of billions of pounds every year. These systems are actively being exploited by governments, criminals and opportunists and have led to loss of life and a loss of wealth. This dependence on software that is vulnerable to exploitation has led to a society with tangible concerns over cyber-crime, cyber-terrorism and cyber-warfare. As well as attempts to eliminate these vulnerabilities, techniques have been developed to mitigate their effects; these prophylactic techniques do not eliminate the vulnerabilities but make them harder to exploit. As software exploitation is an ever evolving battle between the attackers and the defenders, identifying methods to bypass these mitigations has become a new battlefield in this struggle and the techniques that are used to do this require vulnerabilities of their own. As many of the mitigation techniques are dependent upon secrecy of one form or another, vulnerabilities which allow an attacker to view those secrets are now of importance to attackers and defenders. Leaking of the contents of computer memory has always been considered a vulnerability, but until recently it has not typically been considered a serious one. As this can be used to bypass key mitigation techniques, these vulnerabilities are now considered critical to preventing whole classes of software exploitation. This thesis is about detecting these types of leaks and the information they disclose. It discusses the importance of these disclosures, both currently and in the future. It then introduces the first published technique to be able to reliably identify specific classes of these leaks, particularly address disclosures and canary-disclosures. The technique is tested against a series of applications, across multiple operating systems, using both artificial examples and software that is critical, commonplace and complex.
7

RIP-ROP: uma proteção contra ataques de execução de código arbitrário baseados em Return-Oriented Programming

Ferreira, Mateus Felipe Tymburibá 06 August 2014 (has links)
Submitted by Geyciane Santos (geyciane_thamires@hotmail.com) on 2015-06-17T15:20:30Z No. of bitstreams: 1 Dissertação - Mateus Felipe Tymburibá Ferreira.pdf: 4435693 bytes, checksum: da80cc7a540a306b4bc52b8792ffe9e1 (MD5) / Approved for entry into archive by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2015-06-17T20:44:52Z (GMT) No. of bitstreams: 1 Dissertação - Mateus Felipe Tymburibá Ferreira.pdf: 4435693 bytes, checksum: da80cc7a540a306b4bc52b8792ffe9e1 (MD5) / Approved for entry into archive by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2015-06-17T20:45:51Z (GMT) No. of bitstreams: 1 Dissertação - Mateus Felipe Tymburibá Ferreira.pdf: 4435693 bytes, checksum: da80cc7a540a306b4bc52b8792ffe9e1 (MD5) / Made available in DSpace on 2015-06-17T20:45:51Z (GMT). No. of bitstreams: 1 Dissertação - Mateus Felipe Tymburibá Ferreira.pdf: 4435693 bytes, checksum: da80cc7a540a306b4bc52b8792ffe9e1 (MD5) Previous issue date: 2014-08-06 / CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / ReturnOriented Programming (ROP) is the name of a technique used for the development of malicious code that has been widely used to force execution of arbitrary code on vulnerable applications. It is based on the interconnection of small fractions of code belonging to attacked processes, which allows overcoming protections widely disseminated, such as that offered by the execute bit (NX/XD). Because of its wide use in attacks against modern computing systems, protections against ROP based exploits have been widely studied. Nevertheless, it is still not known a solution capable of combining efficacy against all forms of ROP, computational efficiency and feasibility of the employment on applications protection. In order to facilitate the understanding of these requirements and the inherent implications for methods of protection against ROP attacks, this work offers a bibliographic survey of the state of the art about this subject. For this, we propose in this paper: (i) metrics for evaluation and comparison of protections against ROP attacks and (ii) taxonomies to classify these protections depending on blocking strategies and implementation approaches used in each solution. This dissertation also provides a new method of protection against arbitrary code execution attacks based on ROP that seeks to encompass the requirements of effectiveness, efficiency and viability. It was demonstrated that by controlling the frequency of indirect branch instructions performed by applications it is possible to distinguish ROP attacks from authentic codes and thus prevent their consolidation. In a dynamic binary instrumentation framework, it was developed a prototype – named RIPROP – for Windows, Linux, Android and OSX environments. Experiments conducted with malicious codes available in public repositories of exploits confirmed the feasibility of the proposed model for the protection of real applications. In addition, the computational cost imposed by RIPROP is comparable and in some cases lower than that achieved by related protections. / ReturnOriented Programming (ROP) é o nome de uma técnica usada para o desenvolvimento de códigos maliciosos que vem sendo amplamente utilizada para forçar a execução de códigos arbitrários em aplicações vulneráveis. Ela baseiase na interligação de pequenas frações de código pertencentes aos próprios processos atacados, o que permite a superação de proteções largamente difundidas, como aquela oferecida pelo bit de execução (NX/XD). Em função de seu vasto emprego em investidas contra sistemas computacionais modernos, proteções contra exploits baseados em ROP têm sido extensamente estudadas. Apesar disso, ainda não se conhece uma solução capaz de aliar eficácia contra todas as modalidades de ROP, eficiência computacional e viabilidade de emprego na proteção de aplicações. Com o intuito de facilitar o entendimento desses requisitos, bem como das implicações inerentes a métodos de proteção contra ataques ROP, este trabalho oferece um levantamento bibliográfico do estado da arte envolvendo esse tema. Para isso, são propostas neste trabalho: (i) métricas para avaliação e comparação de proteções contra ataques ROP e (ii) taxonomias para classificação dessas proteções em função das estratégias de bloqueio e das abordagens de implementação utilizadas em cada solução. Esta dissertação provê ainda um novo método de proteção contra ataques de execução de código arbitrário baseados em ROP que busca abarcar os requisitos de eficácia, eficiência e viabilidade. Demonstrou-se que, através do controle da frequência de instruções de desvio indireto executadas pelas aplicações, é possível distinguir ataques ROP de códigos autênticos e, assim, evitar a sua consolidação. Em um framework de instrumentação binária dinâmica, foi desenvolvido um protótipo – denominado RIP-ROP – destinado a ambientes Windows, Linux, Android e OSX. Experimentos realizados com códigos maliciosos disponíveis em repositórios públicos de exploits confirmaram a viabilidade do modelo proposto para a proteção de aplicações reais. Além disso, o custo computacional imposto pelo RIP-ROP é comparável e, em alguns casos, inferior àquele alcançado por proteções correlatas.
8

New main group and rare earth ring-opening polymerisation catalysts

Core, Bryony A. January 2015 (has links)
This Thesis describes the synthesis and characterisation of new Group 2, Group 3 and lanthanide amide, alkyl, halide, borohydride and alkoxide complexes, and their uses as catalysts for the living ROP and immortal ring-opening polymerisation (iROP) of rac-, L, D- and meso-lactide. <strong>Chapter One</strong> introduces cyclic esters and possible mechanistic pathways leading to polyesters by ROP. Living and immortal ROP, including their kinetic characteristics are discussed. An overview of ROP from an industrial perspective and a literature review are also given. <strong>Chapter Two</strong> describes the synthesis and characterisation of a new series of magnesium and zinc amide, alkyl, halide, borohydride and alkoxide complexes supported by a carbazole-bis(dimethyloxazoline) ligand. Their activities towards the ROP of rac-, L- and meso-lactide are presented. Detailed mechanistic studies using spectroscopic techniques are discussed and a new mechanism is proposed. <strong>Chapter Three</strong> describes the synthesis and characterisation of a new series of calcium, strontium, yttrium, lanthanum and samarium amide, alkyl, halide, borohydride and alkoxide complexes supported by a carbazole-bis(dimethyloxazoline) ligand. Their activities towards the ROP of rac-, L- and meso-lactide are presented. Detailed mechanistic studies using spectroscopic techniques are discussed. <strong>Chapter Four</strong> describes the synthesis and characterisation of a new series of magnesium, calcium, strontium, yttrium, lanthanum and samarium amide, halide and borohydride complexes supported by a chiral carbazole-bis(isopropyloxazoline) ligand. Their activities towards the ROP of rac-, L-, D- and meso-lactide are presented. <strong>Chapter Five</strong> contains experimental details and characterising data for the new complexes reported in this Thesis. <strong>CD Appendix</strong> contains .CIF files for all the new crystallographically-characterised complexes.
9

Polykaprolakton, jeho syntéza, charakterizace a degradabilita / Polycaprolactone, synthesis, characterization, and degradability

Boháčová, Zdeňka January 2010 (has links)
Presented diploma thesis deals with the study of ring-opening polymerization (ROP) of caprolactone catalyzed by novel organic and organometallic compounds. In the theoretical part of the thesis a summary of polymerization strategies and catalytic/initiators systems for ROP of polyesters is overviewed on the basis of reported background research. In experimental part a series of caprolactone polymerization runs with the view of polymerization conditions (solution/monomer ratio, catalyst/initiator ratio, monomer/initiator ratio and monomer concentration) at the temperature range of 25-70 °C was carried out. The experimental study was focused on catalytic precursors based on organic carbenes (tBuNCH=CHN+tBu)CH Cl- (NHC-tBu) in tetrahydrofuran solution and complex of aluminium{O,O’-[4,5-P(O)Ph2tz]-AlMe2} Ph = phenyl, tz = triazole, (OAlMe2) in chlorobenzene solution. Obtained polymers were precisely characterized by means of 1H NMR spectroscopy (Bruker Avance), Differential scanning calorimetry (TA Instruments Q 2000) and Gel permeation chromatography (Agilent Technologies 1100 series) methods. The microbial degradability of synthesized polymer sample having Mn = 12 kg/mol, Mw/Mn = 2.5 and crystallinity degree of 53 % was examined. The polymer in the form of melt-pressed films and powder form was bacterially aged in Bacillus subtilis (BS) strain inoculated mineral and nutrient media for 42 days. Scanning electron microscopy (SEM) and Confocal laser scanning microscopy (CLSM) confirmed the crack development on the surface of films as the consequence of microbial attack in comparison with unchanged control samples. Moreover, the pink coloration of polymer suspension was observed as the consequence of bacterial activity.
10

Catalytic Hydrogenation and Hydrodesulfurization of Model Compounds

Zhao, Haiyan 06 May 2009 (has links)
This dissertation describes two related studies on hydrogenation and hydrodesulfurization of heterocyclic S-containing compounds. Alkyl substituted thiophenes are promising candidates for hydrogen carriers as the dehydrogenation reactions are known to occur under mild conditions. Four types of catalysts including supported noble metals, bimetallic noble metals, transition metal phosphides and transition metal sulfides have been investigated for 2-methylthiophene (2MT) hydrogenation and ring opening. The major products were tetrahydro-2-methylthiophene (TH2MT), pentenes and pentane, with very little C5-thiols observed. The selectivity towards the desired product TH2MT follows the order: noble metals > bimetallics > phosphides > sulfides. The best hydrogenation catalyst was 2% Pt/Al2O3 which exhibited relatively high reactivity and selectivity towards TH2MT at moderate temperatures. Temperature-programmed desorption (TPD) of hydrogen indicated that the H2 desorption amount was inversely related to the rate of TH2MT formation. Temperature programmed reaction (TPR) experiments revealed that pentanethiol became the major product, especially with HDS catalysts like CoMoS/Al2O3 and WP/SiO2, which indicates that poisoned or modified conventional HDS catalysts would be good candidates for further 2MT hydrogenation studies. The role of tetrahedral Ni(1) sites and square pyramidal Ni(2) sites in Ni2P hydrotreating catalysts was studied by substitution of Ni with Fe. The Fe component was deemed as a good probe because Ni2P and Fe2P adopt the same hexagonal crystal structure, yet Fe2P is completely inactive for hydrodesulfurization (HDS). For this purpose a series of NiFeP/SiO2 catalysts were prepared with different Ni:Fe molar ratios (1:0, 3:1, 1:1, 1:3, and 0:1) and investigated in the HDS of 4,6-dimethyldibenzothiophene at 300 and 340 oC. The uniformity of the NiFe series was demonstrated by x-ray diffraction analysis and by Fourier transform infrared (FTIR) spectroscopy of adsorbed CO. The position of substitution of Fe was determined by extended X-ray absorption fine structure (EXAFS) analysis. It was found that at 300 oC the HDS activity of the catalysts decreased with increasing Fe content and that this could be explained by the substitution of Fe at the more active Ni(2) sites. As temperature was raised to 340 oC, the activity of the Fe-containing samples increased, although not to the level of Ni2P, and this could be understood from a reconstruction of the NiFe phase to expose more Ni(2) sites. This was likely driven by the formation of surface Ni-S bonds, which could be observed by EXAFS in spent samples. / Ph. D.

Page generated in 0.0508 seconds