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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Showing 1 to 2 of 2 (0.027 seconds)

Spelling suggestions: "subject:"rab9"" "subject:"ab9""

1

Studium pohybu polyomavirů z pozdního endozómu směrem k buněčnému jádru / Studies of polyomavirus trafficking from late endosomes towards the cell nucleus

Štach, Martin January 2016 (has links)
Mouse polyomavirus (MPyV) is a model virus of the Polyomaviridae family. Polyomaviruses are small non-enveloped DNA viruses. They cause severe problems to immunocompromised patients. Their oncogenic potential is known in animals and humans. Trafficking of MPyV within the cell is not clear yet. The virus enters via smooth monopinocytic vesicles and continues to early and late endosomes. From there, the virus is transported to the ER by unknown mechanism. It bypasses Golgi aparatus (GA). One possible pathway is from late endosomes to trans-Golgi network (TGN) facilitated by Rab9 GTPase and then in COPI vesicles to the ER. In this thesis, the effect of inhibitors of retrograde transport (Brefeldin A, Golgicide A) on MPyV infection was evaluated. Brefeldin A is not completely specific; it has effect on whole endosomal system. Golgicide A causes specific disruption of transport via TGN and GA. Both inhibitors suppressed infection of MPyV. Confocal microscopy revealed colocalization of some MPyV virions with markers of TGN and COPI vesicles. MPyV didn't colocalize with cis-Golgi marker. Unfortunately, the effect of overexpression of Rab9 dominant negative mutant couldn't been evaluated due to its high cytotoxicity. However, overexpression of wild type Rab9 slightly increased infectivity. The results...
2

Étude des propriétés de signalisation et de trafic du récepteur delta opiacé : vers une meilleure compréhension des bases cellulaires de la tolérance analgésique aux opioïdes

Charfi, Iness 03 1900 (has links)
No description available.
RCPG
DOPr
Signalisation
Internalisation
Sélectivité fonctionnelle
Modèle opérationnel
Recyclage
TGN
Rab9
TIP47
ALIX
Tolérance analgésique
GPCR
Signaling
Internalization
Functional selectivity
Operational model
Recycling
Analgesic tolerance

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