No description available.

Electronic platforms that are able to re-shape and assume different geometries are attractive for the advancing biomedical technologies, where the re-shaping feature increases the adaptability and compliance of the electronic platform to the human body. In this thesis, we present a serpentine-honeycomb reconfigurable electronic platform that has the ability to reconfigure into five different geometries: quatrefoil, ellipse, diamond, star and one irregular geometry. We show the fabrication processes of the serpentine-honeycomb reconfigurable platform in a micro-scale, using amorphous silicon, and in a macro-scale using polydimethylsiloxane (PDMS). The chosen materials are biocompatible, where the silicon was selected due to its superior electrical properties while the PDMS was selected due to its unique mechanical properties. We study the tensile strain for both fabricated-versions of the design and we demonstrate their reconfiguring capabilities. The resulting reconfiguring capabilities of the serpentine-honeycomb reconfigurable platform broaden the innovation opportunity for wearable electronics, implantable electronics and soft robotics.

As the rate and severity of malicious software attacks have escalated, industrial control systems (ICSes) have emerged as a particularly vulnerable target. ICSes govern the automation of the physical processes in industries such as power, water, oil and manufacturing. In contrast to the personal computing space, where attackers attempt to capture information or computing resources, the attacks directed at ICSes aim to degrade or destroy the physical processes or plants maintained by the ICS. Exploits with potentially catastrophic results are sold on brokerages to any interested party. Previous efforts in ICS security implicitly and mistakenly trust internal software. This thesis presents an architecture for trust enhancement of critical embedded processes (TECEP). TECEP assumes that all software can be or has already been compromised. Trust is instead placed in hardware that is invisible to any malicious software. Software processes critical for stable operation are duplicated in hardware, along with a supervisory process to monitor the behavior of the plant. Furthermore, a copy of the software and a model of the plant are implemented in hardware in order to estimate the system's future behavior. In the event of an attack, the hardware can successfully identify the plant's abnormal behavior in either the present or the future and supersede the software's directives, allowing the plant to continue functioning correctly. This approach to ICS security can be retrofitted to existing ICSes, has minimal impact on the ICS design process, and modestly increases hardware requirements in a programmable system-on-chip. / Master of Science

Coarse-Grained Reconfigurable Architectures(CGRAs) can be employed for accelerating computational workloads that demand both flexibility and performance. CGRAs comprise a set of computation elements interconnected using a network and this interconnection of computation elements is referred to as a reconfigurable fabric. The size of application that can be accommodated on the reconfigurable fabric is limited by the size of instruction buffers associated with each Compute element. When an application cannot be accommodated entirely, application is partitioned such that each of these partitions can be executed on the reconfigurable fabric. These partitions are scheduled by an orchestrator. The orchestrator employs dynamic dataflow execution paradigm. Dynamic dataflow execution paradigm has inherent support for synchronization and helps in exploitation of parallelism that exists across application partitions. In this thesis, we present a compiler that targets such CGRAs. The compiler presented in this thesis is capable of accepting applications specified in C89 standard. To enable architectural design space exploration, the compiler is designed such that it can be customized for several instances of CGRAs employing dataflow execution paradigm at the orchestrator. This can be achieved by specifying the appropriate configuration parameters to the compiler. The focus of this thesis is to provide efficient support for various kinds of parallelism while ensuring correctness. The compiler is designed to support fine-grained task level parallelism that exists across iterations of loops and function calls. Additionally, compiler can also support pipeline parallelism, where a loop is split into multiple stages that execute in a pipelined manner. The prototype compiler, which targets multiple instances of a CGRA, is demonstrated in this thesis. We used this compiler to target multiple variants of CGRAs employing dataflow execution paradigm. We varied the reconfigur-able fabric, orchestration mechanism employed, size of instruction buffers. We also choose applications from two different domains viz. cryptography and linear algebra. The execution time of the CGRA (the best among all instances) is compared against an Intel Quad core processor. Cryptography applications show a performance improvement ranging from more than one order of magnitude to close to two orders of magnitude. These applications have large amounts of ILP and our compiler could successfully expose the ILP available in these applications. Further, the domain customization also played an important role in achieving good performance. We employed two custom functional units for accelerating Cryptography applications and compiler could efficiently use them. In linear algebra kernels we observe multiple iterations of the loop executing in parallel, effectively exploiting loop-level parallelism at runtime. Inspite of this we notice close to an order of magnitude performance degradation. The reason for this degradation can be attributed to the use of non-pipelined floating point units, and the delays involved in accessing memory. Pipeline parallelism was demonstrated using this compiler for FFT and QR factorization. Thus, the compiler is capable of efficiently supporting different kinds of parallelism and can support complete C89 standard. Further, the compiler can also support different instances of CGRAs employing dataflow execution paradigm.

<p>  </p> <p>In the pharmaceutical industry, special care must be taken by companies to guarantee high quality medications that are free from byproducts and impurities. The development process involves various considerations including solvent selection, solubility screening, unit operation selection, environmental, and health impact evaluations. Traditionally, pharmaceutical manufacturing consisted of large, centralized facilities to meet pharmaceutical demands; however, there has been a recent shift toward distributed manufacturing. With distributed manufacturing platforms, rapidly changing supply chain needs can be met regionally in addition to supplying small-volume medications and personalized medicines to hospitals and pharmacies. To produce quality pharmaceuticals, distributed manufacturing platforms should integrate digital design, novel unit operations, and process analytical technology (PAT) tools for quality monitoring and control. In this dissertation, a process design and development framework is proposed and implemented for a small-scale pharmaceutical manufacturing platform: MiniPharm.</p> <p>Various approaches to process design are detailed in this dissertation, which include heuristic-based and digital or simulation-based design. For heuristic-based design, the knowledge of the researchers was utilized to provide unit operation evaluation and screening of process alternatives. In cases when unit operations were highly complex, digital or simulation-based design was utilized to conduct sensitivity analyses and simulation-based design of experiments. With the implementation of simulation-based design, material and time needs were reduced while gaining knowledge about the system. The integration of various unit operations comes with increased understanding of start-up dynamics and operational constraints. What was found to be the most successful approach was the combination of heuristics and digital design to combine researcher knowledge and experience with the information gained from process modeling and simulation to create process alternatives that utilized system dynamics to reach desired process outcomes. </p> <p>Additionally, MiniPharm was used for process model development at the small-scale. Various software packages have been made commercially available that focus on production scale; however, models for small-scale operations are not typically implemented in these packages. Models for unit operations were fit with collected experimental data to estimate model parameters for small-scale synthesis, liquid-liquid extraction, and crystallization unit operations. The models were implemented to better capture the heat and mass transfer of the milli-fluidic scale platform, which consist of unit operations housed within microchannels. MATLAB was utilized for estimation of parameters such as kinetic rate constants and overall mass transfer coefficients. These parameters were used for design space determination and process disturbance simulation. The exploration of the impact of various process parameters on quality attributes helps researchers gain a deeper understanding about the manufacturing process and helps to demonstrate how to control the process. </p> <p>An important aspect of MiniPharm is the process development progress that has been demonstrated. With the construction of a modular and reconfigurable platform, various process alternatives can now be experimentally validated. The integration of unit operations operated at a decreased scale makes MiniPharm an example of process intensification. The implementation of integrated unit operations decreases handling time of intermediates and reduces the overall footprint for manufacturing. Designed to allow for increased flexibility of operation, perfluoroalkoxy alkane (PFA) tubing was used for synthesis and purification. With PFA tubing clean in place procedures can be implemented using continuous solvent flow or the low cost, PFA tubing can be replaced. The modular nature of the platform also allows for the investigation of individual unit operations for performance evaluation. </p> <p>Finally, a novel continuous solvent switch distillation unit operation was designed and constructed along with customized reactor and crystallizers for process alternative screening for the synthesis and purification of two compounds: Diphenhydramine hydrochloride and Lomustine. Diphenhydramine hydrochloride is a low-value, high volume allergy medication commonly found in Benadryl and Lomustine is a high-value, low volume cancer medication used to treat glioblastoma and Hodgkin Lymphoma. The production of the compounds demonstrated the flexibility of the manufacturing platform to produce both a generic and a specialty medication. A versatile platform is needed for distributed manufacturing because of quickly changing supply chain needs. Overall, this dissertation successfully demonstrates the process design, development, and simulation for small-scale manufacturing.</p>