Thesis (Ph. D.)--University of Washington, 2001. / Vita. Includes bibliographical references (leaves 65-68).

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 4 uppsatser.

Diss. (sammanfattning) Göteborg : Göteborgs universitet, 2007. / Härtill 4 uppsatser.

After sustaining a traumatic brain injury (TBI), a person’s ability to make daily decisions can be affected. Simple tasks such as, deciding what to wear are no longer effortless choices, but are instead difficult decisions. Incorporating behavioral assays that address decision-making skills after TBI can help a pharmacological treatment become easily translatable, as it is specifically assessing a certain aspect of cognitive functioning. Magnesium is a multimodal treatment that can decrease apoptosis, decrease breakdown of the blood brain barrier, and lessen brain edema after a TBI, which can affect the recovery of a patient. A discrimination task was used in conjunction with a magnesium treatment in order to examine how decision-making is affected after TBI and if the treatment helps to attenuate cognitive and motor deficits. Thirty-one male Sprague-Dawley rats (Harlan, Indianapolis, IN) were used and separated into MAG/TBI, VEH/TBI, or VEH/Sham groups. Before induction of a bilateral frontal injury, rats were shaped to learn to dig in the sand for a reinforcer and then pre-trained on the dig task. After surgery, rats received either an i.p. injection of 2 mmol/kg magnesium chloride or 0.1% phosphate buffer solution (PBS). Magnesium injections occurred 4 hours post-surgery, then at 24 hours and at 72 hours. Dig task testing began 7 days post-injury, lasting for 4 weeks. The discriminations included two scent pairings; basil (baited) versus coffee then the reversal and then cocoa (baited) versus cumin then the reversal. The locomotor placing task was conducted in order to assess for the recovery of motor function after TBI. Fear conditioning was also conducted to examine the role of extinction after TBI. The results indicated that the magnesium treatment was successful at attenuating cognitive and motor deficits after TBI. The results also indicated that the dig task is a sufficient operant conditioning task in the assessment of frontal functioning after TBI. The fear conditioning procedures, however, failed to produce significant results. Discrimination testing and a magnesium treatment both have the potential to positively impact the millions of people suffering from a TBI.

Made available in DSpace on 2014-06-11T19:22:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-07-09Bitstream added on 2014-06-13T19:08:18Z : No. of bitstreams: 1 bastos_fn_me_prud.pdf: 662059 bytes, checksum: e53a8b1da32e59631739cc47d409626e (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / A recuperação pós-exercício consiste em restaurar os sistemas do corpo à sua condição basal, proporcionando equilíbrio e prevenindo a instalação de lesões e, nesse sentido, torna-se aspecto importante de todo programa de condicionamento físico, em quaisquer níveis de desempenho, mas, sobretudo nos mais elevados. O objetivo desta revisão foi reunir informações e descrever as respostas proporcionadas por métodos recuperativos pós-exercício como, crioterapia, contraste, massagem e recuperação ativa, constituindo uma fonte de atualização do referido tema. Utilizou-se os bancos de dados, MedLine, Scielo e Lilacs, como lista de periódicos o SportsDiscus. Foram incluídos no estudo somente ensaios clínicos randomizados controlados e não-controlados além de artigos... / The post-exercise recovery consists in restoring the body systems to baseline condition, providing balance and preventing injuries installation and, in that sense; it becomes an important aspect of every fitness program, at any levels of performance, but especially in higher levels. The objective of this review was to gather information and to describe the responses provided by post-exercise recovery methods, such as cryotherapy, contrast water immersion, massage and active recovery, providing an update on this issue. MedLine, Scielo and Lilacs databases were used, as well as the SportsDiscus list of journals. Only randomized controlled and non-controlled clinical essays, in addition to review articles concerning the proposed topic were included. Our choice was for the search terms: cryotherapy, massage, active recovery, thermotherapy, immersion and exercise, individually and combined. It was observed that some studies report that cryotherapy is harmful concerning post-exercise recovery, once it reduces performance immediately after the technique... (Complete abstract click electronic access below)

The effect of transplants of either fetal hippocampal or dorsal ventricular ridge (DVR) tissue into the brains of adult male rats exposed to TMT was determined for two behavioral tasks. Administration of TMT produced deficits in acquisition and performance of an operant differential reinforcement of low response rates (DRL) schedule and learning in the Morris water maze. The fetal transplants developed well within the TMT damaged brains of the adult rats and numerous axons could be shown to cross the host transplant interface. The transplants significantly recuced the DRL deficit produced by exposure to TMT. However, the TMT-induced deficit in water maze acquisition was made significantly worse by the hippocampal transplants. The improvement in DRL performance is attributed to the effect on the host brain of an unidentified trophic substance produced by the transplants. However, this positive effect may not protect the brain sufficiently to produce recovery in tasks demanding more complex neural computations than are required to withhold lever-press responses. The transplant-induced deficit observed in some aspects of water maze acquisition and performance may be attributable to either a tumor-like deleterious effect of the mass of the transplant or to abnormal neuronal activity transmitted from the transplant to the host brain. The results of the present study, and those from other similar studies, suggest that transplants of fetal tissue may be useful in producing changes in the brain of an animal exposed to an environmental neurotoxin, but that research should be focused upon development of transplant methodology that will minimize adverse effects of the grafts.

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 4 uppsatser.

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 5 uppsatser.

Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 4 uppsatser.

Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 5 uppsatser.