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<p>Evolutionary innovations, at the molecular level, represent the novel establishment of regulation networks among previously unconnected genes. Understanding the cellular and molecular mechanisms that underlies the development of such innovations is of central importance in evolutionary-developmental research (evo-devo). The sex comb of <em>Drosophila</em> is an excellent model to study the molecular basis of evolutionary innovations. Highline and Lowline are two artificial selected <em>D. melanogaster</em> lines differing in the number of sex comb bristles. It was expected that the “cross-regulation loop” between two transcription factors, <em>Doublesex</em> male isoform (DSX^M) and <em>Sexcombs reduced</em> (SCR), evolves rapidly and promotes the morphological evolution of sex combs. We used immunofluorescent technique (antibody staining) to compare the expression of DSX^M and SCR in the forelegs of three different lines (Highline, Wildtype and Lowline). We hypothesized that artificial selection will increase expression of DSX^Mand SCR in the Highline and reduce expression in the Lowline. The fluorescent pictures of antibody staining experiments indicate that the expression region of DSX^M in the Highline is significantly higher than the expression region in the Lowline, and the expression levels of SCR has minor difference among the three lines. DSX^M expression is altered by the artificial selection, but SCR expression is not. The influence of artificial selection appears to have been constrained by development. Our investigation provides an approach to test the validity of the models of cross-regulation s between SCR and DSX^M during development.</p> / Master of Science (MSc)

<p> High Level Synthesis (HLS) is a promising approach to managing design complexity at a more abstract level as integrated circuit technology edges deeper into sub-micron design. One useful facet of HLS is the ability to automatically integrate architectural components that can address potential reliability issues, which may be on the increase due to miniaturization. Research into harnessing HLS for fault tolerance (FT) has been progressing since the early 1990's. There currently exists a large body of work regarding methods to incorporate capabilities such as fault detection, compensation, and recovery into HLS design.</p> <p> While many avenues of FT have been explored in the HLS environment, very little work has considered the effectiveness and feasibility of these techniques in the context of large HLS systems, which presumably is the raison d'etre of HLS. While existing HLS FT approaches are often elegant and involve highly sophisticated techniques to achieve optimal solutions, the costs of HLS infrastructure in regards to scalability are not well reported. The intent of this thesis is to explore the ramifications of applying common HLS techniques to large designs.</p> <p> Furthermore, a new HLS tool entitled RIFT is presented that is specifically designed to mitigate infrastructure costs that mount as greater parallelism is utilized. RIFT is named for its design philosophy of "Reducing Interconnects for Fault Tolerance". RIFT iteratively builds a logical hardware representation, which consists of both the components instantiated and their interconnections, one operation at a time. It chooses the next operation to be "mapped" to the burgeoning design based on scheduling constraints as well as the extra hardware and interconnect costs required to support a particular selection. Emphasis is placed on minimizing the delay of the datapath in effort to reduce the performance cost associated with the extra interconnects needed for FT. RIFT has been used to generate efficient solutions for FT designs requiring as many as a thousand operations.</p> / Thesis / Master of Applied Science (MASc)

To improve the performance of the three-way catalytic (TWC) converter, advanced control strategies and onboard diagnostics (OBD) systems are needed. Both rely on a relatively accurate but computationally efficient TWC converter model. This thesis aims to develop a control-oriented model that can be employed to develop the control strategies and OBD systems of the TWC converter. The thesis consists of two parts, i.e., the high-fidelity model development and the model reduction. Firstly, a high-fidelity model is built using the energy and mass conservation principles. In this model, a constant inlet simulation is used to validate the warming-up characteristics, and a driving cycle simulation is used to calibrate the reaction rate parameters. The results of the simulation show that the high-fidelity model has adequate accuracy. Secondly, a reduced-order model is developed based on phase and reaction simplifications of the high-fidelity model. The aim of the development of the reduced-order model is to propose a computationally efficient model for further development of control strategies and state estimators for OBD systems. The accuracy of the reduced-order model is then validated by means of simulations. / Thesis / Master of Science (MSc)

To improve the performance of the three-way catalytic (TWC) converter, advanced control strategies and on-board diagnostics (OBD) systems are needed. Both rely on a relatively accurate but computationally efficient TWC converter model. This thesis aims to develop a control-oriented model that can be employed to develop the control strategies and OBD systems of the TWC converter. The thesis consists of two parts, i.e., the high-fidelity model development and the model reduction. Firstly, a high-fidelity model is built using the energy and mass conservation principles. In this model, a constant inlet simulation is used to validate the warming-up characteristics, and a driving cycle simulation is used to calibrate the reaction rate parameters. The results of the simulation show that the high-fidelity model has adequate accuracy. Secondly, a reduced-order model is developed based on phase and reaction simplifications of the high-fidelity model. The aim of the development of the reduced-order model is to propose a computationally efficient model for further development of control strategies and state estimators for OBD systems. The accuracy of the reduced-order model is then validated by means of simulations. / Thesis / Master of Applied Science (MASc)