Not often do mathematics teachers instruct to improve students' attitudes toward mathematics. The pressures to cover the state-mandated curriculum drive teachers to instruct for procedural understanding with few connections. The lack of real-life connections results in students with low motivation toward mathematics and results in poor mathematics attitude (Ma andamp; Kishor, 1997). The purpose of this mixed-methods research is to examine self-regulated learning as an instructional technique aimed at increasing mathematical attitudes while also increasing achievement and to reveal barriers to its implementation in the classroom.The research study involved an intervention in a Mid-South urban high school at the 9th grade level. All students who participated were enrolled in the middle track at the school, thus taking an Algebra I course. The intervention took place with four teachers in seven separate classes. Students were given the opportunity to regulate their own learning based on objectives for district and state requirements. In this pre/post design, students were surveyed for their mathematics attitude and achievement using the Attitude Toward Mathematics Inventory (Tapia, 1996) and a polynomial survey designed by the researcher. Teachers were surveyed and interviewed prior to the study to develop a sense of their teaching preferences. During the experiment classroom observations were conducted to assist in developing themes in the intervention. Following the study, extensive interviews took place with each participating teacher.Data analyses revealed no statistically significant difference between the control and experimental group in regards to mathematics attitude and achievement. Qualitative analysis using constant comparative strategies (Denzin andamp; Lincoln, 2000) revealed many teacher barriers and misconceptions. Teachers felt uncomfortable with the technique and were unable to allow the students to fully regulate their learning. The teachers imposed a timeline, quizzes, written tests, and direct instruction techniques on the students during the study. All of these created barriers to the students fully regulating their learning. Also, teachers' perceptions of learning and attitude were not valid. Teachers believed the students achieved at a lower level than with a traditional approach and viewed their attitudes as worse than normal. This was in direct contrast to the quantitative results.

<p>Nowadays there are several contaminated buildings that receive a new field of application. These buildings used to have industrial activities which contaminated the buildings with both organic and inorganic pollutants that can cause serious health problems. Now these buildings get new functions like office work, school buildings or daycare centers. But before these buildings can be used as for instance schools some kind of remediation has to be carried out to remove the contamination. The aim with this report was to make an inventory of available methods for remediation of contaminated buildings and to evaluate the result of some performed remediations. The buildings that were investigated in this report were contaminated with organic pollutants. This report includes a summary of the legislation that concerns contaminated buildings, health problems that solvents and oils can cause and information of available methods for remediation of polluted buildings. A survey was made and property holders of remediated contaminated buildings answered it. According to the survey it emerged that air-regulated floors and new floor constructions were the most commonly used methods for remediation. The choice of method was often a balance between time and economy. After the remediation it’s important to do inspections to make sure that the remediation had removed the contamination. Inspection can be made by measuring the indoor air. Another way to inspect a remediation is to send out surveys to those people who stay in the building. The most important aspect during the remediation is to guarantee peoples health. Results from the survey showed that air-regulated floors are a good remediation method and often used with good results. To make the remediation work easier generic guideline values for different building materials should be developed to be used in the analysis of the degree of the remediation.</p>

Comprised of a cover story and five separate but interrelated articles, this dissertation explores entrepreneurial learning. By connecting multiple theoretical perspectives, reviewing extant literature, using four qualitative datasets, and building theory inductively, the articles explain components to and mechanisms of entrepreneurial learning. This dissertation is one of the first to explore the essence of entrepreneurial learning by incorporating non-entrepreneurs and entrepreneurs simultaneously, cognitive processes, and contextual variables.  Learning lies at the core of entrepreneurship, and scholars have even argued that a theory of entrepreneurship requires a theory of learning. The literature suggests that experiences in the context of entrepreneurship triggers entrepreneurial learning, and that such learning relates to achieving ambitious goals, the discovery of new opportunities and better overall performance. Entrepreneurial learning has also been highlighted in contexts outside entrepreneurship and as a mean to fostering future entrepreneurs and developing people’s entrepreneurial attributes and characteristics. The idea is that entrepreneurship is a way of thinking and acting and that entrepreneurial learning can be of use to anyone, even to those lacking entrepreneurial experience. Entrepreneurial learning literature, both inside and outside the context of entrepreneurship, emphasizes triggers of entrepreneurial learning, but does not recognize components that enable those triggers to be recognized and acted on and the underlying mechanisms that distinguish entrepreneurial learning from other types of learning. This gap makes it difficult to assess what entrepreneurial learning is and how it can be enhanced for both entrepreneurs and people preparing for entrepreneurship. This dissertation explains how and why entrepreneurial learning can be understood as a simultaneous and active regulation of cognition, motivation, and emotions to achieve goals. This elaboration captures core components and the mechanism of entrepreneurial learning, and illustrates how it can be understood and enhanced in various contexts.

I examined the abundance, composition, and distribution of fish communities in the lower Roanoke River, a hydropeaking system in North Carolina. Fishes were sampled at before and after peaking events over three years; 2007 to 2009. I evaluated trends in species richness, diversity, and assemblage composition. There were no significant differences in either richness or diversity suggesting consistent trends in richness and diversity throughout the study. I used non-metric multidimensional scaling (NMDS) to create a community composition model. Fish composition was noticeably greater post-peaking and changed minimally across time and event. There were no statistically significant differences in species composition among pre or post peaking samples, sites, or years (ANOSIM p < 0.05). I concluded that the small amount of fish community variation observed supports the possibility that the present assemblage has adapted to a regulated flow regime, however a direct relationship between peaking and community composition cannot be established. Additionally, fishes were sampled at three longitudinal sites during summer months of 2007 to 2009. I examined fish community composition to assess longitudinal gradients away from the source of peaking. Differences among fish species within each longitudinal site were examined by use of trophic and habitat/reproductive guilds. Statistically significant differences were detected between both trophic and reproductive guilds among sites and therefore aided in creating a pattern of longitudinal separation in community structure. The fish community of the Roanoke River between Roanoke Rapids and Hamilton does not appear to show signs of variation that may be attributed exclusively to hydropeaking. Changes in hydrology, river morphometry and topography, and habitat structure may account for the longitudinal variation observed in the community structure analyses. The Roanoke River has been regulated for over 50 years. It is possible that the existing fish community has adapted to fluctuating flows created by seasonal hydropeaking. I concluded that in order to develop an appropriate community model and evaluate the full extent of changes in fish community characteristics over time long-term monitoring is needed in the Roanoke River.

The purpose of this study is to examine what kindof formative assessments is used in the religious education at middle-schoolin Sweden. A further aim of the study is to examine whether any problems can be observed with formative assessment. Questions that will try to be answered are: What kindof formative assessment occurs in religious education at the middle school in a Swedish school? What problems can be observed with formative assessment in religious education at the middle school in a Swedish school? To answer these questions, six lessons in religious education were observedin total; three teachers held two lessons each which were observed. Earlier studies have showed that formative assessment was used by teachers to give feedback to improve pupils’ learning. In some cases, feedback was also givenwhich did not contribute to the improvement of pupils’learning. Earlier studies also conclude that formative assessment helped teachers to designfuture lessonsbased on pupils’ prior knowledge. Another conclusion highlights that teachers who made the goals of the lesson visible for pupils, resulted in an increased motivation and understanding of the purpose of the lesson. This study concludes that formative assessment has been usedby all three teachers, but in different ways. One conclusion is that when the goals of the lesson was not visible for the pupils, it affected the motivation of some pupils. Another conclusion is that teachers used formative assessment to modify lesson plans to meet the pupils’ current knowledge. Formative assessment was also used to encourage pupils to help each other by using peer-assessment. To improve pupils learning, teachers also used feedback as a strategy

Atlantic salmon Salmo salar has a complex life cycle, including long migrations and habitat shifts for both juveniles and adults. As such, salmon populations are vulnerable to habitat degradation and fragmentation along their migratory routes. This makes management and conservation a complex task requiring knowledge of salmon ecology at different temporal and spatial scales. In this thesis I highlight the use of a holistic life-history based approach in the conservation and management of wild and hatchery-reared salmon in regulated rivers and lakes. Small populations of wild-reproducing landlocked salmon and trout Salmo trutta exist in the regulated River Klarälven, Sweden. Since the 1930s, transportation of adult spawners upstream of eight dams has given the fish access to spawning grounds. The number of returning wild spawners became critically low in the 1960s, but stocking of hatchery smolts resulted in an increase in spawners that continues today. My data show that wild smolt may suffer high mortality due to multiple dam passages. To ensure viable populations of wild populations, future management should include both up- and downstream solutions that ensure connectivity in the system. The recreational and commercial salmonid fishery are maintained by compensatory stockings, yielding annual catches of about 75 tons, and a river return rate of hatchery fish of about 1%. As a large portion of the stocked smolts does not survive downstream migration to the lake, there has been discussion about the quality of the stocked smolt and about stocking strategies. Based on my studies, producing hatchery smolts more closely resembling wild-born conspecifics should result in reduced loss rates. I suggest changes in the hatchery and stocking procedures to increase the survival of stocked smolts. The results of my research should be applicable to other regulated systems, particularly those with mixed stocks of wild and hatchery salmonid populations. / Atlantic salmon Salmo salar has a complex life cycle, including long migrations and habitat shifts for both juveniles and adults. As such, salmon populations are vulnerable to habitat degradation and fragmentation along their migratory routes, which make management and conservation a complex task requiring knowledge of salmon ecology at different temporal and spatial scales. In this thesis, I highlight the use of a holistic approach in the conservation and management of wild and hatchery-reared salmon in regulated rivers and lakes. Small populations of wild-reproducing landlocked salmon and trout Salmo trutta exist in the regulated River Klarälven, Sweden. Since 1930, transportation of adult spawners upstream of eight dams has been done to give the fish access to the spawning grounds. My data indicate that a large proportion of the wild smolts are lost due to multiple dam passages, and future management should include both up- and downstream solutions, ensuring connectivity in the system. The fishery in Klarälven and Lake Vänern is maintained by compensatory stockings, yielding catches of about 75 metric tons and a river return rate of stocked fish of about 1%. I suggest changes in the hatchery and stocking procedures to increase the survival of stocked smolts.

Educators and educational researchers constantly strive to find effective instructional methods that meet the needs of struggling students. There is a well-established relationship between self-regulated learning and academic achievement. Therefore, a great deal of research has been conducted examining the effectiveness of interventions designed to develop self-regulated learning sub-processes including goal setting, help-seeking behavior, self-monitoring, and causal attributions. One particular sub-process that has gained significant attention is self-motivation beliefs, which includes goal orientation. Developing a growth mindset, or the belief that that intelligence is malleable, has been found to increase student learning. Intelligent tutoring systems have also been incorporated into K-12 education to help differentiate instruction and improve learning outcomes. There have been several empirical studies that have attempted to develop help-seeking behavior and growth mindset with interventions delivered by intelligent tutoring systems. Initially, the goal of this dissertation was to increase student learning by developing self-regulated learning through the use of an intelligent tutoring system. Preliminary attempts failed to modify student beliefs and behavior. As a result, a series of additional randomized controlled trials were conducted. This dissertation is a compilation of those studies, which attempted to leverage ASSISTments, an intelligent tutoring system, to improve student learning in mathematics. Each randomized controlled trial introduced an intervention, based on prior work, designed to address at least one aspect of self-regulated learning and measure the effect on learning. Most of the studies were unsuccessful in producing significant changes in either self-regulation or learning, failing to support the findings of prior research. Survey results suggest that students are reluctant to engage in certain self-regulated learning behaviors, like self-recording, because of the frustration caused when answering a question incorrectly. Based on the findings from these studies, recommendations for potential interventions and future research are discussed.

Coopetition, the activity of competing firms cooperating, comes with both benefits and risks for the parties involved. The approach to studying coopetition differ among scholars, however the phenomenon continues to be relevant in the area of research with several articles published in recent years. While coopetition has gained momentum in research, what drives coopetition is still argued to be an area that needs further development. Research on coopetition in regulated environments, is especially called for. Therefore, this study has the purpose to explore what motivational factors and risks in coopetition may apply to a regulated market. A case study was conducted by looking into two ongoing coopetition relationships in the Swedish eHealth market. The findings show that there are previously identified motivational factors and risks that are relevant in the context of a technological and regulated market. The study contributes with two propositions that suggest that customer demand and occasional low competitiveness are motivational factors for coopetition in a regulated market. Additionally, the findings resulted in two propositions that enclose financial risks and cultural differences as risks.

O adenocarcinoma de ducto pancreático (PDAC) é a quarta causa de morte em decorrência de neoplasias nos países ocidentais. Atualmente, a cirurgia ressectiva é a única possibilidade de cura para a doença, porém, a recidiva tumoral acontece em menos de um ano após a intervenção cirúrgica, mesmo com a quimioterapia adjuvante. A terapia fotodinâmica (PDT) é uma alternativa promissora no tratamento do câncer. No entanto, pouco se sabe sobre o uso da PDT em tumores pancreáticos. Portanto, o objetivo deste trabalho foi avaliar a eficiência da PDT com o azul de metileno (MB) como fotossensibilizador (MB-PDT) em induzir a morte de linhagens de PDAC humanas (AsPC-1, Panc-1, MIAPaCa-2 e BxPC-3) e estudar a contribuição de vias de necrose regulada nos efeitos citotóxicos da terapia sobre estes modelos. Os resultados obtidos mostraram que a MB-PDT foi capaz de induzir a morte massiva das células de PDAC. Além disso, eles indicaram que há dois perfis de susceptibilidade entre as quatro linhagens estudadas quando submetidas a MBPDT com 4,5 J/cm2 de energia e 6min de irradiação. De acordo com os dados apresentados, a diferença nas sensibilidades das linhagens à terapia não está associada à diferenças na capacidade de incorporação do MB ou na localização sub-celular do fotossensibilizador nas diferentes células, uma vez que a localização é, predominantemente, lisossomal em todas elas. Adicionalmente, mostrou-se que as linhagens menos susceptíveis ao tratamento, MIAPaCa-2 e Panc-1, apresentam níveis significativamente menores de RIPK3 e MLKL, dois dos componentes do necrossomo, essenciais para a execução da necroptose. Além disso, foi visto que a MB-PDT induz um aumento de fosforilação de MLKL em AsPC-1, demonstrando a ativação da necroptose após a terapia nestas células, mas não em MIAPaCa-2 (menos responsiva à terapia com 4,5 J/cm2 deenergia e 6min de tempo de irradiação). Ainda, a inibição da via de sinalização necroptótica diminuiu significativamente as porcentagens de morte das células mais susceptíveis (BxPC-3 e AsPC-1), não alterando a resposta de Panc-1 e MIAPaCa-2, corroborando a ativação e importância da necroptose para a citotoxicidade da MB-PDT. Finalmente, neste trabalho foi mostrado que o aumento do tempo de irradiação, mantendo-se a quantidade total de energia aplicada no tratamento, melhora a eficiência da MB-PDT em induzir a morte das células que apresentam limitações para executar a necroptose, sugerindo que mais de uma via de morte esteja sendo ativada após a terapia e que o tempo de irradiação atuaria modulando esta ativação. Complementarmente, foi mostrado que os tempos maiores de irradiação aumentam o estresse oxidativo intracelular que é acompanhado por uma diminuição significativa do conteúdo intracelular de glutationa reduzida (GSH), indicando, preliminarmente, que a ferroptose pode estar sendo acionada após os protocolos mais longos de irradiação. Coletivamente, os resultados apresentados neste trabalho confirmam a eficiência da MB-PDT no tratamento de diferentes linhagens de PDAC, indicando que a necroptose está sendo ativada e contribuindo para a citotoxicidade da terapia sobre as células que não apresentam resistência à esta via de morte. Ainda, eles demonstram que o aumento do tempo de irradiação pode transpor a barreira de resistência de algumas linhagens à terapia, provavelmente por induzir a ativação de outras vias de necrose regulada, mostrando a importância da otimização do protocolo de tratamento no aumento da eficiência da MB-PDT sobre os tumores de pâncreas. Finalmente, os resultados confirmam a MB-PDT como alternativa eficaz no tratamento do PDAC, apresentando um amplo espectro de atuação sobre subtipos tumorais resistentes à vias clássicas de morte celular, uma característica importante no contexto de uma terapia anti-cancer. / Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of death due to neoplasms in western countries. Currently, resective surgery is the only therapetical approach to cure this disease, but tumor´s recurrence occurs less than one year after the surgery, even with adjuvant chemotherapy. Photodynamic therapy (PDT) is a promising alternative for the cancer treatment. However, the efficacy of PDT to treat pancreatic tumors as well as the mechanisms involved in the induction of tumorigenic cell death remain unclear. For this purpose, in this study, we set out to evaluate the efficacy of PDT using methylene blue (MB) as a photosensitizer (MB-PDT), in inducing death of human PDAC derived cell lines (AsPC-1, Panc-1, MIAPaCa-2 and BxPC-3) and to deeper investigate the contribution of necroptosis to the cytotoxic effects of the therapy. We observed that MB-PDT was able to induce massive death of PDAC cells. Moreover, our results indicated that upon MB-PDT (4.5 J/cm2 energy and 6min of irradiation time), there were two susceptibility profiles among the four cell lines studied. Data also showed that this differential profile of cell response was neither associated with the differences in the MB incorporation capacity nor with the subcellular location of the photosensitizer, since the localization was predominantly lysosomal in all of tested cell lines. In addition, less susceptible cells, MIAPaCa-2 and Panc-1, showed significantly lower levels of RIPK3 and MLKL, two of the necrosome components, essential for triggering necroptosis. Furthermore, while MB-PDT (4.5 J/cm2 and 6min of irradiation) has been able to increase MLKL´s phosphorylation levels, an essential step in necroptosis induction, in AsPC-1cells, less responsive MIAPaCa-2 cells presented no variations on the phosphorylation state of this pseudokinase. Moreover, pharmacological inhibition of the necroptotic signaling pathway significantly decreased cell death percentages of the most susceptible cells (BxPC-3 andAsPC-1), without altering the response of Panc-1 and MIAPaCa-2, corroborating that activation of necroptosis was strongly involved in the cytotoxicity of MB-PDT. Finally, this work showed that increasing the irradiation time improved the efficacy of MB-PDT in killing cells which display limitations to perform necroptosis, suggesting that the irradiation time would be modulating the degree of oxidative stress generated and this stimuli would in turn, be responsible for triggering other regulated cell death pathways in a RIKP3 and MLKL independent way. Indeed, this increase in oxidative stress was accompanied by a significant decrease in GSH, a global indicatior of less antioxidant cell capacity, preliminarily pointing at the induction of ferroptosis by longer irradiation protocols. In summary, we demonstrated that MB-PDT is able to induce cell death in different PDAC cell lines and that different regulated cell death mechanisms are being activated upon MB-PDT induction. Furthermore, it was demonstrated that increased irradiation time may overcome the resistance barrier of some cell lines, probably inducing the activation of other regulated cell death pathways, showing the importance of optimizing the irradiation protocol in order to maximize the efficacy of the therapy. Finally, our observations point MB-PDT as an alternative and effective therapy for pancreatic cancer treatment, displaying a broad-spectrum action on tumors displaying different resistance mechanisms to classic cell death pathways, a desired property for improving an anticancer therapy.

O presente trabalho investiga estratégias para aperfeiçoar o estudo individual do violonista com base no conceito de autorregulaçaao da aprendizagem e nas informações da literatura musical. Nas últimas décadas, pesquisas tem enfatizado a importância do aspecto qualitativo no estudo individual (Barry, 1992; Nielsen, 1999 e 2001; Williamon e Valentine, 2000; Hallam, 2001) e destacam que saber como estudar eí uma habilidade fundamental para sustentar o contínuo aperfeiçoamento musical. Essa capacidade de regular o próprio estudo se relaciona com o mecanismo da autor regulação, conjunto de processos psicológicos pelos quais o ser humano regula seu comportamento. Como referencia principal para o estudo desse conceito eí utilizado Barry J. Zimmerman (2000, 2002) e também Mcpherson e Zimmerman (2011) que discutem a autor regulação na prática do músico. Da literatura musical as principais referências são os livros de Gerald Klickstein (2009) e dos violonistas Ricardo Iznaola (2000), Richard Provost (1992) e Lee F. Ryan (1991), que discutem viários aspectos relacionados à prática individual do músico. As informações trazidas pelos autores da aéra musical foram discutidas e organizadas de forma a trazer um panorama das estratégias para o aperfeiçoamento da prática e para estimular o comportamento autorregulado do estudante (de universidade ou conservatório superior). O trabalho incluiu também uma etapa prática, na qual as informações levantadas na parte teórica foram aplicadas na rotina de estudos pessoal. A experiência teve o objetivo de observar as implicações desta abordagem e foi registrada como um memorial de estudo através de relatórios e vídeos. Em suma, a análise dessa etapa se alinha com as evidências da pesquisa empírica, de que o engajamento do estudante em procedimentos como analise prévia da tarefa, estabelecimento de metas, planejamento, escolha de estratégias adequadas e reflexão sobre o estudo tem um impacto positivo na eficiência do aprendizado e no desenvolvimento musical. / This research explores strategies to improve the classical guitarist\'s individual practice based on the concept of self-regulated learning and resources from musical literature. During the last decades, a great amount of research has emphasized the relevance of qualitative aspect in music practice (Barry, 1992; Nielsen, 1999 e 2001; Williamon e Valentine, 2000; Hallam, 2001) and suggest that knowing how to practice is an essential ability to support constant musical improvement. The skill of regulating one\'s study is related to self-regulation mechanisms, which is a set of psychological procedures in which the human being regulates his own behavior. It is chosen, as main reference to the self-regulation study, Barry J. Zimmerman (2000, 2002) and also Mcpherson e Zimmerman (2011), that discusses the self-regulation in the musical activity. The main references from the musical literature are the books of Gerald Klickstein (2009) and the classical guitarists Ricardo Iznaola (2000), Richard Provost (1992), Lee F. Ryan (1991), that presents several aspects related to the musician individual practice. The knowledge brought from the authors in musical field were debated and organized in order to provide a panorama of strategies to enhance music practice and to stimulate students\' self-regulated behavior (at university or conservatory level). This paper includes a practical stage as well, in which the collected information from the theoretical stage was applied to my study routine. The experiment has had the aim of observing and discussing the implications of self-regulation strategies, and it was registered as a study report through daily logs, audio recordings and videos. Lastly, the analysis and reflection of this practical process relates to the empirical research evidences, which show that the student\'s commitment in some procedures, such as task analysis, goal setting, planning, the choice of suitable strategies and reflection about the study, leads to a positive impact in practice efficiency and musical development.