Global ETD Search

1	Genetic Variation and Shared Biological Susceptibility Underlying Comorbidity in Neuropsychiatry Palomo, Tomas, Kostrzewa, Richard M., Beninger, Richard J., Archer, Trevor 01 December 2007 (has links) Genetic factors underlying alcoholism, substance abuse, antisocial and violent behaviour, psychosis, schizophrenia and psychopathy are emerging to implicate dopaminergic and cannabinoid, but also monoaminergic and glutamatergic systems through the maze of promoter genes and polymorphisms. Candidate gene association studies suggest the involvement of a range of genes in different disorders of CNS structure and function. Indices of comorbidity both complicate the array of gene-involvement and provide a substrate of hazardous interactivity. The putative role of the serotonin transporter gene in affective-dissociative spectrum disorders presents both plausible genetic variation and complication of comorbidity. The position of genetic variation is further complicated through ethnic, contextual and social factors that provide geometric progressions in the comordity already underlying diagnostic obstacles. The concept of shared biological susceptibilty to two or more disorder conditions of comorbidity seems a recurring observation, e.g., bipolar disorder with alcoholism or schizophrenia with alcohol/substance abuse or diabetes with schizopsychotic disorder. Several lines of evidence seem to suggest that the factors influencing variation in one set of symptoms and those affecting one or more disorders are observed to a marked extent which ought to facilitate the search for susceptibility genes in comorbid brain disorders. Identification of regional genetic factors is awaited for a more compelling outline that ought eventually to lead to greater efficacy of symptom-disorder arrangements and an augmentation of current pharmacological treatment therapies. affective disorder alcoholism ANKKI antisocial personality CNR1 DRD1 DRD2 DRD3 DRD4 DRD5 FAAH genes GRIK4 MAOA schizophrenia treatment strategy Biomedical Sciences
2	Effect of Dopamine Receptor DRD2 and ANKK1 Polymorphisms on Dietary Compliance, Blood Pressure, and BMI in Type 2 Diabetic Patients Abdulnour, Shahad 14 December 2010 (has links) Reduction in dopamine receptor D2, has been associated with insufficient brain reward, food addiction, obesity, and type 2 diabetes (T2D). Our aim was to assess whether the genetic variability responsible for this reduction is associated with poor dietary compliance and life style habits in T2D patients. Genetic-analysis was done for 109 T2D individuals who completed a 24-week randomized clinical trial and were assigned to follow either a low-GI or a high-fibre diet. Polymorphisms of TaqIA and C957T were compared with physical and biochemical measures. Regardless of dietary treatments, individuals with the C957T-T allele and the TaqIA-A2 allele were significantly associated with blood pressure reduction. Carriers of the T allele significantly lowered their body mass index (BMI) over the 24-week trial. Our findings suggest that the presence of the TaqIA-A2 allele is associated with a decrease in blood pressure. The C957T-T allele was associated with decrease in pressure and body weight. dopamine receptor Glycemic Index DRD2 ANKK1 addiction diabetes BMI blood pressure dietary compliance reward obestiy weight genetic glucose C957T TaqIA polymorphism triglycerides cholesterol linkage disequilibrium DNA single nucleotide polymorphism HbA1c insulin resistance eating gene dopamine behaviour nutrition neuroscience Reward Deficiency Syndrome HDL LDL exercise fatty acid LOD neurogenetics 0369 0570 0317 0384
3	Effect of Dopamine Receptor DRD2 and ANKK1 Polymorphisms on Dietary Compliance, Blood Pressure, and BMI in Type 2 Diabetic Patients Abdulnour, Shahad 14 December 2010 (has links) Reduction in dopamine receptor D2, has been associated with insufficient brain reward, food addiction, obesity, and type 2 diabetes (T2D). Our aim was to assess whether the genetic variability responsible for this reduction is associated with poor dietary compliance and life style habits in T2D patients. Genetic-analysis was done for 109 T2D individuals who completed a 24-week randomized clinical trial and were assigned to follow either a low-GI or a high-fibre diet. Polymorphisms of TaqIA and C957T were compared with physical and biochemical measures. Regardless of dietary treatments, individuals with the C957T-T allele and the TaqIA-A2 allele were significantly associated with blood pressure reduction. Carriers of the T allele significantly lowered their body mass index (BMI) over the 24-week trial. Our findings suggest that the presence of the TaqIA-A2 allele is associated with a decrease in blood pressure. The C957T-T allele was associated with decrease in pressure and body weight. dopamine receptor Glycemic Index DRD2 ANKK1 addiction diabetes BMI blood pressure dietary compliance reward obestiy weight genetic glucose C957T TaqIA polymorphism triglycerides cholesterol linkage disequilibrium DNA single nucleotide polymorphism HbA1c insulin resistance eating gene dopamine behaviour nutrition neuroscience Reward Deficiency Syndrome HDL LDL exercise fatty acid LOD neurogenetics 0369 0570 0317 0384

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