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What Is Obesity?: Complementary DiscoursesKuyvenhoven, CASSANDRA 05 November 2012 (has links)
“What Is Obesity?: Complementary Discourses” seeks to present several perspectives on the entity ‘obesity’ in an effort to establish relationships, differences, and the possibility of critiques between and among the biomedical model, fat studies, media, policy and marketing, and Aboriginality. Using Foucault’s tenets of power, discourse, and governmentality, this thesis will demonstrate the ways in which discourses employ techniques of governance and the responses of self-governing individuals. Each chapter will represent a perspective with its own taxonomy, measures, and constructions of ‘obesity’. To conclude, the thesis will look at the possibility for collaboration in interdisciplinary research on the subject of obesity; in a direct exchange between the perspectives, the thesis will attempt provide a comprehensive account of ‘obesity’ as being comprised of several perspectives simultaneously. / Thesis (Master, Sociology) -- Queen's University, 2012-11-02 16:50:34.912
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Leveraging genomics and proteomics to identify therapeutic targets for COVID-19 and cardiometabolic diseases / ゲノム・プロテオーム解析を用いたCOVID-19および心血管代謝疾患の創薬標的同定Yoshiji, Satoshi 25 March 2024 (has links)
京都大学 / 新制・課程博士 / 博士(ゲノム医学) / 甲第25211号 / 医博JD第3号 / 新制||医JD||1(附属図書館) / 京都大学大学院医学研究科ゲノム医学国際連携専攻 / (主査)教授 村川 泰裕, 教授 平井 豊博, 教授 William Foulkes (マギル大学), 准教授 George Thanassoulis (マギル大学), 教授 Krzysztof Kiryluk (コロンビア大学) / 学位規則第4条第1項該当 / Doctor of Agricultural Science / Kyoto University / DFAM
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Promoting physical activity among overweight and obese children : Effects of a family-based lifestyle intervention on physical activity and metabolic markersBäcklund, Catharina January 2010 (has links)
Background Overweight and obesity in childhood is associated with physical, psychological and social consequences. Physical inactivity is regarded as one of the main factors that have contributed to the increase in childhood obesity through out the world. Overweight and obesity as well as physical activity level are shown to track from childhood to adolescence and adulthood, thereby influencing not only the current health status but also long-term health. The general purpose of this thesis was to evaluate the effect of a 2-year family-based lifestyle intervention on physical activity and metabolic health among children with overweight and obesity. Methods Children with overweight or obesity living in northern Sweden were recruited to the study. In total 105 children, mean age 10.5 years (SD±1.09), were randomized into either an intervention or a control group. The intervention group was offered as a 2-year family-based lifestyle intervention; the 1st year consisted of 14 group sessions and during the 2nd year the intervention was web-based. The control group did not participate in any intervention sessions, but performed all measurements. Physical activity was measured in all children using SenseWear Pro2 Armband (SWA) during 4 consecutive days before, in the middle and after the intervention, data regarding anthropometrics and blood values were collected in the same periods. Twenty-two of the children wore SWA during 14 days before the intervention in order to validate energy expenditure (EE) estimated by SWA against EE measured with double labelled water. Results The SWA, together with software version 5.1, proved to be a valid device to accurately estimate EE at group level of overweight and obese children. There were no statistically significant differences between the groups neither before nor after the intervention regarding physical activity and screen-time. All children significantly decreased their time being active ≥3 METs during the study period. After the study period, significantly fewer in the control group achieved the national physical activity recommendation, and they had significantly increased their screen-time. However, these changes were not seen within the intervention group. The intervention group had a significantly lower apolipoprotein B/A1 compared to the control group at 1-year measurement; no other significant differences were found regarding metabolic markers. No statistical difference was found between the groups regarding body mass index after the 2-year study period. Conclusion Even though a comprehensive program, the 2-year family-based lifestyle intervention had limited effects on physical activity and metabolic health in overweight and obese children. SWA is a device that can be used in future studies to measure energy expenditure among free-living overweight or obese children. / SELFH
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Effect of Dopamine Receptor DRD2 and ANKK1 Polymorphisms on Dietary Compliance, Blood Pressure, and BMI in Type 2 Diabetic PatientsAbdulnour, Shahad 14 December 2010 (has links)
Reduction in dopamine receptor D2, has been associated with insufficient brain reward, food addiction, obesity, and type 2 diabetes (T2D). Our aim was to assess whether the genetic variability responsible for this reduction is associated with poor dietary compliance and life style habits in T2D patients. Genetic-analysis was done for 109 T2D individuals who completed a 24-week randomized clinical trial and were assigned to follow either a low-GI or a high-fibre diet. Polymorphisms of TaqIA and C957T were compared with physical and biochemical measures. Regardless of dietary treatments, individuals with the C957T-T allele and the TaqIA-A2 allele were significantly associated with blood pressure reduction. Carriers of the T allele significantly lowered their body mass index (BMI) over the 24-week trial. Our findings suggest that the presence of the TaqIA-A2 allele is associated with a decrease in blood pressure. The C957T-T allele was associated with decrease in pressure and body weight.
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Effect of Dopamine Receptor DRD2 and ANKK1 Polymorphisms on Dietary Compliance, Blood Pressure, and BMI in Type 2 Diabetic PatientsAbdulnour, Shahad 14 December 2010 (has links)
Reduction in dopamine receptor D2, has been associated with insufficient brain reward, food addiction, obesity, and type 2 diabetes (T2D). Our aim was to assess whether the genetic variability responsible for this reduction is associated with poor dietary compliance and life style habits in T2D patients. Genetic-analysis was done for 109 T2D individuals who completed a 24-week randomized clinical trial and were assigned to follow either a low-GI or a high-fibre diet. Polymorphisms of TaqIA and C957T were compared with physical and biochemical measures. Regardless of dietary treatments, individuals with the C957T-T allele and the TaqIA-A2 allele were significantly associated with blood pressure reduction. Carriers of the T allele significantly lowered their body mass index (BMI) over the 24-week trial. Our findings suggest that the presence of the TaqIA-A2 allele is associated with a decrease in blood pressure. The C957T-T allele was associated with decrease in pressure and body weight.
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