Background: Compression Tissue Flossing (CTF) is getting more and more popular. However, it is still unclear about the usability and function of CTF. Objective: The main objective was to investigate the current evidence on the function and usability of CTF by doing a systematic review. Methods: A PRISMA checklist was used to write this systematic review. Inclusion criteria; studies that examined CTF and its different effects published 2013-2021. The exclusion criteria were studies that were not published in English. The information sources used in this systematic review was done on PubMed and EBSCO (MEDLINE, CINAHL, SPORTDiscus) and as hand research. The methodological quality was assessed using the Physiotherapy Evidence Database scale and the AMSTAR. The method used to present the results is by organized tables where the study results are shown.   Results: A total of 25 articles was included in the review. A total of 509 participants (mean age 22,6) was included. The average physiotherapy database score was 56% (range= 18,1%-81,8%). 15 studies were considered as high quality, 10 as low quality. Compression Tissue Flossing showed many different significant effects as increased range of motion, countermovement jump, rate of force development, increased torque, jump height, jump velocity, reduced muscle contraction time, and perception of flexibility. Conclusions: The results of this study suggest that compression tissue flossing has a good potential to be used in different contexts of sports performance/medicine. More studies are needed to validate the use of different floss bands and use them in bigger epidemiological settings as it right now seems to lack in its consistency depending on the pressure and application.