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The thesis describes disadvantages of JavaScript in the context of big web applications and presents how they can be eliminated by compilation from a different language to JavaScript. With Scala as the source language, the thesis shows what it takes to implement such a compiler and how to solve issues that arise with the compilation process (interoperability, library distribution). On top of the compiler with a simple runtime a remote metod invocation (RPC) infrastructue is built. It also involves a dynamic client side script loader and an object graph (de)serializer. Finally the work compares the implemented toolkit to similar projects and proposes several interesting directions the toolkit can evolve into. Powered by TCPDF (www.tcpdf.org)

With the development of mobile devices, people can execute many applications on their personal devices at any time and in any place. However, many limitations of the mobile devices, e.g., CPU, memory, power supply, etc., make them impossible to be completely the same as the desktop PCs. In this paper we present an integrated management architecture for thin-client purpose called Agent and Profile Management System (APMS). The users of mobile devices can use the services from various service providers via this system. On the other hand, the centralized management of service agents provided by the service providers is employed in this system. The users only need to download a simple service agent to their mobile device and install it, then the service agent will connect to the homologous service provider, send an XML-RPC request by ¡§POST¡¨ to the back-end server. After receiving the XML-RPC request, the back-end server executes appropriate processes and returns an XML-RPC response to the mobile device. Most of the procedures are accomplished on the server side that has powerful CPU and large amount of memory. Therefore, the loading of mobile devices is relatively low and the cost of mobile devices can be effectively reduced.

ITC/USA 2010 Conference Proceedings / The Forty-Sixth Annual International Telemetering Conference and Technical Exhibition / October 25-28, 2010 / Town and Country Resort & Convention Center, San Diego, California / In this paper, we discuss ways in which web services can be used in future T&E scenarios, from the initial hardware setup to making dynamic configuration changes and data requests. We offer a comparison of this approach to other standards such as SNMP, FTP, and RTSP, describing the pros and cons of each as well as how these standards can be used together for certain applications.

Syftet med detta arbete är att kartlägga ytjämnheten på stålbanden efter kallvalsning samt hur den erhålla ytjämnheten påverkas av trimvalsningen. Detta för att undersöka om det är möjligt att minska ner användandet av någon valsyta i Tandemverket vid SSAB Borlänge. Genom att mäta ytjämnheten på stålband av olika kallvalsade kvalitéer efter kallvalsning och trimvalsning, mäta ytråheten på texturerade valsar före och efter användning samt genomföra test med nya ytkombinationer har ett antal resultat genererats. Två test där Docol 200 band som skulle levereras med bandyta 23 valsades med en grövre yta i Tandem (valsyta 48 istället för 34) än vad som är brukligt och sedan trimvalsades med ordinarie valsyta visade att det är möjligt att klara kraven på Ra-värde för bandyta 23 även på band som kallvalsats med en grövre valsyta än i vanliga fall. Dock är det inte säkerställt att kraven för yta 23 alltid kan uppnås på band kallvalsade med grövre valsyta. Trimvalsning med valsyta 57 i den kontinuerliga glödgningslinjen har ingen betydande påverkan på ytjämnheten för Docol 600 & 800 DP, dock påverkar den ytan för Docol 200 eftersom att dessa band har mindre spridning i Ra-värde efter trimvalsning jämfört med innan. Trimvalsning med valsyta 57 höjer toppantalet på bandens yta. Band av en högre hållfasthetsklass får lägre Ra-värde jämfört mot mjukare stålsorter. Band med stor tjockleksreduktion i Tandem får lägre Ra-värde, detta gäller speciellt Docol 200 där trenden är tydligast. Ra-värdet på de texturerade valsarna i Tandem sjunker mycket i början när de används, test har visat att redan under kalibreringen kan Ra-värdet minska med 0,8 µm – 1,3 µm.

Abstract As the Internet and wireless technologies become mature, people may use more than one digital device to manage their personal data. However, the complexities and difficulties in personal information management will arise due to various devices and heterogeneous platforms. To cope with this problem, we design an intelligent architecture for personal information management based on the XML-RPC technology, which allows the software running on disparate operating systems and in different environments to make procedure calls over the Internet. We also implement an information server to manage the whole data and handle the synchronization process. The system provides users a simple and convenient environment to manage and synchronize their personal information. Besides, the group facility in this system makes the people in the same group or community capable of sharing their information more easily.

Gemeinsamer Workshop von Universitaetsrechenzentrum und Professur Rechnernetze und verteilte Systeme (Fakultaet fuer Informatik) der TU Chemnitz. Workshop-Thema: Infrastruktur der ¨Digitalen Universitaet¨ Dieser Vortrag beschaeftigt sich mit dem Remote Procedure Call Protokoll XML-RPC, welches auf der Basis von XML und HTTP arbeitet.

The plasma environment of an active comet provides a unique setting for plasma physics research. The complex interaction of newly created cometary ions with the flowing plasma of the solar wind gives rise to a plethora of plasma physics phenomena, that can be studied over a large range of activity levels as the distance to the sun, and hence the influx of solar energy, varies. In this thesis, we have used measurements of the spacecraft potential by the Rosetta Langmuir probe instrument (LAP) to study the evolution of activity of comet 67P/Churyumov-Gerasimenko as it approached the sun from 3.6 AU in August 2014 to 2.1 AU in March 2015. The measurements are validated by cross-calibration to a fully independent measurement by an electrostatic analyzer, the Ion Composition Analyzer (ICA), also on board Rosetta. The spacecraft was found to be predominantly negatively charged during the time covered by our investigation, driven so by a rather high electron temperature of ~5 eV resulting from the low collision rate between electrons and the tenuous neutral gas. The spacecraft potential exhibited a clear covariation with the neutral density as measured by the ROSINA Comet Pressure Sensor (COPS) on board Rosetta. As the spacecraft potential depends on plasma density and electron temperature, this shows that the neutral gas and the plasma are closely coupled. The neutral density and negative spacecraft potential were higher in the northern hemisphere, which experienced summer conditions during the investigated period due to the nucleus spin axis being tilted toward the sun. In this hemisphere, we found a clear variation of spacecraft potential with comet longitude, exactly as seen for the neutral gas, with coincident peaks in neutral density and spacecraft potential magnitude roughly every 6 h, when sunlit parts of the neck region of the bi- lobed nucleus were in view of the spacecraft. The plasma density was estimated to have increased during the investigated time period by a factor of 8-12 in the northern hemisphere and possibly as much as a factor of 20-44 in the southern hemisphere, due to the combined effects of seasonal changes and decreasing heliocentric distance. The spacecraft potential measurements obtained by LAP generally exhibited good correlation with the estimates from ICA, confirming the accuracy of both of these instruments for measurements of the spacecraft potential.

Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2015-04-10T17:04:35Z No. of bitstreams: 1 Rafael AraujoGomes Junior Efeitos....pdf: 34966477 bytes, checksum: 15df6dc2a7def6eca56bbb84930c6ae3 (MD5) / Approved for entry into archive by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2015-04-10T17:04:46Z (GMT) No. of bitstreams: 1 Rafael AraujoGomes Junior Efeitos....pdf: 34966477 bytes, checksum: 15df6dc2a7def6eca56bbb84930c6ae3 (MD5) / Made available in DSpace on 2015-04-10T17:04:46Z (GMT). No. of bitstreams: 1 Rafael AraujoGomes Junior Efeitos....pdf: 34966477 bytes, checksum: 15df6dc2a7def6eca56bbb84930c6ae3 (MD5) Previous issue date: 2014 / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / A candidíase é uma infecção oportunista provocada por diversas espécies de fungos do gênero Candida, frequentemente encontrados integrando a microbiota, da superfície cutânea, no trato gastrointestinal e cavidades mucosas do ser humano desde o seu nascimento. A incidência das infecções fúngicas sistêmicas têm aumentado consideravelmente nas últimas décadas em função do grande número de pacientes com SIDA, a grande quantidade de transplantes e condições crônicas como o câncer, a terapia prolongada com imunossupressores e o uso de agentes corticosteroides. Além disso, a exposição prolongada aos antifúngicos azólicos promove a seleção de patógenos resistentes. No presente estudo avaliou-se a atividade antifúngica do complexo Rutênio-pirocatecol (RPC) frente a um isolado clinico de Candida tropicalis resistente ao fluconazol. A metodologia empregada para os testes de susceptibilidade foi de acordo com o documento M27-A3 do National Committee for Clinical Laboratory Standards (NCCLS, 2008). Esplenócitos de camundongos Balb/c foram obtidos de forma asséptica para avaliar a citotoxicidade do composto para células de mamíferos. O estresse oxidativo promovido pelo composto foi avaliado através da reação ao ácido tiobarbitúrico (TBARS) e ensaios de fluorescência com a sonda diclorodihidrofluoresceína diacetato (DCFH2DA). O Calcofluor White foi empregado para avaliar a integridade da parede celular. A análise ultraestrutural foi realizada através da microscopia eletrônica de varredura e transmissão. Os resultados encontrados para os testes de atividade antifúngica foram analisados através do teste estatístico ANOVA e pós-teste Dunnett. Os resultados encontrados para os testes de atividade antifúngica do RPC mostraram uma Concentração Inibitória de 50% (IC50) de 20,3 μM, enquanto em esplesnócitos a concentração efetiva de 50% foi de 325 μM mostrando um índice de seletividade igual a 16. O referido composto também mostrou um elevado efeito pró-oxidante quando avaliamos os níveis de estresse oxidativo através da TBARS e por meio da sonda DCFH2DA. Quando as leveduras foram tratadas por 24 h com o referido composto, observamos na microscopia de varredura o desenvolvimento de pseudo-hifas com 9 μM, a formação de fissuras em sua parede e uma forte agregação das células com 18 μM, além disso, encontramos uma intensa redução na quantidade de células e muito debris celular com 38 μM. Na microscopia de transmissão observamos estruturas vesiculares no espaço periplasmático associado a grânulos eletrondensos, os quais também foram vistos associados a parede celular, quando tratadas por 3h com 40 μM. No tratamento por 24h com 60 μM observamos a referida estrutura granular eletrondensa no citoplasma envolta por membrana, uma grande quantidade destas estruturas no espaço citoplasmático e associado a parede da célula, além disso, também observamos trechos de membrana associado a estas estruturas no espaço extracelular. Em conclusão, a atividade antifúngica e o índice de seletividade do RPC contra uma cepa resistente é consideravelmente interessante devido as suas possibilidades de aplicações na descoberta de novos antifúngicos / Candidiasis is an opportunistic infection caused by several species of fungi of the genus Candida, often found is the microbiota, on the skin, gastrointestinal tract and mucous cavities of the human beings birth. The incidence of systemic fungal infections have increased considerably in recent decades due to the large number of AIDS patients, the large number of transplants and chronic conditions such as cancer, prolonged therapy promotes the selection of resistant pathogen with immunosuppressant and corticosteroid agents. Also prolonged exposure azole antifungals to make them strong candidates for patients resistance. In the present study we evaluated the antifungal activity of Ruthenium-pyrocatechol complex (RPC) against a clinical isolate of Candida tropicalis resistant to fluconazole. The methodology for susceptibility testing was in accordance with the M27-A3 document of there National Committee for Clinical Laboratory Standards (NCCLS, 2008). Splenocytes from Balb/c mice were obtained aseptically to evaluate the cytotoxicity of the compound to mammalian cells. Oxidative stress caused by the compound was assessed by reaction to thiobarbituric acid (TBARS) and fluorescence assays with the probe diclorodihidrofluoresceína diacetate (DCFH2DA). The Calcofluor White was used to evaluate the integrity of the cell wall. The ultrastructural analysis was performed by scanning and transmission electron microscopy. The results for the antifungal activity tests were analyzed using ANOVA and pos-test Dunnett test statistic. The results for the tests of antifungal activity of the RPC showed a 50% inhibitory concentration (IC50) of 20.3 μM while in splenocytes the 50% effective concentration was 325 μM showing a selectivity index of 16. The compound also showed that a high pro-oxidant effect when evaluated levels of oxidative stress by TBARS and through DCFH2DA staining. When yeast cells were treated for 24 h with this probe, in scanning microscopy we observed the development of pseudohyphae 9 μM, the formation of cracks on their fungal walls and in these cell aggregation with 18 μM furthermore found a remarkable reduction in the number of cells, and cell debris with 38 μM. In transmission microscopy vesicular structures observed in the periplasmic space associated with electrondense granules, which were also seen associated with the cell wall, when there cells were treated for 3 h with 40 μM. In the treatment for 24h with 60 μM observed that the grain structure in the clusters in periplasmic, a large amount of these structures in the cytoplasmic space and associated with the cell wall, moreover, we also observe membrane portions associated with these structures in the extracellular space. In conclusion, the antifungal activity and the selectivity index RPC against a resistant strain is pretty interesting because of its possible applications in the discovery of new antifungal agents.

Le siècle dernier a vu le développement de la physique des particules, avec la fondation du célèbre modèle Standard de la physique des particules. Plus spécifiquement, durant les 70 dernières années de nombreuses particules ont été détecté et étudié. Parallèlement à ces découvertes, les moyens expérimentaux et les détecteurs ont grandement évolué. de la simple chambre à bulles de l'expérience Gargamel, qui a posé la première brique expérimentale du modèle standard, aux détecteurs complexes d'aujourd'hui tel que le LHC. Durant le développement de nouveaux détecteurs, nous pouvons distinguer deux grandes catégories: les détecteurs dits Solid State et les détecteurs gazeux. La première englobe les détecteurs tels que les Cherenkov ou les scintilateurs tandis que les derniers utilisent un gaz comme moyen de détection.Les détecteurs gazeux ont aussi grandement évolué durant le siècle dernier, des tubes Geiger-Muller au chambres à étincelles ou Pestov, qui peuvent faire face aux taux de détections toujours grandissant des accélérateurs de particules. The Parallel Plate Avalanche Chamber est un détecteur gazeux similaire mais fonctionne en mode avalanche, où les signaux électriques sont produits par une multiplication contrôlée des électrons dans le gaz. Les autres détecteurs susmentionnées fonctionnent eux en mode étincelle, où le signal détectée est produit par une décharge électrique dans le gaz.Le mode avalanche permets un taux de détection encore supérieur mais au prix de signaux électriques beaucoup plus faibles. Au début des années 80 un nouveau type de détecteur gazeux commence à se développer, les Resistive Plate Chambers. Ce détecteur présente la particularité de pouvoir fonctionner en mode étincelle ou avalanche, selon le design. Utilisé en mode avalanche, ils présentent un taux de détection particulièrement intéressant au prix de signaux électriques faibles, nécessitant un circuit d'amplification dédié. De nos jours les Resistive Plate Chambers sont très largement utilisés dans de nombreuses expériences de physique des particules, notamment pour leurs performances intéressantes et leur prix contenu. Malgré leur usage répandu, les Resistive Plate Chambers n'ont pas été beaucoup étudié d'un point de vue modélisation et simulation. La simulation d'un détecteur est un outil essentiel pour leur développement et leur fabrication, permettant de tester un design et calculer les performances que l'on est en droit d'attendre. Dans les travaux présentés dans ce document nous nous sommes intéressés à la description des différents phénomènes physiques se produisant durant une avalanche électronique au sein d'un Resistive Plate Chambers fonctionnant en mode avalanche, dans le but de les modéliser et simuler. Nous décrivons un modèle détaillé pour le processus d'ionisation, qui est l'évènement fondamental pour tout détecteur gazeux. Nous décrivons aussi un modèle mis au point par Riegler-Lippmann-Veenhof pour le développement d'avalanche électronique. Une simulation C++ a été produite dans le contexte de cette étude et quelques résultats sont présentés. / The 20th century saw the development of particle physics research field, with the fundationof the famous Standard Model of particle physics. More specifically during the past 70 years numerous particles have been detected and studied. Alongside those discoveries, the experimental means and detectors has greatly evolved. From the simple Gargamel bubble chamber, which lay the first brick to the Standard Model theory, to the nowadays complex detectors such as the LHC. In the development of newer particles detector, one can distinguish two big categories:the solid state detectors et the gaseous detectors. The former encompass detectors suchas Cherenkov and scintillator counters while the later make use of gases as detection medium. The gaseous detectors have also greatly evolved during the past century from theGeiger-Muller tube to the spark or Pestov chambers, which can cope with the increasing detection rate of particles accelerator. The Parallel Plate Avalanche Chamber is a similar gaseous detector but operates in avalanche mode, where the detected signal is producedby a controlled multiplication of electrons in the gas. The aforementioned detectors were operated in spark mode, where the detection is made through a spark discharge in the gas.The avalanche mode allows even greater detection rates at the expense of signal amplitude. In early 80s a new gaseous detector design began to emerge: the Resistive Plate Chambers.This detector has the particularity to operates in spark or avalanche mode depending on its design. Operated in avalanche mode, they present an impressing detection rates at the expense of very small electric signals, requiring dedicated amplification circuitries. Nowadays the Resistive Plate Chambers are widely used in numerous experiments worldwide,because of their interesting performances and relatively small price. Despite their widespread usage, the Resistive Plate Chambers have not been extensively studied from a simulation and modelisation point of view. Simulation of a detectoris an essential tool for its development and construction, as it allows to test a design and predict the performances one may get. In this work we focused on the description of the physics phenomenons occuring during an electronic avalanche inside a Resistive Plate Chambers operated in avalanche mode, in order to properly modelise and simulate them. We review a detailed model of the ionisation process, which is the fundamental event in any gaseous particle detector, alongside theRiegler-Lippmann-Veenhof model for the electronic avalanche. A C++ simulation has been produced in the context of this work and some results are presented.