Polistes dominula and P. fuscatus often nest in bird nest boxes. Potential competition between wasps and birds was studied by removing wasp nests from some boxes. No difference in nesting success of breeding birds was found between boxes with wasp nests and those in which wasp nests were removed. Boxes that never had a wasp nest and boxes from which wasp nests were removed differed greatly in bird occupancy, suggesting that birds detected previous wasp presence. Some bird species gain protection by nesting near wasp nests. Birds may prefer to nest near wasp species that inflict higher sting pain levels. A rank correlation of data from published studies provided no evidence that pain level influences which wasp nests are most attractive to nesting birds. A comprehensive table of bird-wasp nesting associations (listing 121 bird species, 28 wasp species and 4 bee species) is included here.

Nesta dissertação pretendo reler o debate entre Ronald Dworkin e o positivismo jurídico. Farei isto sob o prisma da filosofia analítica, especificamente, contextualizando o debate no âmbito de uma discussão travada entre três teorias semânticas específicas: a descricional, o externalismo semântico e o bi-dimensionalismo ambicioso. Há algum tempo Dworkin lançou uma crítica ao positivismo, qual seja, o positivismo jurídico pretende reduzir a forma direito de como as coisas são à conformação puramente descritiva de como o mundo é. Disse, ainda, que somente quando concebido como uma teoria semântica é que o positivismo jurídico tornar-se-ia inteligível. Os posivistas, a seu turno, argumentam que a Jurisprudência analítica é um projeto teórico pelo direito e não pelo significado do termo direito e que, portanto, deveríamos manter separados dois tipos de questionamentos: O que é direito? e O que é direito?. Se tudo correr bem, ao reler o debate entre os positivistas e Ronald Dworkin a partir do instrumental obtido no âmbito da teoria semântica, poderemos perceber que pode ser verdade que o positivismo jurídico, enquanto projeto teórico, é sobre o direito, o referente, e não sobre o direito, o termo; entretanto, a forma pela qual o positivismo concebe o questionamento O que é direito?, ele mesmo, parece acabar por qualificá-lo, num sentido não trivial, como semântico. / I intend to reread the debate between Ronald Dworkin and legal positivism. I will do that through the prism of analytic philosophy, specifically in the context of the debate between three specific semantic theories: descriptional, externalism and the ambitious bidimensionalism. Dworkin criticized legal positivism: the legal positivism aims to reduce the law-way of things to the purely descriptive form of the world. He also said that only when conceived as a semantic theory is that legal positivism would become intelligible. The posivists argue that analytical Jurisprudence is a theoretical project about law and not about the meaning of \"law\", therefore we should keep separated two types of questions: \"What is law?\" and \"What is \'law\'?\". If all goes well, when rereading the debate through the prism of the discussion in the context of semantic theories, we will realize that it may be true that legal positivism is about law, the referent, and not about \"law\". However, the way in which positivism conceives the question \"What is law?\" seems to qualify it as semantic in a nontrivial sense.

This thesis was funded by the Natural Environment Research Council (NERC) and is presented in an alternative thesis format. The thesis consists of three separate journal articles which form a coherent research project. Paper 1 investigates the development of strong winds in a dry, idealised extratropical cyclone using the horizontal momentum equation. In particular, the southwest wind maximum that develops was found to contain air parcels from three airstreams. The development of the horizontal along-flow forces around the cyclone and along trajectories entering the southwest wind maximum were analysed. An attempt to extend this methodology to a moist, idealised extratropical cyclone was made. However, the effect of adding moisture to the initial condition was found to be negligible. The reasons for this are explored in Paper 2, which documents this finding: that the effect of moisture on the development of an idealised, baroclinic wave is sensitive to the choice of initial condition. Paper 3 applies the horizontal momentum equation diagnostics to an intense, marine extratropical cyclone that brought strong winds to Ireland and the United Kingdom on 12 February 2014. The development of strong winds in Cyclone Tini was investigated by turning off latent heat release and surface fluxes. In the absence of latent heat release a weaker wind maximum developed. However, the simulation without surface fluxes had a very similar vertical structure of the horizontal wind to the full-physics simulation, but a weaker surface wind maximum. The reason for this weaker wind maximum was analysed using the quasigeostrophic omega equation. This analysis demonstrated a maximum in forcing for descent southwest of the low both in the full-physics simulation and in the simulation without surface fluxes, however strong winds were prevented from reaching the surface in the simulation without surface fluxes because of a more stable boundary layer around the bent-back front.

Cytosolic DNA sensing plays a key role in autoimmune and autoinflammatory diseases. STING is a cytosolic adaptor protein which upon activation leads to induction of type I interferons and inflammatory cytokines. Recently, gain-of-function mutations in STING have been identified in patients with an autoinflammatory disease called STING-associated vasculopathy with onset in infancy (SAVI). We compared two independent SAVI mutant mouse models and revealed a hierarchy of immune abnormalities which were dependent on SAVI mutation in lymphocytes. We also showed that bone marrow from the V154M mutant mice transfers disease to the wild-type host, whereas the N153S does not, indicating mutation-specific disease outcomes. Collectively, these mutant mice recapitulate disease features seen in SAVI patients and highlight mutation-specific functions of STING. Other autoimmune mouse models such as DNAseII and DNAseIII-deficient mice, that fail to degrade DNA result in activation of the cGAS STING pathway. Deficiency of this pathway in these mouse models ameliorates lethality. By contrast, we previously reported that STING potently suppresses inflammation in a pristane-induced model of autoimmunity. In this model, we show that both cGAS- and STING-deficient mice exhibit exacerbated disease phenotypes compared to controls. We report that STING constrained TLR activation, and thereby limited autoimmune manifestations. Consistent with this premise, cGAS or STING deficient mice that lack a common TLR chaperone UNC93b develop less severe systemic autoimmunity than cGAS or STING deficient mice that are UNC93b sufficient. Overall, this study demonstrates that STING activation constrains systemic autoimmune disease and has important implications for cGAS STING-directed therapies.

This dissertation examines the creative work of harpsichordist Wanda Landowska, pianist Glenn Gould, and singer/songwriter Sting to address aesthetic and revivalist notions of early-music performance practice in the twentieth and twenty-first centuries. I accomplish this by viewing their early-music recordings through two different but interrelated lenses: sound and otherness. By closely comparing Landowska's performances to those of Gould not just in terms of choice of instruments but, more importantly, of rhythmic projection, structural articulation, and other fundamental musical choices, a definable early-music "sound" emerges that transcends the movement’s traditional borders. Early music becomes a sonically identifiable phenomenon transmitted by performers of various training, affiliations, and epochs, rather than a loosely connected politicized movement precariously perched on claims of historical (authenticity) and timbrel (period instruments) grounds. I further illuminate this sound within the context of a performed "exoticism," signified by exotic instruments, style, and attitude. In these terms, I focus on Landowska's reception in the early twentieth century, comparing it to the reception of Gould's individualized twentieth-century Bach recordings and, as a twenty-first century venture into early music, the reception of Sting's 2006 recording of Elizabethan lute songs by John Dowland. By repositioning "Early" as "Other," a more relevant framework emerges for discussing how early-music performances over time construct and reflect a sense of authenticity in the movement and, conversely, how that construct affects its performers and its public.

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Force and moment balances have proved to be essential in the measurement and calculation of aerodynamic properties during wind tunnel testing. With the recent advancements of technology, new fiber optic sensors have been designed to replace the conventional foil strain gage sensors commonly found on balances, thereby offering several distinct advantages. The use of fiber optic sensors on a balance brings with it some potential advantages over conventional strain gage balances including increased resolution and accuracy, insensitivity to electromagnetic interference, and the capability of use at high temperatures. By using the fiber optic sensors, some of the limitations of the conventional balance can be overcome, leading to a better overall balance design. This thesis considers an initial trial application of new fiber optic sensors on a conventional, six-component sting balance while retaining the original foil strain gage sensors for comparison. Tests were conducted with a blunt, 10º half-angle cone model in the Virginia Tech 9x9 inch Supersonic Wind Tunnel at Mach 2.4 with a total pressure of 48 psia and ambient total temperature of 25.3ºC. Results showed a close comparison between the foil strain gages and the fiber optic sensor measurements, which were set up to measure the normal force and pitching moment on the blunt cone model. A Finite Element Model (FEM) of the sting balance was produced in order to determine the best locations for the fiber optic sensors on the sting balance. Computational Fluid Dynamics (CFD) was also used in order to predict and compare the results acquired from all of the sensors. / Master of Science

京都大学 / 新制・課程博士 / 博士(生命科学) / 甲第25512号 / 生博第528号 / 新制||生||70(附属図書館) / 京都大学大学院生命科学研究科高次生命科学専攻 / (主査)教授 松田 道行, 教授 鈴木 淳, 教授 安原 崇哲 / 学位規則第4条第1項該当 / Doctor of Philosophy in Life Sciences / Kyoto University / DFAM