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Alcohol use can negatively impact financial, cognitive, and psychiatric aspects of human life. In the brain, alcohol can have many devastating effects. Alcohol is a well-known cytotoxic agent that can cause specific brain pathology in humans; however, the exact biological mechanisms are not well-elucidated. Animal models are invaluable tools to investigate potential novel treatments in a substance abuse model. Mice studies can be used to screen for negative outcomes prior to human trials. We hypothesize that the C1q tumor necrosis factor-related protein, CTRP3, overexpression in mice reduces neuroinflammation from ethanol consumption that has been coupled with a high fat diet when compared to control mice. The CTRP family of proteins are adipokines and CTRP3 specifically influences cell viability, metabolism, and peripheral inflammation levels. Antibody specific immunoblotting is used to probe protein expression changes in neuroinflammatory markers in mouse cerebellum brain tissue in an overexpression mouse model of CTRP3 when compared to high-fat ethanol exposed mice and baseline control mice. The two proteins examined are MAG and GFAP. Myelin associated glycoprotein, or MAG, is a protein expressed by oligodendrocytes that mediate axonal growth and myelin interactions with neurons in the brain. Oligodendrocytes are extremely sensitive to oxidative stress to which cognitive deficits in ethanol exposure is thought to be attributed. Glial fibrillary acidic protein, or GFAP, is a marker of astrocyte reactivity. Astrocytes are cells in the brain that are responsible for environmental stabilization and actively participate in neurotransmission. Currently, GFAP alterations in ethanol-exposed animals are dose and age dependent. We chose to use young adult mice where GFAP reactiveness is increased during chronic ethanol exposure. The proposed studies are essential in determining CTRP3’s relationship to detrimental neuroinflammatory effects of alcohol and high fat diet in mice. The data obtained from these studies will provide compelling evidence for future clinical trials to investigate CTRP3 as a therapeutic agent in people with a high fat diet that use alcohol chronically.

Magister Artium (Social Work) - MA(SW) / Substance abuse has become a major concern in the Western Cape Province of South Africa as it devastates many lives and negatively influences families and communities. When there is a substance-abusing sibling in the family, the wellbeing of other family members and non-substance abusing siblings tends to be neglected. This may mean that families could grapple with parental autonomy support to meet the psychological needs of autonomy, competence and relatedness of the non-substance abusing siblings within the family. However, prior to this study, there was scant insight into the perceptions and experiences of adolescents living with a substance-using sibling regarding parental autonomy support.

Magister Artium (Social Work) - MA(SW) / Substance abuse is a global phenomenon and a leading social issue that affects the user and the well-being of the user’s family. Parental substance abuse in particular, has a negative impact on family well-being. South Africa is no exception and is rated by the United Nations as one of the countries in Southern Africa with the highest rate of substance abuse. The Western Cape has very high rates of substance abuse, and the effects on the abuser’s family and community is of great concern for social and health practitioners

Certain substance use disorders, such as nicotine, opioid, and alcohol use disorders, have efficacious pharmacotherapies (National Institute on Drug Abuse, 2014). Medications for these disorders largely target neurotransmitter systems affected by the substance of abuse. Behavioral addictions, in contrast, do not involve ingestion of any substance, and their neurophysiology remains elusive. To date, the U.S. Food and Drug Administration (FDA) has not approved any medication to treat a behavioral addiction. However, initial experimental trials of medications for gambling disorder and other putative behavioral addictions have been conducted. In this chapter, we review research on pharmacotherapy for gambling disorder, Internet gaming disorder, and Internet addiction. We also briefly discuss treatments for other potential behavioral addictions (e.g., shopping, eating), although much less data exist on these conditions. (PsycInfo Database Record (c) 2020 APA, all rights reserved)

This research aimed at identifying patterns of substance abuse among South African adolescents and exploring the relationship between psychological well-being and substance abuse. A thorough understanding of the numerous aetiologies suggested to account for substance abuse were set out at the beginning of the study, as these are crucial to the effective understanding of any high risk behaviour. Psychological well-being was examined as a psychological construct so as to allow for a proper understanding of the term. In this study, 1 918 learners from 13 schools in the Tshwane area participated. The sample consisted of learners from 12 to 19 years of age, 802 males and 1 005 females, from Indian, Coloured, White and Black cultural groups. The students completed a life skills questionnaire that comprised of a Psychological Well-Being Scale, the Life Satisfaction Questionnaire as well as various questions regarding high risk behaviours including substance use. A factor analysis was used to explore characteristics of the Psychological Well-Being Scale. It was found to be a reliable measure for this sample group. Self-report substance abuse patterns of the respondents were recorded. It was found that substance abuse (drinking, binge drinking, drug use) increases with age and that nearly twice as many male adolescents abuse substances. Culture was found to be a determining factor with regard to drinking and binge drinking, however, it was not found to influence drug use. In multifactorial analyses of variance it was found that both psychological well-being and life satisfaction had a significant relationship with drug abuse although no causality can be attributed from the results. Engel’s Biopsychosocial Model and Bronfenbrenner’s Ecological Model were used to explain the complexity of the relationship between psychological well-being and substance abuse. Both models highlighted that in order to understand the adolescent, it is crucial to examine his or her cultural and familial behaviours that support their high risk activities. / Dissertation (MA (Clinical Psychology))--University of Pretoria, 2007. / Psychology / unrestricted

The goal of the study was to explore the perceptions of social workers regarding their role in aftercare and reintegration towards substance-dependent persons. The research was about the quest to unlock the perceptions that social workers, both in the employ of the Gauteng Department of Social Development and SANCA, have about their role in aftercare and reintegration services. Hence, the research approach followed was qualitative. Due to the nature of the study, the researcher used focus group interviews for data collection. An interview schedule, with guiding questions, was prepared in advance. The research also aimed to make comparisons between the Gauteng Department of Social Development and SANCA findings. Consequently, two focus group interviews were conducted for Gauteng Department of Social Development and SANCA, respectively. The findings from the two focus groups conducted were packaged in three sections, namely, findings from Gauteng Department of Social Development, from SANCA Eersterust and the combined data. The key findings from the Gauteng Department of Social Development were that aftercare services were viewed as motivation of clients and providing emotional support. The causes of substance abuse relapse were due to a lack of support, boredom and stigma. There was limited knowledge amongst social workers on how relevant legislation and policies link up with aftercare and reintegration services. There was a lack of manuals or guidelines on how aftercare and reintegration services should be rendered, and lastly, there was a view from social workers that the Department of Social Development should play a leading role on issues of aftercare and reintegration services. The key findings from SANCA were that aftercare and reintegration services were more about a holistic approach. The causes of substance abuse relapse were mainly about triggers and lack of social infrastructure. The stumbling blocks for effective aftercare and reintegration services were part of an external locus of control, shortage of skills development centres and inadequate services in treatment centres. Aftercare and reintegration services should include assessment, support groups for clients and families, skills development programmes and referrals. Lastly, the role of social workers when it came to aftercare and reintegration services included case management and support. The role of the social workers both from the Gauteng Department of Social Development and SANCA according to the participating social workers were as follows: resource management, therapy, empowerment, case management and support. Recommendations were made for effective aftercare and reintegration services and for future research. The recommendations for effective aftercare and reintegration services were: (1) aftercare and reintegration services should include in their programmes sessions and activities on emotional support and motivation; (2) the holistic approach should be adopted when rendering aftercare and reintegration services to substance-dependent persons; (3) the Department of Social Development should take the lead on issues of aftercare and reintegration services and should be supported by NGOs; (4) social workers were best located and more effective as case managers for substance abuse and aftercare and reintegration services in particular; (5) specialisation of social workers in the field of substance abuse was recommended; (6) there was a need for workshops for social workers in the substance abuse field to be trained about relevant policy and legislation in the sector; (7) there was a need for a manual from the Gauteng Department of Social Development and SANCA which should sketch out the process and procedures of rendering aftercare and reintegration services to recovering substance-dependent persons. The recommendations for future research were that this study was based on social workers from the Gauteng Department of Social Development and social workers from SANCA within the jurisdiction of the Tshwane area. It was recommended that a study be conducted in other areas of South Africa to make comparisons of the data. It was established that there were various legislation and policies which deal with issues of aftercare and reintegration services. There was however, a need to determine whether such legislation and policy were in line with the needs of the substance dependent people. Lastly, it was also recommended that there should be more scientific enquiry on issues of aftercare and reintegration services in substance-dependent persons in South Africa. / Dissertation (MSW)--University of Pretoria, 2013. / lmchunu2014 / Social Work and Criminology / unrestricted

Chemical substance abuse remains a major global health and social problem in a South African context. Social workers are one of the professionals who provide social welfare services to adolescents abusing chemical substances. However, social workers are not prepared enough in terms of training and workshops to provide drug dependency treatment to adolescents abusing chemical substances. This study therefore contributes to an emerging body of literature on chemical substance abuse, as there is a lack of information within the Department of Social Development in Lepelle Nkumpi Municipality of Limpopo concerning social workers’ preparedness, experiences and challenges in rendering services to adolescents abusing chemical substances. Furthermore, the study will generate new information that will assist the Department of Social Development to make necessary changes to social welfare services rendered to adolescents abusing chemical substances, and consideration will be given when drafting a framework for treating chemical substance abuse. A qualitative approach was adopted to explore, describe and contextualise social workers’ preparedness, experiences and challenges experienced during their work. Participants were selected using a non-probability technique of purposive sampling. As a data collection method, in-depth, one on one semi-structured interviews were conducted with seven social workers working with adolescents abusing chemical substances. Data was analysed using Tesch’s eight steps and verified using Guba and Lincoln’s model to test the trustworthiness of the data. Ethical considerations adhered to throughout this study were informed consent, right to privacy, avoidance of deception, debriefing of participants and management of information. Findings of the study confirmed that there are no clear guidelines in rendering social welfare services to adolescents abusing chemical substances by social workers. The study further revealed that social workers’ training is generic in nature, therefore they are not well trained to render services to adolescents abusing chemical substances. They therefore lack resources and support to adequately execute social welfare services to adolescents abusing chemical substances. Lack of services for adolescents was also identified as a burning issue. Furthermore, treatment and prevention of chemical substance abuse is overlooked. Based on the research findings, recommendations pertaining to social work practice, social work training and education, social welfare policy, and further research were put forward. / Social Work