Thesis (Ph. D.)--University of Wisconsin--Madison, 1973. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliography.

Thesis (Ph. D.)--University of Notre Dame, 2004. / Thesis directed by Kristin S. Shrader-Frechette for the Program in History and Philosophy of Science. "April 2004." Includes bibliographical references (leaves 385-406).

<p> I consider the claims made by medical ethicists that funding by pharmaceutical companies threaten the integrity of medical research and the claims of philosophers of science that evidence-based medicine can provide a sound epistemic foundation on which to base medical treatment decisions. Drawing on both game theory and medical history, I argue that both medical ethicists and philosophers of science have missed crucial aspects of medical research. I show that both veritistic and commercial aims are enduring and entrenched aspects of medical research. Because these two drives are perpetually pulling medical research in different directions, I identify the resultant conflict as the fundamental antagonism </p><p> The primary task of the dissertation is to provide a framework that incorporates both drivers of medical research. Specifically, I argue that medical research is best conceived of as an asymmetric arms race. Such a dynamic is typified by a series of moves and countermoves between competing parties who are adjusting to one another's behavior, in this case between those who seek to make medical practice more responsive to good evidence and those whose primary motivations are instead commercial in character. </p><p> Such a model presents three challenges to standard evidential hierarchies which equate epistemic reliability with methodological rigor. The first is to show that reliability and rigor can (and do) come apart as a result of the countermeasures employed by manufactures. This fact suggests that in considering policy proposals to improve epistemic reliability, it is robustness (i.e. resistance to manipulation) that should be the crucial desideratum. The second consequence is a reorientation of medical epistemology. One of the primary strategies that manufacturers have employed is to manipulate the dissemination of information. A focus on an isolated knower obscures the impact that industry has in shaping what information is available. To address these problems medical knowledge must be understood from a social epistemological framework. Finally, and most importantly, the arms race account suggests that the goal of identifying the perfect experimental design or inference pattern is chimerical. There is no final resolution to the fundamental antagonism between commercial and scientific forces. There is only a next move.</p>

This thesis investigates how researchers can take advantage of the rapid adoption of mobile technology that has brought with it transformations in social and cultural practice; the expectations of what computers are, what they can do, and the role of digital objects in everyday life. In particular this thesis presents and discuses the use of new App Store style software distribution methods to reduce the cost, in terms of researcher time and hardware, of recruiting a large group of participants for a trial ‘in the wild’ while increasing the potential diversity of users is becoming an attractive option for researchers pursuing the ubicomp vision. It examines the procedures for running large scale trials with the deployment of three applications released to a combined user base of over 135,000 in such a way as to keep the qualitative detail necessary to inform design while gain- ing the diversity of users for claims of generalisability. More generally, it discusses the results that can be expected from this ‘mass participation’ approach, and the ethical responsibilities they place upon researchers. The contributions of this thesis for mobile HCI show that in large-scale trials, relatively rich qualitative data can be collected along with substantial quantitative data, and that a hybrid trial methodology combining a large- scale deployment with a local trial can be a powerful tool in addressing shortcomings of trials that are either solely local or solely global. This thesis also contributes guidelines for researchers running large-scale user trials that give consideration to the established research norms and practices, in an attempt to strike a new balance between invasiveness and utility.

Thesis (Ph.D.)--McMaster University, 2005. / Advisor: P. Travis Kroeker. Includes bibliographical references (p. 234-248). Also available via World Wide Web.

Esta pesquisa abordou a questão do desenvolvimento social e econômico do Parque Estadual Turístico do Alto Ribeira (PETAR), localizado no sul do estado de São Paulo, a partir de um estudo geográfico realizado sob a luz da tríade analítica GTP: Geossistema, Território e Paisagem. Partindo dessa análise geográfica, foi possível identificar como as potencialidades e fragilidades do meio físico influenciaram na territorialização da região onde hoje se encontra o parque, e como a paisagem cultural é construída sobre esta realidade. Com isso foi possível contrapor a interpretação dos dados levantados ao Plano de Manejo proposto para o PETAR em 2010, que se encontra, desde aquele ano, sob análise no Conselho Estadual do Meio Ambiente do estado de São Paulo. O documento apresenta contradições internas no que tange à exploração dos recursos minerais. Com a aprovação da Lei Estadual 16.260/2016, que concede 25 unidades de conservação para a exploração da iniciativa privada, é necessário que não restem pontos obscuros no Plano de Manejo, para que fique claro quais são os recursos que poderão ou não serem explorados. Há indícios de que neste processo os interesses econômicos se sobrepuseram tanto ao objetivo de preservação da área como ao do desenvolvimento socioeconômico. Com essa problemática em foco, discutimos como a Geografia e as ciências, de maneira geral, podem ser úteis ao processo civilizatório ao estabelecer critérios éticos de forma objetiva, apontando assim, as causas dos problemas regionais relacionados à territorialização, as contradições políticas deste processo e de que forma seria possível promover o desenvolvimento socioambiental na região. Um dos principais problemas que levantamos foi a questão das restrições às atividades econômicas impostas pela legislação ambiental. Tendo o turismo como única fonte de sustento possível, a região se tornou altamente dependente dos programas de transferência de renda que, nos últimos anos, provaram ser cruciais para a redução da pobreza extrema e evolução dos índices de desenvolvimento humano. Uma vez que uma flexibilização muito grande das restrições ambientais seria desaconselhável e, levando em consideração que a área do parque é ocupada, historicamente, por populações tradicionais, como comunidades quilombolas, concluímos que seria razoável demandar do estado alguma compensação financeira. Esta medida evitaria que recaíssem, exclusivamente sobre a população local, os custos de uma conservação ambiental que é de interesse do conjunto da sociedade. / This research addressed the issue of the social and economic development of the Upper Ribeira State Tourist Park (PETAR), in the state of São Paulo, Brazil, from a geographic study conducted under the light of the analytical triad GTL: Geosystem, Territory and Landscape. Based on this geographical analysis, it was possible to identify how the potentialities and fragilities of the physical environment influenced the territorialization of the region where the park is today, and how the cultural landscape is built on this reality. Thus, it was possible to counter the interpretation of the data collected with the proposed Management Plan for PETAR in 2010, which has been under analysis by the State Environmental Council of the state of São Paulo since that year. The document presents internal contradictions regarding the exploitation of mineral resources. With the approval of State Law 16.260 / 2016, which grants 25 conservation units for the exploitation of the private initiative, it is necessary that there are no obscure points in the Management Plan so it is clear which resources may or may not be exploited. There are indications that, in this process, economic interests overshadowed both the objective of preserving the area and that of socioeconomic development. With this problematic in focus, we discuss how Geography and the sciences, in general, can be useful to the civilizational process by establishing objective ethical criteria, thus pointing to the causes of regional problems related to territorialization, the political contradictions of this process and how it would be possible to promote socio-environmental development in the region. One of the main problems raised is the issue of the restrictions on economic activities imposed by the environmental legislation. With tourism as the only possible source of income, the region has become highly dependent on income transfer programs which, in recent years, have proved to be crucial for the reduction of extreme poverty and the improvement of the human development indexes in the area. Since a significant relaxation of environmental restrictions would be inadvisable, and considering that the area of the park has historically been occupied by traditional populations such as quilombola communities, we have concluded that it would be reasonable to demand financial compensation from the state. This would prevent the local population from paying, alone, for the costs of an environmental conservation, that is in the best interest of society, as a whole.

Thesis (Ph. D.)--University of Notre Dame, 2008. / Thesis directed by Michael P. Zuckert for the Department of Political Science. "April 2008." Includes bibliographical references (leaves 281-293).

Zugl.: Uppsala, University, Diss., 2008. / Includes bibliographical references (p. 304-308).

Esta pesquisa abordou a questão do desenvolvimento social e econômico do Parque Estadual Turístico do Alto Ribeira (PETAR), localizado no sul do estado de São Paulo, a partir de um estudo geográfico realizado sob a luz da tríade analítica GTP: Geossistema, Território e Paisagem. Partindo dessa análise geográfica, foi possível identificar como as potencialidades e fragilidades do meio físico influenciaram na territorialização da região onde hoje se encontra o parque, e como a paisagem cultural é construída sobre esta realidade. Com isso foi possível contrapor a interpretação dos dados levantados ao Plano de Manejo proposto para o PETAR em 2010, que se encontra, desde aquele ano, sob análise no Conselho Estadual do Meio Ambiente do estado de São Paulo. O documento apresenta contradições internas no que tange à exploração dos recursos minerais. Com a aprovação da Lei Estadual 16.260/2016, que concede 25 unidades de conservação para a exploração da iniciativa privada, é necessário que não restem pontos obscuros no Plano de Manejo, para que fique claro quais são os recursos que poderão ou não serem explorados. Há indícios de que neste processo os interesses econômicos se sobrepuseram tanto ao objetivo de preservação da área como ao do desenvolvimento socioeconômico. Com essa problemática em foco, discutimos como a Geografia e as ciências, de maneira geral, podem ser úteis ao processo civilizatório ao estabelecer critérios éticos de forma objetiva, apontando assim, as causas dos problemas regionais relacionados à territorialização, as contradições políticas deste processo e de que forma seria possível promover o desenvolvimento socioambiental na região. Um dos principais problemas que levantamos foi a questão das restrições às atividades econômicas impostas pela legislação ambiental. Tendo o turismo como única fonte de sustento possível, a região se tornou altamente dependente dos programas de transferência de renda que, nos últimos anos, provaram ser cruciais para a redução da pobreza extrema e evolução dos índices de desenvolvimento humano. Uma vez que uma flexibilização muito grande das restrições ambientais seria desaconselhável e, levando em consideração que a área do parque é ocupada, historicamente, por populações tradicionais, como comunidades quilombolas, concluímos que seria razoável demandar do estado alguma compensação financeira. Esta medida evitaria que recaíssem, exclusivamente sobre a população local, os custos de uma conservação ambiental que é de interesse do conjunto da sociedade. / This research addressed the issue of the social and economic development of the Upper Ribeira State Tourist Park (PETAR), in the state of São Paulo, Brazil, from a geographic study conducted under the light of the analytical triad GTL: Geosystem, Territory and Landscape. Based on this geographical analysis, it was possible to identify how the potentialities and fragilities of the physical environment influenced the territorialization of the region where the park is today, and how the cultural landscape is built on this reality. Thus, it was possible to counter the interpretation of the data collected with the proposed Management Plan for PETAR in 2010, which has been under analysis by the State Environmental Council of the state of São Paulo since that year. The document presents internal contradictions regarding the exploitation of mineral resources. With the approval of State Law 16.260 / 2016, which grants 25 conservation units for the exploitation of the private initiative, it is necessary that there are no obscure points in the Management Plan so it is clear which resources may or may not be exploited. There are indications that, in this process, economic interests overshadowed both the objective of preserving the area and that of socioeconomic development. With this problematic in focus, we discuss how Geography and the sciences, in general, can be useful to the civilizational process by establishing objective ethical criteria, thus pointing to the causes of regional problems related to territorialization, the political contradictions of this process and how it would be possible to promote socio-environmental development in the region. One of the main problems raised is the issue of the restrictions on economic activities imposed by the environmental legislation. With tourism as the only possible source of income, the region has become highly dependent on income transfer programs which, in recent years, have proved to be crucial for the reduction of extreme poverty and the improvement of the human development indexes in the area. Since a significant relaxation of environmental restrictions would be inadvisable, and considering that the area of the park has historically been occupied by traditional populations such as quilombola communities, we have concluded that it would be reasonable to demand financial compensation from the state. This would prevent the local population from paying, alone, for the costs of an environmental conservation, that is in the best interest of society, as a whole.

The Concept of Politics in the Realist Tradition of the Theory of International Relations. Juraj Laššuth Abstract: Aim of this thesis is a reconstruction of the notion of politics in the school of classical realism in Theory of International Relations, using the texts of Hans Morgenthau primarily. This aim is followed in four steps - four chapters. First chapter describes relation between antropological/moral background of Morgenthau's political thinking and political sphere. Four images of the relations between anthropology and the evaluation of political sphere are identified and compared ("emacipation", "gay politics", "katechon" and "circles and antinomies") - the final one will be shown as connected with the notion of Hans Morgenthau's realism. Morgenthau's work, built up on tradition of the Pauline epistles, treats evil (defined by lust for power) as inherently present, indispensable from any human acts. Political sphere, defined according "the second principle of realism" by interest defined in terms of power, is a place, where morally ambivalent logic of power stands as the reason of acting. Second chapter addresses Morgenthau's notion of political science by comparing it with the project of Weberian social science, analyses its reason, ethos, complicated relations with its subject, dilemmas which...