[EN] The main objective of this thesis is the development of new sensors and actuators using Printed Electronics technology. For this, conductive, semiconductor and dielectric polymeric materials are used on flexible and/or elastic substrates. By means of suitable designs and application processes, it is possible to manufacture sensors capable of interacting with the environment. In this way, specific sensing functionalities can be incorporated into the substrates, such as textile fabrics. Additionally, it is necessary to include electronic systems capable of processing the data obtained, as well as its registration. In the development of these sensors and actuators, the physical properties of the different materials are precisely combined. For this, multilayer structures are designed where the properties of some materials interact with those of others. The result is a sensor capable of capturing physical variations of the environment, and convert them into signals that can be processed, and finally transformed into data. On the one hand, a tactile sensor printed on textile substrate for 2D gesture recognition was developed. This sensor consists of a matrix composed of small capacitive sensors based on a capacitor type structure. These sensors were designed in such a way that, if a finger or other object with capacitive properties, gets close enough, its behaviour varies, and it can be measured. The small sensors are arranged in this matrix as in a grid. Each sensor has a position that is determined by a row and a column. The capacity of each small sensor is periodically measured in order to assess whether significant variations have been produced. For this, it is necessary to convert the sensor capacity into a value that is subsequently digitally processed. On the other hand, to improve the effectiveness in the use of the developed 2D touch sensors, the way of incorporating an actuator system was studied. Thereby, the user receives feedback that the order or action was recognized. To achieve this, the capacitive sensor grid was complemented with an electroluminescent screen printed as well. The final prototype offers a solution that combines a 2D tactile sensor with an electroluminescent actuator on a printed textile substrate. Next, the development of a 3D gesture sensor was carried out using a combination of sensors also printed on textile substrate. In this type of 3D sensor, a signal is sent generating an electric field on the sensors. This is done using a transmission electrode located very close to them. The generated field is received by the reception sensors and converted to electrical signals. For this, the sensors are based on electrodes that act as receivers. If a person places their hands within the emission area, a disturbance of the electric field lines is created. This is due to the deviation of the lines to ground using the intrinsic conductivity of the human body. This disturbance affects the signals received by the electrodes. Variations captured by all electrodes are processed together and can determine the position and movement of the hand on the sensor surface. Finally, the development of an improved 3D gesture sensor was carried out. As in the previous development, the sensor allows contactless gesture detection, but increasing the detection range. In addition to printed electronic technology, two other textile manufacturing technologies were evaluated. / [ES] La presente tesis doctoral tiene como objetivo fundamental el desarrollo de nuevos sensores y actuadores empleando la tecnología electrónica impresa, también conocida como Printed Electronics. Para ello, se emplean materiales poliméricos conductores, semiconductores y dieléctricos sobre sustratos flexibles y/o elásticos. Por medio de diseños y procesos de aplicación adecuados, es posible fabricar sensores capaces de interactuar con el entorno. De este modo, se pueden incorporar a los sustratos, como puedan ser tejidos textiles, funcionalidades específicas de medición del entorno y de respuesta ante cambios de este. Adicionalmente, es necesario incluir sistemas electrónicos, capaces de realizar el procesado de los datos obtenidos, así como de su registro. En el desarrollo de estos sensores y actuadores se combinan las propiedades físicas de los diferentes materiales de forma precisa. Para ello, se diseñan estructuras multicapa donde las propiedades de unos materiales interaccionan con las de los demás. El resultado es un sensor capaz de captar variaciones físicas del entorno, y convertirlas en señales que pueden ser procesadas y transformadas finalmente en datos. Por una parte, se ha desarrollado un sensor táctil impreso sobre sustrato textil para reconocimiento de gestos en 2D. Este sensor se compone de una matriz formada por pequeños sensores capacitivos basados en estructura de tipo condensador. Estos se han diseñado de forma que, si un dedo u otro objeto con propiedades capacitivas se aproxima suficientemente, su comportamiento varía, pudiendo ser medido. Los pequeños sensores están ordenados en dicha matriz como en una cuadrícula. Cada sensor tiene una posición que viene determinada por una fila y por una columna. Periódicamente se mide la capacidad de cada pequeño sensor con el fin de evaluar si ha sufrido variaciones significativas. Para ello es necesario convertir la capacidad del sensor en un valor que posteriormente es procesado digitalmente. Por otro lado, con el fin de mejorar la efectividad en el uso de los sensores táctiles 2D desarrollados, se ha estudiado el modo de incorporar un sistema actuador. De esta forma, el usuario recibe una retroalimentación indicando que la orden o acción ha sido reconocida. Para ello, se ha complementado la matriz de sensores capacitivos con una pantalla electroluminiscente también impresa. El resultado final ofrece una solución que combina un sensor táctil 2D con un actuador electroluminiscente realizado mediante impresión electrónica sobre sustrato textil. Posteriormente, se ha llevado a cabo el desarrollo de un sensor de gestos 3D empleando una combinación de sensores impresos también sobre sustrato textil. En este tipo de sensor 3D, se envía una señal que genera un campo eléctrico sobre los sensores impresos. Esto se lleva a cabo mediante un electrodo de transmisión situado muy cerca de ellos. El campo generado es recibido por los sensores y convertido a señales eléctricas. Para ello, los sensores se basan en electrodos que actúan de receptores. Si una persona coloca su mano dentro del área de emisión, se crea una perturbación de las líneas de los campos eléctricos. Esto es debido a la desviación de las líneas de campo a tierra utilizando la conductividad intrínseca del cuerpo humano. Esta perturbación cambia/afecta a las señales recibidas por los electrodos. Las variaciones captadas por todos los electrodos son procesadas de forma conjunta pudiendo determinar la posición y el movimiento de la mano sobre la superficie del sensor. Finalmente, se ha llevado a cabo el desarrollo de un sensor de gestos 3D mejorado. Al igual que el desarrollo anterior, permite la detección de gestos sin necesidad de contacto, pero incrementando la distancia de alcance. Además de la tecnología de impresión electrónica, se ha evaluado el empleo de otras dos tecnologías de fabricación textil. / [CA] La present tesi doctoral té com a objectiu fonamental el desenvolupament de nous sensors i actuadors fent servir la tecnologia de electrònica impresa, també coneguda com Printed Electronics. Es va fer us de materials polimèrics conductors, semiconductors i dielèctrics sobre substrats flexibles i/o elàstics. Per mitjà de dissenys i processos d'aplicació adequats, és possible fabricar sensors capaços d'interactuar amb l'entorn. D'aquesta manera, es poden incorporar als substrats, com ara teixits tèxtils, funcionalitats específiques de mesurament de l'entorn i de resposta davant canvis d'aquest. Addicionalment, és necessari incloure sistemes electrònics, capaços de realitzar el processament de les dades obtingudes, així com del seu registre. En el desenvolupament d'aquests sensors i actuadors es combinen les propietats físiques dels diferents materials de forma precisa. Cal dissenyar estructures multicapa on les propietats d'uns materials interaccionen amb les de la resta. manera El resultat es un sensor capaç de captar variacions físiques de l'entorn, i convertirles en senyals que poden ser processades i convertides en dades. D'una banda, s'ha desenvolupat un sensor tàctil imprès sobre substrat tèxtil per a reconeixement de gestos en 2D. Aquest sensor es compon d'una matriu formada amb petits sensors capacitius basats en una estructura de tipus condensador. Aquests s'han dissenyat de manera que, si un dit o un altre objecte amb propietats capacitives s'aproxima prou, el seu comportament varia, podent ser mesurat. Els petits sensors estan ordenats en aquesta matriu com en una quadrícula. Cada sensor té una posició que ve determinada per una fila i per una columna. Periòdicament es mesura la capacitat de cada petit sensor per tal d'avaluar si ha sofert variacions significatives. Per a això cal convertir la capacitat del sensor a un valor que posteriorment és processat digitalment. D'altra banda, per tal de millorar l'efectivitat en l'ús dels sensors tàctils 2D desenvolupats, s'ha estudiat la manera d'incorporar un sistema actuador. D'aquesta forma, l'usuari rep una retroalimentació indicant que l'ordre o acció ha estat reconeguda. Per a això, s'ha complementat la matriu de sensors capacitius amb una pantalla electroluminescent també impresa. El resultat final ofereix una solució que combina un sensor tàctil 2D amb un actuador electroluminescent realitzat mitjançant impressió electrònica sobre substrat tèxtil. Posteriorment, s'ha dut a terme el desenvolupament d'un sensor de gestos 3D emprant una combinació d'un mínim de sensors impresos també sobre substrat tèxtil. En aquest tipus de sensor 3D, s'envia un senyal que genera un camp elèctric sobre els sensors impresos. Això es porta a terme mitjançant un elèctrode de transmissió situat molt a proper a ells. El camp generat és rebut pels sensors i convertit a senyals elèctrics. Per això, els sensors es basen en elèctrodes que actuen de receptors. Si una persona col·loca la seva mà dins de l'àrea d'emissió, es crea una pertorbació de les línies dels camps elèctrics. Això és a causa de la desviació de les línies de camp a terra utilitzant la conductivitat intrínseca de el cos humà. Aquesta pertorbació afecta als senyals rebudes pels elèctrodes. Les variacions captades per tots els elèctrodes són processades de manera conjunta per determinar la posició i el moviment de la mà sobre la superfície del sensor. Finalment, s'ha dut a terme el desenvolupament d'un sensor de gestos 3D millorat. A l'igual que el desenvolupament anterior, permet la detecció de gestos sense necessitat de contacte, però incrementant la distància d'abast. A més a més de la tecnologia d'impressió electrònica, s'ha avaluat emprar altres dues tecnologies de fabricació tèxtil. / Ferri Pascual, J. (2020). Tactile and Touchless Sensors Printed on Flexible Textile Substrates for Gesture Recognition [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/153075 / TESIS

Cílem této práce je vývoj světelného zdroje založeného na technologii tlustostěnného elektroluminiscenčního panelu napájeného střídavým napětím (ACPEL). V současné době se jedná se o jedinou technologii založenou na metodách materiálového tisku vhodnou pro přípravu velkoplošných, flexibilních a vzorovaných zdrojů světla. Důraz je v této práci kladen na představení, prozkoumání a odstranění typických problémů, které jsou spojovány s touto technologií. Tyto problémy jsou omezený odstín barvy emitovaného světla a dlouhodobá stabilita elektroluminiscenčního prvku, který je vystaven vlivům prostředí. Rešeršní část dizertační práce je zaměřena na představení a identifikaci depozičních technik, vhodných pro reprodukovatelnou přípravu ACPEL panelů. Dalším cílem je identifikace fyzikálních parametrů, vhodných pro charakterizaci velkoplošných zdrojů světla. Praktickým cílem práce je nalezení vhodné metodologie pro popis a charakterizaci panelů, jakožto plošných světelných zdrojů. Fotometrická veličina jas L a spotřeba elektrické energie P byly vyhodnoceny jako vhodné parametry, určující aplikaci ACPEL panelů. Na modrém panelu bylo dosaženo maximální hodnoty jasu L = 133 cd•m2 při napětí Upp = 500 V a frekvenci f = 1000 Hz. Hodnoty spotřeby elektrické energie, vztažené na jednotkovou plochu panelů zkoumaných v této práci, jsou (7±3) mW. Tyto dosažené hodnoty dělají ze světelných zdrojů založených na ACPEL technologii zajímavé kandidáty pro různé aplikace. Vlivu rostoucí amplitudy a frekvence budícího napětí na dlouhodobou stabilitu panelů je důležitým cílem této práce. Pro popis stability byly zavedeny parametry L50 and L75. Bylo zjištěno, že rostoucí frekvence budícího napětí zkracuje životnost panelů. Laminovaný panel napájený napětím s přibližně trojnásobně vyšší frekvencí vykazoval přibližně třetinové hodnoty parametrů L50 a L75. Nejvyšších hodnot stabilitních parametrů dosahoval panel enkapsulován mezi skleněné pláty – přibližně sedminásobnou hodnotu oproti laminovanému panelu s trojnásobnou frekvencí. Optimální stability panelů lze dosáhnout při nastavení frekvence v rozmezí 400–800 Hz a zapouzdřením mezi sklo. Úzká paleta odstínů barev emitovaného světla je jeden z typických problémů, který dále zkoumán v dizertační práci. Tato práce zkoumá nadějnou metodu, přídavek vhodného materiálu pro konverzi barvy (CCM). Nový derivát diketopyrrolopyrrolu (DPP), absorbující v modré oblasti, byl přidán k modrému fosforu a byl pozorován sedminásobný narůst hodnot absolutního spektrálního ozáření v oblasti vlnových délek odpovídajících maximální emisi CCM materiálu. Jednoduchost přípravy vyvinutých zdrojů světla spolu s velmi nízkou spotřebou a vysokou dobou života dělají z ACPEL panelů zajímavé kandidáty pro podsvícení prvků například v automobilovém průmyslu, pro dekorativní osvětlení, pro „branding“ – zvýraznění reklamních značek.

This diploma thesis focuses on electrochemical sensors to detect radiation in the blue region of the visible spectrum. As a semiconducting material for the manufacture of the sensor, a suspension of tungsten trioxide was found. The individual elements of the sensor were applied by pad printing techniques or screen printing. Using linear voltammetry and chronoamperometry, the magnitude of the generated current was measured and radiometric calibration was performed. The properties of the layers were characterized by profilometry, optical and electron microscopy.

This work deals with the problem of the thick-film pastes and their printing. In the main chapter of this work, the realization of a workplace for thick-film pastes' printing is described. The construction of the realized plotter and the controlling electronics of the plotter is depicted in detail.In the following chapter, the console, through which the plotter is controlled via PC, and the CAD program, which serves for projecting of the motives printed, are described.In the final chapter of this work, the measured profiles of the paste printed for various settings of printing parameters and the photographs of the motives printed are stated.

This thesis describes optimization and modification of standard thick-film electrochemical sensor to be able to be used for detection in microvolumes. In the theoretical part, the thick film technology is described. The work is then focused on the wettability of surfaces followed by introduction to electrochemistry and electro-analytical methods. In the experimental part, screen-printing of various types of thick film pastes on ceramic substrates for determination of their wettability and the following modification of the sensors with thick-film paste and with Parylene vaporization can be found, as well as the basic electrochemical measurements in microvolume using the modified sensor. Finally the results are summarized in conclusion.

Diploma thesis is focused on manufacturing process of waveguide filter. Thesis is divided to 8 chapters. There is summarized theory of possible execution of waveguide filter, used materials, their influence and risks during production. Then are described possible steps of realization and necessary relations for its design, simulation and also practical realization. At conclusion are summarized, compared and described reached results.

Der Schwerpunkt dieser Arbeit liegt auf der Entwicklung von Technologien und Prozessen, welche die Marktakzeptanz organischer Leuchtdioden (OLED) durch Steigerung der Effizienz und Leuchtdichtehomogenität erhöhen. Dazu werden die Fertigungskosten durch neuartige Herstellungsverfahren reduziert und die Realisierung von effizienten, großflächigen (> 300×300 mm2) und homogen leuchtenden OLED-Modulen in beliebiger Modulform ermöglicht. Um dies zu erreichen, wurden folgende drei Ansätze verfolgt: 1. Die Optimierung der Strukturierung dünner Schichten bei Substraten für die organische Elektronik unter Verwendung der Technologien Siebdruck und Laserablation. Es werden neuartige Druckpasten auf ihre Eigenschaften hin untersucht und deren Eignung für die Substratstrukturierung bei OLEDs mittels Testmodulen elektro-optisch charakterisiert. Weiterhin steht die Verringerung der parasitären Leckströme durch einen optimierten Laserablationsprozess zur Grundelektrodenstrukturierung und einer Variation der Dicke der Löchertransportschicht im Fokus. 2. Die Realisierung einer schattenmasken- und photolithografiefreien seriellen elektrischen Verschaltung von mehreren kleinen OLED-Segmenten zu einem großen Gesamtmodul. Dazu werden ein Verfahren für die Erzeugung einer elektrischen Verbindung zwischen Top- und Grundelektrode sowie zwei hochinnovative Verfahren zur Separation einer vollflächig abgeschiedenen Topelektrode entwickelt und auf ihre Eignung hin validiert. 3. Die Verbesserung der Lichtauskopplung aus OLED-Modulen mittels einer modulinternen Streuschicht. Es werden fünf unterschiedliche Streupartikelarten und zwei Matrixmaterialien untersucht und deren Auswirkungen auf die Lichtauskopplung anhand von OLED-Testmodulen charakterisiert. Die entwickelten Verfahren und Prozessen basieren auf den Technologien Siebdruck und Laserablation, sind explizit für die Fertigung flexibler Module auf Basis von Trägermaterialien wie Dünnglas oder Polymerfolien sowie einem Rolle-zu-Rolle-Herstellungsverfahren geeignet und können direkt in eine großserientechnische Herstellung von OLED-Modulen überführt werden. / The focus of this work is upon the development of technologies and processes to increase the efficiency and brightness homogeneity of organic light-emitting diodes (OLEDs) in order to improve their market acceptance. Additionally, manufacturing costs will be reduced by adopting the new processes and it will be shown that the production of efficient, large-area (up to 300 × 300 mm2) and uniformly bright OLED modules of an arbitrary shape is possible. To achieve this, three approaches were followed: 1. The optimization of the structuring of thin layers on substrates for organic electronics using screen printing and laser ablation. To achieve this, the properties of novel printing pastes were determined, and their suitability for structuring substrates was assessed using results from the electro-optical characterization of test modules. Furthermore, the parasitic leakage current was minimized by optimizing the laser ablation process used for the structuring of the bottom electrode, together with the thickness of the hole transport layer. 2. The electrical connection in series of several small OLED segments to make a larger module without the need for shadow masks or photolithographic processes was studied. This included the development of a technique to connect the top and bottom electrodes, as well as two highly innovative methods to produce a completely separated top electrode using structuring by laser ablation. The suitability of these methods for OLED production was confirmed. 3. A scattering layer within the modules was developed to improve the light outcoupling. Five types of scattering particle in two different matrix materials were examined, and the effects of the resulting scattering layer on the outcoupling from an OLED test module were characterized. The newly developed processes make use of screen printing and laser ablation and are thus well suited to the production of flexible OLED modules using support materials such as thin glass or polymer foils with roll-to-roll processing. Accordingly, such technologies could readily be transferred to the large volume production of OLED modules.

This work deals with the problem of the thick-film pastes and their printing. In the main chapter of this work, the realization of a workplace for thick-film pastes' printing is described. The construction of the realized plotter and the controlling electronics of the plotter is depicted in detail.In the following chapter, the console, through which the plotter is controlled via PC, and the CAD program, which serves for projecting of the motives printed, are described.In the final chapter of this work, the measured profiles of the paste printed for various settings of printing parameters and the photographs of the motives printed are stated.

Die vorliegende Arbeit beschäftigt sich mit der Entwicklung von anwendungsspezifisch angepassten und drucktechnisch herstellbaren Antennen für Radio‐Frequency‐Identification (RFID) Anwendungen im Ultra‐High‐Frequency (UHF) und Super‐High‐Frequency (SHF) Frequenzbereich. Dabei werden alle Entwicklungsschritte und deren Abhängigkeiten vom Antennenentwurf über die Simulation, die Herstellung im Druckverfahren und die Antennenvermessung betrachtet. Die Alleinstellungsmerkmale der vorliegenden Arbeit liegen in der Erforschung von Antennen, welche eine hohe Funktionalität in herausfordernden dielektrischen oder metallischen Umgebungen (Glas, Holz, Papier, Aluminium, …) aufweisen sowie im Druckverfahren hergestellt werden. Mit Hilfe von FEM‐ und MoM‐Berechnungen werden neu entwickelte Antennenkonzepte wie 898 MHz‐Dipolantennen, 868 MHz‐Längsstrahler‐ Antennenkonfigurationen, 868 MHz‐(Reflektor)‐Antennenkonfigurationen und 5.8 GHz‐3D‐Dipol‐ Antennendesigns zur Erhöhung der Kommunikationsfähigkeit untersucht und beschrieben. Dabei werden hinsichtlich der 868 MHz‐Längsstrahler‐Antennenkonfiguration, zur Funktion in direkter metallischer Umgebung, Performance mindernde Depolarisationseffekte nachgewiesen. Eine Minimierung dieser Effekte wird mit der gezielten Krümmung elektromagnetischer Wellenfronten zwischen abstrahlendem Antennenelement und Reflektor erreicht. Der Nachweis wird anhand einer selbst entwickelten 868 MHz‐(Reflektor)‐Antennenkonfiguration geführt. Um die Leistungsfähigkeit gedruckter Antennen weiter zu steigern, werden Antennen mit gerichteter Abstrahlcharakteristik mit einer Resonanzfrequenz von 5.8 GHz und einer Frequenzbandbreite von 150 MHz entworfen. Als ein Ergebnis werden Antennen mit dreidimensionaler Geometrie vorgestellt. Die Besonderheit hierbei liegt in der planaren Herstellung der Antenne im Druckverfahren und der anschließenden dreidimensionalen Aufrichtung. Die entwickelten Antennen sind direkt in kommerzielle und industrielle Anwendung überführbar. / This doctoral thesis focuses on research and development in the field of novel, optimized and printed antenna structures for UHF and SHF-RFID applications in challenging dielectric and metallic environments. These antenna structures have a high level of functionality, the manufacturing costs are low and they can easily be integrated. At the beginning of this work, based on wave equations it had been deduced that the propagation of electromagnetic waves in different media is dependent on the two material parameters permeability and permittivity. Based on this knowledge and further application- and manufacturing-specific parameters (resonance frequency, radiation characteristics, impedance, properties of the object which is to be identified (form, geometry, permeability and permittivity) and manufacturing-specific properties (substrate, material and printed layer thereof)), dipole antenna designs for different dielectric environments (air, paper, glass or wood) were designed, investigated with the help of a simulation tool, manufactured employing screen and gravure printing technologies and characterized in an anechoic chamber. The employed printing technologies are very dynamic processes which depend on various process parameters. In order to improve the functionality of printed antenna structures, several dependencies between the printing processes and the achieved antenna properties have been investigated. Summed up, it can be stated that next to all manufacturing-specific dependencies, the antenna design itself is the most significant factor influencing the achievable antenna properties. Next to carrying out research on dielectric antennas in the near field, finding novel antenna concepts for the realization of highly functional UHF-RFID-transponder-antennas for the application on metallic objects was also part of this investigation. Important to account for is that the metallic objects influence the propagation of electromagnetic waves. In order to efficiently use this physical property of the reflection of electromagnetic waves, novel UHF-reflector-antenna configurations have been designed. Afterwards, its antenna-polarizations behavior was investigated in several simulations before the antenna was manufactured employing screen printing technology and characterized in an anechoic chamber. The developed antenna-configuration showed impressive RFID-reading distances up to 8.1 m (with a RFID-reader transmitting power of 1 W ERP) and compared to the state-of-the-art technology (reading distance approx. 5 m). Therefore this technology enhances the reading performance (distance) by approximately 60 %. In order to improve the communication quality of future RFID-systems, also novel, multi-directional 3D-RFID transponder antenna structures with a resonance frequency of 5.8 GHz were designed. Because of the increased resonance frequency compared to already existing UHF-RFID systems, the usage of a broader-band RFID-frequency range is possible (5.725 GHz – 5.875 GHz (150 MHz) instead of just several kHz). This allows identifying significantly more objects (> 100) in parallel. The three-dimensional layout of two antenna parts vertical to each other allows a directional (not omni-directional) radiation characteristic outside the enclosed volume of space. Because of this, the influence of dielectric materials (for instance content of product packages) on the functionality of the antenna could be significantly reduced. Also, it was shown that the designed 3D-antenna structure could easily be integrated directly on the interior of for instance product packages employing screen printing technology. After folding/erecting the product package, the antenna receives its three dimensional shape and its verified improved performance.

Объектами исследования служили фармацевтическая субстанция «Аргамид» и готовая лекарственная форма 1% крем «Аргамид» на основе серебряной соли сульфадимидина (Приоритетная справка на выдачу патента № 2015153574 от 14.12.2015). Данная соль и лекарственные средства на ее основе были разработаны на базе кафедры фармации УГМУ с целью обеспечения российского фармацевтического рынка эффективными антибактериальными и ранозаживляющими лекарственными препаратами отечественного производства согласно стратегии развития фармацевтической промышленности «ФАРМА-2020». Цель работы: разработка и валидация методик количественного определения серебра в исследуемых лекарственных средствах. Анализ литературных данных показал, что оптимальным методом определения серебра является метод осадительного титрования с потенциометрической индикацией конечной точки титрования. При этом, учитывая содержание серебра в анализируемых лекарственных средствах, для его определения в субстанции был выбран метод роданометрического, а в готовой лекарственной форме – йодометрического титрования. Для анализируемых лекарственных средств были подобраны оптимальные условия пробоподготовки: масса навески, концентрация растворителя; время и температура обработки пробы. В качестве индикаторного вместо дорогостоящего импортного серебряного дискового электрода использовали отечественный толстопленочный серебросодержащий электрод. Положительные результаты валидационной оценки разработанных методик, проведенной согласно требованиям Государственной Фармакопеи РФ XIII изд., позволяют считать их приемлемыми и рекомендовать для включения в проекты фармакопейных статей на исследуемые лекарственные средства. Контроль содержания серебра по разработанным методикам не требует дорогостоящего оборудования, привлечения высококвалифицированного персонала, отличается относительно коротким временем анализа, а, следовательно, может применяться испытательными лабораториями предприятия в процессе производства и центрами контроля качества во время обращения на фармацевтическом рынке исследуемых лекарственных средств. / The objects of study were pharmaceutical substance "Argamid" and finished dosage form of 1% cream "Argamid" based on silver salt sulfadimidine (Priority reference patent number 2015153574 from 14.12.2015). This salt and drugs based on it have been developed at the Department of Pharmacy UGMU to ensure that the Russian pharmaceutical market effective antibacterial and wound healing medicines domestic production according to the strategy of development of the pharmaceutical industry "Pharma 2020". Objective: Development and validation of methods of quantitative determination of silver in the investigational medicinal product. Analysis of published data shows that the best method of determining silver is the method of precipitation titration with potentiometric indication end point. However, given the content of silver in the analyzed medicaments for identification substance rodanometricheskogo method was selected, and in the final dosage form - iodometric titration. optimal conditions for sample preparation were selected to be analyzed drugs: sample weight, the concentration of solvent; Sample processing time and temperature. As an indicator instead of expensive imported silver disk electrode used domestic thick-film silver-electrode. Positive results validation assessment developed techniques conducted in accordance with the requirements of the RF State Pharmacopoeia XIII ed., Allow us to consider them acceptable and recommended for inclusion in the draft articles on the pharmacopoeia investigational medicinal products. Control of the silver content by developed techniques does not require expensive equipment, highly skilled personnel, has a relatively short analysis time, and, therefore, can be applied testing laboratories of the enterprise in the production process and quality control center during handling in the pharmaceutical market of investigational medicinal products.