Zürich, Univ., Diss., 2000.

Proefschrift Universiteit Maastricht. / Met lit. opg. - Met samenvatting in het Engels.

Proefschrift Universiteit Maastricht. / Met bibliogr., lit. opg. - Met samenvatting in het Nederlands.

Proefschrift Universiteit van Amsterdam. / Met bibliogr., lit. opg. - Met samenvatting in het Nederlands.

?rea de concentra??o: Farmacologia. / Submitted by Nivaldo Melo (nivaldo.melo@ufvjm.edu.br) on 2015-11-30T16:02:46Z No. of bitstreams: 2 amine_becheleni_pimenta.pdf: 1766840 bytes, checksum: 6c26ee2619fece6619b42bf5cce87cb9 (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-12-02T16:37:33Z (GMT) No. of bitstreams: 2 amine_becheleni_pimenta.pdf: 1766840 bytes, checksum: 6c26ee2619fece6619b42bf5cce87cb9 (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) / Made available in DSpace on 2015-12-02T16:37:34Z (GMT). No. of bitstreams: 2 amine_becheleni_pimenta.pdf: 1766840 bytes, checksum: 6c26ee2619fece6619b42bf5cce87cb9 (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) Previous issue date: 2014 / As plantas do g?nero Kielmeyera, cujos efeitos farmacol?gicos j? foram demonstrados, s?o plantas nativas da regi?o do Vale do Jequitinhonha e conhecidas como Pau Santo. A Kielmeyera rubriflora ? utilizada na medicina caseira, entretanto, at? o momento n?o existem dados dispon?veis na literatura de estudos farmacol?gicos a seu respeito. O objetivo do trabalho foi avaliar os efeitos ansiol?ticos e antidepressivos do extrato bruto das partes a?reas da K. rubriflora sobre a atividade do sistema nervoso central (SNC) de camundongos su??os albinos machos. O extrato bruto das partes a?reas foi administrado via oral nas doses de 100 mg/Kg, 250 mg/Kg e 500 mg/Kg em camundongos albinos, su??os, machos, com idade entre 9 e 13 semanas, com peso entre 25 e 40 g. Foram utilizados os testes de triagem farmacol?gica comportamental (agudo), movimenta??o espont?nea (agudo), potencializa??o do tempo de sono induzido por tiopental s?dico (agudo), placa perfurada (agudo), labirinto em cruz elevado (agudo), nado for?ado (cr?nico) e suspens?o da cauda (cr?nico). Na de triagem farmacol?gica comportamental, foram detectados efeitos de depress?o do SNC pela dose de 100mg/Kg e de est?mulo do SNC nas doses de 250 e 500 mg/Kg. O tempo de sono que foi reduzido pelo extrato em 20 e 26% nas doses de 100 e 500 mg/Kg respectivamente. A ambula??o foi significativamente aumentada nas doses de 100 e 500 mg/Kg sugerindo efeito ansiol?tico e significativamente diminu?da na dose de 250 mg sugerindo efeito sedativo. As propriedades ansiol?ticas foram investigadas nos testes da placa perfurada e do labirinto em cruz elevado, onde houve diminui??o do tempo de perman?ncia nos bra?os fechados com a doses de 100mg/Kg e aumento significativo de entradas no bra?o aberto na doses de 250mg/Kg sugerindo atividade ansiol?tica nestas doses. No teste da placa perfurada houve diminui??o significativa de mergulhos de cabe?a na dose de 250mg/Kg e 500mg/Kg sugerindo a??o sedativa e aumento significativo de mergulhos de cabe?a na dose de 100 mg/Kg sugerindo a??o ansiol?tica. A atividade antidepressiva foi investigada com os testes de suspens?o da cauda e nado for?ado. No teste da suspens?o da cauda houve diminui??o dose-dependente, por?m n?o significativa do tempo de imobilidade. No teste de nado for?ado houve diminui??o significativa do tempo de imobilidade em todas as doses investigadas sugerindo atividade antidepressiva, principalmente na dose de 100 mg/Kg. Sendo assim os dados encontrados sugerem a??o sedativa, ansiol?tica e antidepressiva dose-dependente do extrato bruto da Kielmeyera rubriflora. / Disserta??o (Mestrado) ? Programa de P?s-gradua??o em Ci?ncias Farmac?uticas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2014. / ABSTRACT The plants of the genus Kielmeyera, whose pharmacological effects have been reported, are native to the Vale do Jequitinhonha region and are known as ?Pau Santo?. The Kielmeyera rubriflora is used in folk medicine; however, no data are available in the literature on pharmacological studies regarding this species. The aim of the study was to evaluate the anxiolytics and antidepressants effects of the crude extract from the aerial parts of K. rubriflora activity on the central nervous system (CNS) of Swiss albino male mice. The crude extract of the aerial parts was administered orally at doses of 100 mg/kg, 250 mg/kg and 500 mg/kg to albino Swiss, male mice, between 9 and 13 weeks of age, weighing between 25 and 40 g. Behavioral pharmacological screening (acute), spontaneous movement (acute), potentiation of sleeping time induced by sodium thiopental (acute), elevated plus maze (acute), hole board (acute), forced swimming (chronic) and tail suspension (chronic) tests were performed. In the behavioral pharmacological screening of CNS depression, effects were detected with the 100 mg/kg dose, and CNS stimulation was detected with the doses of 250 and 500 mg/kg. The duration of sleep was reduced by the extract at 20 and 26% with doses 100 and 500 mg/kg, respectively. The ambulation was significantly higher at doses of 100 and 500 mg/kg, suggesting an anxiolytic effect, and significantly lower at a dose of 250 mg, suggesting a sedative effect. Anxiolytic properties were investigated in the tests of the hole board and the elevated plus maze, where there is less time spent in the closed arms with doses of 100 mg/kg and a significant increase in open arms entries with doses of 250 mg/kg, suggesting an anxiolytic activity with these doses. In the hole board test, head dipping decreased significantly with doses of 250 mg/kg and 500 mg/kg, suggesting a sedative action. A significant increase in head dipping was observed with the doses of 100 mg/Kg, suggesting na anxiolytic action. The antidepressant activity was investigated with the tail suspension and forced swim tests. In the tail suspension test, a dose-dependent, but not significant, decrease in the immobility time, was observed. In the forced swim test, a significantly lower immobility time was observed at all the doses, suggesting an antidepressant activity, especially at a dose of 100 mg / kg. Thus, the data suggests a sedative, anxiolytic and antidepressant dose-dependent action of the crude extract of Kielmeyera rubriflora.

No description available.

Background: Sedatives and hypnotics are substances to calm or relieve anxiety and to induce sleep. Long term prescription of benzodiazepines/Z-drugs may lead to the development of tolerance and the need to increase the dose. It is important to be aware of the risks of uncontrolled use of these drugs, such as harmful interactions with other substances, side effects and potential for abuse or addiction. Aim: The aim of this research was to describe abuse of sedatives and hypnotics from the user's perspective, to focus on circumstances leading to drug abuse, to describe beginning and course of the use of these drugs and self-awareness of the problem. The aim was also to describe the current state of users and their needs. Sample: The research sample consisted of 6 participants, of which 4 women and 2 men currently or recently using sedatives and hypnotics (specifically benzodiazepines/Z-drugs). Methods: Data were collected through a qualitative approach using a semi-structured interview. Interviews were conducted, rewritten into protocol summary, further analysed using thematic analysis, modified using open and axial coding and categorization methods. Results: Respondents may have misused sedatives and hypnotics to self-medicate symptoms. These drugs were prescribed for the first time with...