Foi estudado o efeito de priming negativo associado à supressão do distrator palavra-cor de Stroop (Estudo 1), à supressão do local (Estudo 2) e à identidade do distrator (Estudos 3 e 4). No Estudo 1 constatou-se que a prática prévia em palavras-cor eliminou o efeito da ordem das condições experimentais sobre o índice de priming negativo. No Estudo 2, o efeito de priming negativo foi observado somente no hemicampo direito. A execução concorrente de uma tarefa verbal eliminou os efeitos de lateralidade, mas o efeito de priming negativo permaneceu significante. Estes achados são discutidos em termos de processamento interhemisférico sob condições que exigiriam maior controle da atenção. Os estudos 3 e 4 apresentam tarefas de comparação de pares de dígitos. A versão de papel e lápis da tarefa de comparação de dígitos permitiu avaliar de maneira simples e rápida o efeito de priming negativo. A versão computadorizada, revelou uma interação entre os componentes espacial e de identidade. Ambos os grupos de adultos jovens e idosos revelaram priming negativo nas tarefas de Stroop e de localização espacial. Nas tarefas de identificação do alvo somente os adultos jovens mostraram efeito de priming negativo. Os presentes achados são consistentes com a proposta de mecanismos inibitórios diferenciados na supressão da identidade e de localização espacial. / The development of sensitive and simple tests for the assessment of the negative priming effect has theoretical relevance to the elucidation of selective attention models, and also practical and potential clinical implications. The negative priming effect has been regarded as an index of inhibitory attentional processing and was proposed for the detection of syndromes that involve cognitive impairment. Diminished negative priming was reported in studies of individual differences, developmental stage, and clinical populations. However, evidences suggest that tasks requiring responses to the color feature, location or object identity of the stimuli may comprise distinct types of negative priming tasks. The following studies presents data for computerized and paper-and-pencil tasks to examine negative priming for Stroop color-word, location and identity distractors. All four studies take into account aging effects across the tasks. For comparisons between age-groups, proportional performance scores (ratio) were used. A first study employed a reading-sheet Stroop-color-word task, in which the participant is asked to name the colors of the ink in which words with incongruent color names have been printed. Color-word interference is indicated by increased time to complete the conflicting color-word condition compared with a nonconflicting condition with patches of color or strings of Xs. The greater strength of the interference, when the target ink-color of the present stimulus is the distracting color name of the previous stimulus, is attributed to the negative priming effect. A pilot experiment showed that the order of the list conditions containing unrelated and related stimuli affected the negative priming index. The analysis of data demonstrated that a practice trial in color naming of conflicting color-words before the color-word conditions eliminated the effect of the order of the lists. In addition, there was a reliable Stroop reverse interference after practice in color naming, as indicated by the fact that the incongruent color-ink affected post-test word-reading, whereas it had no effect in the pretest word-reading. With practice procedure, older and younger subjects did not differ in their proportional interference scores, whereas the negative priming and reverse effects were increased for older adults. Study 2 examined the negative-priming effect in a spatial localization task under single- and dual-task conditions. The task required the subject to detect the location of a target letter, ‘O’, while ignoring a distractor letter, ‘X’, when it was present. Significant negative-priming effects were observed under both task conditions, with increased response times for trials in which target location had matched the location of the distractor on the preceding. The magnitude of the negative priming effect was not different for older and younger adults. The performance in the single-task condition showed laterality effects with a right visual field advantage for control and target-alone trials, but not for related trials. In consequence, in the single-task condition, negative priming was observed only for targets displayed in the right hemifield. However, a concurrent digit span task, with a load level that had shown no affect on the dual-task coordination capacity, eliminated the laterality effects, but the negative priming effect remained. These results are considered as neuropsychological evidence that interhemispheric processes may operate under more controlled conditions. Studies 3 and 4 examined negative priming by using an identity-based task that required participants to select the greater of two-digits display or the digit that was paired with an asterisk. Study 3 presents data for a computerized version of the task. Negative-priming was expressed as a slowing in the time to name the digit that had been ignored in the preceding trial, compared to control trials with consecutive targets and distractors always different. Analysis of data revealed that negative priming was reliable only for younger adults, and only when target probe and distractor prime appeared at the same location, suggesting that suppression for location of distractor was underpinning the negative priming effect. However, response latencies for the control trials were facilitated when the target probe and the distractor prime shared the same location. Thus, local suppression affected negative priming for attended distractors with a cost in the response latency for ignored-repetition trials and with a gain in response latency for control trials when the locus of target-probe and distractor-prime was the same. In contrast, older adults’ performance showed local suppression for both ignored-repetition and control trials. This may explain the lack of negative priming for older adults in the digit-comparison task. Study 4 presents data for a new paper-and-pencil version of the digit-comparison task to obtain a practical measure of negative priming that do not require cumbersome technical equipment. In that task, subjects were asked to circle digits that were paired with asterisks and the greater of two digits in a series of digit pairs listed on a sheet of paper. For younger participants, but not for older participants, the time to complete the sheet with related pairs was slower than for unrelated pairs. In addition, the reduced scores of negative priming in older adults were associated with the lowest sustained attention scores from Toulouse-Piéron test. These results suggest that older adults’ performance in the digit-comparison task were mainly related to flexibility and sustained attentional scores, and the lower sustained attentional coefficient seemed to be the best predictor of diminished or reversed negative priming in older adults. Younger adults showed reliable negative priming across all tasks. In contrast, older adults showed negative priming in Stroop and spatial tasks, when compared with younger subjects performance, but reduced negative priming in identity suppression tasks. The findings are consistent with neurophysiological and behavioural evidence that identity and location suppressing may rely on separate inhibitory mechanisms, and that not all of these processes are weakened by factors associated with age.

Injuries involving the nervous system are among the most devastating and life altering of all neurological disorders. The resulting loss of sensation and voluntary muscle control represent a drastic change in the individuals lifestyle and independence. Spinal cord injury affects over two hundred thousand people within the United States alone. While there have been many attempts to develop neural interfaces that can be used as part of a prosthetic device to improve the quality of life of such patients and contribute to the reduction of ongoing health care costs, the design of such a device has proved elusive. Direct access to the spinal cord requires potentially life threatening surgery during which the dura, the protective covering surrounding the cord, must be opened with a resulting high risk of infection. For this reason research has been focussed on the stimulation of and recording from the peripheral nerves in an attempt to restore the functionality that has been lost through spinal cord injury. This thesis is concerned with the current status and limitations of peripheral nerve interfaces that are designed for recording electrical signals directly from the nervous system using a technique called velocity selective recording. This technique exploits the relationship between axonal diameter, which is linked via anatomy to function, and the speed with which the axon conducts excitation. New techniques are developed that improve current methods for identifying and simulating neural signals and power efficient implementations of these methods are presented in modern microelectronic platforms. Results are presented from pioneering experiments in rat and pig that for the first time demonstrate the recording and analysis of the physiological electroneurogram using velocity based methods. New methods are developed that enable the extraction of neuronal firing rates and thus the extraction of the information encoded within the nervous system.

"Porous materials have been a focus of researchers for their applications as molecular storage, molecular sensing, catalysis, asymmetric synthesis and host materials. Metal-organic frameworks (MOFs) represent a promising new class of porous crystalline solids because they exhibit large pore volumes, high surface areas, permanent porosity, high thermal stability, and feature open channels with tunable dimensions and topology. We are currently investigating the design, synthesis, and structures of a new family of MOFs derived from transition metals complexes of 4-(imidazole-1-yl)benzoic acids. Here we present our effort in continuing design and synthesis MOFs composed of 4-(imidazole-1-yl)benzoic acids to expand our knowledge about 4-(imidazole-1-yl)benzoic acid MOF family. A series of ligands are synthesized and Cu MOF-3N, 4, 5 and Cd MOF-3 were synthesized, structure determination found out metal-ligand complex follows our proposal, while Cu MOF-4,5 exhibit porous framework structure via absolute structure determination. Sorption behavior is a key focus in MOF application because the great potential applications MOF bears. Here we carry out a fundamental study about MOF texture and selectivity on MOF-5 and Cd MOF-2. Non-polar polyaromatic hydrocarbons such as naphthalene, phenanthrene, and pyrene, polar molecules such as 2-naphthol, ibuprofen were selected to test our hypothesis that sorption is influenced by the degree of tight fitting, and guest-host interaction such as van der waals and hydrogen bonding. By determining Langmuir isotherms of selected guest molecules, we are able to demonstrate our hypothesis that tighter the fit of the guest molecule and the pores, the higher the amount it would sorb. The sorption difference of non-polar and polar molecules suggest hydrogen bonding is not involved in guest sorption and the dominating force of sorption is hydrophobic interaction. Polymorphism is an interesting phenomenon that bears great value in pharmaceutical industry. Here we report the first case for MOF to serve as a heterogeneous surface that induced nucleation of indomethacin. It is also a first report of this polymorph form of indomethacin. PXRD, DSC, TGA, NMR are conducted as our initial investigation effort. This polymorph exhibits exceptionally thermal stability and low solubility, indicating an unusual tight binding between indomethacin and ethanol solvate. "

This Dissertation describes the development of chemical looping for selective oxidations. Chemical looping is a reactor technology that achieves simultaneous reaction and separation. For a large subset of reactions (viz. abstraction or insertion of oxygen), this technology is based upon the use of oxygen carriers. These materials, typically metal oxides, reversibly store and release oxygen, and there is growing interest in using these materials for selective oxidations. This Dissertation describes work on the development of oxygen carriers for selective oxidations, including foundational work on a method for analysing periodic non-catalytic gas-solid reactions, of which chemical looping selective oxidations are a subset. The oxygen chemical potential of Ca2Fe2O5 was exploited to improve the efficiency of the steam-iron process to produce hydrogen. The ability of reduced Ca2Fe2O5 to convert a higher fraction of steam to hydrogen than chemically unmodified Fe was demonstrated in a packed bed. This demonstrates how the oxygen chemical potential might be manipulated and exploited for chemical looping reactions. The oxygen chemical potential determines the selectivity in thermodynamically-controlled selective oxidations, and, depending on the reaction mechanism, kinetically-controlled selective oxidations. A generic method for enhancing the oxygen-carrying capacity of oxygen carriers for use in selective oxidations is presented, where one material that is selective in the reaction is deposited on the surface of a second material acting as a reservoir of oxygen and as a support. The presence of ceria in the support was found to supply lattice oxygen additional to that provided by the bismuth oxide, without affecting the selectivity of bismuth oxide. The surface chemistry was decoupled from the bulk properties of the support, thus simplifying the design and formulation of composite oxygen carriers. Building upon the concepts of oxygen chemical potential and composite oxygen carriers, chemical looping epoxidation was demonstrated for the first time. The oxygen carrier was composed of Ag, for its unique catalytic properties, and SrFeO3 as the support, for its high oxygen chemical potential at low temperatures. A reaction mechanism was proposed based on the observations. Nonlinear frequency response theory was used to analysis a periodic non-catalytic gas-solid reaction. Generalised frequency response functions (which are higher order analogues to traditional, linear transfer functions) were derived to obtain the nonlinear frequency response of the archetypal reactor. Such a method lies between the traditional frequency response theorem and numerical methods in terms of accuracy and speed. A niche application was proposed for the analysis of experimental kinetics, avoiding convolution of measurements with the response time of measuring equipment. In summary, this Dissertation describes how materials might be formulated for selective oxidations in chemical looping mode. This was demonstrated for an industrially-significant reaction for the production of ethylene. A novel application of nonlinear frequency response theory was also demonstrated for chemical looping reactions.

Magister Scientiae Dentium - MSc(Dent) (Paediatric Dentistry) / The use of glass ionomer cement (GIC) restorative materials assists in the prevention of dental caries due to its long-term fluoride release. However, poor physical strength is one of the main drawbacks of GIC. A surface coating is recommended to improve the physical strength and is considered necessary during the overlapping stages of setting reactions of GIC restorative materials. The development of resin based coatings has improved the properties of the material but the effect on fluoride release needs investigation.

Anxiety and depression are among the most common psychiatric disorders in childhood and adolescence (Costello, Egger, & Angold, 2005). Although the parental environment appears to play a role in the development of emotional disorders (e.g., Abramson & Alloy, 2006), cognitive styles within the families of adolescents with internalising disorders have received little attention. The main aim of this thesis was to increase the understanding of maternal cognitions in relation to internalising disorders experienced by adolescents. Specifically, maternal attributional style, catastrophic worries, selective attention and perceptions of adolescents' social competence were examined through a combination of cross-sectional, correlational and experimental designs in the programme of five studies conducted with a clinical sample. Three groups of adolescents and their mothers participated in the studies: adolescents with clinical internalising disorders, adolescents with clinical externalising disorders and a non-referred group of school-children along with their mothers. In support of the hypotheses, mothers of adolescents with clinical internalising disorders had more negative attributional biases than the mothers in the two control groups. When parental attributions were examined from the child's perspective, adolescents in the clinical internalising group perceived that their parents had more negative attributions than both control groups. Examination of maternal evaluations of adolescents' social skills, revealed that even though adolescents did not have social deficits according to objective ratings, mothers of adolescents with internalising disorders underestimated the performance of their children compared to the non-referred control group. Significant relationships were found between maternal and adolescent attributions and perceptions of social competence, suggesting a link between maternal and adolescent cognitive style. Furthermore, mothers of the clinical internalising group produced a greater number of worries which were more catastrophic in content than mothers in the control groups. Contrary to predictions, mothers of adolescents with clinical internalising disorders did not selectively attend to threatening information related to adolescents' behaviours. Analyses using combined data from the four studies that showed significant relationships provided evidence that different cognitions in mothers and their children are interrelated, highlighting the importance of interactions between various cognitions within the family. Additionally, attributional style, catastrophic worries and negative perceptions were found to discriminate families with adolescents with internalising disorders from those with adolescents with externalising disorders or non-referred adolescents. The studies included in this thesis extend the current literature on maternal cognitions and adolescent internalising disorders and suggest that mothers of adolescents with internalising disorders are characterised by cognitive biases that should be taken into consideration in both research and clinical practice.

Forster and Lavie (2008) and Lavie, Lin, Zokaei and Thoma (2009) have demonstrated that meaningful stimuli, such as objects, are ignored under conditions of high perceptual load but not low. However, objects are seldom presented without context in the real world. Given that context can reduce the threshold for object recognition (Barenholtz, 2013), is it possible for context to reduce the processing load of objects such that they can be processed under high load? In the first experiment, I attempted to obtain similar findings of the aforementioned studies by replicating their paradigm with photographs of real-world objects. The findings of the experiment suggested that objects can cause distractor interference under high load conditions, but not low load conditions. These findings are opposite of what the perceptual literature suggests (e.g., Lavie, 1995). However, these findings are aligned with a two-stage dilution model of attention in which information is first processed in parallel and then selectively (Wilson, Muroi, and MacLeod, 2011). Experiment 2 assessed if this effect was specific to semantic objects by introducing meaningless, abstract objects. The results suggest that the dilution effect was not due to the semantic features of objects. The third experiment assessed the influence of context on objects under load. The results of the experiment found an elimination of all interference effects in both the high and low load conditions. Comparisons between scene-object congruency revealed no influence of semantic information from scenes. It appears that the presentation of a visual stimuli prior to the flanker task diluted attention such that the distractor effects previously observed in the high load condition were minimized. Thus, it does not appear that context reduced the threshold for object recognition under load. All three experiments have demonstrated strong evidence for the dilution approach of attention over perceptual load models. / Includes bibliography. / Dissertation (Ph.D.)--Florida Atlantic University, 2019. / FAU Electronic Theses and Dissertations Collection

Noble metal nanomaterials have numerous uses in plasmonic and surface enhanced Raman scattering (SERS) detection applications; however, upon the addition of analytes, nanomaterials often undergo uncontrolled aggregation which leads to inconsistent signal intensities. To overcome this limitation, the effect of gold nanosphere concentration, column purification, and surface chemistry functionalization using internally etched silica stabilization methods was investigated on SERS assays for small molecule detection. Nanostructure composition, size, shape, stability, surface chemistry, optical properties, and SERS-activity were monitored using localized surface plasmon resonance (LSPR or extinction) spectroscopy, transmission electron microscopy (TEM), and Raman spectroscopy. First, the behavior of citrate-stabilized gold nanospheres was monitored as a function of molecular surface coverage. Both extinction and SERS spectral intensities increased linearly below monolayer functionalization. Above this value, however, uncontrolled nanoparticle aggregation occurred and large but irreproducible SERS signal intensities were monitored. Next, gold nanoparticles were encapsulated with varying silica shell thicknesses and purified using traditional centrifugation steps and/or column chromatography. Relative to the traditionally purified (i.e. centrifuged) samples, the SERS responses from small molecules using the column purified nanoparticle samples followed a well-known SERS distance-dependence model. Thus, surface chemistry cannot form more than a 2 nm thick layer on gold nanospheres if SERS applications were targeted. To overcome these challenges, gold nanospheres encapsulated with a thick silica shell were made SERS-active by etching the internal silica layer near the metal surface. During the synthesis of these internally etched silica-coated gold nanospheres, the LSPR wavelength shift, a parameter related to the effective local refractive index near the gold core, was monitored instead of etching time, in order to produce nanostructures with more uniform internal silica etching from sample to sample. The SERS-activity of a target molecule using these nanostructures was measured as a function of LSPR wavelength shift. SERS signal intensity increased, which suggested that more analyte molecules were able to bind to the gold surface because of the larger pore size in the silica layer near the metal core. Further exploration of these findings should increase the integration of solution-phase nanoparticles in more predictable functions in future applications, resulting in more quantitative and reproducible molecular detection in complex sample matrices, including biological and environmental samples.

Previous work shows that young children focus on holistic (or overall) similarity and older children focus on dimensional similarity (selectively attending to one property to the exclusion of others). Research on early word learning, however, suggests that process of learning new words trains attention towards category-relevant dimensions via regularities in the linguistic and physical environment. Thus, over development, children learn to attend to specific dimensions when making nominal category judgments--they selectively attend to shape, for example, when learning names for solid objects. In four experiments, I asked a question fundamental to our understanding of dimensional attention: does word learning scaffold attention to dimensional similarity in more general contexts. The results of Experiment 1 showed that children who are holistic classifiers are slower than dimensional classifiers to learn categories of objects that vary along both a category-relevant dimension (e.g. size) and a category-irrelevant dimension (e.g. brightness). However, the results of Experiment 2 showed that when children were presented with incidental labels during category learning, holistic classifiers learn the categories as quickly as dimensional classifiers. In a follow-up similarity classification task, children who had been holistic classifiers showed an increase in dimensional attention only if they had been in the label experiment. In Experiments 3 and 4, I examined category learning with and without a label in children who preferred to selectively attend to one dimension of similarity (e.g. brightness) regardless of whether this means selecting dimensional or holistic matches in a classification task. The results of these experiments provide a more complete picture of the continuous developmental trajectory of increasing selective and flexible dimensional attention. By showing how labels support dimensional attention, these results clarify the processes involved in development of similarity perception and potentially unify our understanding of attentional processes in word learning with those in a broader context.

In recent years, millions of customers all over the world have been subscribing to mobile telephony services which are based on modern digital transmission. At the high transmission bit rates that these systems use, the mobile radio channel exhibits frequency-selective fading characteristics. Under such conditions, the received signal could experience significant intersymbol interference (ISI) from severe distortion to the waveform of the received baseband signal. Therefore, such techniques as adaptive waveform equalisation or adaptive maximum likelihood sequence estimation (MLSE) are used in modern digital mobile radio telephone systems to combat this undesirable ISI. These adaptive schemes have almost always been used in conjunction with coherent demodulation in the receivers.This study examines the application of noncoherent demodulation, in the form of frequency discriminator detection, as an alternative to coherent demodulation. The GSM (Global System for Mobile Communications) standard has been used as the basis for this investigation. It has been shown analytically that in the presence of frequency-selective fading, a propagation environment common to the GSM system, the use of frequency discriminator detection gives rise to nonlinear ISI in the demodulated signal. It has also been shown that frequency-selective fading could cause large unwanted "spikes" to appear in the demodulated signal, thus leading to a severe degradation in the bit-error-rate (BER) performance. Consequently, several waveform distortion cancellation schemes for combatting the nonlinear ISI have been formulated. The BER performances of these proposed schemes, under various propagation conditions, have been studied by computer simulation.Furthermore, it has been observed that the undesirable "spikes", that occur in the demodulated signal due to frequency-selective fading, could be ++ / suppressed by the use of inverse-limiting in conjunction with frequency discriminator detection. As a result, an effective adaptive detection scheme has been formulated, based on modelling the combination of the GMSK modulator, the mobile channel, the frequency discriminator, and any transmit and receive fitters, as a finite-state machine. The transmitted data is then detected using an MLSE. The BER performance of this proposed adaptive detection scheme has been extensively investigated by computer simulation. This has been carried out assuming various propagation conditions, including the two-ray fading channel model with equal path powers and relative delays of up to four bit periods, the maximum relative delay considered in the GSM system. Also, the effectiveness of the proposed adaptive detection scheme in combatting IS] has been investigated by computer simulation based on the six-ray GSM empirical propagation models for typical urban (TU), hilly terrain (HT) and rural area (RA) environments. The computer simulated results confirm that the voice grade performance required for the GSM system could be achieved by the proposed adaptive detection scheme in all the recommended GSM propagation models considered. Furthermore, the BER performance of the receiver remains unaffected by a carrier frequency offset of up to 2 kHz.