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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
241

Self-assembly of peptoid-based materials and biomedical application / べプトイド基盤材料の自己組織化とバイオ医療応用

Okuno, Yota 23 March 2022 (has links)
京都大学 / 新制・課程博士 / 博士(工学) / 甲第23920号 / 工博第5007号 / 新制||工||1781(附属図書館) / 京都大学大学院工学研究科高分子化学専攻 / (主査)教授 秋吉 一成, 教授 大内 誠, 教授 大塚 浩二 / 学位規則第4条第1項該当 / Doctor of Philosophy (Engineering) / Kyoto University / DGAM
242

A study of hybridisation of DNA immobilised on gold: strategies for DNA biosensing

Mearns, Freya Justine, Chemistry, Faculty of Science, UNSW January 2006 (has links)
This thesis outlines a study of the physical changes that hybridisation imposes on single-stranded DNA (ssDNA) immobilised by one end to a substrate, and of how such physical changes can be exploited to detect specific sequences of DNA in a target solution. The system studied was composed of a mixed monolayer of 20mer ssDNA with C6 alkanethiolate modifications on their 3??? ends and short-chain hydroxyterminated alkanethiolates, on a gold substrate. It was prepared using the self-assembly properties of alkanethiols on gold. Atomic force microscopy images showed that the end-immobilised ssDNA is flexible enough to lie over the diluent hydroxy-terminated self-assembled monolayer (SAM). Hybridisation was shown to cause the DNA to become more rigid and stand up off the substrate due to an increase in persistence length. Such physical changes of the DNA upon hybridisation were significant enough to be exploited in the development of a DNA recognition interface. The recognition interface was designed with the view of keeping it both simple to make and simple to use, and was coupled with electrochemical transduction. A label-free recognition interface was developed that relied on the oxidation of the sulfur head group of the alkanethiolate SAM to detect hybridisation (firstly air oxidation and then electrochemical oxidation). It produced a positive signal upon hybridisation with complementary target DNA. Improvements in the reliability and robustness of the recognition interface were made using a labelled approach. The labelled version employed electroactive molecules as labels on the 5??? ends of the probe DNA strands. Two labels were investigated ??? anthraquinone and ferrocene. The flexibility of the ssDNA ensured that the redox labels were able to directly access the underlying gold electrode. Hybridisation was expected to remove the labels from the electrode due to an increase in the DNA???s persistence length, and thus perturb the electrochemical signal. The use of ferrocene as a label provided a ???proof-of-concept??? for the system. The labelled recognition interface provides a foundation for the future development of a simple, reliable, and selective DNA hybridisation biosensor.
243

Structure and physical properties of surfactant and mixed surfactant films at the solid-liquid interface.

Blom, Annabelle January 2005 (has links)
The adsorbed layer morphology of a series of surfactants under different conditions has been examined primarily using atomic force microscopy (AFM). The morphologies of single and double chained quaternary ammonium surfactants adsorbed to mica have been characterised using AFM at concentrations below the cmc. Mixing these different types of surfactants systematically allowed a detailed examination of the change in adsorbed film curvature from the least curved bilayers through to most curved globules. From this study a novel mesh structure was discovered at curvatures intermediate to bilayers and rods. A mesh was again observed in studies examining the morphology change of adsorbed nonionic surfactant films on silica with variation in temperature. Other surfactant mixtures were also examined including grafting non-adsorbing nonionic surfactants and diblock copolymers into quaternary ammonium surfactant films of different morphologies.
244

Capillary-force driven self-assembly of silicon microstructures /

Morris, Christopher J. January 2007 (has links)
Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (p. 133-150).
245

Electrochemical self-assembly of alkanethiols on gold

Anshuman, Anshuman. January 2008 (has links)
Thesis (M.M.S.E.)--University of Delaware, 2008 / Principal faculty advisor: Robert L. Opila, Dept. of Materials Science & Engineering Includes bibliographical references.
246

Physical immobilization of Photosystem I (PSI) at self-assembled monolayers on gold : directed adsorption, electron transfer, and biomimetic entrapment

Kincaid, Helen A. January 2006 (has links)
Thesis (Ph. D. in Chemical Engineering)--Vanderbilt University, May 2006. / Title from title screen. Includes bibliographical references.
247

Engineering the macro-nano interface : designing the directed self-assembly and interfacial interactions of gold nanoparticle monolayers. /

Jespersen, Michael L., January 2007 (has links)
Thesis (Ph. D.)--University of Oregon, 2008. / Typescript. Includes vita and abstract. Includes bibliographical references (leaves 164-192). Also available online in Scholars' Bank; and in ProQuest, free to University of Oregon users.
248

Molecularly mediated assembly of nanoparticles towards functional nanostructures

Lim, I-Im Stephanie. January 2008 (has links)
Thesis (Ph. D.)--State University of New York at Binghamton, Department of Chemistry, 2008. / Includes bibliographical references.
249

Supramolecular block and random copolymers in multifunctional assemblies

Burd, Caroline Glenn January 2008 (has links)
Thesis (Ph.D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2009. / Committee Chair: Marcus Weck; Committee Member: Bunz, Uwe; Committee Member: Collard, David; Committee Member: Jones, Christopher; Committee Member: Payne, Christine
250

The "Universal Polymer Backbone" concept

Pollino, Joel Matthew. January 2004 (has links) (PDF)
Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2005. / Weck, Marcus, Committee Chair ; Jones, Christopher, Committee Member ; Collard, David, Committee Member ; Liotta, Charles, Committee Member ; Bunz, Uwe, Committee Member. Includes bibliographical references.

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