Animal and human studies have consistently demonstrated that recurrent hypoglycaemia (RH) blunts both hormonal and behavioral counter regulatory responses (CRR) to further episodes of hypoglycaemia. It is now well established that the brain is involved in regulating whole-body glucose homeostasis, including the CRR to hypoglycaemia. The aim of the current study was to investigate if adaptations occur, following RH, which are intrinsic to glucose-sensing neurons in the absence of synaptic/glial inputs or signals from the periphery. Utilising the GT1-7 hypothalamic mouse cell line as an in vitro model of homogenous glucose-excited neurons, the current study has demonstrated that recurrent low glucose exposure reprograms intracellular metabolism towards a “hypometabolic state”. This result occurs in conjunction with an attenuated ability of the cells to hyperpolarise in response to low glucose and a reduction in the sensitivity of the KATP channel to activation by MgADP. In an attempt to reverse the changes observed in KATP channel activity, the SUR1-selective KATP channel opener, NN414, was applied chronically to GT1-7 cells. However, chronic KATP channel activation severely reduced channel conductance and sensitivity to activation by MgADP and further NN414 application. These results suggest that chronic activation of the KATP channel leads to the induction of a negative feedback mechanism to reduce channel activity. This may be in an attempt to maintain neuronal membrane potential within a physiological range. These results also suggest activation of central KATP channels during RH may be driving the resulting defective CRR. However, adaptations in metabolism following RH may also be altering the function of central KATP channels.

O presente trabalho tem por objeto a análise da influência do psiquismo do juiz no modo como preside o processo estilo de colheita de dados e relacionamento com os demais sujeitos (partes e advogados, principalmente) e produz suas decisões. Há, portanto, uma interface entre Direito e Psicologia, tomando-se como paradigma a teoria dos tipos psicológicos de Carl Gustav Jung e seguidores, com os acréscimos que lhe foram feitos por Isabel Briggs Myers e Katharine Cook Briggs. Para fins de contraste, a teoria de Jung é confrontada com a tipologia psicanalítica de Freud. No âmbito jurídico, especial atenção é dada à relação das funções pensamento e sentimento com o senso de justiça, sugerindo se que a teoria tridimensional do Direito, de Miguel Reale, seja a expressão jurídica do uso equilibrado das funções perceptivas e judicativas. Esta a primeira parte do trabalho. Na segunda, são analisados tipologicamente seis magistrados do Tribunal de Justiça do Estado de São Paulo, tomando-se por base sua atuação profissional, conforme por eles expressa em entrevista. A entrevista foi feita a partir de um questionário padrão, de modo a estabelecer paralelos discursivos e daí colher semelhanças e diferenças, analisadas à luz do tipo psicológico aferido. Para aferição do tipo psicológico de cada entrevistado, além da análise do conteúdo de sua fala, foi aplicado um segundo questionário, de natureza específica. A título de conclusão, verificou-se haver grande consistência no postulado de que existe correlação entre o tipo de personalidade do magistrado e o resultado de seu trabalho. Isso abre grandes perspectivas seja de estudo-aprendizado na área, seja de aperfeiçoamento profissional e pessoal destes agentes, cuja atividade é tão vital para o processo de produção de justiça no caso concreto. / This paper is aimed at analyzing the influence of the judges psyche as s/he presides over the process the way s/he collects data and relates with the other parties (to the lawsuit and attorneys, mainly) and makes his/her decisions. There is therefore an interface between Law and Psychology, since we have selected as a paradigm the theory of psychological types of Carl Gustav Jung and his followers, with the additions made by Isabel Briggs Myers and Katharine Cook Briggs. For contrasting purposes, Jung\'s theory is compared with Freud\'s psychoanalytical typology. From a legal perspective, special attention is given to the correlation between thought and feeling functions and the «sense of fairness», and it is suggested that Miguel Reales three-dimensional theory of Law be the legal expression of the balanced use of perceptive and judicative functions. This is the first part of the paper. In the second, six judges of the São Paulo State Court are typologically analyzed, based on their professional activities, as stated by them during an interview. The interview was based on a standard questionnaire so as to draw discursive parallels and be able to collect similarities and differences in the light of the psychological type assessed. To assess the psychological type of each interviewee, in addition to analyzing their speech content, a second questionnaire, of a specific nature, was applied. In conclusion, the assumption that there is a correlation between a judges type of personality and the result of his/her work has proven to be greatly consistent. This could bring great prospects, both in area studies and learning and the personal and professional improvement of these agents, whose activity is so vital to the actual process of administering justice.

O presente trabalho tem por objeto a análise da influência do psiquismo do juiz no modo como preside o processo estilo de colheita de dados e relacionamento com os demais sujeitos (partes e advogados, principalmente) e produz suas decisões. Há, portanto, uma interface entre Direito e Psicologia, tomando-se como paradigma a teoria dos tipos psicológicos de Carl Gustav Jung e seguidores, com os acréscimos que lhe foram feitos por Isabel Briggs Myers e Katharine Cook Briggs. Para fins de contraste, a teoria de Jung é confrontada com a tipologia psicanalítica de Freud. No âmbito jurídico, especial atenção é dada à relação das funções pensamento e sentimento com o senso de justiça, sugerindo se que a teoria tridimensional do Direito, de Miguel Reale, seja a expressão jurídica do uso equilibrado das funções perceptivas e judicativas. Esta a primeira parte do trabalho. Na segunda, são analisados tipologicamente seis magistrados do Tribunal de Justiça do Estado de São Paulo, tomando-se por base sua atuação profissional, conforme por eles expressa em entrevista. A entrevista foi feita a partir de um questionário padrão, de modo a estabelecer paralelos discursivos e daí colher semelhanças e diferenças, analisadas à luz do tipo psicológico aferido. Para aferição do tipo psicológico de cada entrevistado, além da análise do conteúdo de sua fala, foi aplicado um segundo questionário, de natureza específica. A título de conclusão, verificou-se haver grande consistência no postulado de que existe correlação entre o tipo de personalidade do magistrado e o resultado de seu trabalho. Isso abre grandes perspectivas seja de estudo-aprendizado na área, seja de aperfeiçoamento profissional e pessoal destes agentes, cuja atividade é tão vital para o processo de produção de justiça no caso concreto. / This paper is aimed at analyzing the influence of the judges psyche as s/he presides over the process the way s/he collects data and relates with the other parties (to the lawsuit and attorneys, mainly) and makes his/her decisions. There is therefore an interface between Law and Psychology, since we have selected as a paradigm the theory of psychological types of Carl Gustav Jung and his followers, with the additions made by Isabel Briggs Myers and Katharine Cook Briggs. For contrasting purposes, Jung\'s theory is compared with Freud\'s psychoanalytical typology. From a legal perspective, special attention is given to the correlation between thought and feeling functions and the «sense of fairness», and it is suggested that Miguel Reales three-dimensional theory of Law be the legal expression of the balanced use of perceptive and judicative functions. This is the first part of the paper. In the second, six judges of the São Paulo State Court are typologically analyzed, based on their professional activities, as stated by them during an interview. The interview was based on a standard questionnaire so as to draw discursive parallels and be able to collect similarities and differences in the light of the psychological type assessed. To assess the psychological type of each interviewee, in addition to analyzing their speech content, a second questionnaire, of a specific nature, was applied. In conclusion, the assumption that there is a correlation between a judges type of personality and the result of his/her work has proven to be greatly consistent. This could bring great prospects, both in area studies and learning and the personal and professional improvement of these agents, whose activity is so vital to the actual process of administering justice.