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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
41

Plasma protein changes in open cardiac surgery

Lloyd, Allan Henry January 1970 (has links)
The literature on biochemical changes in open cardiac surgery with especial reference to plasma protein and amino acids has been reviewed. The changes that take place in plasma proteins during oxygenation of blood of open cardiac surgery have been investigated with emphasis on denaturation. This phenomena has been examined by the assay of blood and plasma sulfhydryl groups by different reagents and also viscosity and turbidity changes. The limitations of the two latter investigations has been discussed. Haemolytic changes in plasma have been examined and the related importance of sulfhydryl groups discussed. Plasma protein changes have been investigated by methods depending on net charge, shape, size, and molecular weight of individual molecules. Although adrenal cortical response to open cardiac surgery has been investigated it has been pertinent to reinvestigate adrenal cortical secretion pari passu with amino acid data from blood and urine samples of patients not only because of their metabolic associations, but also because of the opportunity of comparing surgical patients receiving supplementary haydrocortisone throughout open cardiac surgery with those not supplemented - the latter therefore depending on their own intrinsic secretion during surgical stress. A review of relevant literature has accordingly been presented with emphasis on the difficulties involved in ACTH assay of plasma from surgical patients, and the practical advantages of 17-hydroxycorticostereid assay in lieu of ACTH assays. The plasma and urinary amino acid increase have been examined together in detail comparing not only the increase in each amino acid at each operation but also comparing the increase of an amino acid in all the operations investigated thus obtaining mean values of each amino acid at regular intervals of time throughout each perfusion.
42

PRODUCTION AND CHARACTERIZATION OF ANTILYMPHOCYTIC SERA TO GUINEA PIG LEUKOCYTES

Ahmed, Aftab, 1944- January 1970 (has links)
No description available.
43

Comparison of antilymphocytic sera against guinea pig cells

Wongsri, Achara Poovatanasedj, 1946- January 1975 (has links)
No description available.
44

Studies on serum somatedin activity and cartilage responsiveness in the regulation of growth

Beaton, G. R. January 1976 (has links)
A Thesis Submitted to the Faculty of Science University of the Witwatersrand, Johannesburg for the Degree of Doctor of Philosophy Johannesburg 1976 / This thesis describes the results of experimental investigation of aspects of the endocrine regulation of growth in the rabbit, rat and man. In particular the role of serum somatomedin and cartilage responsiveness to somatomedin have been examined. Throughout a relationship between the physiological control mechanisms, namely the stimulus and the degree of end- organ responsiveness, and the velocity of growth has been sought. / IT2017
45

Speciation of Manganese in blood serum- analytical methods developmentand optimization for the extraction, pre-concentration and determination

Pole, Stephen 22 March 2006 (has links)
Master of Science - Science / The analytical methods for speciation of manganese in three different types of matrices (water, milk and blood serum) was studied. Supported liquid membrane (SLM) extraction was optimized and successfully used for the extraction and preconcentration on Mn(II) from water, milk and blood serum. The extractant used was 15% (v/v) DEHPA with an organic membrane modifier, 10% (v/v) TOPO. All determinations of Mn(II) were carried out using Adsorptive Stripping Voltammetry. A SLM membrane probe was developed and used for the extraction of Mn(II) from smaller water, milk and blood serum samples. Membrane probe depth was optimized: probe depth - 2mm below donor solution. The membrane probe yielded higher extraction efficiencies compared to the flat spiral disk SLM unit. The Adsorptive Stripping Voltammetry method used for the determination of Mn(II) in water was optimized and used in other applications (determination of Mn(II) in aged and fractionated blood serum). The optimum conditions obtained: pH = 7.5-8.0, deposition potential = -(1.9V-2.0V), deposition time = 45-65s, equilibration time = 5s, stirring speed = 2000rpm, and no gelatin addition. The AdSV optimized parameters were then used for the analysis of Mn(II) in aged whole and fractionated blood serum. Size exclusion chromatography was used to obtain the blood serum fractions. It was determined that with aging, the concentration and thus extraction efficiency of free Mn(II) in blood serum matrix decreases. The spiked blood serum fractions were extracted and Mn(II) was determined with adequate reproducibility.
46

The role of serum and the physiology of delivery in determining the bioactive fraction of estradiol and xenoestrogens

Nagel, Susan C. January 1998 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 1998. / Typescript. Vita. Includes bibliographical references (leaves 103-110). Also available on the Internet.
47

The role of serum and the physiology of delivery in determining the bioactive fraction of estradiol and xenoestrogens /

Nagel, Susan C. January 1998 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 1998. / Typescript. Vita. Includes bibliographical references (leaves 103-110). Also available on the Internet.
48

Some factors influencing serum triglyceride in man

Mann, Joel Ivor 16 July 2020 (has links)
Part I of this thesis deals with general methodology and the experimental work can be clearly divided into two sections. Part II deals with studies carried out chiefly to determine further the epidemiological factors influencing serum lipid (and in particular, serum triglyceride) levels in the population groups of Southern Africa. The original objectives are described on page 70 and the main conclusions summarised on page 114. Part III describes three studies which were conducted in an attempt to fill some of the gaps in the considerable literature on the relationship between dietary carbohydrate and serum lipids in man. Both in the review of the literature at the beginning of this section and in the interpretation of the results of each of the studies, discussion has been chiefly limited to experiments conducted in man. There is a great deal of information available on studies carried out in experimental animals which show marked species differences from man with regards kinetic behaviour of serum and liver triglycerides(l). Where relevant, of course, reference has been made to these studies. The significance of each of the three studies has been discussed separately, but the principal objectives are mentioned on page 138 and the general conclusions are summarised on page 205.
49

Crystallographic studies of Helicobacter pylori chaperone HspB and human serum transferrin : metalloprotein as a template for heavy metal ions and their relevance to bismuth antiulcer drug

Wang, Minji, 汪旻稷 January 2014 (has links)
Iron is important for human health and serves as a co-factor in a variety of proteins and enzymes. Human serum transferrin (hTF) is an Fe(III) transporter in blood plasma which delivers metal to cells via a receptor-mediated endocytosis. In the first part, crystal structures of FeNFeC-hTF and BiNFeC-hTF have been characterized. The N-lobes of the two structures adopt “partially opened” conformations between holo-hTF’s “closed” and apo-hTF’s “fully-opened” states. The N-lobe of BiNFeC-hTF opens wider than FeNFeC-hTF. Their metal-bound C-lobes are totally closed. Rigid-body movement and different inter-lobal hydrogen bonds for the “partially opened” conformations are observed. The binding affinities of four putative binding residues are in the order: Tyr188>Tyr95>Asp63~His249. In the N-lobe of BiNFeC-hTF, Tyr188, bicarbonate and a nitrilotriacetate (NTA) ion bind to Bi(III), whilst Tyr95 and Asp63 interact with NTA ligand. One (BiNFeC-hTF) or two (FeNFeC-hTF) glycan molecules are identified on the surface area of C-lobe. In the second part, biocoordination chemistry of selected metal ions was investigated using hTF as a template. The Al(III), Fe(III), Ga(III), Dy(III) and Yb(III)-bound hTF exhibit closed conformations in the C-lobe and “fully-opened” conformations in the N-lobe. In these structures, malonate serves as an anion in the C-lobe and provides two tunable ligation sites that lead to a less distorted octahedral coordination geometry. As a result, the large lanthanide ions (Dy(III) and Yb(III)) turn from their favored high coordination numbers (8~12) and fit into the protein’s hexadental pocket. Unexpectedly, in the presence of malonate ion and the excess amount of Dy(III) ion, the Ga(III) can be partially replaced by Dy(III), although Ga(III) has a much higher affinity than Dy(III) towards the protein. The chaperone system in Helicobacter pylorithat helps protein refold is assembled with HspB and HspA. In the third part, preliminary crystallographic work is reported for HspB and HspA. The chaperone HspB has been crystallized under various conditions and currently the diffraction resolution is 6.8Å. The co-chaperone HspA, which binds Bi(III) tightly, although its crystals diffract to 1.6Å, still needs improvement for data collection due to radiation damage.The crystal structure of HspB revealed that HspB presents as a single-ring heptamer, though it is a mixture of dimer, tetramer and a higher oligomer in solution. The interactions between HspB monomers in crystal structure are significantly weaker than that of GroEL (counterpart in Escherichia coli) monomers which may makes the HspB heptamer easier to dissociate in solution. / published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy
50

Growth factors in ovarian cancer

Sowter, Heidi Michelle January 1999 (has links)
No description available.

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