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Carbachol- and ACPD-Induced Phosphoinositide Responses in the Developing Rat NeocortexHartgraves, Morri D. 08 1900 (has links)
Signal transduction via the phosphoinositide (PI) second messenger system has key roles in the development and plasticity of the neocortex. The present study localized PI responses to individual cortical layers in slices of developing rat somatosensory cortex. The acetylcholine agonist carbachol and the glutamate agonist trans-1-amino-1,3-cyclopentanedicarboxylic acid (ACPD) were used to stimulate PI turnover. The PI responses were compared to the distribution of the corresponding PI-linked receptors in order to investigate the regional ontogeny of PI coupling to receptors in relation to neural development. The method for assessing PI turnover was modified from Hwang et al. (1990). This method images the PI response autoradiographically through the localizaton of [3H]cytidine that has been incorporated into the membrane-bound intermediate, cytidine diphosphate diacylglycerol. In each age group (postnatal days 4-30), carbachol resulted in more overall labeling than ACPD. For both agonists, the response peaked on postnatal day 10 (P10) and was lowest in the oldest age group. The laminar distribution of the carbachol PI response from P4-P16 corresponded fairly well with the laminar distribution of [3H]quinuclidinyl benzilate binding (Fuchs, 1995). However, in the subplate layer the carbachol response was strong while receptor binding was minimal. The carbachol response decreased after postnatal day 10, while the overall levels of receptor binding continued to increase. From P5 - P14, PI-linked metabotropic glutamate receptors are most concentrated in layer IV (Blue et al., 1997), whereas only on P6 was there a correspondingly high ACPD-initiated PI response in this layer. Unlike receptors, the PI response was strong in upper V (P4 - P12) and within layers II/III (P8 - P16). From P4 - P21, the subplate showed relatively high PI labeling compared to receptor binding. The several differences between the distribution of PI response and receptors suggest spatiotemporal heterogeneity of receptor coupling to second messenger systems.
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Functional segregation of the highly conserved basic motifs within thethird endoloop of the human secretin receptorChan, Yuen-yee, Kathy, 陳婉儀 January 2001 (has links)
published_or_final_version / Zoology / Doctoral / Doctor of Philosophy
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The role of phosphorylation in the interaction between eukaryotic initiation factor elF4E and 4E-BP1 in rat adipocytesAvison, Matthew B. January 1998 (has links)
No description available.
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A study of the pathways mediating agonist-stimulated contraction and endothelium-dependent relaxation of vascular smooth muscleParsons, Sarah Jane Wilde January 1997 (has links)
No description available.
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Cellular and genomic effects of long-wavelength laser irradiationJoyce, Kevin Michael January 1998 (has links)
No description available.
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Gravitropic perception, angle determination and early responses in Tradescantia fluminensis and Arabidopsis thalianaWagstaff, Carol January 1999 (has links)
No description available.
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Cannabinoid receptors in preparations of the mouse and hamster vas deferens and guinea-pig small intestineBegg, Malcolm January 2001 (has links)
No description available.
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Studies of cytosolic phospholipase Aâ†2Creaney, Ann January 1996 (has links)
No description available.
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Modular design of a eukaryotic transcription repressor protein : QUTR of Aspergillus nidulansSi-Hoe, Shi Ming January 1999 (has links)
No description available.
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Regulation of glycogen synthase kinase 3 in cultured human muscleRochford, Justin J. January 1998 (has links)
No description available.
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