Thesis (M.S.)--University of Michigan, Ann Arbor, 1966. / Typescript (photocopy). Includes bibliographical references (leave 55). Also issued in print.

Thesis (M.S.)--University of Michigan, Ann Arbor, 1966. / Typescript (photocopy). eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leave 55).

Thesis (doctoral)--Karolinska Institutet, Stockholm, 1994. / Added t.p. with thesis statement inserted. Includes bibliographical references.

Thesis (doctoral)--Karolinska Institutet, Stockholm, 1994. / Added t.p. with thesis statement inserted. Includes bibliographical references.

No description available.

No description available.

As próteses faciais e intraorais tem um importante papel na devolução da estética e de algumas funções para os pacientes. Por meio da restauração da imagem corporal é possível reintegrá-lo a sociedade, resgatando assim a identidade do indivíduo. A boa condição dessas próteses é primordial para que estas possam exercer suas funções adequadamente e manter o local, onde estão inseridas, livre de infecções e inflamações. Portanto, a não formação de colônias e biofilmes bacterianos em materiais eleitos para confecção dessas próteses, trarão benefícios aos pacientes reabilitados. Visando isso, a presente dissertação verificou a capacidade de inclusão e a eficiência bactericida do biocida policloreto de dialildimetilamônio (PDADMAC) em resina acrílica autopolimerizável (RAAQ) e termopolimerizável (RAAT), e silicone de uso médico. Os resultados mostraram que o biocida PDADMAC quando dissolvido no tetrahidrofurano apresentou boa incorporação tanto nas resinas acrílicas, quimicamente ativas e termo ativas, quanto no silicone de uso médico e que apenas os corpos de prova que receberam 2 mililitros do PDADMAC em massa polimérica tiveram uma resposta bactericida eficaz. / The facial and intraoral prosthesis has an important role in the aesthetics and return of some functions to patients. Through restoration of the body image can reistante to can society , thus recovering the individual\'s identity . The good condition of these prostheses is essential so they can perform their function properly and maintain the the area where the prostheses are inserted free of infection and inflammation. Therefore, no formation of bacteria colonies and biofilms in the chosen materials for making these prostheses , will bring benefits to patients rehabilitated. The present work evaluated the capability of inclusion and the bactericidal efficiency of the biocide poly(diallyldimethylammonium chloride) ( pDADMAC ) of acrylic resin autopolymmerized ( RAAQ ) and thermal polymerized ( RAAT ) , and silicone medical use. The results showed that the biocide pDADMAC when dissolved in tetrahydrofuran presented a good incorporation in both acrylic resins and in the medical grade silicone and that only the samples that received 2 ml of pDADMAC in polymer had an effective bactericidal response.

The need for safe and functional implants has led to anincreased demand for improved biomaterials. The performance invivo depends on the interaction between the biologicalsurrounding and the surface of the material. By tailoring thesurface of a material with suitable bulk properties,biomaterials with an ability to interact with the biologicalsystem in a specific and controlled way are obtained. Siliconeelastomers have been used as biomaterials for several decades,but it is widely recognized that they are difficult to modifyby the conventional methods used for organic polymers due tothe partly inorganic structure of silicone. This thesis presents a strategy to obtain siliconebiomaterials by covalent coupling of molecules to the surfaceusing silicon chemistry. The first step is to introduce Si-Hgroups onto the surface of silicone elastomers by plasmatreatment. The second step is to react a terminal double bondof a molecule with the formed Si-H group by a catalyzedhydrosilylation reaction. The coupled molecule may eitherprovide the desired properties itself, or have a functionalitythat is able to couple another molecule with suitablecharacteristics. The influence of plasma treatment in hydrogen, argon andoxygen on the silicone elastomer was characterized by X-rayphotoelectron spectroscopy (XPS). To quantify the effect ofplasma treatment, the method of ternary XPS diagrams wasdeveloped. It was found that undesired silica-like layers wereformed under severe treatment conditions. Argon plasma at lowpower and short treatment time was the most suitable parametersetting. Subsequent hydrosilylation grafting ofallyltetrafluoroethylether, aminopropylvinylether andN-vinylformamide showed that it was possible to functionalizethe surface via a covalent link to the surface. The primaryamino groups introduced onto the surface were accessible forfurther coupling reactions. Heparin surfaces were obtained by acoupling reaction with the introduced amino groups. Keywords:Silicone elastomers, PDMS, XPS, ESCA, surfacemodification, plasma

<p>The need for safe and functional implants has led to anincreased demand for improved biomaterials. The performance invivo depends on the interaction between the biologicalsurrounding and the surface of the material. By tailoring thesurface of a material with suitable bulk properties,biomaterials with an ability to interact with the biologicalsystem in a specific and controlled way are obtained. Siliconeelastomers have been used as biomaterials for several decades,but it is widely recognized that they are difficult to modifyby the conventional methods used for organic polymers due tothe partly inorganic structure of silicone.</p><p>This thesis presents a strategy to obtain siliconebiomaterials by covalent coupling of molecules to the surfaceusing silicon chemistry. The first step is to introduce Si-Hgroups onto the surface of silicone elastomers by plasmatreatment. The second step is to react a terminal double bondof a molecule with the formed Si-H group by a catalyzedhydrosilylation reaction. The coupled molecule may eitherprovide the desired properties itself, or have a functionalitythat is able to couple another molecule with suitablecharacteristics.</p><p>The influence of plasma treatment in hydrogen, argon andoxygen on the silicone elastomer was characterized by X-rayphotoelectron spectroscopy (XPS). To quantify the effect ofplasma treatment, the method of ternary XPS diagrams wasdeveloped. It was found that undesired silica-like layers wereformed under severe treatment conditions. Argon plasma at lowpower and short treatment time was the most suitable parametersetting. Subsequent hydrosilylation grafting ofallyltetrafluoroethylether, aminopropylvinylether andN-vinylformamide showed that it was possible to functionalizethe surface via a covalent link to the surface. The primaryamino groups introduced onto the surface were accessible forfurther coupling reactions. Heparin surfaces were obtained by acoupling reaction with the introduced amino groups.</p><p><b>Keywords:</b>Silicone elastomers, PDMS, XPS, ESCA, surfacemodification, plasma</p>

Thesis (M.S.)--University of Michigan, 1964.