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No / The purpose of our study was to compare the effectiveness of 3.2 mm, 5 mm and 7.5 mm slice thicknesses in the detection and characterisation of liver lesions found on CT in patients with known or suspected malignant disease. 110 patients underwent portal phase imaging using four-slice MDCT. Two blinded observers independently read hard copy images at each slice thickness. The size and location of each lesion detected was recorded by each observer on a diagram of liver segmental anatomy. Each lesion was characterised as benign, malignant or indeterminate in nature. A diagnostic confidence score was allocated for each lesion on a scale of 1-4. The pathology or behaviour of lesions was assessed using surgery with intra-operative ultrasound (IOUS) and histology, or interval imaging with MRI, CT, or sonography. 294 lesions were detected, 64 (22%) of which were malignant. Both observers detected significantly more lesions on the 3.2 mm versus 7.5 mm slice thickness (p < 0.0001). Both observers detected more malignant lesions on 3.2 mm and 5 mm slice thicknesses versus 7.5 mm. As slice thickness decreased there was a significant increase in the sensitivity of malignant lesion detection for observer 1 (p < 0.001) and borderline significance for observer 2 (p = 0.07). As slice thickness decreased the proportion of lesions characterised as indeterminate by both observers fell. With thinner slices, both detection and characterisation of liver lesions were improved. A slice thickness no greater than 5 mm should be used to maximise both detection and correct characterisation of liver lesions.

This thesis constitutes a comprehensive study of the fundamental properties of an analytic function theory over quaternions, which is known as slice regularity, as introduced in Gentili et al. (Gentili et al., 2022). In 2006, an approach to analysis over quaternions was introduced by G. Gentili and D.C. Struppa. This approach gave rise to a new notion of regularity for quaternion-valued functions called slice regularity. Functions satisfying this regularity were termed slice-regularity functions. This new theory heavily relies on complex analysis and has found applications in geometry. The primary objective of this project is to present this new theory, encompassing polynomials and power series in slice regular functions with quaternionic coefficients. Various properties, such as slice regular products, extend to polynomials, and convergent power series in the form of slice regular functions are defined.Consequently, this thesis offers an overview of the latest developments in regularity theory and the fundamentals of quaternion-valued slice regularity functions. I assume the reader isfamiliar with the basics of complex analysis or has read my bachelor’s thesis (Fathian Pourkondori, 2022) in advance. Given that my master’s thesis builds upon the foundations laidin my bachelor’s thesis, I have refrained from rewriting certain chapters on quaternions and Fueter’s regularity theory. These chapters are prerequisites for understanding slice regularity, and I provide the link to the previous thesis (Fathian Pourkondori, 2022) for reference.

The key to improving drying quality and reducing drying time and energy consumption lies in understanding and controlling moisture movement during drying. As wood dries, strains and stresses develop as a result of restraints imposed by moisture gradients and differential shrinkage in wood. So accurately measuring the moisture gradient in wood during drying will be helpful to improving drying quality. In this project, moisture gradients in red oak will be measured through four different techniques----<i><b>bandsaw slicing, Forstner bit layering, flaking and razor blade slicing</i></b>. The first two techniques are found in the literature. The last two are developed in this study. The results obtained with these four techniques were compared, and it was found that the newly developed techniques could get moisture gradients that were closer to the true value. The <i><b>thickness</i></b> of the slice was assumed to affect measuring the moisture gradient because of the environmental influences. So a thickness series was tested with the two new technique----flaking and razor blade slicing. The results showed that there was no slice or flake thickness effect on the moisture gradients.And an optimum slice and flake thickness was determined for the wood industries and research studies. Finally, the <i><b>directional</i></b> effect on transverse moisture movement during kiln drying was examined through measuring moisture gradients in the tangential and radial directions of wood. The results showed that moisture moved slightly faster in the radial direction than in the tangential direction during kiln drying and the moisture gradients in the tangential direction were slightly steeper than those in the radial direction. / Master of Science

[pt] Este trabalho descreve um processador de sinais em tempo real e o algoritmo de Bruun para o processamento da transformada rápida de Fourier. O hardware utiliza bancos de memória comutáveis entre si e processador do tipo bit-slide para atender ao requisito de tempo real. Embora projetado especificamente para executar o algoritmo de Bruun, permite qualquer tipo de processamento de sinais, sendo necessário apenas o desenvolvimento de software. / [en] This work describes a real time signal processor and Bruun s algorithm for the Fast Fourier Transform. Hardware employs switching banks of memories and a bit-slice processor to achieve real time processing. The sistem was designed specifically for the Bruun s algorithm, but it allows any type of signal processing, only software development being required.

<p>Slice-ribbon conjecture has been proved for some special families of knots. In this thesis, we briefly mention some of these results.</p> / Master of Science (MSc)

This session is a crash course in integrated STEM and project-based learning for HS teachers and students. We will share PBL strategies and resources that integrate all core subjects.

In the United States, 2.8 million people suffer a traumatic brain injury (TBI) annually. Between 25%-50% of TBI injuries happen under alcohol intoxication. It is not understood how alcohol impacts patient outcomes via secondary injury pathways. Secondary injury pathways offer a window for therapeutic interventions, but there has been little success finding effective medications. Slice cultures offer a way to study secondary injury mechanisms in a controlled manner. The transection injury can model excitotoxicy seen following TBI. The current studies examined the effect of alcohol intoxication and withdrawal at the time of injury, and the effect of a calpain inhibitor (MDL-28170) on cell death following a transection injury. Intoxication had no effect on cell death compared to the TBI condition. In the ethanol withdrawal (EWD) study, EWD did not increase cell death following the TBI except at 72 hours. There was no effect of MDL on cell death. The severity of the model may have caused a ceiling effect. Additionally, imaging points may not have been sufficient for proper characterization. Future studies should use a different injury mechanism and other imaging times should be considered.

The last decade witnessed a wild growth of the Internet traffic, promoted by bandwidth-hungry applications such as Youtube, P2P, and VoIP. This explosive increase is expected to proceed with an annual rate of 34% in the near future, which leads to a huge challenge to the Internet infrastructure. One foremost solution to this problem is advancing the optical networking and switching, by which abundant bandwidth can be provided in an energy-efficient manner. For instance, with Wavelength Division Multiplexing (WDM) technology, each fiber can carry a mass of wavelengths with bandwidth up to 100 Gbits/s or higher. To keep up with the traffic explosion, however, simply scaling the number of fibers and/or wavelengths per fiber results in the scalability issue in WDM networks. One major motivation of this dissertation is to address this issue in WDM networks with the idea of waveband switching (WBS). This work includes the author's study on multiple aspects of waveband switching: how to address dynamic user demand, how to accommodate static user demand, and how to achieve a survivable WBS network. When combined together, the proposed approaches form a framework that enables an efficient WBS-based Internet in the near future or the middle term. As a long-term solution for the Internet backbone, the Spectrum Sliced Elastic Optical Path (SLICE) Networks recently attract significant interests. SLICE aims to provide abundant bandwidth by managing the spectrum resources as orthogonal sub-carriers, a finer granular than wavelengths of WDM networks. Another important component of this dissertation is the author's timely study on this new frontier: particulary, how to efficiency accommodate the user demand in SLICE networks. We refer to the overall study as the resource management in multi-granular optical networks. In WBS networks, the multi-granularity includes the fiber, waveband, and wavelength. While in SLICE networks, the traffic granularity refers to the fiber, and the variety of the demand size (in terms of number of sub-carriers).

The objective of this research is to develop a three-dimensional (3-D) microfluidic/ electronic interface system for sustaining and monitoring 3-D neuronal networks. This research work is divided into two parts. One is the development of a 3-D multi-electrode array (MEA) with integrated microfluidic channels. The other is a microneedle array with embedded microelectrodes and microfluidic channels. The 3-D MEA is composed of three elements that are essential for the development and monitoring of 3-D cultures of neurons. These components consist of scaffolds for cellular growth and structural stability, microfluidic channels for cell maintenance and chemical stimulation, and electrodes for electrical stimulation and recording. Two kinds of scaffold structures have been fabricated. The first scaffolding scheme employs a double exposure technique that embeds SU-8 towers into an SU-8 substrate. The second scaffolding mechanism introduces interconnects between towers for the purpose of mechanically supporting 3-D cell cultures and facilitating 3-D synaptic connections. Microfluidic channels are combined for fine control of the cellular microenvironment by means of diffusive and convective fluidic processes. Hollow towers with three-layer side ports were developed by using double exposure techniques and excimer laser ablation. The electrodes are combined into an integrated system that is capable of monitoring electrical activities and the cellular impedances of neurons which are attached to the electrodes. The second part of this research is to fabricate a microneedle array for monitoring brain slices, which will directly detect electrical signals from living brain slices. Although the microneedle array is targeting different 3-D neuronal networks, it also has three components and the fabrication steps are the same as those for the 3-D MEA. To generate the sharp tip, isotropic reactive ion etching (RIE) is performed on tapered SU-8 towers. High aspect ratio tower structures can be effectively generated with SU-8 and tapered shapes are created by backside exposure. The resulting systems will enable a new field of neurobiological research, in which the collective properties of 3-D neuronal circuits can be observed and manipulated with unprecedented detail and precision, and at a level of control not possible in living animals.