Thesis (M.S.)--University of Nevada, Reno, 2008. / "May, 2008." Includes bibliographical references (leaves 42-46). Online version available on the World Wide Web.

Thesis--University of London. / Without thesis statement. Bibliography: p. 169-176.

Thesis--University of London. / Without thesis statement. Bibliography: p. 169-176.

Thesis (M.A.L.S.)--East Tennessee State University, 2003. / Vita. Includes bibliographical references (leaves 58-62). Original full text .pdf file available via the Internet. Requires Adobe Acrobat Reader software.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1971. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin, 1966. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Loneliness, or the perceived discrepancy of ones relationships in terms of quality, is known as Perceived Social Isolation (PSI). Studies have shown that PSI is both increasing and is correlated with health risks. Specifically, PSI is not only related with risks of mortality but is also linked with variations in the brain. Having few social contacts, or being Objectively Socially Isolated (OSI) does not qualify as PSI. The aim of this thesis is to investigate the neural correlates of PSI, as distinguished from OSI. The true role of PSI is still unknown, however, arguments can be made that PSI serves an important role in survival. The social brain, which allows for social cognition is used as a basis for understanding PSI in this thesis. In this thesis, I found that individuals suffering from PSI have increased attention towards social threat, and a preference to engage in positive social stimuli. Further, PSI affects both social cognition and the social brain. However, regional brain activity was not confined to the social brain. The results showed that PSI may be related to both affective and attentional networks of the brain. PSI also affects activity in the ventral striatum. Further, PSI is related to varied regional brain size. I argue that PSI can be reduced by mainly fixing maladaptive cognitive patterns.

Close relationships play an integral role in human health (Coan & Sbarra, 2015). It follows, then, that the dissolution of an important relationship can have a variety of negative health consequences (Amato, 2010; Kitson & Morgan, 1990; Sbarra, Law, & Portley, 2011), and social loss confers vulnerability to a range of morbidities and early mortality. Disrupted marital status is one of the strongest sociodemographic predictors of stress-induced physical illness (Somers, 1979) and marital disruption has long been reported as one of life's most stressful events (Bloom, Asher, & White, 1978). Robust evidence links divorce or separation to poorer health outcomes; however, the exact mechanisms through which relationship dissolution influences our health so profoundly are not yet fully elucidated (Sbarra, Hasselmo, & Bourassa, 2015). The current study investigated how changes in psychological responses to divorce are associated with changes in immune responding in recently-separated adults (N = 55). I followed participants over an average of five months, collecting psychological distress measures at three visits, each one month apart, and immune measures at two visits, five months apart. To assess how variability in social engagement is associated with immunological responses following the end of a marriage, I incorporated naturalistic, observational data using a new methodology. I found that an objectively derived composite of social behaviors including (a) time spent with others; (b) time spent socializing/entertaining; (c) time spent in substantive conversation; and (d) time spent receiving positive support predicted concurrent immune outcomes over and above the effects of psychological distress and/or loneliness, and that psychological distress may exert indirect influence on immune outcomes through social integration. Furthermore, attachment style revealed differential longitudinal associations between social integration and immune outcomes. This research expands current knowledge on the immune-relevant outcomes of divorce and separation, and includes new methodology for naturalistically-derived measures of social engagement in determining how this common life stressor is associated with health over time.

Accessibility is a key tenet of the Canadian health care system. As many older persons, age 60 years and older, are managing ongoing chronic health conditions as part of their everyday lives, issues of access to health services are particularly important. Vancouver has a substantial number of older Korean immigrants, yet little is known about their experience and perceptions about accessing Primary Health Care (PHC) services. This study explored issues related to PHC access by older (aged 60 years and older) Korean immigrants. This qualitative study employed purposive sampling and interpretive description methodology. Open-ended interview data and field notes were gathered from 10 older Korean immigrants (five male and five female) recruited in Vancouver from mid-October 2006 to April 2007. The findings revealed that older Korean immigrants have had difficulty gaining access to appropriate PHC services because of the shifts in their social positioning and other barriers which contributed to an inappropriate use of PHC services, delays in care and lack of continuity in PHC. Also, the data revealed a number of ways the PHC system is unresponsive to the health care needs of older Korean immigrants. This study offers insights that may assist health care professionals to understand the nature of the challenges older Korean immigrants face when seeking health care and how they seek to resolve them. The analysis proposes a number of interventions that respect the older Korean immigrants’ values and interventions that may improve their access to PHC. / Applied Science, Faculty of / Nursing, School of / Graduate

Autophagy is a nonspecific catabolic mechanism, important for maintaining the cellular homeostasis. Stress condition can increase the activity and support the cell survival. It is well known that normal and pathological aging are associated with a reduced autophagic potential and that experimental induction of autophagy leads to higher longevity of certain model organisms. This decreasing may be facilitated by other factors, such as chronic stress. Higher age and chronic stress are two factors contributing to the development of neurodegenerative diseases, in this context the mechanism of autophagy is now actively studied. We wanted to know if and how the combination of these two factors may influence the activity of autophagy. In our study, we investigated the role of aging and chronic stress, induced by social isolation in Wistar rats at the age of 6 (N= 16) and 12 (N= 16) months. The animals in experimental groups were separated in the individual cages for 4 weeks. Control groups animals were housed in the pair. We measured the markers of autophagy expression (Beclin-1, LC3-II, mTOR) in the hippocampus and striatum of socially isolated and control groups animals. We measured the expression of NMDA receptor subunits (NR1, NR2A, NR2B) in the hippocampus of the same animals. Our results showed that older...