This work is aimed to research the most effective way of using ADO.NET data access components in medicine system development process. This document we start from evaluating current situation of e-medicine in Lithuania and world wide. Consider the problems, which originate doing a lot of “paper work”, introduce with EMR (Electronic Medical Record) systems, list the advantages of using EMR in medicine organizations. Later we give a brief description of EMR functionality, used standards ant technologies in EMR creation process. After all we concentrate on data manipulating problem, trying to discover the best solution to solve it by using ADO.NET data access components. Beside, we analyze all the components of ADO.NET architecture, describe situations in which different component is most suitable, suggest how to avoid performance degradation in data manipulation processes. Data is most expensive worth in medicine. So, we must ensure that data manipulating process will be effective and will not cause any additional problems for medicine personal.