This paper seeks to understand the persistence of disenfranchisement policies and the disproportionate impact these policies have on marginalized groups of the American electorate, specifically black Americans. Felon disenfranchisement, or the restriction of voting rights for criminals convicted of felonies, has been a long-standing policy throughout the United States. Using public opinion data from the 2014 General Social Survey (GSS), this paper analyzes how certain characteristics, such as race, age, and political party identification, can influence opinions about democratic rights and whether criminals should lose theirs once convicted. The results of this analysis could help explain why disenfranchisement policies have persisted throughout U.S. history, especially if these policies have consistently high levels of support from the general public.

The desire to gather acoustic data of a propeller in simulated hover without environmental effects is met with the challenge of recirculating flow in a closed anechoic chamber. Flow recirculation in an anechoic chamber is not ideal because the effects of it being ingested by the rotor cause unsteady loadings on the propeller. This unsteady loading causes vortex noise from the turbulence introduced by the recirculation of the flow. The aim is to study the acoustic signature of a propeller separate from external factors and engine noise. Two different propellers with three different screen combinations were tested in a closed anechoic chamber. The results of these tests showed that the screens are able to reduce the vortex and broadband noise levels, with the reduction being more pronounced when the dual screen was installed.

This thesis explores data anonymization techniques within the context of a Swedish municipality with a focus on safeguarding data privacy, enhancement of decision-making, and assessing re-identification risks. The investigation, grounded in a literature review and an experimental study, employed the ARX anonymization tool on a sample municipality employee database. Three distinct human resource management (HRM) datasets, analogous to the employee database, were created and anonymized using the ARX tool to ascertain the efficacy and re-identification risks of the employed techniques.  A key finding indicates an inverse relationship between dataset size and re-identification risk, enhancing data utility with larger datasets. This suggests that larger datasets are more conducive to anonymization, motivating organizations to engage in anonymization efforts for internal analytics and open data publishing.  The study contributes to Information Security discourse, emphasizing the criticality of data anonymization in preserving privacy and ensuring data utility in the era of big data. The research faced constraints due to privacy considerations, necessitating the use of similar, rather than actual, datasets, potentially affecting the results and limiting full representation for future techniques. The thesis primarily addresses HRM applications, indicating the scope for future research into other municipal or organizational governance areas. In conclusion, it underscores the necessity of data anonymization in the face of tightening regulations and sophisticated privacy breaches. This positions the organization strategically for compliance, minimizes data breach risks and upholds anonymization as a fundamental principle of Information Security.

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Indiana University-Purdue University Indianapolis (IUPUI) / More than 200,000 American women are diagnosed with breast cancer each year. Although therapies effective in treating metastatic breast cancer currently exist, each year approximately 40,000 women die from this disease. Current evidence indicates that anti-cancer immune responses can be induced by vaccination in situ to the growth of metastasis and protect patients from the tumor recurrence. However, induction of anticancer immune responses may be limited in their efficacy due to immune suppression mechanisms induced by the developing cancer. Myeloid-derived suppressor cells are one population of immune regulators comprised of immature cells of myeloid origin with important roles in blocking immune activation and promoting tumor progression. Elimination or maturation of these cells has been found to promote enhanced anti-tumor effects and improve overall survival. This thesis identifies a new role for interleukin-12 as a modulator of myeloid-derived suppressor cell activity. Interleukin-12 was found to promote up-regulation of cell maturation markers on the surface of myeloid-derived suppressor cells with an accompanying decrease in factors responsible for conferring suppressive activity such as nitric oxide synthase 2 and arginase I. The alterations in myeloid-derived suppressor cells were observed following both in vitro and in vivo treatment with interleukin-12. Further analysis of the anti-tumor efficacy of interleukin-12 revealed that at least part of its suppression of tumor growth can be linked to reductions in myeloid-derived suppressor cell populations in the tumor microenvironment and an influx of active CD8+ T cells into the tumor microenvironment. The findings outlined in this thesis show that interleukin-12 alters the suppressive function of myeloid-derived suppressor cells leading to significant immune infiltration and activation resulting in increased overall survival and a reduction in metastasis.

No description available.

The area of wireless transceiver design is becoming increasingly important due to the rapid growth of wireless communications market as well as diversified design specifications. Research efforts in this area concentrates on schemes that are capable of increasing the system capacity, providing reconfigurability/reprogrammability and reducing the hardware complexity. Emerging topics related to these goals include Software Defined Radio, Multiple-Input-Multiple-Output (MIMO) Systems, Code Division Multiple Access, Ultra-Wideband Systems, etc. This research adopts space diversity and statistical signal processing for digital interference suppression in wireless receivers. The technique simplifies the analog front-end by eliminating the anti-aliasing filters and relaxing the requirements for IF bandpass filters and A/D converters. Like MIMO systems, multiple antenna elements are used for increased frequency reuse. The suppression of both image signal and Co-Channel Interference (CCI) are performed in DSP simultaneously. The signal-processing algorithm used is Independent Component Analysis (ICA). Specifically, the fixed-point Fast-ICA is adopted in the case of static or slow time varying channel conditions. In highly dynamic environment that is typically encountered in cellular mobile communications, a novel ICA algorithm, OBAI-ICA, is developed, which outperforms Fast-ICA for both linear and abrupt time variations. Several practical implementation issues are also considered, such as the effect of finite arithmetic and the possibility of reducing the number of antennas.

The current study assessed the relationship between individuals' tendency to suppress thoughts, particularly related to food and body weight/shape, and outcomes such as weight loss maintenance and diet sabotaging experiences (e.g., binge eating). Community and university individuals (N = 347) who are or previously were overweight completed self-report measures of thought suppression, weight history, and eating behaviors. Suppression of specific thoughts about food/weight/shape was related to weight cycling, binge eating, and food cravings. Participants who believed thoughts of food lead to eating were more likely to attempt suppression of food-related thoughts. Results have implications for improving weight loss maintenance and support further exploration of third wave interventions, such as Acceptance and Commitment Therapy and Mindfulness, in the treatment of obesity.

The research discussed here examines how normal healthy aging affects spatial suppressive mechanisms in a variety of visual tasks using both static and dynamic stimuli. Prior research has suggested that younger adults demonstrate a center-surround antagonistic pattern in which they show spatial summation at low contrast and spatial suppression at high contrast in brief motion direction discrimination tasks. Older adults have been shown to have reduced spatial suppression at high contrast and this is thought to be related to reduced GABAergic inhibition in the visual cortex. The results obtained from this program of research suggest that age-related changes in optical and neural visual mechanisms do not affect spatiotemporal mechanisms for static stimuli when the target is presented with the mask (embedded masking). However, when the mask appears immediately before (forward masking) or after (backward masking) the target, older adults require more contrast to detect the target (Chapter 2). In addition, spatial suppression is not reduced for older adults in a task with moving stimuli presented at long durations, even with increasing speed (Chapter 3). In Chapter 4, we used static stimuli presented at brief durations to induce a sudden motion onset and found that although there was no significant age difference in spatial suppression, there was a trend showing reduced levels of spatial suppression in older adults. These results taken together suggest that inhibitory neural mechanisms in the visual cortex may mediate spatial suppression for briefly presented stimuli only. / Thesis / Doctor of Philosophy (PhD)

College students with ADHD tend to struggle with their academic performance and are less likely to graduate college than their neurotypical peers. Emotion dysregulation, a common symptom of ADHD, can cause significant functional impairment throughout life. Acute exercise improves ADHD symptom severity, yet medication is the first line of treatment. Less is understood about the effectiveness of habitual exercise or ADHD medication on emotion dysregulation and quality of life (QoL). Therefore, the purpose of this mixed-methods study was to examine the relationship between habitual exercise, emotion regulation, and QoL in college students with ADHD, and the possible moderating effects of ADHD medication. A sample of 53 participants completed a Qualtrics survey that included items on recent exercise, emotion regulation strategies, medication status, and QoL. A subset of participants (n=6) also completed a semi-structured interview. A moderated mediation model of linear regression was used to examine the relationships between habitual exercise, emotion regulation, and QoL, and explore the moderating effects of ADHD medication. A 6-step thematic analysis was used to analyze the interview data. Results found a positive main effect of habitual exercise on expression suppression, (p=0.007). Greater use of cognitive reappraisal was associated with greater QoL (p=0.02). There was a stronger association between habitual exercise and cognitive reappraisal in participants taking ADHD medication (p=0.006), than those who were not taking ADHD medication (p=0.942). Medication status did not show a moderating effect. Qualitative analysis identified primary themes of both ADHD-related exercise benefits (increased focus, reduced hyperactivity, improved emotion regulation), and non-ADHD related exercise benefits (feelings of accomplishment, elevated mood, coping mechanism, improved health and fitness). Although further research is necessary, habitual exercise in conjunction with ADHD medication may be an effective treatment for emotion dysregulation associated with ADHD.