Yes / Measuring the spatial extent of defects may be advantageous in advanced glaucoma where conventional perimetric sensitivity measurements are unreliable. We test whether suprathreshold tests on a higher density grid can more efficiently map advanced visual field loss. Data from 97 patients with mean deviation / Supported by a College of Optometrists Research Fellowship (to JD).

No / Z. W. Pylyshyn and R. W. Storm (1988) have shown that human observers can accurately track four to five items at a time. However, when a threshold paradigm is used, observers are unable to track more than a single trajectory accurately (S. P. Tripathy & B. T. Barrett, 2004). This difference between the two studies is examined systematically using substantially suprathreshold stimuli. The stimuli consisted of one (Experiment 1) or more (Experiments 2 and 3) bilinear target trajectories embedded among several linear distractor trajectories. The target trajectories deviated clockwise (CW) or counterclockwise (CCW) (by 19°, 38°, or 76° in Experiments 1 and 2 and by 19°, 38°, or 57° in Experiment 3), and observers reported the direction of deviation. From the percentage of correct responses, the ¿effective¿ number of tracked trajectories was estimated for each experimental condition. The total number of trajectories in the stimulus and the number of deviating trajectories had only a small effect on the effective number of tracked trajectories; the effective number tracked was primarily influenced by the angle of deviation of the targets and ranged from four to five trajectories for a ±76° deviation to only one to two trajectories for a ±19° deviation, regardless of whether the different magnitudes of deviation were blocked (Experiment 2) or interleaved (Experiment 3). Simple hypotheses based on ¿averaging of orientations,¿ ¿preallocation of resources,¿ or pop-out, crowding, or masking of the target trajectories are unlikely to explain the relationship between the effective number tracked and the angle of deviation of the target trajectories. This study reconciles the difference between the studies cited above in terms of the number of trajectories that can be tracked at a time.

It is considered that coincident inputs from multiple presynaptic axons are required to achieve both the suprathreshold level of excitation for the central neurons and the activation of NMDA receptors. The aim of the present study was to determine, whether a discharge of single retinal ganglion cell, which axon terminates in the tectum layer F, can evoke a suprathreshold excitation of frog tectum neurons and activate the NMDA receptors. Extracellular recordings of the neuronal activity elicited by the electrical stimulation of single optic fiber were made in frog tectum. We conclude, that: (1) a train of action potentials of single optic fiber, which terminates in the frog tectum layer F, surely elicits a suprathreshold excitation of tectal neurons at physiological conditions. The suprathreshold level is achieved due to the frequency facilitation of the fast non-NMDA retinotectal synaptic potentials. (2) The train of action potentials of higher frequency activates the NMDA receptors of the tectal neurons at physiological conditions. The activation of NMDA receptors is achieved due to the temporal summation and frequency facilitation of the fast synaptic potentials. (3) Two different kinds of optic fibers (likely darkness and moving edge detectors) exhibit different efficiency to achieve both the suprathreshold excitation of the tectal neurons and the activation of NMDA receptors. Findings of the present study improve the understanding of how the local neural network operates... [to full text]

Yes / PURPOSE. Glaucoma raises contrast detection thresholds, but our natural visual environment is dominated by high contrast that may remain suprathreshold in early to moderate glaucoma. This study investigates the effect of glaucoma on the apparent contrast of visible stimuli. METHODS. Twenty participants with glaucoma with partial visual field defects (mean age, 72 ± 7 years) and 20 age-similar healthy controls (mean age, 70 ± 7 years) took part. Contrast detection thresholds for Gabor stimuli (SD, 0.75°) of four spatial frequencies (0.5, 1.0, 2.0, and 4.0 c/deg) were first measured at 10° eccentricity, both within and outside of visual field defects for participants with glaucoma. Subsequently, the contrast of a central Gabor was matched to that of a peripheral Gabor with contrast fixed at two times or four times the detection threshold. Data were analyzed by linear mixed modelling. RESULTS. Compared with controls, detection thresholds for participants with glaucoma were raised by 0.05 ± 0.025 (Michelson units, ± SE; P = 0.12) and by 0.141 ± 0.026 (P < 0.001) outside and within visual field defects, respectively. For reference stimuli at two times the detection contrast, matched contrast ratios (matched/reference contrast) were 0.16 ± 0.039 (P < 0.001) higher outside compared with within visual field defects in participants with glaucoma. Matched contrast ratios within visual field defects were similar to controls (mean 0.033 ± 0.066 lower; P = 0.87). For reference stimuli at four times the detection contrast, matched contrast ratios were similar across all three groups (P = 0.58). Spatial frequency had a minimal effect on matched contrast ratios. CONCLUSIONS. Despite decreased contrast sensitivity, people with glaucoma perceive the contrast of visible suprathreshold stimuli similarly to healthy controls. These results suggest possible compensation for sensitivity loss in the visual system. / Supported by a College of Optometrists PhD Scholarship. / Research Development Fund Publication Prize Award winner, June 2020

Glaucoma is the leading cause of irreversible blindness worldwide but the effect of glaucoma on patients’ vision under suprathreshold conditions relevant to their natural visual environment is poorly understood. This project aimed to investigate and further understand the effects of glaucoma on three aspects of suprathreshold vision; apparent contrast of suprathreshold stimuli, detection and discrimination of image blur and crowding of peripheral vision. Psychophysical methods were employed to assess these three visual functions by measuring contrast matches of Gabor stimuli, blur detection and discrimination thresholds of edge stimuli and crowding ratios of Vernier targets. These measures were obtained from glaucoma observers tested within and outside of visual field defects and the data compared with healthy controls. Contrast matching ratios were similar between glaucoma and healthy age similar controls despite sensitivity loss in the glaucoma group. Blur detection and discrimination thresholds were similar between glaucoma observers’ tested within and outside of visual field defects and age-similar controls, though thresholds were slightly elevated for high contrast stimuli in the glaucoma visual field defect group. Crowding ratios were similar between participants with glaucoma and healthy young controls. The results demonstrate that aspects of suprathreshold visual function can be maintained in early glaucoma despite sensitivity loss at threshold. The results provide empirical evidence as to the asymptomatic nature of the disease in its early stages. It appears that in early glaucoma, there may be compensatory mechanisms at work within the visual system under suprathreshold conditions that can overcome loss of sensitivity at threshold. / The College of Optometrists

No description available.