Made available in DSpace on 2014-06-11T19:27:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2002-03-27Bitstream added on 2014-06-13T20:36:32Z : No. of bitstreams: 1 barreto_gm_me_arafo.pdf: 3623132 bytes, checksum: db9fb43ddd8274b3769a6a8b9a1696a5 (MD5) / A intervenção precoce na ortodontia vem sendo bastante realizada, evitando que alterações simples da oclusão necessitem tratamentos complexos futuramente. Dentre as más-oclusões mais frequentemente encontradas na infância e passíveis de intervenção precoce, estão as mordidas cruzadas posteriores que normalmente são caracterizadas por deficiência no crescimento transversal do arco superior. Nos casos de atresia maxilar o tratamento mais indicado é a expansão rápida, que pode ser realizada por diferentes terapias. Na presente pesquisa utilizou-se o aparelho Hyrax tendo como objetivo avaliar as alterações transversais e verticais da maxila. Foram selecionados 20 pacientes de ambos os sexo, entre 7 e 11 anos que apresentavam mordida cruzada posterior uni ou bilateral. Realizou-se telerradiografias em norma frontal (P.A.) antes e após a expansão. A fim de evitar que a falta de padronização dessas radiografias pudesse influenciar nos resultados, idealizou-se um método de padronização para tais radiografias. Os resultados mostraram que a correção da mordida cruzada posterior como o aparelho Hyrax, que ocorreu em todos os casos, foi em função tanto da abertura da sutura palatina mediana como também pela inclinação dos molares. A medida JgE-JgD relacionada com a expansão maxilar aumentou significantemente em todos os casos tratados. Nas avaliações dentárias as medidas verticais não apresentaram diferenças significantes, o contrário das medidas transversais (FTE-FTD; FBE-FBD; LO.BTE; LO.BTD; BTE.BTD). A largura da cavidade nasal também aumentou significantemente (CNE-CND). O método de padronização proposto permite, portanto, utilizar as medidas que avaliam a expansão rápida da maxila, através das radiografias posteroanteriores, com segurança, inclusive no sentido vertical. / Early treatment is frequently proposed in orthodontics as it prevent that mild malocclusions require more complex procedures futhermore. Among the most frequent malocclusion observed in childhood and that can be early treated are the posterior crossbites. These are usually characterized by a decreased transversal growth of the upper arch. In the constriction maxillary cases, the most indicated treatment is rapid maxillary expansion that can be achieved by different therapies. In the present research the Hyrax appliance was used in order to evaluate the transverse and vertical outcomes in maxillary base. Twenty patients of both gender, from 7 to 11 years old, presenting uni or bilateral posterior crossbite were selected. Posteroanterior radiographs were performed before and after expansion. These radiographs were standardized in order to avoid that problems with lack of standardization influence the results. The obtained data showed that the posterior crossbite correction with Hyrax appliance, observed in all the cases, was consequent either to midpalatal suture opening and molar buccal tipping. JgE-JgD measurement related to maxillary expansion increased significantly in all the treated cases. According to dental evaluation, vertical measurements did not show significant differences, which is in opposition to the transverse measurements (FTE-FTD; FBE-FBD; LO.BTE; LO.BTD; BTE.BTD). The nasal cavity width also increased significantly (CNE-CND). The standardization method proposed showed to be reliably useful for maxilla rapid expansion evaluation with posteroanterior radiographs even for vertical considerations.

Craniosynostosis is a disorder characterized by the premature fusion of one or more cranial sutures in the infant skull, resulting in an abnormal shape of the cranium. An effective surgical procedure for treatment of this disorder has been developed and is currently use called "Dynamic Spring Mediated Craniofacial Reshaping." This technique involves surgical removal of the fused suture and insertion of springs to expand the gap created by the suture removal in order to gradually reshape the skull to a more desirable shape. There were three primary objectives of this research: develop a device that could fabricate type 316 stainless steel wireform springs having consistent mechanical characteristics, evaluate the performance of the device, and develop a mathematical model to predict the mechanical characteristics of the fabricated springs. Use of the mathematical model facilitates further research to be performed that could determine the most effective use of the "Dynamic Spring Mediated Craniofacial Reshaping" surgical procedure. / Master of Science

Objetivo: Estudar e compreender aspectos topográficos e temporais do osso pré-maxilar e da sutura pré-maxilar - maxilar, por serem elementos anatômicos fundamentais pouquíssimos explorados clinicamente. Material e métodos: Foram avaliados 1138 crânios secos humanos, sendo que 116 (10,19%) dos espécimes eram crianças, e 1067 (89,81%) adultos. Os crânios foram fotografados e determinada a porcentagem de abertura da sutura pré-maxilar - maxilar. Posteriormente os dados foram tabulados e submetidos a análise estatística, adotando-se nível de significância de 5%. Resultados: A progressão de fechamento da sutura pré-maxila - maxilar foi de 3,72% ao ano. Em 100% dos crânios até 12 anos observou-se a sutura pré-maxilar - maxilar abertas na região palatina, enquanto 6,16% dos adultos. Conclusões: A pré-maxila existe de forma independente dentro do complexo maxilar e a presença da sutura pré-maxila - maxilar justifica o sucesso de expansões anteroposterior para o crescimento do terço médio da face e solução problemas anatômicos e funcionais / Objective: To study and understand topographic and temporal aspects of premaxillary bone and premaxillary-maxillary suture, because they are fundamental anatomical elements that are rarely explored clinically. Material and methods: 1138 human dry skulls were evaluated, of which 116 (10,19%) of the specimens were children, and 1067 (89,81%) were adults. The skulls were photographed and the percentage of opening of the premaxillary - maxillary suture was determined. Subsequently the data were tabulated and submitted to statistical analysis, adopting a level of significance of 5%. Results: The progression of premaxillary suture closure was 3.72% per year. In 100% of the skulls up to 12 years the premaxillary suture was observed open in the palatal region, while 6.16% of adults. Conclusions: The premaxilla exists in an independ way within the maxillary complex and the presence of the premaxilla-maxillary suture justifies the success of anteroposterior expansions of the maxillary complex and solves anatomical and functional problems

Cell therapy, including human mesenchymal stem cell (hMSC) therapy, has the potential to treat different pathologies, including myocardial infarctions (heart attacks). Biological sutures composed of fibrin have been shown to effectively deliver hMSCs to infarcted hearts. However, hMSCs rapidly degrade fibrin making cell seeding and delivery time sensitive. To delay the degradation process, we propose using aprotinin, a proteolytic enzyme inhibitor that has been shown to slow fibrinolysis. This project investigated the effects of aprotinin on hMSCs and suture integrity. Viability of hMSCs incubated with aprotinin, examined using a LIVE/DEAD stain, was similar to controls. No differences in proliferation, as determined by Ki-67 presence, and were observed. hMSCs incubated in aprotinin differentiated into adipocytes, osteocytes, and chondrocytes, confirming multipotency. CyQuant assays were used to determine the number of cells adhered to fibrin sutures. The number of adhered cells was increased through aprotinin supplementation at Days 2, 3, and 5 time points. To examine the effect of aprotinin on suture integrity, sutures were loaded to failure to determine ultimate tensile strength (UTS) and modulus (E). Sutures exposed to aprotinin had higher UTS and E when compared to sutures exposed to standard growth media. Degradation of fibrin was quantified using an ELISA to quantify fibrin degradation products (FDP) and by measuring suture diameter. Fibrin sutures incubated in aprotinin had larger diameters and less FDP compared to the controls, confirming decreased fibrinolysis. These data suggest that aprotinin can reduce degradation of biological sutures, providing a novel method for extending the implantation window and increasing the number of cells delivered for hMSC seeded biological sutures.

Thesis (Ph. D.)--Ohio State University, 2006. / Title from first page of PDF file. Includes bibliographical references (p. 137-153).

Thesis--University of Goteborg, 1973. / Includes bibliographical references (p. 137-146).

Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 184-204).

Thesis (M.S.)--University of Alabama at Birmingham, 2008. / Description based on contents viewed Oct. 14, 2008; title from PDF t.p. Includes bibliographical references (p. 66-71).

Thesis--University of Goteborg, 1973. / Includes bibliographical references (p. 137-146).

Orientador: Luiz Gonzaga Gandini Junior / Banca: Dirceu Barnabé Raveli / Banca: Lídia Parsekian Martins / Banca: Saturnino Aparecido Ramalho / Banca: Ana Cláudia Moreira Melo / Resumo: A intervenção precoce na ortodontia vem sendo bastante realizada, evitando que alterações simples da oclusão necessitem tratamentos complexos futuramente. Dentre as más-oclusões mais frequentemente encontradas na infância e passíveis de intervenção precoce, estão as mordidas cruzadas posteriores que normalmente são caracterizadas por deficiência no crescimento transversal do arco superior. Nos casos de atresia maxilar o tratamento mais indicado é a expansão rápida, que pode ser realizada por diferentes terapias. Na presente pesquisa foram utilizados os aparelhos Hyras e Haas, tendo como objetivo avaliar as alterações transversais e verticais da maxila. Foram selecionados 40 pacientes de ambos os gêneros, entre 7 e 11 anos que apresentavam mordida cruzada posterior uni ou bilateral. Realizou-se telerradiografias em norma frontal (P.A.) antes e após a expansão. A fim de evitar que a falta de padronização dessas radiografias pudesse influenciar nos resultados, idealizou-se um método de padronização para tais radiografias. Os resultados, idealizou-se um método de padronização para tais radiografias. Os resultados mostraram que a correção da mordida cruzada posterior com ambos aparelhos ocorreu em todos os casos em função tanto da abertura da sutura palatina mediana como também pela inclinação dos molares. A medida JgE-JgD relacionada com a expansão maxilar esquelética aumentou significantemente em todos os casos tratados. Nas avaliações dentárias as medidas verticais não apresentaram diferenças significantes, o contrário das medidas transversais (FTE-FTD; FBE-FBD; LO.BTE; LO.BTD; BTE.BTD). A largura da cavidade nasal também aumentou significantemente (CNE-CND). Desta forma, podemos concluir com confiança que ambos os aparelhos tiveram efeitos similares. / Abstract: Early treatment is frequently proposed in orthodontics as it prevent that mild malocclusions require more complex procedures furthermore. Among the most frequent malocclusion observed in childhood and that can be early treated are the posterior crossbites. These are usually characterized by a decreased transversal growth of the upper arch. In the constriction maxillary cases, the most indicated treatment is rapid maxillary expansion that can be achieved by different therapies. In the present research the Hyrax and Haas appliances was used in order to evaluate the transverse and vertical outcomes in maxillary base. Fourty patients of both gender, from 7 to 11 years old, presenting uni or bilateral posterior crossbite were selected. Posteroanterior radiographs were performed before and after expansion. These radiographs were standardized in order to avoid that problems with lack of standardization influence the results. The obtained data showed that the posterior crossbite correction with both appliances, observed in all the cases, was consequent either to midpalatal suture opening and molar buccal tipping. JgE-JgD measurement related to maxillary expansion increased significantly in all the treated cases. According to dental evaluation, vertical measurements did not show significant differences, which is in opposition to the transverse measurements (FTE-FTD; FBE-FBD; LO.BTE; LO.BTD; BTE.BTD). The nasal cavity width also increased significantly (CNE-CND). Therefore, we can to conclude with trust that the both appliances had the similar effects. / Doutor