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Objektiv: Temporomandibulär dysfunktion (TMD) utgör vanligaste formen av kronisk orofacial smärta. Kronisk TMD har negativ inverkan på det psykosociala tillståndet vilket påverkar livskvaliteten. Syftet är att utreda huruvida en korrelation mellan TMD, katastrofiering, kinesofobi och fysiska symtom föreligger. Material och metod: Studien baseras på data från TMJ Impact Project som utvärderar 401 individer (333 kvinnor, 86 män, medelålder 45.8) från den initiala studien The Validation Project som utvärderar diagnostiken enligt RDC/TMD, insamlingen utfördes på University of Minnesota, University of Washington och University of Buffalo (2003-2006). 218 individer hade smärtsam TMD, 111 icke-smärtsam TMD, 63 smärtfria kontroller och data saknades för 9 individer. Deltagarna genomgick diagnostik enligt RDC/TMD som inkluderar en klinisk- och radiologisk undersökning (axel I) och en psykosocial utvärdering (axel II). För att undersöka en potentiell korrelation mellan TMD, katastrofiering, kinesofobi och fysiska symptom användes följande instrument: Pain Catastrophizing Scale, Tampa Scale for Kinesiophobia, The Patient Health Questionnaire och Areas of Pain.Resultat: Deltagare med smärtsam TMD uppvisade statistisk signifikant grad av kinesofobi, somatisering och fysiska symtom jämfört med kontroller. Deltagare med smärtfri TMD uppvisade högre grad av kinesofobi jämfört med kontroller. Det råder en låg- till moderat positiv korrelation mellan katastrofiering och kinesofobi hos deltagare med smärtsam TMD (r=0,37 p<0,001) och smärtfri TMD (r=0,53 p<0,001).Konklusion: Resultaten uppvisar associationer mellan katastrofiering och kinesofobi hos patienter med TMD oberoende av smärtförekomst. Överlag föreslår resultaten att utvärderingen av kinesofobi och katastrofiering, utspridd smärta och multipla icke-TMD relaterade symtom kan vara av klinisk vikt vid utvärderingen av patienter med TMD. / Objectives: Temporomandibular disorders (TMD) are the most common causes of chronic orofacial pain and affects both psychological and social aspects of life. The aim was to investigate the possible relationship between TMD, catastrophizing, kinesiophobia and physical symptoms. Methods: The study was based on 401 participants (333 women, 86 men, mean age 45.8 years) in the TMJ Impact Project recruited at University of Minnesota, University of Washington and University of Buffalo 2003-2006. Of these, 218 had TMD pain, 111 non-painful TMD, 63 were pain-free controls and data was missing for 9 individuals. Participants were diagnosed in accordance with the Diagnostic Criteria for TMD, including a clinical and radiographic examination (axis I) and a psychosocial assessment (axis II). The possible correlations between TMD, catastrophizing, kinesiophobia and physical symptoms were evaluated with the Pain Catastrophizing Scale, Tampa Scale for Kinesiophobia, the Patient Health Questionnaire, together with Areas of Pain. Results: Compared to controls, participants with TMD pain showed a statistically significant degree of kinesiophobia, somatic symptoms, and areas of pain and participants with non-painful TMD showed a higher degree of kinesiophobia. There was a positive, low to moderate correlation between catastrophizing and kinesiophobia for participants with TMD pain (r=0.37, p<0.001) and non-painful TMD (r=0.53, p<0.001).Conclusions: The results suggest an association between catastrophizing and kinesiophobia in individuals with TMD regardless of presence of pain. The findings suggest that evaluating fear of movement and catastrophizing, as well as widespread pain and multiple non-TMD symptoms can be useful in the assessment of patients with TMD.

Indiana University-Purdue University Indianapolis (IUPUI) / US military personnel often experience ongoing distress after being exposed to traumatic events, and many develop posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). Both general theories of stress and coping and cognitive theories of PTSD suggest that traumatic events give rise to distress by negatively influencing important beliefs and goals related to the self, other people, and the world. According to these theories, more positive belief- and goal-systems are associated with less severe symptoms of distress. Two constructs that tap into these systems are general self-efficacy and subjective meaning in life. The overall goal of the current study was to examine the ways general self-efficacy and subjective meaning in life relate to posttraumatic stress and depressive symptoms and symptom clusters in US military personnel, both cross-sectionally and longitudinally. Data from a VA-funded intervention study (n = 191) were examined. Results demonstrated that meaning in life is consistently associated with posttraumatic stress and depressive symptoms and symptom clusters cross-sectionally, whereas general self-efficacy is only associated with some aspects of depressive symptoms. Longitudinal analyses further revealed that meaning in life is associated with the Cluster D symptoms of PTSD and the cognitive-affective symptoms of depression. Interpretations, possible explanations, implications, and future directions are provided. Continued research in this area may identify important targets for treatment that enhance ongoing efforts to facilitate recovery from trauma.

This study examined links of cumulative and present depressive symptoms with present cortisol diurnal profiles in oldest-old adults. Five waves of data from 50 older adults (M age = 89.05 years; 64% women) who participated in the Australian Longitudinal Study of Ageing were used to combine 15 years of longitudinal data with seven cortisol samples per day over a one-week period. Findings revealed that individuals with more past depressive symptoms showed a lower cortisol awakening response (CAR). Interestingly, present depressive symptoms were not associated with the CAR. These findings inform our understanding of distal health factors in very old age.

Dysfunction of the visual cortex is implicated in psychosis and recently, the extrastriate visual cortex (V5/MT) has been causally linked to visual hallucinations through lesion network mapping. Transcranial electric stimulation (tES) has been shown to improve psychotic symptoms and cognition in psychosis spectrum disorders. However, few investigations have used novel approaches, such as high definition tES (HD-tES) to target specific brain circuits. Previously, we showed that stimulation delivered to V5/MT using HD-tDCS (direct current) reduced Positive and Negative Syndrome Scale (PANSS) general symptoms in the short-term (5 days), while HD-tACS (alternating current) improved general symptoms and functioning in the long-term (30 days). Here, we aim to determine if HD-tES to V5/MT has altering effects on cognition and self-reported symptoms of psychosis, and to investigate the differences between self-reported and clinician-reported symptoms. A pilot open label study with a within-subjects, single blind, crossover design was conducted in order to characterize the efficacy of cathodal HD-tDCS and 2Hz delta HD-tACS for psychosis treatment. Enrolled patients received 20 mins of HD-tES twice daily for 5 consecutive days applied bilaterally to V5/MT with a washout between conditions. Assessments were performed at baseline, day 5, and day 30. HD-tACS treatment was found to improve cognition on Digit Sequencing, Tower of London, Semantic Fluency, and “S” Letter Fluency tasks as measured by brief assessment of cognition in schizophrenia (BACS) as well as symptoms of paranoid ideation and anger/hostility as measured by the symptom checklist 90 (SC-90) 1 month after treatment. HD-tDCS treatment yielded significant improvement on “F” Letter Fluency as measured by BACS and did not yield any significant improvement on SC-90 symptoms. Lastly, correlations between SC-90 and PANSS described a distinct relationship between the two scales and their measures of psychiatric morbidity. Ultimately, delta wave tACS may be able to improve cognition and certain symptoms of psychosis by altering cortico-cortico communication between relevant brain structures. Future large-scale investigations are needed to further solidify these results. / 2026-03-04T00:00:00Z