Recent research interests in studying the performance of different seismic force resisting systems (SFRS) have been shifting from component- (individual walls) to system-level (complete building) studies. Although there is wealth of knowledge on component-level performance of reinforced masonry shear walls (RMSW) under seismic loading, a gap still exists in understanding the response of these components within a complete system. Consequently, this study’s main objective is to investigate the influence of the diaphragm’s out-of-plane stiffness on the seismic response of RMSW buildings. In addition, the study aims to synthesize how this influence can be implemented in different seismic design approaches and assessment frameworks. To meet these objectives a two-story scaled asymmetrical RMSW building was tested under quasi-static cyclic loading. The analysis of the test results showed that the floor diaphragms’ out-of-plane stiffness played an important role in flexurally coupling the RMSW aligned along the loading direction with those walls orthogonal to it. This system-level aspect affected not only the different wall strength and displacement demands but also the failure mechanism sequence and the building twist response. The results of the study also showed that neglecting diaphragm flexural coupling influence on the RMSW at the system-level may result in unconservative designs and possibly undesirable failure modes. To address these findings, an analytical model was developed that can account for the aforementioned influences, in which, simplified load-displacement relationships were developed to predict RMSW component- and system-level responses under lateral seismic loads. This model is expected to give better predictions of the system response which can be implemented, within the model limitations, in forced- and displacement-based seismic design approaches. In addition, and in order to adapt to the increasing interest in more resilient buildings, this study presents an approach to calculate the system robustness based on the experimental data. Finally, literature shows that the vast majority of the loss models available for RMSW systems were based on individual component testing and/or engineering judgment. Consequently, this study proposes system damage states in lieu of component damage states in order to enhance the prediction capabilities of such models. The current dissertation highlights the significant influence of the diaphragm out-of-plane stiffness on the system-level response that may alter the RMSW response to seismic events; an issue that need to be addressed in design codes and standards. / Dissertation / Doctor of Philosophy (PhD)