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Distress tolerance is often defined as one’s ability to tolerate and withstand negative and/or uncomfortable emotional states (Simons & Gaher, 2005; Zvolensky et al., 2001). However, after nearly two decades of research, there is still no consensus on how to best conceptualize and measure distress tolerance. A historical account of the conceptualization and measurement of distress tolerance demonstrates that the distress tolerance literature may have missed a crucial step in theory development: obtaining a thorough understanding of the concept in question (Dubin, 1969). Without adequately addressing this important step in theory development, it is likely that continued efforts to research distress tolerance will ultimately fail to progress science in a meaningful way. Thus, the goal of this study was to conduct an in-depth, mixed methods investigation into how individuals define key terms used in self-report measures of distress tolerance: “distress” and “upset,” and what (if any) intraindividual or domain-specific differences they report. Thematic analysis showed no consensus on participants’ understandings of the key terms—a finding that poses deep questions regarding its potential utility to advance knowledge in the field of psychopathology. The thematic analysis revealed important intraindividual differences in distress tolerance that can aid in future investigation.

Chironomus riparius are the least sensitive aquatic species in the U.S. EPA (2000) species sensitivity distribution (SSD) for cadmium (Cd). LC50 values over 25,000 times the Criterion Maximum Concentration suggest that chironomids have an extraordinary capacity to excrete or sequester cadmium as a means of increasing their overall tolerance to toxic metals. Using atomic absorption spectroscopy, we have shown saturable uptake of cadmium by whole chironomids and isolated guts. The transport of Cd from the gut lumen to the hemolymph exposes other tissues such as the nervous system and muscles to Cd. To quantify the movement of Cd2+ from the main point of entry, the digestive tract, we have identified regional differences of Cd transport along the gut using a Cd2+ -selective microelectrode in conjunction with the Scanning Ion Selective Electrode Technique (SIET). Cd2+ fluxes were determined in high mucosal or serosal Ca2+ to analyze the contribution of Ca2+ transporters to Cd2+ uptake. The major tissues responsible for elimination of Cd2+ from the hemolymph are the posterior midgut and the ileum. In addition, experiments using an isolated Malpighian tubule preparation (the Ramsay assay) have shown that the Malpighian tubules both sequester and secrete Cd2+. The tubules can secrete the entire hemolymph burden of Cd^2+ in~ 18 hours. / Thesis / Master of Science (MSc)

京都大学 / 新制・課程博士 / 博士(医学) / 甲第25489号 / 医博第5089号 / 新制||医||1073(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 林 康紀, 教授 岩田 想, 教授 寺田 智祐 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

Experiences with computer systems indicate an inconvenient truth: computers fail and they fail in interesting ways. Although using redundancy to protect against fail-stop failures is common practice, non-fail-stop computer and network failures occur for a variety of reasons including power outage, disk or memory corruption, NIC malfunction, user error, operating system and application bugs or misconfiguration, and many others. The impact of these failures can be dramatic, ranging from service unavailability to stranding airplane passengers on the runway to companies closing. While high-stakes embedded systems have embraced Byzantine fault tolerant techniques, general purpose computing continues to rely on techniques that are fundamentally crash tolerant. In a general purpose environment, the current best practices response to non-fail-stop failures can charitably be described as pragmatic: identify a root cause and add checksums to prevent that error from happening again in the future. Pragmatic responses have proven effective for patching holes and protecting against faults once they have occurred; unfortunately the initial damage has already been done, and it is difficult to say if the patches made to address previous faults will protect against future failures. We posit that an end-to-end solution based on Byzantine fault tolerant (BFT) state machine replication is an efficient and deployable alternative to current ad hoc approaches favored in general purpose computing. The replicated state machine approach ensures that multiple copies of the same deterministic application execute requests in the same order and provides end-to-end assurance that independent transient failures will not lead to unavailability or incorrect responses. An efficient and effective end-to-end solution covers faults that have already been observed as well as failures that have not yet occurred, and it provides structural confidence that developers won't have to track down yet another failure caused by some unpredicted memory, disk, or network behavior. While the promise of end-to-end failure protection is intriguing, significant technical and practical challenges currently prevent adoption in general purpose computing environments. On the technical side, it is important that end-to-end solutions maintain the performance characteristics of deployed systems: if end-to-end solutions dramatically increase computing requirements, dramatically reduce throughput, or dramatically increase latency during normal operation then end-to-end techniques are a non-starter. On the practical side, it is important that end-to-end approaches be both comprehensible and easy to incorporate: if the cost of end-to-end solutions is rewriting an application or trusting intricate and arcane protocols, then end-to-end solutions will not be adopted. In this thesis we show that BFT state machine replication can and be used in deployed systems. Reaching this goal requires us to address both the technical and practical challenges previously mentioned. We revisiting disparate research results from the last decade and tweak, refine, and revise the core ideas to fit together into a coherent whole. Addressing the practical concerns requires us to simplify the process of incorporating BFT techniques into legacy applications. / text

The main purpose of this research was to investigate the phenomenon of tolerance to cocaine. Tolerance is operationally defined as a decreased drug effect due to prior history of drug administration. The animal model that was chosen to investigate tolerance to cocaine was the drug discrimination model, which is an animal analogue of human subjective drug effects. In the drug discrimination procedure, animals are trained to emit one behavior when injected with saline. In the present experiments, rats were trained to press one lever when injected with cocaine, 10 mg/kg, and a different lever when injected with saline for food reinforcement. Once rats are trained, they can accurately detect the cocaine stimulus greater than 95% of the time.

The economic development in Sweden in recent years has led to increased financial savings in Swedish households. Financial savings have mostly increased on bank accounts with low interest rates, since private individuals generally have a more cautious position on stocks and stock trading. The reason for this passive position is believed to be due to the fact that decisions that benefit most economically often challenge the feeling of being in control. At the same time, cautious position that a particular individual possess is affected by the risk-tolerance. As a consequence, the risk tolerance of private individuals affects the investment decision and hence the development of the stock market. Savings and investment are two important factors that affect a nation's economic growth, which makes it important to study underlying factors to what affects an individual when making a financial decision. When talking about risk tolerance in everyday life, previous research has revealed that there are four different aspects that affect this complex concept, namely the economic aspect, physical aspect, social aspect and ethical aspect. As investment decisions are affected by financial risk tolerance and the four aspects in turn, affect risk tolerance, the issue becomes how these aspects affect a private investor's financial risk tolerance when investing in stocks. The purpose of this study has been to explain the four aspects of a person’s risk tolerance when investing in stocks. The study has been conducted using a quantitative method and deductive approach. The selection group that the study turned to is Swedish stock investors and the data collection has been done by a survey that was answered by 232 people. The underlying factors for the four aspects tested in the study are income, gender, age, education, marital status and ethical character. The study shows that all four aspects together have a combined impact on private individuals' financial risk tolerance. The study has also shown that all the four aspects, each one separately, are linked to financial risk tolerance, by the underlying factors, income level, gender, marital status and ethical character. / De senaste årens ekonomiska utveckling i Sverige har lett till ett ökat finansiellt sparande i de svenska hushållen. Detta sparande har mestadels ökat på bankkonton med låga räntor då privatpersoner i allmänhet har ett mer försiktigt ställningstagande till aktie och börshandel. Anledningen till detta passiva ställningstagande tros bero på att beslut som gynnar mest ekonomiskt ofta utmanar känslan av att ha kontroll. Samtidigt påverkas ställningstagandet av den risktoleransnivå som en viss individ besitter. Följden av detta blir att privatpersoners risktolerans påverkar investeringsbeslutet och därmed även utvecklingen av aktiemarknaden. Sparande och investering är två viktiga faktorer som påverkar en nations ekonomiska tillväxt vilket gör det viktigt att studera bakomliggande faktorer till vad som påverkar en privatperson när ett finansiellt beslut ska tas. När det pratas om risktolerans i vardagslivet har tidigare forskning delgett att det finns fyra olika aspekter som påverkar detta komplexa begrepp, nämligen den ekonomiska aspekten, fysiska aspekten, sociala aspekten och etiska aspekten. Då investeringsbeslut påverkas av den finansiella risktoleransen och risktoleransen i sin tur påverkas av de fyra aspekterna blir problemfrågan hur dessa aspekter påverkar en privatpersons finansiella risktolerans vid investering i aktier.  Syftet med denna studie har varit att förklara de fyra aspekterna för privatpersoners finansiella risktolerans vid aktieinvestering. Studien har genomförts med hjälp av en kvantitativ metod och deduktiv ansats. Den urvalsgrupp som studien vänt sig till är svenska aktieinvesterare och datainsamlingen har gjorts med hjälp av en enkätundersökning som besvarats av 232 personer.  De bakomliggande faktorerna för de fyra aspekterna som har testats i studien är inkomst, kön, ålder, utbildning, civilstånd och etisk karaktär. Studien visar att alla fyra aspekter tillsammans har sammantagen påverkan på privatpersoners finansiella risktolerans. Studien har även visat att alla de fyra aspekterna har en koppling till den finansiella risktoleransen, var och en för sig, genom de underliggande faktorerna inkomstnivå, kön, civilstånd och etisk karaktär.

Quality control (QC) plan is an important component of manufacturing planning for mass customization. QC planning is to determine the operational tolerances and the way to control process variation for assuring the production quality against design tolerances. It includes four phases, i.e., tolerance stack-up analysis, tolerance assignment, in-process inspection design, and the procedure of error source diagnosis & process control. Previous work has been done for tolerance stack-up modeling based on the datum-machining surface relationship graph (DMG), machining error analysis, and worst-case/statistical method. In this research, the tolerance stack-up analysis is expanded with a Monte-Carlo simulation for solving the tolerance stack-up problem within multi-setups. Based on the tolerance stack-up model and process capability analysis, a tolerance assignment method is developed to determine the operation tolerance specifications in each setup. Optimal result is achieved by using tolerance grade representation and generic algorithm. Then based on a process variation analysis, a platform is established to identify the necessity of in-process inspection and design/select the inspection methods in quality control planning. Finally a general procedure is developed to diagnose the error sources and control the process variation based on the measurements.

The main contribution of this thesis, is to define similarity measures between two images with the main focus on content-based image retrieval (CBIR). Each image is considered as a set of visual elements that can be described with a set of visual descriptions (features). The similarity between images is then defined as the nearness between sets of elements based on a tolerance and a fuzzy tolerance relation. A tolerance relation is used to describe the approximate nature of the visual perception. A fuzzy tolerance relation is adopted to eliminate the need for a sharp threshold and hence model the gradual changes in perception of similarities. Three real valued similarity measures as well as a fuzzy valued similarity measure are proposed. All of the methods are then used in two CBIR experiments and the results are compared with classical measures of distance (namely, Kantorovich, Hausdorff and Mahalanobis). The results are compared with other published research papers. An important advantage of the proposed methods is shown to be their effectiveness in an unsupervised setting with no prior information. Eighteen different features (based on color, texture and edge) are used in all the experiments. A feature selection algorithm is also used to train the system in choosing a suboptimal set of visual features.