Global ETD Search

1	Myokines, Measurement, and Technical Considerations Willis, Craig R.G., Deane, C.S., Etheridge, T. 22 November 2023 (has links) No / Skeletal muscle has long been established as a highly multifunctional organ, playing a vital role in locomotion, whole-body metabolic and energy homeostasis, and thermoregulation. More recently, emergent evidence has highlighted a potent secretory role for muscle, producing and releasing “myokine” molecules that act in autocrine, paracrine, or endocrine fashion to govern muscle physiology and regulate whole-body homeostasis via multi-tissue cross talk mechanisms. Myokines represent promising therapeutic targets in health and disease, with their discovery, measurement, and functional importance being a hotbed of research across numerous physiological contexts. Here, we provide an overview of myokines and summarize current understanding of their biological role(s). We also outline primary approaches for myokine analysis, including detailed methodology for performing omics-driven myokine prediction, while further appraising both method-specific and general technical considerations to provide an evidence-based approach for designing and conducting myokine experiments. Skeletal muscle Secretome Myokine Measurement Analysis Omics Technical considerations
2	Technical Optimization of a Long Span Beam made of Glulam Elements Bulgarini, Mario January 2021 (has links) Timber constructions have during the past two or three decades become more andmore common, mostly due to the easy prefabrication and the cheap, sustainablematerial. For long-span applications it is vital to find design solutions that optimizethe structure from the point of view of material consumption, number of theconnections, structural reliability etc.This thesis focuses on the structural optimization of a long span timber structureearlier developed by a Swedish glulam company for industry buildings and sport hallapplications. The main goal of this study has been the minimization of the volume ofwood required to built the structure, given a set of geometrical restrictions and theassigned loads.The optimal shape of the structure and the arrangement of the different elementshas been investigated by means of theoretical analyses taking into account theprincipal directions of stress which would occurr in similar structures with massivecross sections. The results of this investigations give some guidelines to design newtypes of structures, where both mechanical efficiency and manufacturing issues havebeen taken into consideration.Comparisons of the structural models proposed in this thesis with the originalproposal provided by the Swedish glulam company conclude the work, suggestingsome possible improvements. Glulam structures long span ceilings optimal arrangement technical considerations self weight minimum. Engineering and Technology Teknik och teknologier
3	A Conductor's Insight Into Performance and Interpretive Issues in Give Us This Day by David Maslanka Denney Wright, Lauren Ann 08 May 2010 (has links) The purpose of this essay is to provide performance and interpretive background and suggestions for David Maslanka's Give Us This Day. This essay serves as the first significant research document on the work and is intended as a source for musicians seeking information about the work. The essay includes a biography of David Maslanka, as well as descriptions of the history and commissioning of Give Us This Day, its compositional process, and its performance and interpretive issues. Information was accumulated through interviews with David Maslanka, Gary D. Green, director of bands at the University of Miami, and the consortium head, Eric Weirather. Interpretation Expression Conducting Band Contemporary Vater Unser In Himmelreich Bach Wind Ensemble Modern Premier Band Repertoire Rehearsal Frost School Of Music Works List Gary Green Technical Considerations Program Notes Manuscript Premiere Repertoire

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