Based on preliminary reports, an extended series of bolamphiphilic oligoester compounds with structural symmetry were synthesized and then tested using a planar bilayer experiment with the voltage-clamp technique. The main structures of these compounds are identical, consisting of a mono or tri-aromatic core, two octamethylene chains and two benzoyl headgroups which are all connected through ester linkages. The structural variance was provided by the four differently functionalized benzoyl headgroups. The synthetic methods of three to five steps were mainly adapted from the previously reported method.1 The methods successfully produced eight compounds with overall yields of 20 to 30%. The voltage-clamp data suggested voltage-dependent behaviors occur at low concentrations while Ohmic behaviors require at high concentrations. The activity at low potentials showed relatively erratic behavior but the channels frequently switched between opening and closing states. The activity at high potential lasted longer as the channel maintained a longer state of opening. The exponential voltage-dependent behaviors were observed at higher potential while the voltage-independent Ohmic behaviors occur at low potential. These channel behaviors are highly time-dependent as there is no control over the stability and the aggregation level for the compounds forming active channels in the membrane. In some cases the current-voltage responses appear to be asymmetrical between the positive and the negative potentials. Mechanisms consistent with the observations are proposed. / Graduate / 0485 / 0490 / yzong@uvic.ca

We investigate the linear stability and perform the bifurcation analysis for Hopfield neural networks with a general distribution of delays, where the neurons are identical. We start by analyzing the scalar model and show what kind of information can be gained with only minimal information about the exact distribution of delays. We determine a mean delay and distribution independent stability region. We then illustrate a way of improving on this conservative result by approximating the true region of stability when the actual distribution is not known, but some moments or cumulants of the distribution are. We compare the approximate stability regions with the stability regions in the case of the uniform and gamma distributions. We show that, in general, the approximations improve as more moments or cumulants are used, and that the approximations using cumulants give better results than the ones using moments. Further, we extend these results to a network of n identical neurons, where we examine the stability of a symmetrical equilibrium point via the analysis of the characteristic equation both when the connection matrix is symmetric and when it is not. Finally, for the scalar model, we show under what conditions a Hopf bifurcation occurs and we use the centre manifold technique to determine the criticality of the bifurcation. When the kernel represents the gamma distribution with p=1 and p=2, we transform the delay differential equation into a system of ordinary differential equations and we compare the centre manifold computation to the one we obtain in the ordinary differential case.

The thesis explores the nature and characteristics of the independent regulatory agencies, which become a crucial component of the current administrative structures,as well as the possible sources and dynamics behind their emergence. The study begins with investigating in what way the methodological premises of the theories of public choice, new public management, and governance affected the formation, functioning and justification of these agencies and makes an inquiry into the connection between them and the neo-liberal policies implemented since the 1980s.It then focuses on the independent regulatory agencies in the Turkish case and examines the impact of the economic and political conditions in the neo-liberal period in the emergence of these agencies. The thesis seeks to explain the peculiarity of the emergence of IRAs in Turkey, as compared to their American and European counterparts, with special reference to the process of European Integration and to the pressures exerted by the international financial agencies within the context of economic crisis. As geared to the achievement of these objectives, a critical assessment of the debates on independent regulatory agencies in the literature has been made within the scope of the study.

農林水産研究情報センターで作成したPDFファイルを使用している。

In developing training for new technologies, designers encounter many options in an effort to increase system knowledge and produce effective system usage. Technological advancements do, however, provide the opportunity for more dynamic and interactive training methods. Moreover, technology may require the acquisition of time-sensitive skills. Many technologies have automatic shut-off or low-power functions, like the shutting off the backlight of a cell phone after 30 seconds. These system functions may lead to errors for novice users or for infrequent tasks. To develop effective training for time-sensitive tasks, the learner needs instruction on how to accurately perform the task at a particular pace. One potentially fruitful avenue of exploration is to provide the learning goal during training through the pace of the training materials. This presentation pace is the rate at which training tasks are presented to the learner during training; this pace may be fixed or self-regulated. The goal of the current study was to examine the role of presentation in learning a complex technology using four types of pacing for younger adults (Experiment 1) and older adults (Experiment 2). The results of this study show there seems to be a benefit of self-paced training for younger adults and older adults. These findings provide insight into future studies investigating the underlying mechanisms related to the benefits of self-paced training. Additionally, the findings have implications for the development of training paradigms for time-sensitive technologies.

This thesis investigates the ways in which higher education in Africa has been construing its mission for Africa’s development and how such constructions are shaped by particular global regimes of knowledge on development. The thesis unpacks the ways in which such regimes are deployed using specific technologies: neo-liberal precepts on economic development. To that end, I pose a set of questions which can be summarized in these two: How has higher education in Africa discursively construed Africa’s experiences? Second, in which terms such constructions have helped responding to Africa’s problems of development? Taking Mozambican higher education as a unit of analysis, I used postcolonial theory to unsettle neo-liberal regimes of development and to show how contingent they are. Methodologically, a historical critique was carried out to historize neo-liberal globalization as a contingent process and to understand multiple possibilities of construing Africa’s experiences. My data consisted of texts discussing ways in which Africa is discursively understood by both, African and Western scholarship, higher education policy in Mozambique, interviews with senior administrators of some Mozambican higher education institutions and text materials from higher education institutions’ websites in Mozambique. The findings suggest that, on the one hand, constructions of Africa as being in crisis are not new. In fact, for centuries Africa has always been a subject of knowledge from which the West constructs its differences. It is from such differences that the West assumed a civilizing mission in order to integrate African peoples in the world order. On the other hand, African scholars’ responses to Western constructions of Africa’s experiences end up building another crisis at the theoretical level: the difficulties of thinking effectively on Africa so as to solve its problems. The second finding is that Mozambican higher education’s responses to the crisis have been marked by a development agenda within the broader context of Mozambique’s history from late the 1970s onwards: first, within the socialist model of central planning economy and, second, within the international agenda of global neo-liberal market economy. My analysis suggests that both development practices reflect, to some extent, continuities of colonial regimes of development which did not take into account the contextualities of the colonized. Finally, my investigation found that higher education institutions in Mozambique are responding to development challenges based on very technological conceptions of development following global trends. The thesis contends that an engagement with the ethics of knowledge and development would lead to a development model more preoccupied with the social contexts beyond market rationalities.

This thesis investigates the ways in which higher education in Africa has been construing its mission for Africa’s development and how such constructions are shaped by particular global regimes of knowledge on development. The thesis unpacks the ways in which such regimes are deployed using specific technologies: neo-liberal precepts on economic development. To that end, I pose a set of questions which can be summarized in these two: How has higher education in Africa discursively construed Africa’s experiences? Second, in which terms such constructions have helped responding to Africa’s problems of development? Taking Mozambican higher education as a unit of analysis, I used postcolonial theory to unsettle neo-liberal regimes of development and to show how contingent they are. Methodologically, a historical critique was carried out to historize neo-liberal globalization as a contingent process and to understand multiple possibilities of construing Africa’s experiences. My data consisted of texts discussing ways in which Africa is discursively understood by both, African and Western scholarship, higher education policy in Mozambique, interviews with senior administrators of some Mozambican higher education institutions and text materials from higher education institutions’ websites in Mozambique. The findings suggest that, on the one hand, constructions of Africa as being in crisis are not new. In fact, for centuries Africa has always been a subject of knowledge from which the West constructs its differences. It is from such differences that the West assumed a civilizing mission in order to integrate African peoples in the world order. On the other hand, African scholars’ responses to Western constructions of Africa’s experiences end up building another crisis at the theoretical level: the difficulties of thinking effectively on Africa so as to solve its problems. The second finding is that Mozambican higher education’s responses to the crisis have been marked by a development agenda within the broader context of Mozambique’s history from late the 1970s onwards: first, within the socialist model of central planning economy and, second, within the international agenda of global neo-liberal market economy. My analysis suggests that both development practices reflect, to some extent, continuities of colonial regimes of development which did not take into account the contextualities of the colonized. Finally, my investigation found that higher education institutions in Mozambique are responding to development challenges based on very technological conceptions of development following global trends. The thesis contends that an engagement with the ethics of knowledge and development would lead to a development model more preoccupied with the social contexts beyond market rationalities.

This thesis investigates the ways in which higher education in Africa has been construing its mission for Africa’s development and how such constructions are shaped by particular global regimes of knowledge on development. The thesis unpacks the ways in which such regimes are deployed using specific technologies: neo-liberal precepts on economic development. To that end, I pose a set of questions which can be summarized in these two: How has higher education in Africa discursively construed Africa’s experiences? Second, in which terms such constructions have helped responding to Africa’s problems of development? Taking Mozambican higher education as a unit of analysis, I used postcolonial theory to unsettle neo-liberal regimes of development and to show how contingent they are. Methodologically, a historical critique was carried out to historize neo-liberal globalization as a contingent process and to understand multiple possibilities of construing Africa’s experiences. My data consisted of texts discussing ways in which Africa is discursively understood by both, African and Western scholarship, higher education policy in Mozambique, interviews with senior administrators of some Mozambican higher education institutions and text materials from higher education institutions’ websites in Mozambique. The findings suggest that, on the one hand, constructions of Africa as being in crisis are not new. In fact, for centuries Africa has always been a subject of knowledge from which the West constructs its differences. It is from such differences that the West assumed a civilizing mission in order to integrate African peoples in the world order. On the other hand, African scholars’ responses to Western constructions of Africa’s experiences end up building another crisis at the theoretical level: the difficulties of thinking effectively on Africa so as to solve its problems. The second finding is that Mozambican higher education’s responses to the crisis have been marked by a development agenda within the broader context of Mozambique’s history from late the 1970s onwards: first, within the socialist model of central planning economy and, second, within the international agenda of global neo-liberal market economy. My analysis suggests that both development practices reflect, to some extent, continuities of colonial regimes of development which did not take into account the contextualities of the colonized. Finally, my investigation found that higher education institutions in Mozambique are responding to development challenges based on very technological conceptions of development following global trends. The thesis contends that an engagement with the ethics of knowledge and development would lead to a development model more preoccupied with the social contexts beyond market rationalities.

This thesis investigates the ways in which higher education in Africa has been construing its mission for Africa’s development and how such constructions are shaped by particular global regimes of knowledge on development. The thesis unpacks the ways in which such regimes are deployed using specific technologies: neo-liberal precepts on economic development. To that end, I pose a set of questions which can be summarized in these two: How has higher education in Africa discursively construed Africa’s experiences? Second, in which terms such constructions have helped responding to Africa’s problems of development? Taking Mozambican higher education as a unit of analysis, I used postcolonial theory to unsettle neo-liberal regimes of development and to show how contingent they are. Methodologically, a historical critique was carried out to historize neo-liberal globalization as a contingent process and to understand multiple possibilities of construing Africa’s experiences. My data consisted of texts discussing ways in which Africa is discursively understood by both, African and Western scholarship, higher education policy in Mozambique, interviews with senior administrators of some Mozambican higher education institutions and text materials from higher education institutions’ websites in Mozambique. The findings suggest that, on the one hand, constructions of Africa as being in crisis are not new. In fact, for centuries Africa has always been a subject of knowledge from which the West constructs its differences. It is from such differences that the West assumed a civilizing mission in order to integrate African peoples in the world order. On the other hand, African scholars’ responses to Western constructions of Africa’s experiences end up building another crisis at the theoretical level: the difficulties of thinking effectively on Africa so as to solve its problems. The second finding is that Mozambican higher education’s responses to the crisis have been marked by a development agenda within the broader context of Mozambique’s history from late the 1970s onwards: first, within the socialist model of central planning economy and, second, within the international agenda of global neo-liberal market economy. My analysis suggests that both development practices reflect, to some extent, continuities of colonial regimes of development which did not take into account the contextualities of the colonized. Finally, my investigation found that higher education institutions in Mozambique are responding to development challenges based on very technological conceptions of development following global trends. The thesis contends that an engagement with the ethics of knowledge and development would lead to a development model more preoccupied with the social contexts beyond market rationalities.

Thesis (D. Min.)--Covenant Theological Seminary, 1995. / Abstract. Includes bibliographical references (leaves [1-11] (2nd group)).