This thesis deals with issues of project financing in a non-profit sector. Using management decisions approach tries to contribute to finding a suitable portfolio of financing the Experience Pilsen! project. The goal is to identify, through the decision-making process, such possible solutions that lead to ensuring financial stability in the new project period. The thesis reviews the decision-making process from the analyzing the situation to the selection of the optimum variants. Analysis to determine the decision-making situation, consultations with experts and decision tree methods such as causal relations, the Six thinking hats method and other methods are used. Based on the gathered information a support resources portfolio is designed. It represents a set of optimal variants of solving the decision-making problem.

This thesis deals with the research of consumer behavior and specifics of buyer decision-making process of Czechs during booking of their foreign holidays and methodology of market segmentation in tourism, or in the segment of cruises. Analysis of current trends and determinants on the supply and demand helps to build a competitive marketing strategy emerging of travel agency in the segment of cruises.

Consumer satisfaction is key for retailers to retain loyal consumers. Retailers use apparel brands as a strategy to differentiate themselves in the market place, to attract potential consumers and to retain loyal consumers. Retailers have discovered the potential of the fuller figure sector as a lucrative market which can assist them to make profits and to increase their sales. The aim of this research is firstly to explore and describe the needs and expectations that the fuller figure South African working women have with branded career wear secondly, how they evaluate branded career wear apparel against the two broad quality dimensions namely functional and aesthetic dimensions and thirdly the problems they experience with the functional and aesthetic quality dimensions of branded career wear. The study also describes how fuller figure South African working women consumers further evaluate the branded apparel during the decision-making process which can ultimately lead to her either accepting or rejecting the branded career wear. This research is descriptive in nature, as an attempt is made to describe and understand how working fuller figure females evaluate branded apparel against certain quality dimensions and make decisions to purchase branded apparel to satisfy their needs. The Sproles and Burns’ (1994:264) decision-making model theoretical underpins the study. A quantitative research style was chosen for this study and the objectives and sub- objectives related to the needs and problems of the quality dimensions of the branded career wear were examined. A self-administered, structured questionnaire was designed to gain demographic information of the sample group, their store preferences, where they get their fashion information from as well as their needs and problems with regard to branded career wear apparel. Purposive sampling and snowball sampling techniques were used to select a sample of working fuller figure females in the Tshwane, South Africa area. The responses to the 150 questionnaires were coded, captured and analysed using descriptive and inferential statistics. The results of this study revealed that most of the respondents ranked the functional quality dimensions higher than the aesthetic quality dimensions. It is clear that most of the fuller figure consumers regard comfort as the most important need, followed by durability (that the material of the branded career wear should be of good quality). The sample group also regarded the emotional aesthetic aspects very important (that the styles are beautiful and make her feel feminine). It is contradictory, that these fuller figure working women experienced major problems with the quality dimensions that they ranked as highly important. The sample group experienced problems with fit at the functional and aesthetic level, although fit is one of the most important factors that consumers use during the evaluation of apparel items. This study makes certain recommendations to apparel retailers, fashion theorists and image consultants how to obtain optimal consumer satisfaction. The South African apparel retailers should take cognisance of the needs and problems of this growing market related to the functional and aesthetic quality dimensions. The study also revealed how age and income play a role regarding the needs and problems this sample group experienced with branded career wear and how this can influence their decision to either accept or reject a brand. The results contribute to the body of knowledge regarding the needs and problems of branded career wear apparel for the fuller figure market related to certain functional and aesthetic quality dimensions Copyright / Dissertation (MConsumer Science)--University of Pretoria, 2012. / Consumer Science / unrestricted

Magister Administrationis - MAdmin / The research investigation explores the topic from the point of view of intergovernmental institutions and the regional (departmental) decision-making process in Santa Cruz- Bolivia. The purpose was to determine if these institutions influence the decision-making process of actors in the area of road infrastructure. The topic is explored from the viewpoint of Actor-Centered Institutionalism from Scharpf. It states that the solutions to solve social problems can be explained as the outcome of interactions among intentional actors, but that these interactions are structured and outcomes are influenced by the characteristics of the institutional setting in which they occur. For that purpose, the study identifies the actor constellations participating in the process, their modes of interaction and the constraints they face as a result of the institutional setting. The research starts by distinguishing the formal, informal and fiscal lOR institutions and determine their importance; for this purpose, the classification by Agranoff is used. Afterwards, the investigation portrays the decision-making process in the area and analyzes the final decisions of actors as a result of the institutions shaping them. It is argued that mostly fiscal arrangements are shaping the decision-making process in the area. The formal and informal arrangements are determining the actor constellations participating in the process and how they interact, as well as which institutional constraints they face. It is concluded that there are missing channels of intergovernmental cooperation between the national and the departmental level, and it generates misunderstandings and uncertainty. The channels of cooperation between the department and the provinces exist, but training and technical advice is needed to enhance actors' capacities at this level. The mini-thesis concludes with the policy implications derived from the dynamics at the regional level and identifying other factors influencing the decision-making process.

This diploma thesis is focused on examining the activities of production planning and examining the efficiency of the selected machine in the selected company. The theoretical part summarizes the most important findings and methods of lean manufacturing and corrective measures to prevent or eliminate downtime. In the analytical part, the selected machine is examined in terms of the production process, then an analysis of the current state and assessment of the collected data is performed. Furthermore, an analysis of the decision-making process in production planning for a selected machine was performed and shortcomings in planning were assessed. The practical part contains suggestions for removing the identified bottlenecks.

This thesis responds to the need of the company ILLKO, s.r.o. to develop and unify the decision-making process for cases when there is a customer request for a special or extraordinary type of product. In the thesis, the business area of the company, supplier and customer spectrum are described as well as a summary of the company’s capacity and capabilities. The output is a formalized decision-making process reflecting both theoretical knowledge based on the academic bibliography and long-term approved experience gained from the business practice. This process is clearly illustrated in schematic flow charts which are described in detail in corresponding chapters. The developed methodological procedure will help the top management of the company to facilitate, automate and improve future decision-making on the specific customer requirements.

This diploma thesis deals with the evaluation of supplier risk for a chosen company Vinařství Soška using the fuzzy logic principles. This company like many others is forced to shift its sales to the Internet environment due to the government restrictions established to reflect the pandemic situation. For a successful Internet business, it is necessary to choose an optimal ecommerce software based on the company requirements. For this purpose, two fuzzy logic models are built in Microsoft Excel and MATLAB software. Their aim is to evaluate the potential risk of all of the suppliers. Based on this evaluation, the results are transformed into specific recommendations on how to choose the optimal solution for the company. The first chapters deal with the general theory that is later used in the analytical part.

The master’s thesis deals with a use of artificial intelligence as a support for decision in a company. The thesis contains application which is based on techniques of genetic algorithms and sets of conditions to determine the deployment of transmitters for internet connection in a given location.

Cílem této diplomové práce je navrhnout vhodnou metodu pro vyhodnocení dodavatelů průmyslových větráku pro společnost První brněnská strojírna a.s. (PBS Brno). Společnost existuje více než 200 let na trhu a má více než 100 dodavatelů po celém světě. Proto je potřeba navrhnout adekvátní systém hodnocení dodavatelů. Pro vyhodnocení budou použité programy MS Excel a MATLAB.

L’addiction à la nicotine est une pathologie qui concerne un tiers de la population adulte mondiale et qui est souvent associée avec d’autres troubles psychiatriques tels que la dépression, la schizophrénie ou encore les troubles liés au stress. Chaque année, près de 8 millions de personnes décèdent des conséquences de la consommation de tabac. Cette pathologie constitue la première cause de morts évitables dans le monde. Ce phénomène de dépendance au tabac est induit par la nicotine, principale substance addictive et psychoactive du tabac, qui va agir sur les récepteurs nicotiniques de l’acétylcholine (nAChR) et ainsi détourner le fonctionnement normal de différents circuits neuronaux. De manière aigüe, la nicotine agit directement sur les nAChR ce qui va globalement activer les réseaux neuronaux. A plus long terme, elle va induire une plasticité synaptique et perturber la transmission nicotinique endogène. La nicotine va notamment détourner le système dopaminergique, acteur majeur de l’apprentissage par renforcement, de la motivation et de l’évaluation de la récompense. Ces modifications neuronales conduisent non seulement au renforcement mais entrainent aussi une perturbation de différents traits comportementaux (prise de décision, exploration, vulnérabilité au stress, etc.). Ces relations entre symptômes et traits pourraient expliquer les fortes comorbidités observées entre la dépendance aux drogues d’abus, et particulièrement au tabac, et d’autres manifestations pathologiques telles que les troubles liés au stress. Au cours de cette thèse j’ai tout d’abord abordé les bases neurophysiologiques qui sous-tendent ces comorbidités, en proposant la dopamine comme un substrat commun aux effets du stress social, de la nicotine et des perturbations de la prise de décision associées (impulsivité, sensibilité à la récompense, évaluation du risque, etc.). J’ai pu montrer que l’augmentation de l’activité des neurones dopaminergiques observée après une exposition à la nicotine ou à un stress social est responsable des perturbations des comportements de choix chez la souris. En effet, nous avons pu reproduire ces altérations comportementales en élevant artificiellement le niveau d’activité des neurones dopaminergiques à l’aide de stimulations optogénétiques. La dissection des mécanismes par lesquels la nicotine détourne les circuits neuronaux se heurte aujourd’hui à un manque d’outils permettant une manipulation sélective, réversible et avec une résolution spatio-temporelle suffisante des acteurs moléculaires impliqués. Une deuxième partie de mon travail de thèse a consisté en l’implémentation in vivo chez la souris, de la pharmacologie optogénétique pour les nAChR. La photo-inhibition des nAChR contenant la sous-unité beta2 nous a permis de mettre en évidence l’impact de la modulation cholinergique endogène sur l’activité des neurones dopaminergiques. Nous avons pu, en outre, inhiber la réponse de ces mêmes neurones à l’injection intraveineuse aiguë de nicotine et le renforcement associé dans une tâche de préférence de place conditionnée pour la nicotine. / Nicotine addiction is a condition that affects one third of the world's adult population and is often associated with other psychiatric disorders such as schizophrenia, mood- and stress-related disorders. Every year, nearly 8 million people die from the consequences of tobacco use. This pathology is the leading cause of preventable death in the world. This phenomenon of tobacco dependence is induced by nicotine, the main addictive and psychoactive substance in tobacco, which acts on nicotinic acetylcholine receptors (nAChRs) and thus hijacks the normal functioning of various neuronal circuits. Acute nicotine directly acts on nAChRs and activates neural networks. In the longer term, it will induce synaptic plasticity and disrupt endogenous nicotinic transmission. In particular, nicotine disrupts the dopaminergic system, a key player in reinforcement learning, motivation and reward evaluation. These neural changes not only lead to reinforcement but also to a disruption of different behavioral traits such as decision-making, exploration, vulnerability to stress, etc. These relationships between symptoms and features could explain the strong comorbidities observed between substance abuse, and particularly tobacco addiction, and other pathologies such as stress-related disorders. During this thesis, I first addressed the neurophysiological bases underlying these comorbidities, by proposing dopamine as a common substrate for the effects of social stress, nicotine and associated decision-making disorders (impulsivity, reward sensitivity, risk assessment, etc.). I have shown that the increase in dopamine neuron activity observed after exposure to nicotine or social stress is responsible for disrupting choice behavior in mice. Indeed, we could reproduce these behavioral maladaptations by artificially increasing the activity level of dopaminergic neurons using optogenetic stimuli. The dissection of the mechanisms by which nicotine diverts neuronal circuits is currently hampered by a lack of tools for selective, reversible, spatially and temporally precise manipulation of the molecular players involved. A second part of my thesis work consisted in the in vivo implementation in mice of optogenetic pharmacology for nAChR. The photoinhibition of beta2-containing nAChRs revealed the impact of endogenous cholinergic modulation on the activity of dopaminergic neurons. We could optically inhibit the response of these same neurons to acute intravenous injection of nicotine and the associated reinforcement in a task of conditioned place preference for nicotine.