No description available.

A problem in modern, agile aircraft is the possibility of the pilot losing consciousness during manoeuvres which can impose forces (G) many times that of gravitational acceleration. There is a possibility that the next generation of agile aircraft will exceed the level of anti-G protection presently available and the possibility of pharmacological intervention had been considered as an additional means of raising G-tolerance. Arginine vasopressin plays an active role in maintaining blood pressure, particularly in hypovolaemic situations, by its powerful vasoconstrictive action and control of heart output. As a potential G protection agent AVP has the appeal of not appearing to produce hypertension. The human centrifuge has normally been used to investigate problems of acceleration protection, but because of the hostile environment and space restraints, it has been difficult to carry out systematic biochemical investigations and lower body negative pressure has been used to simulate the cardio-vascular stress of G. The level of plasma catecholamines and arginine vasopressin has been measured during different exposure levels to lower body negative pressure and following b blockade with Propranolol combined with lower body negative pressure. No correlation could be established between peripheral circulating plasma levels of catecholamines and arginine vasopressin for any of the experimental conditions. However, dramatic oscillations in plasma noradrenaline levels were seen and a distinct pattern of arginine vasopressin secretion was observed at presyncope. The role of arginine vasopressin during syncope was investigated and small increases in plasma levels of this vasoactive hormone appeared to play a protective role in some subjects. In subsequent experiments, a bolus of arginine vasopressin was injected prior to exposure to lower body negative pressure, but this did not appear to have any effect on tolerance to lower body negative pressure and in some subjects it was positively detrimental.

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No description available.

No description available.

The purpose was to directly assess the relative contributions of the anaerobic energy releasing pathways to ATP provision during very brief (2-14s) maximal isometric contractions in human skeletal muscle, and to examine the recovery processes following such exercise. Eleven males performed unilateral sustained maximal isometric contractions of the knee-extensor muscles. Ten needle biopsy samples [2 pre-exercise (PreEx), 4 exercise (Ex), and 4 recovery (Rec) samples] were obtained from each subject over 3 separate testing sessions. Circulation was occluded at the upper thigh prior to all biopsies. Ex samples were taken immediately following 2-14s of maximal voluntary contraction. Contraction times were randomly pre-determined such that 6 biopsies were obtained following each of 2, 4, 6, 8, 10, 12, and 14s of contraction. Rec samples were collected 10, 20, 30, 40, 60, 120, and 180s following 14s maximum contractions. Significant changes occurred for both phosphocreatine (PCr) and lactate concentration within the initial 2s (n=7, p≤0.05) of contraction. In 14s, PCr concentration decreased to 53.3% of the PreEx value at a rate of 2. 53±0 .18 mmol· kg⁻¹dm · s⁻¹, while muscle lactate increased to approximately 8 times the initial value, at a steady rate of 1. 52±0 .10 mmol ·kg⁻¹ s⁻¹. Following contraction, PCr returned to the PreEx value within 60s of recovery (n=4, p>O. OS) , but muscle lactate concentration was still significantly elevated above resting after 180s of recovery (n=4, ≤0.05). Total ATP production over 14s was 69.03±4.47 ⁻¹dm, with an average turnover rate of 4.93±0.32 mmol·kg⁻¹dm·s⁻¹. The initial ATP turnover rate was 7. 26±1. 94 mmol· kg⁻¹ dm· s⁻¹ with 67% of the ATP being derived from PCr degradation and 33% from glycogenolysis. As contraction continued, however, there was an almost equal contribution to ATP provision from the 2 anaerobic energy delivery pathways, and (with the exception of the first 2 seconds) the proportion changed very little over time. This study was supported by the Natural Sciences and Engineering Research Council of Canada. / Thesis / Master of Science (MSc)

published_or_final_version / Environmental Management / Master / Master of Science in Environmental Management

This novel is a work of historical fiction that explores the aftermath of the execution of a local doctor who became infamous after preserving the corpse of his beloved. The two protagonists journey to Key West from Miami during the summer of 1952 to investigate the disappearance of the girl's missing bones, but soon find themselves embroiled in a mystery that plumbs the most terrifying depths of love and its disquieting entanglements. The tale follows the protagonists, Lens Burnside and Iris Elliot, as they navigate the island's darkest corridors and expose a few of its most unusual secrets on a journey of love, mayhem and madness as they fall under the spell of the island and fall in love with each other. / by Courtney Watson. / Thesis (M.F.A.)--Florida Atlantic University, 2009. / Electronic reproduction. Boca Raton, Fla., 2009. Mode of access: World Wide Web.

Thesis (doctoral)--Université de Genève, 1981. / At head of title: Université de Genève, Faculté des sciences économiques et sociales. Includes bibliographical references (p. [738]-790) and index.

Thesis (Ph.D.)--York University, 2005. Graduate Programme in History. / Typescript. Includes bibliographical references (leaves 382-415). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:NR19818