En esta investigación se busca identificar cuáles son las estrategias discursivas utilizadas en la narrativa audiovisual de los canales de YouTube La habitación de Henry Spencer y El diario de Curwen. A partir de ello, se podrán establecer las similitudes y diferencias que poseen ambos personajes al momento de elaborar su puesta en escena. El análisis está principalmente enfocado en el abordaje de los temas que tratan Spencer y Curwen, el lenguaje coloquial que utilizan para dirigirse a sus seguidores, el escenario o la ambientación donde se desenvuelven y el personaje que construyen para acompañar su discurso. Las premisas mencionadas para la revisión del contenido de estos canales de YouTube, nacen a partir de los argumentos que plantean algunos autores como Laura León (2018), Santiago Torrente (2015) y Erving Goffman (1997), quienes hablan de la importancia del personaje y de su puesta en escena para la creación de contenido, en este caso de los youtubers. Por otro lado, Márquez y Ardévol (2018) explican que el uso de un lenguaje adecuado es fundamental para lograr conectar con el público. Con las teorías mencionadas se llevó a cabo el estudio de algunos videos difundidos en los canales de ambos personajes y se identificaron las estrategias que ellos utilizan para lograr la atención de sus seguidores y diferenciarse de otros emisores que forman parte del escenario digital YouTube. / This research seeks to identify what are the discursive strategies used in the audiovisual narrative of the YouTube channels of La habitación de Henry Spencer and El diario de Curwen From this, it will be possible to establish certain similarities and differences that both characters possess at the time of creating their staging. The analysis is mainly focused on addressing the issues that Spencer and Curwen deal with, the colloquial language they use to address their followers, the setting or setting where they perform, and finally the character they build to accompany their speech. The premises mentioned for the review of the content of these YouTube channels are born from the arguments raised by some of the authors of the theoretical framework such as, on the one hand, Laura León (2018), Santiago Torrente (2015) and Erving Goffman (1997), who talk about the importance of the character and its staging for the creation of content, in this case of youtubers. On the other hand, Márquez and Ardévol (2018) explain that the use of appropriate language is essential to connect with the public. With the mentioned theories, the study of the product of both characters was carried out, and the strategies they used to get the attention of their followers and differentiate themselves from other youtubers that are part of the YouTube digital stage were established. / Tesis

Thesis advisor: Masayuki Wasa / This dissertation describes the development of novel catalyst systems that could promote the regio- and enantioselective transformations of C-H bonds contained in N-alkylamines and ethers through Lewis acid-mediated hydride abstraction processes. The progress made in C-H functionalization of N-alkylamines and ethers that served as the intellectual foundation of this dissertation research are summarized in Chapter 1. Despite notable advances, the development of broadly applicable, enantioselective, and catalytic protocols to functionalize C-H bonds in N-alkylamines and ethers with high regio- and stereo-selectivity was regarded as an unsolved problem when we started this dissertation research. In an effort to overcome these fundamental limitations, we first identified a B(C6F5)3/Cu-PyBOX cooperative catalyst system for the enantioselective conversion of a-amino C-H bonds through the generation of an iminium by (F5C6)3B-catalyzed hydride abstraction process (Chapter 2). We then envisioned that in situ generated iminium ions could be further deprotonated to furnish an enamine intermediate, which may react with electrophilic species for a-amino C-H functionalization. The design and development of such a catalyst system were discussed in Chapter 3. Finally, we disclose enantioselective Cu–BOX-catalyzed hetero Diels-Alder reactions of enol ethers generated through Ph3C+-mediated oxidation of alkyl ethers. (Chapter 4). / Thesis (PhD) — Boston College, 2022. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Chemistry.

Joint models for longitudinal and survival data are a class of models that jointly analyse an outcome repeatedly observed over time such as a bio-marker and associated event times. These models are useful in two practical applications; firstly focusing on survival outcome whilst accounting for time varying covariates measured with error and secondly focusing on the longitudinal outcome while controlling for informative censoring. Interest on the estimation of these joint models has grown in the past two and half decades. However, minimal effort has been directed towards developing diagnostic assessment tools for these models. The available diagnostic tools have mainly been based on separate analysis of residuals for the longitudinal and survival sub-models which could be sub-optimal. In this thesis we make four contributions towards the body of knowledge. We first developed influence diagnostics for the shared parameter joint model for longitudinal and survival data based on Cook's statistics. We evaluated the performance of the diagnostics using simulation studies under different scenarios. We then illustrated these diagnostics using real data set from a multi-center clinical trial on TB pericarditis (IMPI). The second contribution was to implement a variance shift outlier model (VSOM) in the two-stage joint survival model. This was achieved by identifying outlying subjects in the longitudinal sub-model and down-weighting before the second stage of the joint model. The third contribution was to develop influence diagnostics for the multivariate joint model for longitudinal and survival data. In this setting we considered two longitudinal outcomes, square root CD4 cell count which was Gaussian in nature and antiretroviral therapy (ART) uptake which was binary. We achieved this by extending the univariate case i based on Cook's statistics for all parameters. The fourth contribution was to implement influence diagnostics in joint models for longitudinal and survival data with multiple failure types (competing risk). Using IMPI data set we considered two competing events in the joint model; death and constrictive pericarditis. Using simulation studies and IMPI dataset the developed diagnostics identified influential subjects as well as observations. The performance of the diagnostics was over 98% in simulation studies. We further conducted sensitivity analyses to check the impact of influential subjects and/or observations on parameter estimates by excluding them and re-fitting the joint model. We observed subtle differences, overall in the parameter estimates, which gives confidence that the initial inferences are credible and can be relied on. We illustrated case deletion diagnostics using the IMPI trial setting, these diagnostics can also be applied to clinical trials with similar settings. We therefore make a strong recommendation to analysts to conduct influence diagnostics in the joint model for longitudinal and survival data to ascertain the reliability of parameter estimates. We also recommend the implementation of VSOM in the longitudinal part of the two-stage joint model before the second stage.

Masters of Art / Many empirically supported versions of stage and componential models of the cognitive processing underlying the completion of various tasks spanning a wide range of domains have been developed by cognitive scientists of various kinds. These include models of scientific (e.g. Dunbar 1999), mathematical (e.g. Schoenfeld 1985), artistic (e.g. Getzels and Csikszentmihalyi 1976), engineering (e.g. Purzer et al 2018), legal (e.g. Ronkainen 2011), medical (e.g. Vimla et al 2012) and even culinary cognition (e.g. Stierand and Dörfler 2015) (and this list is nowhere near exhaustive). Yet, despite the existence of fields such as experimental and metaphilosophy which take philosophy as their object, often by using methods from the cognitive sciences, a stage or componential model of philosophizing is conspicuously missing from even an exhaustive list of the kind just produced.

Thesis advisor: Masayuki Wasa / This dissertation describes the development of cooperative catalyst systems for the functionalization of monocarbonyl compounds and stereoselective transformations of alpha-C–H bonds of N-alkylamines, inspired by the concepts of frustrated Lewis pairs (FLPs). Prior to this dissertation research, practical and broadly applicable C–C and C–heteroatom bond forming reactions involving the FLP complexes that provide synthetically desirable products with high enantioselectivity remained to be developed. Chapter 1 of this dissertation describes the recent advances in the transformations involving FLPs and B(C₆F₅)₃-catalyzed reactions. Inspired by the unique capability of FLP catalysts to activate otherwise unreactive molecules, and circumvent undesirable acid–base complexation, we have developed potent cooperative acid/base catalysts for C–C bond forming reactions of various monocarbonyl compounds and an appropriate electrophile, which will be discussed in Chapter 2. Another reactivity of FLPs to be explored has to do with the catalytic and enantioselective reactions of N-alkylamines, where two Lewis acid catalysts with potentially overlapping functions, work cooperatively to activate alpha-amino C–H bonds and promote the enantioselective C–C bond forming reaction between N-alkylamines and a nucleophilic species. In Chapter 3, B(C₆F₅)₃-catalyzed union of N-alkylamines and silicon enolates followed by the enantioselective B(C₆F₅)₃/Mg–PyBOX-catalyzed alpha-alkylation of N-alkylamines and alpha,beta-unsaturated compounds to form beta-amino carbonyl compounds will be described. In Chapter 4, B(C₆F₅)₃/Cu–PyBOX-catalyzed alpha-C–H alkynylation of N-alkylamines and the applications in late-stage functionalization and stereoselective synthesis will be discussed. / Thesis (PhD) — Boston College, 2020. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Chemistry.

Background Glomerulonephritis is a major cause of end-stage kidney disease (ESRD) in Africa. There is scanty data on the clinico-pathological characteristics and outcome of the mesangioproliferative glomerulonephritides in Africa, despite the non-IgA subtype being reported as a common cause of nephrotic syndrome. This study will assess the outcome of patients with biopsy proven mesangioproliferative glomerulonephritis (MesPGN) from a single centre in Cape Town, South Africa. Methods The study is designed as 10-year retrospective analysis of patients with biopsy proven MesPGN. The MesPGN patterns were divided into non-IgA MesPGN and IgA nephropathy (IgAN), depending on the predominant type of immune deposit. Univariate cox regression analysis was used to determine factors associated with ESRD. Results Data of 109 patients with renal biopsy-proven MesPGN were included for the period between 2005-2014. The mean age at biopsy was 33.8 ±14.9 years, 53.2% were males, and 39.4% were black Africans. Clinically, 58.7% presented with nephrotic syndrome. On histology 79.8% had non-IgA MesPGN, and 20.2% had IgAN. Compared to the non-IgA group, most patients with IgAN were not treated with immunosuppression (72.7% vs. 40.2%; p=0.006). At the last visit, 10.1% reached ESRD (40.9% vs. 2.3%; p<0.0001) and 30.2% achieved complete remission (9.1% vs. 35.7%; p=0.015) for IgAN and non-IgA MesPGN respectively. The 5-year renal survival for IgAN and non-IgA MesPGN respectively, were: 63.3% vs. 97.6%, log rank p=0.001. Overall, hypertension (p=0.019), not receiving immunosuppression (p=0.046) and having IgAN (p=0.007) were independent predictors of progression to ESRD. Conclusion There is a significantly higher ESRD-free survival of patients with biopsy proven non-IgA MesPGN than IgAN. Whether this is related to the limited use of immunosuppressive therapy in IgAN patients or represents a true nature of the disease still requires further research.

It has always been for me a personal source of regret that so much dramatic art is wasted, so to speak, on the unknowing times . The performances of many actors and actresses have often been of greater creative value and artistic invention than the efforts of the playwrights themselves. Yet the annals of history preserve, for all time, the written word, while the sound and emotion of great acting is lost with its moment. Only the scant impressions of the casual playgoer survive to bring back a faded view of what glory the stage must have known when great talents graced its boards.

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Research was conducted in 2013 and 2014 to evaluate the postemergence control of Palmer amaranth [Amaranthus palmeri (S.) Wats.] with mesotrione alone and in mixtures with fomesafen and/or glyphosate and to evaluate the impact of lactofen and planting date on growth, development, and yield of indeterminate soybean [Glycine max (L.) Merr.]. Studies included a greenhouse evaluation of different rates of mesotrione on the control of 5- and 10-cm Palmer amaranth and field studies evaluating the control of 5- to 10-cm Palmer amaranth with three rates of mesotrione applied alone and in mixtures with fomesafen and/or glyphosate. Lactofen studies include a planting date study evaluating one rate of lactofen applied at V2 soybean stage with planting dates of April 15, May 1, May 15, and June 1 and a lactofen timing study where one rate of lactofen was applied at soybean growth stages ranging from V1 to R5.