Submitted by Franciele Moreira (francielemoreyra@gmail.com) on 2017-09-12T17:30:52Z No. of bitstreams: 2 Dissertação - Táric Ramon Marques Martins - 2017.pdf: 2380133 bytes, checksum: 33d24de03c73f9a88934ebdeafa14222 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-09-19T13:43:32Z (GMT) No. of bitstreams: 2 Dissertação - Táric Ramon Marques Martins - 2017.pdf: 2380133 bytes, checksum: 33d24de03c73f9a88934ebdeafa14222 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2017-09-19T13:43:32Z (GMT). No. of bitstreams: 2 Dissertação - Táric Ramon Marques Martins - 2017.pdf: 2380133 bytes, checksum: 33d24de03c73f9a88934ebdeafa14222 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2017-08-04 / Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEG / The drugs have had a great positive impact on humanity, contributing directly to the prevention of diseases, and increased quality and expectancy of life. However, with widespread use among the population, several microorganisms have become resistant to marketed drugs, being necessary to discover new formulations and substances effective against the main mechanisms of resistance. The classes of compounds called semicarbazones (SCs) and thiosemicarbazones (TSCs) have received great attention from the researchers. This is due to its pharmacological activities, such as antibacterial activity. Thus the objective of this work was to synthesize new organic compounds, to characterize them spectroscopically and structurally, and to perform biological tests against pathogens. Two hydrazones, one semicarbazone and one thiosemicarbazone were synthesized and characterized. Biological tests with the four compounds for evaluation of antibacterial and antifungal activity determined the Minimum Inhibitory Concentration (MIC). The compound N-methyl-2- [1,1,1-trifluoro-4-oxo-4- (thiophen-2-yl) butan-2-ylidene] hydrazine carbothioamide (compound 1) showed antibacterial activity against Gram negative Serratia marcescens (MIC 64 μg/mL) and Gram positive bacteria Enterococcus faecalis (MIC 64 μg/mL). The compound (2Z)-2-[1,1,1-trifluoro-4-oxo-4-(thiophen-2-yl) butan-2-ylidene] hydrazine carboxamide (compound 4) showed antibacterial and antifungal activity with the minimum inhibitory concentration between 32 μg/mL and 256 μg/mL. / Os medicamentos trouxeram um grande impacto positivo sobre a humanidade; contribuindo diretamente para a prevenção de doenças, contribuindo para qualidade e aumento da expectativa de vida. No entanto com o uso amplamente difundido entre a população, vários microrganismos tem adquirido resistência aos medicamentos comercializados, sendo necessário a descoberta de novas formulações e substancias efetivas contra os principais mecanismos de resistência. As classes de compostos denominadas semicarbazonas (SCs) e tiossemicarbazonas (TSCs) vêm recebendo grande atenção dos pesquisadores. Esse fato se deve as suas atividades farmacológicas, como por exemplo a atividade antibacteriana. Dessa forma o objetivo deste trabalho foi sintetizar novos compostos orgânicos, caracterizar espectroscopicamente e estruturalmente, e realizar testes biológicos frente a agentes patogênicos. Foram sintetizadas e caracterizadas duas hidrazonas, uma semicarbazona e uma tiossemicarbazona. Os testes biológicos com os quatro compostos para avaliação da atividade antibacteriana e antifúngica, determinaram a Concentração inibitória mínima (MIC). O composto N-methyl-2- [1,1,1-trifluoro-4-oxo-4- (thiophen-2-yl) butan-2-ylidene] hydrazine carbothioamide (composto 1) apresentou atividade antibacteriana contra a bactéria Gram negativa Serratia marcescens (MIC 64 μg/mL) e a bactéria Gram positiva Enterococcus faecalis (MIC 64 μg/mL). O composto (2Z)-2-[1,1,1-trifluoro-4-oxo-4-(thiophen-2-yl)butan-2-ylidene] hydrazinecarboxamide (composto 4) apresentou atividade antibacteriana e antifúngica com a concentração inibitória mínima entre 32 μg/mL a 256 μg/mL.