Thesis (doctoral)--Rostock, 1934.

Thesis (doctoral)--Rostock, 1934.

Thesis (doctoral)--Rostock, 1933.

Thesis (doctoral)--Rostock, 1933.

This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).

No description available.

Human papillomavirus is connected with induction of cervical carcinoma as well as for some other anogenital carcinomas and subset of carcinomas of head and neck. Presence of viral E6 and E7 oncoproteins may induce cell transformation, higher load of oncoproteins is caused by the regulatory E2 protein inactivation. Aims of recent study are mechanisms of E2 protein inactivation. One option is integration of viral DNA into the host genome, which is located into the E2 gene region. Some carcinomas, where virus with extrachromosomal form was presented, were found. It appears that epigenetic changes can play the role in the development of this type of tumors, especially DNA methylation or mutation in the regulatory region of the virus. The methylation degree analysis on samples of tonsillar carcinomas with extrachromosomal and integrated form of the virus was conduced, as well as viral load of both groups was compared and the expression of E6 and E7 gene was confirmed. The results of methylation analysis showed increased methylation of the virus with integrated DNA. Mutations in the E2 protein binding sites are not revealed. The expression of the viral oncogenes were confirmed in all tumors regardless of the form of the viral genome. The mechanism of tumors induction, especially for virus with...

Propôs-se a caracterização morfológica, funcional e de ocorrência das tonsilas linguais laterais. Compondo o Grupo experimental I, 25 espécimes de línguas humanas foram fixados em solução de formol a dez por cento e assim mantidos até o processamento. Os espécimes foram submetidos à exposição radiográfica para detecção de algum tecido mineralizado. As peças anatômicas foram examinadas a olho nu e com a utilização do estereomicroscópio. Obtiveram-se três blocos de tecido para a análise microscópica de cada espécime: um advindo da tonsila lingual e outros dois das margens laterais da região posterior do terço médio lingual, direito e esquerdo, respectivamente. Após o processamento histotécnico de rotina para coloração em hematoxilina-eosina de Harris, os espécimes foram analisados microscopicamente. Compondo-se o Grupo experimental II, procedeu-se à análise clínica dos tecidos moles bucais de 420 crianças em idade escolar, advindas da rede pública de ensino da cidade de Monte Negro, Estado de Rondônia, com o objetivo de se detectar a presença de tonsilas linguais laterais. Todas as análises, laboratoriais e clínicas, foram realizadas de forma descritiva e os dados obtidos, organizados e demonstrados comparativamente em tabelas e gráficos, com dados de freqüências absolutas e relativas. A análise clínica teve seus dados coletados correlacionados com a utilização do teste do quiquadrado. Aplicou-se a estatística kappa. Ao exame macroscópico: dos 25 espécimes de línguas humanas, nove apresentavam tonsilas linguais laterais (36%); o número de cristas nas papilas folhadas variou de um a seis. Ao microscópio óptico notou-se a presença de 16 espécimes com presença de tonsilas linguais laterais (64%, n=25); epitélio estratificado pavimentoso não queratinizado, com formação de criptas tonsilares e presença subepitelial de folículos linfóides. Na análise clínica, Grupo experimental II, o percentual de ocorrência de tonsilas linguais laterais (3,09%, n=420) foi proporcionalmente menor do que aquele obtido nos espécimes do Grupo experimental I (36%, n=25). Conclui-se que a ocorrência de tonsilas linguais laterais é maior quando obtida por análise microscópica, em comparação com a análise clínica. A presença e a morfologia das papilas folhadas linguais são inconstantes, quer no mesmo espécime, quer de um espécime para outro e podem mascarar a presença de tonsilas linguais laterais. / This study aimed to characterize the lateral lingual tonsils as to their morphology, function and occurrence. The experimental group I was composed of 25 specimens of human tongues fixated and kept in 10% formalin until processing. The specimens were radiographed for detection of any mineralized tissue. The specimens were examined by naked eye and with aid of a stereomicroscope. Three blocks of tissue were obtained from each specimen for microscopic analysis: one from the lingual tonsil and two from the lateral borders of the posterior region of medium, right and left thirds, respectively. After routine histotechnical processing and staining with Harris hematoxylin and eosin, the specimens were microscopically analyzed. The experimental group II was achieved by clinical analysis of oral soft tissues of 420 schoolchildren attending public schools at the city of Monte Negro, State of Rondônia, to investigate the presence of lateral lingual tonsils. All laboratory and clinical analyses were performed descriptively and data were organized and comparatively demonstrated on tables and graphs, presenting absolute and relative frequencies. The results of clinical analysis were correlated by utilization of the chisquare test. The kappa statistics was applied. Macroscopic examination of 25 specimens of human tongues revealed that nine presented lateral lingual tonsils (36%); the number of crests in each foliate papilla ranged from one to six. At the microscopic analysis of 25 specimens revealed that 16 presented lateral lingual tonsils (64%, n=25); non-keratinized stratified squamous epithelium with formation of tonsillar crypts and subepithelial presence of lymphoid follicles. With regard to clinical analysis of experimental group II, the percentage of occurrence of lateral lingual tonsils (3.09%, n=420) was proportionally lower than observed on specimens in experimental group I (36%, n=25). It was concluded that the occurrence of lateral lingual tonsils is higher when analyzed by microscopic analysis compared to clinical analysis. The presence and morphology of foliate papillae of the tongue are inconstant, both within and between specimens. They can mask lateral lingual tonsils.

Propôs-se a caracterização morfológica, funcional e de ocorrência das tonsilas linguais laterais. Compondo o Grupo experimental I, 25 espécimes de línguas humanas foram fixados em solução de formol a dez por cento e assim mantidos até o processamento. Os espécimes foram submetidos à exposição radiográfica para detecção de algum tecido mineralizado. As peças anatômicas foram examinadas a olho nu e com a utilização do estereomicroscópio. Obtiveram-se três blocos de tecido para a análise microscópica de cada espécime: um advindo da tonsila lingual e outros dois das margens laterais da região posterior do terço médio lingual, direito e esquerdo, respectivamente. Após o processamento histotécnico de rotina para coloração em hematoxilina-eosina de Harris, os espécimes foram analisados microscopicamente. Compondo-se o Grupo experimental II, procedeu-se à análise clínica dos tecidos moles bucais de 420 crianças em idade escolar, advindas da rede pública de ensino da cidade de Monte Negro, Estado de Rondônia, com o objetivo de se detectar a presença de tonsilas linguais laterais. Todas as análises, laboratoriais e clínicas, foram realizadas de forma descritiva e os dados obtidos, organizados e demonstrados comparativamente em tabelas e gráficos, com dados de freqüências absolutas e relativas. A análise clínica teve seus dados coletados correlacionados com a utilização do teste do quiquadrado. Aplicou-se a estatística kappa. Ao exame macroscópico: dos 25 espécimes de línguas humanas, nove apresentavam tonsilas linguais laterais (36%); o número de cristas nas papilas folhadas variou de um a seis. Ao microscópio óptico notou-se a presença de 16 espécimes com presença de tonsilas linguais laterais (64%, n=25); epitélio estratificado pavimentoso não queratinizado, com formação de criptas tonsilares e presença subepitelial de folículos linfóides. Na análise clínica, Grupo experimental II, o percentual de ocorrência de tonsilas linguais laterais (3,09%, n=420) foi proporcionalmente menor do que aquele obtido nos espécimes do Grupo experimental I (36%, n=25). Conclui-se que a ocorrência de tonsilas linguais laterais é maior quando obtida por análise microscópica, em comparação com a análise clínica. A presença e a morfologia das papilas folhadas linguais são inconstantes, quer no mesmo espécime, quer de um espécime para outro e podem mascarar a presença de tonsilas linguais laterais. / This study aimed to characterize the lateral lingual tonsils as to their morphology, function and occurrence. The experimental group I was composed of 25 specimens of human tongues fixated and kept in 10% formalin until processing. The specimens were radiographed for detection of any mineralized tissue. The specimens were examined by naked eye and with aid of a stereomicroscope. Three blocks of tissue were obtained from each specimen for microscopic analysis: one from the lingual tonsil and two from the lateral borders of the posterior region of medium, right and left thirds, respectively. After routine histotechnical processing and staining with Harris hematoxylin and eosin, the specimens were microscopically analyzed. The experimental group II was achieved by clinical analysis of oral soft tissues of 420 schoolchildren attending public schools at the city of Monte Negro, State of Rondônia, to investigate the presence of lateral lingual tonsils. All laboratory and clinical analyses were performed descriptively and data were organized and comparatively demonstrated on tables and graphs, presenting absolute and relative frequencies. The results of clinical analysis were correlated by utilization of the chisquare test. The kappa statistics was applied. Macroscopic examination of 25 specimens of human tongues revealed that nine presented lateral lingual tonsils (36%); the number of crests in each foliate papilla ranged from one to six. At the microscopic analysis of 25 specimens revealed that 16 presented lateral lingual tonsils (64%, n=25); non-keratinized stratified squamous epithelium with formation of tonsillar crypts and subepithelial presence of lymphoid follicles. With regard to clinical analysis of experimental group II, the percentage of occurrence of lateral lingual tonsils (3.09%, n=420) was proportionally lower than observed on specimens in experimental group I (36%, n=25). It was concluded that the occurrence of lateral lingual tonsils is higher when analyzed by microscopic analysis compared to clinical analysis. The presence and morphology of foliate papillae of the tongue are inconstant, both within and between specimens. They can mask lateral lingual tonsils.

Objective: To evaluate outcome of two types of tonsil surgery (tonsillectomy+adenoidectomy or tonsillotomy +adenoidectomy) on vocal function perceptually and acoustically. Study Design: Sixty-seven children, aged 50-65 months, on waiting list for tonsil surgery were randomized to tonsillectomy (n=33) or tonsillotomy (n=34). Fifty-seven age and gender matched healthy pre-school children were controls. Twenty-eight of them, aged 48-59 months, served as control group before surgery, and 29, aged 60-71 months, after surgery Methods: Before surgery and six months postoperatively, the children were recorded producing three sustained vowels (/A, u, i/) and 14 words. The control groups were recorded only once. Three trained speech and language pathologists performed the perceptual analysis using Visual Analogue Scales (VAS) for eight voice quality parameters. Acoustic analysis from sustained vowels included average fundamental frequency, jitter percent, shimmer percent, noise-to-harmonic ratio and the centre frequencies of formants 1-3 Results: Before surgery the children were rated to have more hyponasality and compressed/throaty voice (p<0,05) and  lower mean pitch (p<0,01) in comparison to the control group. They also had higher perturbation measures and lower frequencies of the second and third formant. After surgery there were no differences perceptually. Perturbation measures decreased but were still higher compared to the control group’s, p<0, 05. Differences in formant frequencies for /i/ and /u/ remained. No differences were found between the two surgical methods. Conclusion: Voice quality is affected perceptually and acoustically by adenotonsillar hypertrophy. After surgery the voice is perceptually normalized but acoustic differences remain. Outcome was equal for both surgical methods.