Thesis (doctoral)--München, 1934.

Thesis--Helsinki. / English summary. Includes bibliographical references (p. 47-50).

Thesis (doctoral)--Westfalen, 1933.

Thesis. / Includes bibliographical references.

The study deals with the question of minor oral surgery procedures, dental extractions especially, in patients suffering from haemocoagulation disorder. The aim of this study was 1) the clinical attestation of the risk of bleeding that may follow the dental extraction in patients with non-interrupted oral administration of drugs with the anticoagulant and antiplatelet effects and 2) suggestion of the schedules of surgical procedures suitable for this kind of patients and for the realization in the standard dental office. The opening theoretical part analyses the principle of haemocoagulation, the surway of individual inherited and acquired bleeding disorders and the main principles of treatment of bleeding patients in dental offices with the emphasis on the local security of the surgical wound. In the proper study we present the observation and evaluation of bleeding complications after the standard dental extractions in 3 groups of persons (age range, 19 to 93 years). In all patients, one or more extractions were performed. 99 patients were treated with oral anticoagulant therapy without any interruption and underwent 199 extractions. 149 patients, treated with antiplatelet therapy (acetylsalicylic acid) without interruption, underwent 347 extractions. 160 healthy subjects with 316 extractions served as a...

Made available in DSpace on 2014-06-11T19:27:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-01-23Bitstream added on 2014-06-13T18:56:32Z : No. of bitstreams: 1 fragelli_cmb_me_arafo.pdf: 308999 bytes, checksum: bf695c8170f901a2176a432528b18208 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Os objetivos deste estudo foram: observar a evolução clínica dos pacientes com HMI, para estabelecer a relação entre a sua severidade com fatores socioeconômicos, índice CPO-D e a presença de DDE, avaliar a evolução clínica do dente afetado por HMI, para estabelecer a relação com a presença de cárie, necessidade de tratamento e a ocorrência de perdas estruturais. Foram acompanhados 49 pacientes com HMI com idade entre 6 e 9 anos, totalizando 588 molares e incisivos com e sem alterações, que receberam tratamento preventivo e proteção com CIV quando indicados. As coletas de dados foram realizadas ao longo de 1 ano, com intervalos de 6 meses por meio de exame clínico, moldagem e fotografias. Um questionário semi-estruturado foi respondido pelas mães a fim de identificar a renda familiar, a escolaridade dos responsáveis e a fonte de água consumida. A análise descritiva, o teste Exato de Fisher, Qui-quadrado, McNemar e análise de sobrevida pelo método Kaplan-Meier foram usados para demonstrar os resultados encontrados. Houve uma associação significante entre o agravamento da HMI e o aumento do CPO-D. O nível sócio-econômico do paciente e a presença de DDE na dentição decídua não foram fatores relacionados à severidade. As fraturas pós-eruptivas ocorreram em 7 dos dentes afetados por manchas de HMI. Das restaurações acompanhadas, 16 apresentaram fratura, ocorridas todas nos primeiros molares permanentes. A presença de HMI apresentou estreita relação com a necessidade de tratamento e com o índice CPO-D. Com a grande possibilidade da estrutura afetada por HMI se manter hígida, 95% para manchas e 77% para restaurações atípicas, não se justifica a remoção, por completo ou prematuramente, da área afetada / The goals of this study were to evaluate the clinic prognostic of patients with molar-incisor-hypomineralization (MIH), to establish the relation between its severity with socioeconomic background factors, DMTF index and the presence of dental enamel defects (DED), evaluate the clinical progress of the tooth affected by that injury, to establish the relation with the presence of dental decay, treatment needs and the occurrence of structural lost. The sample was constituted by 49 patients with HMI aging from 6 to 9 years old. This sample presented 588 molars and incisors teeth with and without abnormalities, which received preventive treatment and protection with conventional glass ionomer cement (GIC) when indicated. The data were collected along of one year with one period of 6 month of interval to clinical exam, impressions and intrabucal photographs. A semi-structured questionnaire was answered by the main guardians aimed to identify the family income, level of schooling and the source of water intake. The descriptive analysis, Fisher Exact test, Quis-square, McNemar and the Kaplan-Meier method (survive analysis) were performed. As results, there was a significant association between the MIH progression with the increase of DMTF index. The patient socioeconomic status and the presence of DED in the primary dentition were not the main factors related to severity. There were 7 post eruptive fractures in the group with MIH spots. Of all restored teeth, 16 first permanent molars presented fractures. The presence of MIH showed a close relation with the need of treatment and with the DMTF index. The results showed a high index of success of this treatment in maintain the sound structure of the teeth affected by HMI with 95% related to spots and 77% to atypical restorations procedures. Thus, remove the affected structure completely or prematurely is not a justified clinical decision

Resumo: O objetivo dessa tese foi avaliar os efeitos da intrusão ortodôntica no processo de reparação de lesão de furca grau III em cães, e da presença de fator de necrose tumoral alfa (TNFα) e/ou interleucina-1 beta (IL-1ß) na mecanoresposta de células com característica de osteócitos e osteoblastos in vitro. No estudo in vivo, lesões de furca grau III foram criadas em pré-molares inferiores de sete cães. Após 75 dias, as lesões foram aleatoriamente tratadas com cirurgia a retalho (OFD) associada ou não à regeneração tecidual guiada (GTR) e enxerto ósseo autógeno (BA). Após um mês, iniciou-se a intrusão ortodôntica (I) em parte dos dentes tratados pelas duas diferentes abordagens (grupos teste), por meio de ancoragem em miniimplantes. Os cães foram sacrificados após três meses de movimentação e um mês de contenção. Todas as lesões de furca grau III foram reduzidas para grau II ou I nos grupos teste. O mesmo foi observado em 50% das lesões nos grupos controle (sem movimentação). O nível de inserção clínico foi reduzido nos grupos teste, no final da contenção (p<0.01). O grupo OFD+I apresentou maior preenchimento ósseo que os demais grupos (p<0.05), demonstrando superioridade desta associação, no tratamento de lesões de furca grau III, em cães. Esses resultados levantaram a hipótese de que o processo de degradação da membrana e/ou enxerto ósseo interagiria negativamente sobre o processo de reparo quando associado a forças ortodônticas, pois a presença de mediadores inflamatórios estaria intensificada. É conhecido que a alteração tecidual proveniente da movimentação ortodôntica é resultado da ação de mediadores químicos sobre as células dos tecidos periodontais. Portanto, buscamos avaliar in vitro a ação de duas citocinas pró-inflamatórias, TNFα e IL-1ß, sobre células ósseas em presença e ausência de carga mecânica. / Abstract: The aim was to assess the effects of orthodontic intrusion on the healing of class III furcation lesions in dogs, and of the presence of tumor necrosis factor alpha (TNFα) and/or interleukin-1 beta (IL-1ß) on the mechanoresponse of osteocyte and osteoblast-like cells in vitro. In the in vivo study, class III furcation lesions were created in lower pre-molars of seven mongrel dogs. After 75 days, teeth were randomly treated with open flap debridment (OFD) associated or not to guided tissue regeneration (GTR) and bone autograft (BA). After one month, teeth were randomly assigned to orthodontic intrusion using mini-implants anchorage or no movement. Dogs were sacrificed after three months of movement and one month contention. All class III furcations were closed or reduced to class II or I lesions in the intrusion groups while 50% of the class III lesions in non-moved teeth remained unchanged. Clinical attachment level was reduced in the intrusion groups by the end of contention (p<0.01). OFD + I presented smaller soft tissues area and larger bone tissue area than other groups (p<0.05). Orthodontic intrusion with mini-implants anchorage improved healing of class III furcation defects after OFD in dogs. Based on these results we hypothesized that degradation of membrane and/or bone autograft can negatively interfere on repair when associated to orthodontic movement because inflammatory mediators are intensified. It's known that cytokines are present during orthodontic movement which are acting on periodontal cells. Therefore we evaluated in vitro the effects of two pro-inflammatory cytokines, TNFα and IL-1ß, on bone cells in presence or absence of mechanical loading. / Orientador: Joni Augusto Cirelli / Coorientador: Rosemary Adriana Chiérici Marcantonio / Banca: Ana Cláudia Moreira Melo / Banca: Enilson Antonio Sallum / Banca: Ary dos Santos Pinto / Banca: Silvana Regina Perez Orrico / Doutor

Orientadores: Marcelo Giannini, Cinthia Pereira Machado Tabchoury / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-16T09:10:08Z (GMT). No. of bitstreams: 1 Berger_SandrineBittencourt_D.pdf: 2055436 bytes, checksum: 7fb4b7b2c3d494b9ad94c29793baf2d4 (MD5) Previous issue date: 2010 / Resumo: O objetivo geral deste estudo foi avaliar o efeito de géis clareadores contendo cálcio ou fosfato de cálcio amorfo (ACP) no módulo de elasticidade da dentina bovina desmineralizada e desmineralização do esmalte hígido ou com lesão inicial de cárie artificial. Capítulo 1: Este estudo avaliou o efeito de agentes clareadores no módulo de elasticidade (ME) da matriz orgânica da dentina bovina. Oitenta e cinco fatias foram obtidas de dentes bovinos e separadas em 5 grupos: grupo controle - sem tratamento (GC), peróxido de hidrogênio 4% (PH4), PH4+0,05% Ca (HP4/Ca), PH 7,5% + ACP (PH7,5) e peróxido de carbamida 10% (PC10). Os grupos PH4, PH4/Ca e PC10 foram tratados com os géis clareadores por 8 horas / dia durante 14 dias, enquanto as amostras do grupo PH7,5 foi submetida ao clareador por 30 minutos, 2 vezes ao dia, durante 14 dias. O esmalte das amostras foi removido e foram preparados 17 espécimes (0,5 x 1,7 x 7,0 mm) por grupo. Em seguida, estas foram desmineralizados em solução de ácido fosfórico 10% por 5 horas e o ME foi mensurado: 24 horas, 7 e 14 dias após o clareamento, utilizando o teste de micro-flexão de 3 pontos. Os dados foram submetidos a ANOVA e teste de Fisher (p<0,05). As amostras clareadas após 24 horas e 7 dias mostram menor ME que o GC. Os grupos clareados foram similares ao GC após 14 dias, exceto o grupo PH7,5. O uso de peróxidos pode promover diminuição do módulo de elasticidade da matriz orgânica da dentina bovina. Capítulo 2: O propósito nesta parte da tese foi avaliar o efeito de um clareador experimental e um comercial no esmalte sadio (ES) ou esmalte com lesão inicial de cárie artificial (LC), utilizando microscópio confocal laser de varredura (CLSM). Oitenta blocos (4 x 5 x 5 mm) de esmalte bovino foram usados, sendo que quarenta destes foram desmineralizados com ciclagem de pH para induzir a lesão inicial de cárie artificial. Oito grupos experimentais foram formados a partir dos produtos clareadores e a condição do esmalte dental (ES ou LC), com n=10: Grupos ES: G1 - sem tratamento (controle); G2 - peróxido de hidrogênio 4% (PH4); G3: PH4 contendo 0,05%Ca (Ca); G4 - peróxido de hidrogênio 7,5% (PH7,5) contendo fosfato de cálcio amorfo (ACP). Grupos LC: G5 - não clareado; G6 - PH4; G7 - PH4 contendo Ca; G8 - PH7,5 contendo ACP. Os grupos G2, G3, G6 e G7 foram tratados com o gel clareador por 8 horas/dia durante 14 dias, enquanto as amostras dos grupos G4 e G8 foram submetidas ao clareador por 30 minutos/duas vezes ao dia, durante 14 dias. Os blocos de esmalte foram corados com solução de rodamina e área fluorescente de desmineralização foi quantificada utilizando CLSM. Os dados foram submetidos a ANOVA e teste de Fisher (p<0,05). Para ES, os tratamentos clareadores aumentaram significativamente a área de desmineralização quanto comparado com os grupos não clareados, entretanto, para LC não foi observado diferença estatística significante entre os grupos. A adição de ACP e Ca na composição dos géis clareadores não resultou em redução da desmineralização promovida pelos tratamentos clareadores / Abstract: The aim of this study was to evaluate the effect of bleaching agents containing calcium or amorphous calcium phosphate (ACP) on the elastic modulus of demineralized bovine dentin and demineralization in sound enamel or early artificial caries lesion. Chapter 1: This study evaluated the effect of tooth whitening agents on the elastic modulus (EM) of bovine dentin organic matrix. Eighty?five slices were obtained from bovine teeth and divided into five groups: unbleached control group (CG), 4% hydrogen peroxide (4HP), 4HP+0.05% Ca (4HP/Ca), 7.5% HP (7.5HP) and 10% carbamide peroxide (10CP). The 4HP, 4HP/Ca and 10CP groups were treated with the whitening agents for 8 hours/day during 14 days, while the samples of 7.5HP group were exposed to peroxides for 30 minutes twice a day during 14 days. The enamel of the samples was removed and 17 dentin specimens (0.5 x 1.7 x 7.0 mm) were prepared per group. The specimens were demineralized in 10% phosphoric acid solution for 5 hours and E was assessed using a micro-flexural three-point bend method at 24 hours, 7 and 14 days post-bleaching. The mean values of EM for each group were statistically analyzed using ANOVA and Fisher's test (p<0.05). Bleached specimens tested after 24 hours and 7 days showed lower EM than CG. The bleached groups were similar to CG after 14 days, except for the 7.5HP group. The use of peroxides can promoted decrease of EM of bovine dentin organic matrix. Whitening agents can significantly affect of the dentin organic matrix and irreversible damage is observed for selected agents. Chapter 2: The purpose of this study was evaluated to effect of experimental and one commercial bleaching agents on the sound enamel (SE) and with early artificial caries lesions (CL) enamel using confocal laser scanning microscopy (CLSM). Eighty blocks (4 mm thickness x 5 wide x 5 length) of bovine enamel were used and half of them were demineralized with a pH cycling to induce artificial caries lesions. Eight experimental groups were investigated following the bleaching treatments or not and SE or CL (n=10): SE groups: G1 - unbleached (control); G2 - 4% hydrogen peroxide (4HP); G3 - 4HP containing 0.05% Ca (Ca); G4 - 7.5% hydrogen peroxide (7.5HP) containing amorphous calcium phosphate (ACP). CL groups: G5 - unbleached; G6 - 4HP; G7 ? 4HP containing Ca; G8 ? 7.5HP containing ACP. The G2, G3, G6, G7 groups were treated with the bleaching agents for 8 hours/day during 14 days, while the samples of G4 and G8 groups were exposed to bleaching agent for 30 minutes twice a day during 14 days. The enamel blocks were stained with rhodamine solution and the quantification of fluorescence demineralization areas of the samples were evaluated using a CLSM. Data were analyzed using ANOVA and Fisher's tests (p<0.05). For the SE, the bleaching treatments significantly increased the demineralization area when compared to unbleached group, however, in CL no statistically significant difference was observed among the groups. The addition of ACP or Ca in the composition of the whitening products did not result in the decreasing of the enamel demineralization promoted by bleaching treatments / Doutorado / Materiais Dentarios / Doutor em Materiais Dentários

Orientador: Rafael Leonardo Xediek Consani / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-14T14:57:31Z (GMT). No. of bitstreams: 1 Lopes_MichelleCristina_M.pdf: 433524 bytes, checksum: 7d01d350cce34280c9bae82f9e766739 (MD5) Previous issue date: 2009 / Resumo: O propósito neste estudo foi verificar a movimentação linear de dentes em prótese total superior confeccionada em resina acrílica, com conteúdo de monômero na proporção monômero-polímero indicado pelo fabricante, com 25% de excesso e com 25% a menos, nas técnicas de polimerização convencional e por microondas. Foram confeccionados 30 modelos em gesso pedra tipo III, a partir de um molde de silicone, representando uma arcada maxilar desdentada com rebordo normal. As bases de prova foram confeccionadas com espessura de ±2,5mm e os planos de orientação em cera, com 1cm de altura posterior e 2 cm de altura anterior. O modelo de gesso com o plano de orientação em cera foi fixado no ramo superior do articulador semi-ajustável, com distância intercondilar média, ângulo de Bennet em 15 graus e guia condilar em 30 graus. Em seguida, um modelo de arcada mandibular dentada foi posicionado sobre o plano de cera do modelo superior e fixado na haste inferior do articulador, posicionando o pino incisal em zero. Depois da montagem dos dentes artificiais, o modelo da prótese foi removido do articulador e moldado com silicone. Os dentes foram colocados no molde e sobre eles foi vertida cera rosa liquefeita, até o completo preenchimento do molde. Antes da solidificação da cera, o modelo de gesso foi adaptado no molde e mantido em posição até o completo esfriamento da cera, quando o conjunto modelo de gesso-base de prova com dentes artificiais foi removido do molde. Foram confeccionados pontos referenciais sobre a região mediana da borda incisal dos incisivos centrais, cúspide vestibular dos primeiros pré-molares e cúspide disto-vestibular dos segundos molares, por meio de perfurações para fixação de segmentos de alfinetes metálicos com adesivo instantâneo à base de cianoacrilato. As mensurações foram realizadas nas distâncias transversais entre: incisivos centrais; primeiros pré-molares; e segundos molares, e ântero-posteriores entre: incisivo central direito e molar direito; incisivo central esquerdo e molar esquerdo, com microscópio comparador linear antes da inclusão e depois do acabamento das próteses. Nos grupos com proporção recomendada pelos fabricantes, as próteses foram prensadas convencionalmente. Nos demais grupos, os mesmos procedimentos foram adotados, com exceção da proporção de monômero que foi de 25% a mais ou 25% a menos. Os dados de deslocamento dental foram submetidos à análise de variância e ao teste de Tukey (5%). Não houve diferença estatística entre os grupos com quantidade de monômero recomendada pelo fabricante (grupo controle) e os demais grupos tanto na polimerização convencional como por microondas. A alteração na quantidade de monômero para mais ou para menos em relação à proporção monômero-polímero não influenciou a movimentação dental linear nos sentidos transversal e ântero-posterior. / Abstract: The purpose of the study was to verify the linear displacement of the teeth in complete upper denture made with acrylic resin, with monomer content indicated by the manufacturer, with 25% in excess and 25% less, in the conventional and microwaves polymerization techniques. Thirty casts were made with type III stone plaster, based on silicone mould, representing an edentulous maxillary arch with normal edge. The wax baseplates were manufactured in a ±2.5mm thickness and the wax rims with 10 mm of posterior height and 20 mm of anterior height. The stone cast related with the wax rim was fixed at the top stem of semi-adjustable articulator, adjusting the intercondylar distance in Medium, the angle of Bennet in 15 degrees and the condylar guidance in 30 degrees. A mandibular arch with teeth was placed on the wax rim and fixed on the bottom shaft of the articulator, positioning the incisal pin to zero. After mounting the artificial teeth, the denture was removed from the articulator and impressed with silicone. The teeth were placed in the impression mold and over them it was poured a liquid wax, until the mold filling was completed. Before solidification of the wax, the stone cast mold was adapted in the impression and kept in position until the wax setting. After wax setting, the stone cast- denture with artificial teeth set was removed from the silicone impression. Reference points were fixed over the median region of the incisal edge of central incisors, buccal cusp of the first premolar and distal-buccal cusp of the second molars in drill holes performed for fixation of the metal pin segments with instantaneous adhesive based on cyanoacrylate. The measurements were made in the transverse distances among: central incisors; first premolar; second molar, and anteroposterior among: central right incisor and right molar; central left incisor and left molar, with a linear comparator microscope before and after denture procedure. In the groups with monomer content recommended by the manufacturer, the dentures were conventionally pressed. In the other groups, the same procedures were adopted, with exception of the monomer content that was 25% in excess or 25% less. The dental displacement data were submitted to ANOVA and Tukey's test (5%). There was no statistically significant difference among the groups with the monomer content recommended by the manufacturer and other groups, in both conventional and microwaved activations. To change the content of monomer to more or less in relation to monomer-polymer proportion did not influence the linear displacement of the teeth in transverse or anteroposterior directions. / Mestrado / Protese Dental / Mestre em Clínica Odontológica

Thesis (D.Sc.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 1999. / Includes bibliographical references (leaves 90-106). / Tooth eruption provides an excellent model to examine osseous metabolism as bone resorption (occlusal area), and formation (apical area), occur simultaneously and are spatially separated. Monocytes are thought to play an important role in regulation of bone metabolism. The goal of this study was to examine recruitment of monocytes to bone undergoing developmental remodeling in C57BL/6J mice. To account for potential mechanism for monocyte recruitment, we investigated expression of monocyte chemoattractant protein-1 (MCP-1) in tissues surrounding an erupting tooth. TNF and IL1 are potent stimulators of bone resorption. Recent evidence shows that these proinflammatory cytokines are expressed during embryogenesis and may participate in developmental tissue remodeling. To establish their role in tooth eruption and bone remodeling, we carried out experiments using mice with genetic deletions of TNFR1/IL-1R1 or TNFR1/TNFR2. Mandibles were obtained from animals sacrificed at various time points from birth to 14 days of age. Histological sections were stained using immuno/histochemistry to identify mononuclear phagocytes, osteoclasts, MCP-1-positive and apoptotic cells. The results demonstrated that a significant time-dependent increase in recruitment of monocytes in the occlusal area (bone resorption) at days 5 and 9 was associated with significant increase in number of osteoclasts at similar time points. In contrast, in the apical area (bone formation), a significant time-dependent increase in monocyte recruitment was coupled with a decrease in number of osteoclasts, found in high numbers at earliest time points (up to day 3 postnatally). The number of MCP-1 positive cells also increased with time in both areas and was generally proportional to the recruitment of mononuclear phagocytes. Osteoblasts were the principal bone cell type expressing MCP-1. Our results suggest that monocytes have different functional roles in areas of bone resorption and bone formation. Furthermore, the expression of MCP-1 is developmentally regulated and may provide mechanistic basis to explain the recruitment of monocytes. Functional deletion of TNFR1/IL-1R1 resulted in later onset of molar eruption. However, histological findings showed that only monocyte physiology in the occlusal connective tissue was affected by loss of TNFR1/IL-1R1 signaling. Increased number of monocytes in the area was observed during tooth eruption through subgingival connective tissue (day 13). Presence of monocytes in the dental follicle or presence of osteoclasts at the adjacent bone surface was not altered. Deletion of TNFR1/R2 affected recruitment/function/survival of monocytes and rate of apoptosis only in the apical area during intraosseous stage of tooth eruption (day 9). No changes in monocyte or osteoclast markers were noted in the occlusal area. Loss of TNFR1/R2 signaling had no effect on the rate of molar eruption. Lack of striking differences between the experimental and the wild type groups indicates that TNF and IL-1 do not play a critical role during tooth eruption and remodeling of surrounding bone, supporting the suggested hypothesis that tooth eruption is a redundantly regulated process.