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No / A Web of Prevention provides a timely contribution to the current debate about life science research and its implications for security. It is an informative guide for both experts and the public¿ It is a forward-looking contribution covering both ends of the equation and creates momentum for the current discussion on effective preventive measures and effective control measures¿ While there are no guarantees for preventing misuse, there are nonetheless crucial steps the world community can take towards the overarching goal of a global network for the life sciences. This book sheds light on concrete steps toward the achievement of this worthy goal.¿ This book with its collection of essays provides an in-depth analysis of the various mutually reinforcing elements that together create and strengthen a web of prevention - or of assurance - that is vital to ensure that the advances in the life sciences are not misused to cause harm. All those engaged in the life sciences and in policy making in governments around the world should read this book so they can take steps to strengthen the web preventing biological weapons.¿ Since September 11, 2001 in many countries renewed attention has been given to how research in the life sciences might inadvertently or intentionally facilitate the development of biological or chemical weapons. This state-of-the-art volume examines the full extent of the issues and debates. Coverage includes an overview of recent scientific achievements in virology, microbiology, immunology and genetic engineering with a view to asking how they might facilitate the production of weapons of mass destruction by state, sub-state or terrorist organizations. Consideration is given to what we have and haven¿t learned from the past. Employing both academic analysis and reflections by practitioners, the book examines the security-inspired governance regimes for the life sciences that are under development. Ultimately the authors examine what is required to form a comprehensive and workable `web of prevention¿ and highlight the importance of encouraging discussions between scientists, policy makers and others regarding the governance of vital but potentially dangerous research.

Cadmium accumulation, retention and sequestering by protein were measured in two Mycobacterium scrofulaceum strains differing in their susceptibility to that toxic heavy metal cation. Cadmium accumulation was energy-dependent and temperature-sensitive. The tolerant strain had lower K_m and V_max values than did the susceptible strain. Cd⁺² accumulation was antagonized by both Zn⁺² and Mn⁺², which agreed with the observation that both cations protected the strains from Cd⁺² toxicity. Further, Zn⁺² and Mn⁺² did not reduce Cd⁺² accumulation to the same extent in the tolerant strain as in the susceptible strain, suggesting that cadmium resulted in more extensive zinc and manganese starvation in the cadmium-susceptible strain. Cd⁺² was retained to the same extent in both the susceptible and tolerant strains by a Cd⁺²-specific, energy-dependent exchange mechanism. Thus, tolerance was not due to accelerated efflux. Though a cadmium-inducible, soluble protein was discovered only in the tolerant strain, its inability to bind Cd⁺² and exclusive production during the stationary phase of growth argued against its role in cadmium tolerance. / M.S.

CHDS State/Local / Approved for public release; distribution is unlimited / The concept of biosecurity as it pertains to Biological Select Agents and Toxins in American biomedical research institutions is explored in some depth. Posing the research question "How can specific public biomedical research universities securely use and store biological select agents?" the thesis outlines the dynamics of the select agent and toxin list, the relevant history of the control of biological agents both in the international and domestic settings, including federal regulations pertaining to biosecurity (42CFR73). Two specific case studies are presented in the thesis. The biosecurity strategies and tactics at these two distinct biomedical research are compared. An answer to the research question is proposed and additional areas for research are outlined. / Captain, the University of Texas at Houston Police Department

Thesis (M.S.)--University of North Carolina at Wilmington, 2006. / Includes bibliographical references (leaves: 36-40)

Thesis (Ph. D.)--University of Washington, 2000. / Vita. Includes bibliographical references (leaves 175-193).

Source: Masters Abstracts International, Volume: 47-06, page: 3546. Advisers: Zhi-Dong Jiang; Linda B. Piller. Includes bibliographical references.

Diss. (sammanfattning) Stockholm : Karol inst., 2004. / Härtill 5 uppsatser.

Thesis--Copenhagen. / At head of title: Johs. Ipsen. "The translation from Danish is by Mr. Einar Christensen."--Pref. "Dansk resume": p. [151]-157. "Literature": p. [246]-248.

Thesis--Copenhagen. / At head of title: Johs. Ipsen. "The translation from Danish is by Mr. Einar Christensen."--Pref. "Dansk resume": p. [151]-157. "Literature": p. [246]-248.