Machine Space is an essay film that explores the city of Detroit as a space of movement and circulation. This city is negotiated in the moving image as a palimpsest of maps, spatial metrics and automotive infrastructure; illustrating the material and discursive layers that have constructed this now post-industrial metropolis. This is a city where, in the words of the urban thinker Henri Lefebvre, 'the production of space itself replaces - or, rather, is superimposed upon - the production of things in space.' (Lefebvre 1991, p.62) This practice-as-research doctoral project explores an interface of Lefebvre's 'production of space' with the cinema; as visual artefact, a phenomenological document; and as media exhibited in a screening space. The result is a productive discourse of 'Spatial Cinema'.

Three strains of the green alga Scenedesmus quadricauda were selected to be specifically resistant to the presence of high concentrations of inorganic Se. The strain SeIV was found to be resistant to high doses of selenite, the strain SeVI was resistant to selenate, and the strain Se(IV+VI) to the presence of both Se compounds. It has been shown that both the dose and chemical form of Se are the critical factors in the cellular response. In this PhD. thesis are results from experiments with the resistant strains (activity of thioredoxin reductase, content of selenium and selenomethionine, effect of sulphur deficiency).

This practice-based PhD takes the institution of the archive as its primary locus, and the position of the photograph within it. This approach opens up an interdisciplinary and post-representational investigation into the photographic image and its relationship to the companion descriptive text, as well as instigating a consideration of the structure and the management of both objects and descriptions in an archive situation. More specifically, the model of the visual content-based archive description is taken out of the confines of the institution and into visual practice. Different kinds of sets and collections of photographs are examined here, as well as traditional archives, but all through techniques of archival description, listing and organisation. The restricted institutional language structure becomes a conceptual writing technique when employed within this archive-related art practice. Positioned outside of the field of hermeneutical image analysis, this writing system is a form of information management, and, following archival conventions, does not attempt to assign meaning to the objects with which it engages. The practice predominantly takes the form of moving image or performance, always with text present (written or spoken). The image itself, paralleling a common archival situation, is often hidden or obscured, and the description allows a novel exploration of the image to take place and to be discussed. The largely decontextualised type of visual content-based description used emphasises the discrete and atemporal nature of the photograph and the synchrony of the moment of capture. It is acknowledged though, that the message and meaning of the single image is located outside of this moment of capture, and so may be subject to some speculation. The spatiotemporal context of the image, denied by the visual contentbased description, is brought back through ‘reading’ the archived image in its natural habitat, the archive list or catalogue. This relational situation reveals the fixed associations between images themselves and between images and their wider organisational structures. The description is ultimately identified as a ‘narrative pause’ (Fowler: 1991, p.25), and is celebrated as such. Inside the indexical and diachronic arrangement of the archive, images and descriptions are viewed through something other than a narrative gaze, as lists, and the juxtapositions therein, expose the acutely shallow time and non-chronological advancement of the archive.

Dissertação (mestrado)—Universidade de Brasília, Faculdade de Ciências da Saúde, 2008. / Submitted by Jaqueline Oliveira (jaqueoliveiram@gmail.com) on 2008-12-15T15:42:29Z No. of bitstreams: 1 DISSERTACAO_2008_KarineFigueiredoAndrade.pdf: 2642799 bytes, checksum: b0e5e80dabb84b6d64996da26c9f430b (MD5) / Approved for entry into archive by Georgia Fernandes(georgia@bce.unb.br) on 2009-02-26T16:49:13Z (GMT) No. of bitstreams: 1 DISSERTACAO_2008_KarineFigueiredoAndrade.pdf: 2642799 bytes, checksum: b0e5e80dabb84b6d64996da26c9f430b (MD5) / Made available in DSpace on 2009-02-26T16:49:13Z (GMT). No. of bitstreams: 1 DISSERTACAO_2008_KarineFigueiredoAndrade.pdf: 2642799 bytes, checksum: b0e5e80dabb84b6d64996da26c9f430b (MD5) / Os receptores nucleares (NRs) são de grande importância para o mercado mundial de fármacos por estarem envolvidos em mecanismos que influenciam diversas doenças que afetam a humanidade como, por exemplo, o Diabetes Mellitus (DM2), dislipidemia, aterosclerose, obesidade. Dentre os NRs, os Receptores Ativados por Proliferadores Peroxissomais (PPARs) e os Receptores do Hormônio Tireoideano (TRs) controlam importantes ações fisiológicas como regulação de processos inflamatórios, homeostase de glicose e lipídios (PPAR), diferenciação e crescimento celular e metabolismo (TR). Atualmente, o tratamento do DM2 é feito majoritariamente com tiazolidinadionas (TZD), classe de fármacos que diminui a resistência insulínica. A terapia com hormônio tireoideano (HT) para reduzir o colesterol sérico apresenta limitações terapêuticas e efeitos cardíacos indesejáveis. Os compostos sintetizados nesse trabalho: (4-formil-3,5-dimetilfenóxi)-acetoacetato de etila (KF01), (2-formil-3,5-dimetilfenóxi)-acetoacetato de etila (KF02) e o (3,5-dimetilfenóxi)-acetoacetato de etila (KF03) foram submetidos a ensaios para avaliar sua atividade biológica. No ensaio de toxicidade utilizando larvas de Artemia salina, todos os compostos avaliados apresentaram atividade e o composto KF03 mostrou-se 5,7 vezes mais ativo que o padrão positivo (K2Cr2O7). Esse resultado indica que KF01, KF02 e KF03 possuem atividade citotóxica contra larvas de Artemia salina. Os ensaios de transfecção e generepórter em culturas de células U937, mostraram que KF02 apresentou ação panagonista mediada pelas três isoformas do PPAR (α, β/δ e γ), além de efeito sinérgico na presença de bezafibrato e de rosiglitazona (agonistas sintéticos do PPAR), KF03 apresentou um duplo agonismo na transcrição mediada por PPARα e PPARγ, e atuou sinergicamente com os ligantes sintéticos desses receptores. Nos receptores do hormônio tireoideano (TRα e TRβ), foi verificada ação agonista de KF02 e efeito sinérgico de KF01, KF02 e KF03 na presença do hormônio tireoideano (T3). KF02 e KF03 mostraram-se promissores quanto à atividade biológica mediada por PPAR e TR e contribuem para trabalhos futuros no desenvolvimento de pan e duplo agonistas de PPAR e ainda na busca de tiromiméticos β-seletivos capazes de atuar no controle do DM2, obesidade, aterolsclerose e dislipidemia. ________________________________________________________________________________________ ABSTRACT / Nuclear receptors (NRs) are of great importance for the worldwide drug market since they are involved in mechanisms which influence several diseases that affect humanity like, for instance, diabetes mellitus (DM2), obesity, dislypemia and atherosclerosis. Peroxisome Proliferator-Activated Receptors (PPAR) and Thyroid Hormone Receptors (TR) control important physiologic actions as the regulation of inflammatory processes, glucose and lipid homeostasis (PPAR), differentiation and cellular growth and metabolism (TR). Currently, the DM2 treatment is carried mainly by thiazolidinediones (TZD), a pharmacon category that reduces the insulin resistance. The therapy with thyroid hormone (TH) to reduce the serum cholesterol shows therapeutical limitations and undesirable cardiac effects. The compounds synthesized in this project: (4-phormyl-3,5- dimethylphenoxi)-acet ethyl acetate (KF01), (2-phormyl-3,5-dimethylphenoxi)-acet ethyl acetate (KF02) and (3,5-dimethylphenoxi)-acet ethyl acetate (KF03), were submitted to trials to evaluate its biological activity. In the cytotoxicity test, using Artemia salina larvae, all compounds evaluated presented activity and the compound KF03 showed itself 5.7 more active then the positive pattern (K2Cr2O7). This result indicates that KF01, KF02 and KF03 have antitumor activity. In the transfection and reporter gene trials in cell culture (U937 cells), the results showed that KF02 presented a pan-agonist action mediated by the three PPAR isoforms (α, β/δ and γ), besides a synergic effect in the presence of bezafibrate and rosiglitazone (PPAR synthetic ligants), KF03 presented a double agonism in the transcription mediated by PPARα and γ, and acted synergically with the synthetic ligants of these receptors. In the thyroid hormone receptors (TRα and TRβ), it was verified an agonist action of KF02 and a synergic effect of KF01, KF02 and KF03 in the presence of the thyroid hormone (T3). The B fragment derivatives (KF02 and KF03) showed themselves promising due to their biological activity mediated by PPAR and TR and these findings contribute to future studies in the development of pan and double PPAR agonists and also in the search for β-selective thyromimetic substances able to act in the metabolic syndrome control.

This thesis draws on psychoanalytic theories of trauma to interrogate works produced by Polish photographers after the Second World War. The aim of this thesis is to excavate traces of trauma latently embedded in post-war Polish art photography. By closely analysing a selection of photographs produced between the years 1945 and 1970, I argue that the events of the war cast a shadow over the lives of Polish artists. Rather than looking at photographs which directly visualise these traumatic events, I explore the ways in which these experiences manifest themselves indirectly or obliquely in the art of the period, through abstraction, a tendency towards ‘dark realism,’ and an interest in traces of human presence. Drawing on the photographs of Zbigniew Dłubak, Zdzisław Beksiński, Jerzy Lewczyński, Bronisław Schlabs, Andrzej Różycki, Józef Robakowski and other post-war photographers, I argue that the events of the war were not the only traumas to cast their shadow on the Polish psyche. Between 1945 and 1970, Poland underwent a series of transitions and changes in leadership, population and Party politics. Periods of optimism and leniency oscillated with phases of repression and social unrest. In my analysis, I suggest that multiple traumas can be discerned in these decades. What is at stake in this thesis is the proposition that a photograph can bear imperceptible traces of events that have wounded the psyche, which could not be articulated at the time, but which were made visible at a later date. Photographs made in the post-war years provided a space to belatedly return to encrypted traumas, to relay ideas that could not otherwise be articulated, and to acknowledge events that had been disavowed.

Made available in DSpace on 2016-08-29T15:32:40Z (GMT). No. of bitstreams: 1 tese_2267_Tese Doutorado Paulo Jose Mello Menegaz.pdf: 12899709 bytes, checksum: 435d730ee4dc2945e70fde927db9a610 (MD5) Previous issue date: 2005-06-10 / Este trabalho apresenta duas famílias de conversores ZVT-PWM não isolados que utilizam um acoplamento magnético para implementar a fonte de tensão auxiliar do conversor. A primeira família proposta pertence ao grupo dos conversores ZVT com fonte de tensão auxiliar CC chaveada. Ela apresenta um snubber regenerativo magneticamente acoplado aplicado ao interruptor auxiliar do conversor ZVT a fim de garantir um bloqueio em zero de tensão para este interruptor. A entrada em condução do interruptor auxiliar ocorre em zero de corrente e o interruptor principal apresenta tanto o bloqueio quanto a entrada em condução em zero de tensão, assim como na estrutura ZVT convencional. O acoplamento magnético é responsável por produzir as condições necessárias para que ocorra a descarga ressonante do capacitor do snubber, enviando a energia nele armazenada para a entrada e/ou saída do conversor. Uma estrutura mais compacta é obtida ao utilizar-se a própria dispersão do acoplamento magnético para implementar o indutor ressonante do snubber, reduzindo assim o número de componentes magnéticos da estrutura. A segunda família proposta pertence ao grupo de conversores ZVT com fonte de tensão auxiliar CC. Nesta família, utiliza-se um acoplamento magnético entre o indutor principal e o indutor ressonante do conversor, a fim de se garantir a operação do conversor no ponto de mínima perda total no interruptor auxiliar. A comutação dos interruptores principal e auxiliar permanece inalterada se comparada com a do conversor convencional sem acoplamento magnético. Uma vez que tanto o indutor principal quanto o indutor ressonante do conversor são construídos a partir do mesmo núcleo magnético, consegue-se reduzir o número de componentes magnéticos do circuito, bem como o número de fontes de interferência eletromagnética irradiada (EMI). Para ambas as famílias de conversores propostas, são apresentadas equações que descrevem o comportamento das tensões e correntes nos principais elementos do conversor. Além disso, é apresentada uma metodologia de projeto que permite dimensionar de forma simples e rápida os elementos da célula de comutação magneticamente acoplada do conversor. Também são apresentados resultados de simulação e resultados experimentais obtidos a partir da construção de protótipos dos conversores que validam as equações desenvolvidas e comprovam a eficiência dos conversores propostos.

Made available in DSpace on 2018-08-01T23:39:29Z (GMT). No. of bitstreams: 1 tese_11344_EDUARDO20170829-114254.pdf: 861549 bytes, checksum: d420207538ec5a973440095a7ad3a8d8 (MD5) Previous issue date: 2017-05-31 / O trabalho se propõe a abordar a problemática da realização de acordos pela Administração Pública nos processos tributários. Para tanto, inicialmente, faz-se a análise da evolução do conceito de legalidade. Nesse passo, será abordado o impacto do novo Código de Processo Civil que, ao adotar o sistema multiportas, acaba por positivar uma mudança de paradigma na resolução de conflitos, demonstrando a necessidade de redução da litigiosidade, com incentivo à autocomposição. Assim, pretende-se demonstrar a evolução do conceito de interesse público e enfrentar a problemática acerca de sua indisponibilidade, o que em tese, poderia dificultar a realização destes acordos. Examina-se, assim, os mecanismos disponíveis para se promover a disposição de interesses e direitos, especificamente analisando os institutos da transação e composição, notadamente no âmbito do Direito Tributário. Essa análise busca, após a constatação da ausência de efetividade do atual modelo, demonstrar que é imperiosa a aplicação dos mencionados institutos de autocomposição como ferramentas de concretização dos princípios da pacificação social, da supremacia do interesse público e da legalidade. Soma-se a isso, a expressa adoção pelo Código Processual Civil, da teoria dos precedentes judiciais, cujo dever de observância restou positivado com a finalidade de conferir integridade, coerência e estabilidade ao ordenamento. Ao final, traz-se a conclusão de que a celebração de acordos por meio dos institutos da composição e da transação em matéria tributária devem ser aprimorados, com a superação de antigos entraves e adoção da principiologia autocompositiva do CPC. O primeiro, por meio de legislação específica e o segundo, por meio de uma mudança de postura da Administração Pública, eis que a esta é vedado litigar em desconformidade com o ordenamento jurídico. Palavras-chave: Direito Processual Civil. Direito Administrativo. Direito Tributário. Advocacia Pública. Legalidade. Interesse Público.Transação. Composição.

This portfolio and commentary documents an approach to audiovisual composition that utilises sound and photographic images in an effort to create immersive, affective art which I call audio-photographic art. When presented in an immersive context, I contend that the temporal dissonance between still image and sound opens up a space between the materials. I draw upon Gernot Böhme's writings on the aesthetic of 'atmosphere', as well as the the theoretical writings of Roland Barthes, Paul Ricoeur and Eleni Ikoniadou among others to illustrate how this experience is constituted. This space between is an affective conceptual space in which the participant enters into a relationship with the materials of the piece, transcending their usual perception of time as they are immersed in the internal times of the artwork, their own memories and atmosphere. Through the use of maximal aesthetics and atmosphere as compositional tool, these themes are explored and developed throughout the creative portfolio. In the written submission I study the practical and theoretical concerns of the space between from three perspectives: 'The Temporal Space', 'The Memorial Space' and 'The Atmospheric Space'.

Functional behavior assessment refers to the broad range of behavioral assessment methods used to identify or clarify the purpose or maintaining contingencies of problem behavior in order to design and implement function-based interventions designed to reduce the occurrence of the problem behavior and teach appropriate replacement skills. FBAs are required in the educational setting for students whose problem behavior is displayed to such a significant level that their learning or the learning of their peers is impacted. As such, previous researchers have conducted trainings on FBA for school-based personnel using a wide variety of methods. Unfortunately, the findings of these studies have yielded mixed results suggesting the need for further inquiry in this line of research. Therefore, the purpose of this study was to evaluate whether FBA training would produce significant changes in participants’ knowledge and acceptability of FBA measures and procedures. In addition, the current study evaluated if a significant relationship existed between the FBA knowledge and acceptability measures. The study also evaluated if the use of vignettes and the provision of feedback following training impacted participants’ accuracy and acceptability on an FBA informant method. Results revealed a statistically significant change in all variables on the second administration of the measures of knowledge or acceptability. In addition, results from the study revealed a significant relationship between the second administration of knowledge and the second administration of FBA Evaluation Scales. Conversely, no significant relationship was found between the first administration of knowledge and the first administration of acceptability measures. Overall, the study demonstrated that the specific strategies utilized in the FBA training series were effective in increasing FBA knowledge and acceptability. As such, the current study contributes to the FBA literature by providing further evaluation of training methods designed to increase participant knowledge and acceptability of FBA policies and procedures. Limitations and implications for practice and research are discussed.

Made available in DSpace on 2015-04-14T14:27:09Z (GMT). No. of bitstreams: 1 458455.pdf: 2470087 bytes, checksum: 352ec141a259daa79ba90f018371f2ef (MD5) Previous issue date: 2014-03-19 / The present study has origins in the possibility to evaluate the efficacy of the fixed and mobile speed cameras as a mean to reduce the number of victims in the transit ?of the biggest streets in the capital city of the state of Rio Grande do Sul, Porto Alegre. To perform such analysis we used data from the Departamento Estadual, de Tr?nsito (DETRAN/RS), Departamento Aut?nomo de Estradas e Rodagem (DAER) and from authorities that work in the control of the traffic in the city of Porto Alegre, the Empresa P?blica de Transporte e Circula??o (EPTC) and the Departamento Estadual de Pol?cia Judici?ria de Tr?nsito (DPTRAN), these data is available at the portal #DATAPOA. The period extracted from the portal was from January 2008 to December 2012, which makes possible to identify the relation between fixed and mobile enforcement in avenues and the consequences of accidents on these streets, mainly on the severity of the crashes and on the number of injured people. This study has organized the data in a longitudinal panel, allowing the analysis using the Poisson regression technique, which searches for differences between control and treatment groups over time. The results found were very relevant for the analysis of the injuries, and make possible an outlook on the severity of the crashes by the methodology of the severity standardized unit (UPS). The fixed position speed cameras were able to reduce the number of injured and the severity only at the specific location, but did not affect the overall street outcomes. The mobile speed Camera program was able to reduce the number of injuries but only at non rush hours, when the accidents and its outcomes might be influenced more by human factors other than the speed of vehicles. At last, this study could use many variables related to urban transit and verify how each one affect the consequences of an accident, such as, the type of vehicle, the period of the day, climatic conditions and the type of the accident. / O presente trabalho se originou na possibilidade de avaliar a efic?cia de radares fixos e m?veis como forma de redu??o de v?timas no tr?nsito nas principais ruas e avenidas da capital do Rio Grande do Sul, a cidade de Porto Alegre. Para efetuar tal an?lise foram utilizados dados do Departamento Estadual de Tr?nsito (DETRAN/RS), Departamento Aut?nomo de Estradas e Rodagem (DAER) e das entidades de controle de tr?fego que atuam na cidade de Porto Alegre: a Empresa P?blica de Transporte e Circula??o (EPTC) e o Departamento Estadual de Pol?cia Judici?ria de Tr?nsito (DPTRAN), estando estes dados. dispon?veis no portal #DATAPOA. O per?odo extra?do do portal foi de janeiro de 2008 a dezembro de 2012, tornando poss?vel identificar a rela??o entre fiscaliza??o de avenidas com radares fixos e m?veis e as consequ?ncias dos acidentes nas mesmas, principalmente no que diz respeito a feridos, mortos e severidade dos acedentes. O estudo organizou tais dados na forma de painel longitudinal, permitindo an?lise atrav?s da regress?o de Poisson, que busca as diferen?as entre os grupos de tratamento e controle ao longo do tempo. Os resultados encontrados foram muito relevantes em termos da an?lise de feridos e tamb?m possibilitaram a observa??o da severidade dos acidentes pela metodologia da unidade padr?o de severidade. Os radares fixos foram capazes de reduzir o n?mero de feridos e a severidade em alguns trechos das avenidas, mas n?o modificaram o n?vel de ocorr?ncias ao longo de toda ela. Os radares m?veis modificaram o n?vel de feridos ao longo de toda avenida apenas fora do hor?rio de pico, quando os acidentes podem ser influenciados mais pelo fator humano que pela velocidade dos ve?culos. Por fim, este estudo p?de ainda utilizar diversas vari?veis relacionadas ao tr?nsito, tais como, o tipo do ve?culo, o per?odo do dia, as condi??es clim?ticas e o tipo do acidente, verificando como cada uma delas afeta o desfecho dos acidentes.