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<p>There has been a steady increase in the number of patients with chronic kidney disease. The etiology has been linked to excessive fibrosis progression until the kidney function becomes compromised. We are investigating tubulointerstitial fibrosis (TIF) specifically, as it correlates strongly with the decline of renal function.</p> <p>In our study we investigated the role that active SREBP may play in apoptosis and fibrosis in vivo and in vitro. Treating HK-2 cells with TNFα resulted in the cleavage of SREBP and activation of its SRE promoter. By utilizing a number of inhibitors, we found TNFα induced SREBP cleavage through both a caspase independent and dependent manner.</p> <p>We used fatostatin, a SCAP inhibitor, to reduce the amount of active SREBP in animals in the unilateral ureter obstruction (UUO) model. This model is well known for its development of TIF. Fatostatin decreased SREBP-1 and SREBP-2 activation in mice after 7 and 14 days. Fatostatin increased glomerulotubular integrity and proximal tubular mass as evaluated using lectin staining, along with reducing the number of cells undergoing apoptosis as evaluated by TUNEL staining. Using the Masson Trichrome, Picrosirius red and fibronectin staining, we found a reduction of fibrosis. Fatostatin was also found to attenuate the accumulation of infiltrating myofibroblasts and T cells. These results point to a pathological role for SREBP in TIF.</p> / Master of Health Sciences (MSc)

This paper presents the behaviour and design of axially loaded concrete filled stainless steel circular and square hollow sections. The experimental investigation was conducted using different concrete cube strengths varied from 30 to 100 MPa. The column strengths and load-axial shortening curves were evaluated. The study is limited to cross-section capacity and has not been validated at member level. Comparisons of the tests results together with other available results from the literature have been made with existing design methods for composite carbon steel sections ¿ Eurocode 4 and ACI. It was found that existing design guidance for carbon steel may generally be safely applied to concrete filled stainless steel tubes, though it tends to be over-conservative. A continuous strength method is proposed and it is found to provide the most accurate and consistent prediction of the axial capacity of the composite concrete filled stainless steel hollow sections due largely to the more precise assessment of the contribution of the stainless steel tube to the composite resistance.

No / This study explores the lateral deflections of diagonal braces in concentrically-braced earthquake-resisting frames. The performance of this widely-used system is often compromised by the flexural buckling of slender braces in compression. In addition to reducing the compressive resistance, buckling may also cause these members to undergo sizeable lateral deflections which could damage surrounding structural components. Different approaches have been used in the past to predict the mid-length lateral deflections of cyclically loaded steel braces based on their theoretical deformed geometry or by using experimental data. Expressions have been proposed relating the mid-length lateral deflection to the axial displacement ductility of the member. Recent experiments were conducted on hollow and concrete-filled circular hollow section (CHS) braces of different lengths under cyclic loading. Very slender, concrete-filled tubular braces exhibited a highly ductile response, undergoing large axial displacements prior to failure. The presence of concrete infill did not influence the magnitude of lateral deflection in relation to the axial displacement, but did increase the number of cycles endured and the maximum axial displacement achieved. The corresponding lateral deflections exceeded the deflections observed in the majority of the previous experiments that were considered. Consequently, predictive expressions from previous research did not accurately predict the mid-height lateral deflections of these CHS members. Mid-length lateral deflections were found to be influenced by the member non-dimensional slenderness ( ) and hence a new expression was proposed for the lateral deflection in terms of member slenderness and axial displacement ductility. / TATA Steel

yes / The behaviour of seismic-resistant buildings relies heavily upon the inclusion of energy dissipating devices. For concentrically-braced frames, this function is accomplished by diagonal bracing members whose performance depends upon both cross-sectional properties and global slenderness. Traditionally preferred rectangular hollow sections are susceptible to local buckling, particularly in cold-formed tubes, owing to the residual stresses from manufacture. This paper explores the response of hollow and concrete-filled circular tubes under cyclic axial loading. The uniformity of the circular cross-section provides superior structural efficiency over rectangular sections and can be further optimised by the inclusion of concrete infill. A series of experiments was conducted on filled and hollow specimens to assess the merit of the composite section. Comparisons were drawn between hot-finished and cold-formed sections to establish the influence of fabrication on member performance. Two specimen lengths were utilised to assess the influence of non-dimensional slenderness. Parameters such as ductility, energy dissipation, tensile strength and compressive resistance are presented and compared with design codes and empirically derived predictions.

Yes / In this work, experimental and numerical investigations were performed on the behaviours of circular concrete filled double steel tubular (CFDST) slender columns and beams, in which the external tube employed stainless steel tube. Eighteen specimens, 12 slender columns and 6 beams, were tested to obtain the failure patterns, load versus deflection relationships and strain developments of stainless steel tube. A finite element (FE) model was developed and verified by experimental results. The validated FE model was then employed to investigate the effects of key parameters, including hollow ratio, eccentric ratio and material strength, on the load-carrying capacity. The load distribution among the components and contact stress between steel tube and sandwiched concrete were also analyzed. Finally, the design methods for CFDST, hollow CFST and solid CFST members with carbon steel external tube respectively suggested by Han et al. (2018), Chinese GB 50936-2014 (2014) and AISC 360-16 (2016) were employed to evaluate their applicability for the circular CFDST slender columns and beams with stainless steel outer tube. / The authors gratefully acknowledge the Shanxi Province Outstanding Youth Fund (No. 201701D211006) and the National Natural Science Foundation (No. 51838008).

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