Global ETD Search

1	MRI OF TUMOR pH AND PERFUSION Zhang, Xiaomeng January 2010 (has links) In the early 1920s, Otto Warburg demonstrated that tumor cells have a capacity to convert glucose and other substrates into lactic acid instead of CO2 and water, even under aerobic conditions. Consequently, Warburg assumed that the intracellular pH (pHi) of tumor was acidic. However, later studies have shown that maintenance of pHi within a pH range of 7.0-7.2 is necessary for normal cellular proliferation and that the extracellular pH (pHe) is partially acidic in solid tumors. A low pHe may be an important factor inducing invasive behavior in tumor cells. Research into causes and consequences of this acid pH of tumors are highly dependent on accurate, precise and reproducible measurements. Techniques for measuring tissue pHi and pHe have undergone great changes since 1950s. From microelectrode and dye distribution studies, measurement of pH underwent a revolution with the advent of pH-sensitive dyes that could be loaded into the cytosol. Further significant advances have come from the measurement of cell and tissue pH in whole organisms by magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI) and pH-sensitive Positron Emission Tomography (PET) radiotracers. Perfusion MRI pH imaging Tumor microenvironment Tumor pH Tumor vasculature
2	QUANTIFICATION OF FLOW PARAMETERS IN COMPLEX VASCULATURE FLOW PHANTOMS USING CONTRAST-ENHANCED ULTRASOUND METHOD Pawar, Asawari 27 August 2015 (has links) No description available. Acoustics
3	The Roles of the Phosphatases of Regenerating Liver (PRLs) in Oncology and Normal Physiology Frederick Georges Bernard Nguele Meke (16671573) 03 August 2023 (has links) <p> </p> <p>The phosphatases of regenerating liver are a subfamily of protein tyrosine phosphatases that consist of PRL1, PRL2 and PRL3. The overexpression of PRLs promote cell proliferation, migration and invasion and contribute to tumorigenesis and metastasis to aggravate survival outcome. Although there is increasing interest in understanding the implication of these phosphatases in tumor development, currently, limited knowledge is available about their mechanism of action and the efficacy of PRL inhibition in <em>in vivo</em> tumor models, the tumor extrinsic role of PRLs that allow them to impact tumor development, as well as <em>in vivo</em> physiological function of PRLs that could implicate them in diseases other than cancer. The work presented here aims to address these limitations.</p> <p><br></p> Signal transduction Tumour immunology Haematological tumours Solid tumours Phosphatase of regenerating liver Tp53 PTEN tumor microenviroment (TME) tumor immunogenic microenvironment tumor vasculature formation T cell activation Dendritic cell Obesity mitochondrial function-related genes Tp53 deficiency mouse models syngeneic MC38 mouse model

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